Hugo ten Cate

Professor

Prof. Hugo ten Cate graduated in Medicine at the University of Amsterdam in 1987. The title of his PhD thesis was 'Clinical and experimental studies with a low molecular weight heparinoid'. Hugo had his post-doctoral training at the laboratory of Prof. Robert Rosenberg and Dr Kenneth Bauer at the Beth Israel Hospital and Harvard Medical School Boston on mechanisms of inflammation associated coagulation activity (1988-1990). He completed his internal medicine training in 1996 and became a general internist in conjunction with research at Academic Medical Center (laboratory of Experimental Internal medicine, Prof. Pieter Reitsma). He received a Clinical Established Investigator grant from the Dutch Heart Foundation in 1998.

In 2002, Hugo ten Cate was appointed Professor of Clinical Thrombosis and Haemostasis at CARIM. In addition, Prof. ten Cate was appointed adjunct professor at the Center for Thrombosis and Haemostasis (CTH) at Gutenberg University Medical Center, Mainz, Germany in 2017

Since the transfer to CARIM in 2002 his research focus shifted from coagulation-inflammation research in sepsis models, to the broader field of cardiovascular (CV) disease (atherothrombosis and 'thrombo-inflammation'). A specific focus of current research is the pleiotropic actions of coagulation proteases in atherosclerosis, atherothrombosis and ischemia reperfusion injury. Clinical research is aimed at chronic thrombotic disease including peripheral artery disease, high risk patients with coronary disease on antithrombotic medication and, together with Dr Arina ten Cate-Hoek, on venous thrombosis and post thrombotic syndrome (PTS). He is workpackage leader in CVON consortia RACE-5 (coagulation and its impact on atrial fibrillation) and CONTRAST (acute ischemic stroke) and involved in the ITN consortia TAPAS and TICARDIO. His group has an ongoing target finding programme with Bayer (steered from CARIM by Dr Henri Spronk and Prof. Hugo ten Cate) as well as with 2M (on POC development).

Department of Biochemistry
Department of Internal Medicine
Universiteitssingel 50, 6229 ER Maastricht
PO Box 616, 6200 MD Maastricht
Room number: 4.344
T: +31(0)43 388 42 62

  • 2019
    • Kremers, B. M. M., Birocchi, S., van Oerle, R., Zeerleder, S., Spronk, H. M. H., Mees, B. M. E., Luken, B. M., ten Cate, H., & ten Cate-Hoek, A. J. (2019). Searching for a Common Thrombo-Inflammatory Basis in Patients With Deep Vein Thrombosis or Peripheral Artery Disease. Frontiers in cardiovascular medicine, 6, 1-11. [33]. https://doi.org/10.3389/fcvm.2019.00033
    • Panova-Noeva, M., Neu, M. A., Eckerle, S., Spix, C., Schneider, A., Schmidtmann, I., Spronk, H. M., Pfeiffer, N., Beutel, M., Lackner, K. J., Muenzel, T., ten Cate, H., Merzenich, H., Faber, J., & Wild, P. S. (2019). Cardiovascular risk factors are important determinants of platelet-dependent thrombin generation in adult survivors of childhood cancer. Clinical research in cardiology, 108(4), 438-447. https://doi.org/10.1007/s00392-018-1374-4
    • Posthuma, J. J., Posma, J. J. N., Schep, G., Bender, M. M. H., van Oerle, R., van der Wal, A. C., Ten Cate, H., & Spronk, H. M. H. (2019). Protease-activated receptors are potential regulators in the development of arterial endofibrosis in high-performance athletes. Journal of Vascular Surgery, 69(4), 1243-1250. https://doi.org/10.1016/j.jvs.2018.05.220
    • Posthuma, J. J., Posma, J. J. N., van Oerle, R., Leenders, P., van Gorp, R. H., Jaminon, A. M. G., Mackman, N., Heitmeier, S., Schurgers, L. J., ten Cate, H., & Spronk, H. M. H. (2019). Targeting Coagulation Factor Xa Promotes Regression of Advanced Atherosclerosis in Apolipoprotein-E Deficient Mice. Scientific Reports, 9, [3909]. https://doi.org/10.1038/s41598-019-40602-w
    • Donkel, S. J., Benaddi, B., Dippel, D. W. J., ten Cate, H., & de Maat, M. P. M. (2019). Prognostic Hemostasis Biomarkers in Acute Ischemic Stroke: A Systematic Review. Arteriosclerosis Thrombosis and Vascular Biology, 39(3), 360-372. https://doi.org/10.1161/ATVBAHA.118.312102
    • Vries, M. J. A., Macrae, F., Nelemans, P. J., Kuiper, G. J. A. J. M., Wetzels, R. J. H., Bowman, P., Verhezen, P. W. M., ten Cate, H., Ariens, R. A. S., & Henskens, Y. M. C. (2019). Assessment and determinants of whole blood and plasma fibrinolysis in patients with mild bleeding symptoms. Thrombosis Research, 174, 88-94. https://doi.org/10.1016/j.thromres.2018.12.004
    • Kuiper, G. J. A. J. M., van Egmond, L. T., Henskens, Y. M. C., Roekaerts, P. M., Maessen, J. G., ten Cate, H., Buhre, W. F., & Lance, M. D. (2019). Shifts of Transfusion Demand in Cardiac Surgery After Implementation of Rotational Thromboelastometry-Guided Transfusion Protocols: Analysis of the HEROES-CS (HEmostasis Registry of patiEntS in Cardiac Surgery) Observational, Prospective Open Cohort Database. Journal of Cardiothoracic and Vascular Anesthesia, 33(2), 307-317. https://doi.org/10.1053/j.jvca.2018.08.203
    • Grottke, O., van Ryn, J., Zentai, C., Gan, G., Honickel, M., Rossaint, R., Ten Cate, H., & Spronk, H. M. H. (2019). Volume replacement strategies do not impair the binding of dabigatran to idarucizumab: Porcine model of hemodilution. PLOS ONE, 14(1), e0209350. [0209350]. https://doi.org/10.1371/journal.pone.0209350
    • Moenen, F. C. J., Vries, M. J. A., Nelemans, P. J., van Rooy, K. J. M., Vranken, J. R. R. A., Verhezen, P. W. M., Wetzels, R. J. H., ten Cate, H., Schouten, H. C., Beckers, E. A. M., & Henskens, Y. M. C. (2019). Screening for platelet function disorders with Multiplate and platelet function analyzer. Platelets, 30(1), 81-87. https://doi.org/10.1080/09537104.2017.1371290
    • Leader, A., Ten Cate, V., Ten Cate-Hoek, A. J., Spectre, G., Beckers, E. A. M., Raanani, P., Giaccherini, C., Pereg, D., Schouten, H. C., Falanga, A., & Ten Cate, H. (2019). Managing Anti-Platelet Therapy in Thrombocytopaenic Patients with Haematological Malignancy: A Multinational Clinical Vignette-Based Experiment. Thrombosis and Haemostasis, 119(1), 163-174. https://doi.org/10.1055/s-0038-1676520
    • Ratzon, R., Tamir, S., Friehmann, T., Livneh, N., Dudnik, E., Rozental, A., Hamburger-Avnery, O., Pereg, D., Derazne, E., Brenner, B., Raanani, P., ten Cate, H., Spectre, G., & Leader, A. (2019). Thrombosis, anticoagulation and outcomes in malignant superior vena cava syndrome. Journal of Thrombosis and Thrombolysis, 47(1), 121-128. https://doi.org/10.1007/s11239-018-1747-6
    • Seelig, J., Pisters, R., Hemels, M. E., Huisman, M. V., ten Cate, H., & Alings, M. (2019). When to withhold oral anticoagulation in atrial fibrillation - an overview of frequent clinical discussion topics. Vascular health and risk management, 15, 399-408. https://doi.org/10.2147/VHRM.S187656
  • 2018
    • Leader, A., ten Cate, H., Spectre, G., Beckers, E. A. M., & Falanga, A. (2018). Antithrombotic medication in cancer-associated thrombocytopenia: Current evidence and knowledge gaps. Critical Reviews in Oncology/Hematology, 132, 76-88. https://doi.org/10.1016/j.critrevonc.2018.09.014
    • Prochaska, J. H., Goebel, S., Nagler, M., Knoepfler, T., Eggebrecht, L., Lamparter, H., Panova-Noeva, M., Keller, K., Coldewey, M., Bickel, C., Lauterbach, M., Hardt, R., Espinola-Klein, C., ten Cate, H., Rostock, T., Muenzel, T., & Wild, P. S. (2018). Sustained atrial fibrillation increases the risk of anticoagulation-related bleeding in heart failure. Clinical research in cardiology, 107(12), 1170-1179. https://doi.org/10.1007/s00392-018-1293-4
    • Amin, E. E., Bistervels, I. M., Meijer, K., Tick, L. W., Middeldorp, S., Mostard, G., van de Poel, M., Serne, E. H., Otten, H. M., Klappe, E. M., Joore, M. A., ten Cate, H., ten Wolde, M., & ten Cate-Hoek, A. J. (2018). Reduced incidence of vein occlusion and postthrombotic syndrome after immediate compression for deep vein thrombosis. Blood, 132(21), 2298-2304. https://doi.org/10.1182/blood-2018-03-836783
    • Favresse, J., Lippi, G., Roy, P-M., Chatelain, B., Jacqmin, H., ten Cate, H., & Mullier, F. (2018). D-dimer: Preanalytical, analytical, postanalytical variables, and clinical applications . Critical Reviews in Clinical Laboratory Sciences, 55(8), 548-577. https://doi.org/10.1080/10408363.2018.1529734
    • Amin, E. E., ten Cate-Hoek, A. J., Bouman, A. C., Meijer, K., Tick, L., Middeldorp, S., Mostard, G., ten Wolde, M., van den Heiligenberg, S., van Wissen, S., van de Poet, M., Villalta, S., Serne, E., Otten, H. M., Klappe, E., Prandoni, P., Prins, M. H., ten Cate, H., & Joore, M. A. (2018). Individually shortened duration versus standard duration of elastic compression therapy for prevention of post-thrombotic syndrome: a cost-effectiveness analysis. The Lancet Haematology , 5(11), E512-E519. https://doi.org/10.1016/S2352-3026(18)30151-0
    • Goebel, S., Prochaska, J. H., Eggebrecht, L., Schmitz, R., Juenger, C., Lamparter, H., Nagler, M., Keller, K., Coldewey, M., Troebs, S-O., Diestelmeier, S., Schwuchow-Thonke, S., Bickel, C., Lauterbach, M., Lackner, K. J., ten Cate, H., Muenzel, T., Hardt, R., & Wild, P. S. (2018). Management of Oral Anti-Coagulation in Patients with Heart Failure-Insights from the ThrombEVAL Study. Thrombosis and Haemostasis, 118(11), 1930-1939. https://doi.org/10.1055/s-0038-1673380
    • ten Cate, H., Lensing, A. W. A., Weitz, J. I., Middeldorp, S., Beyer-Westendorf, J., Kubitza, D., Brighton, T., Raskob, G. E., Mismetti, P., Prandoni, P., Gebel, M., & Prins, M. H. (2018). The prothrombin time does not predict the risk of recurrent venous thromboembolism or major bleeding in rivaroxaban-treated patients. Thrombosis Research, 170, 75-83. https://doi.org/10.1016/j.thromres.2018.08.008
    • Vries, M. J., van der Meijden, P. E., Kuiper, G. J., Nelemans, P. J., Wetzels, R. J., van Oerle, R. G., Lance, M. D., ten Cate, H., & Henskens, Y. M. (2018). Preoperative screening for bleeding disorders: A comprehensive laboratory assessment of clinical practice. Research and practice in thrombosis and haemostasis, 2(4), 767-777. https://doi.org/10.1002/rth2.12114
    • Eggebrecht, L., Prochaska, J. H., Schulz, A., Arnold, N., Juenger, C., Goebel, S., Laubert-Reh, D., Binder, H., Beutel, M. E., Pfeiffer, N., Blankenberg, S., Lackner, K. J., Spronk, H. M., ten Cate, H., Muenzel, T., & Wild, P. S. (2018). Intake of Vitamin K Antagonists and Worsening of Cardiac and Vascular Disease: Results From the Population-Based Gutenberg Health Study. Journal of the American Heart Association, 7(17), [008650]. https://doi.org/10.1161/JAHA.118.008650
    • ten Cate, H. (2018). Testing direct oral anticoagulants: embedding in structured long-term care. Blood Transfusion, 16(5), 410-412. https://doi.org/10.2450/2017.0197-17
    • Baaten, C. C. F. M. J., Moenen, F. C. J. I., Henskens, Y. M. C., Swieringa, F., Wetzels, R. J. H., van Oerle, R., Heijnen, H. F. G., ten Cate, H., Holloway, G. P., Beckers, E. A. M., Heemskerk, J. W. M., & van der Meijden, P. E. J. (2018). Impaired mitochondrial activity explains platelet dysfunction in thrombocytopenic cancer patients undergoing chemotherapy. Haematologica-the Hematology Journal, 103(9), 1557-1567. https://doi.org/10.3324/haematol.2017.185165
    • Amin, E. E., Joore, M. A., ten Cate, H., Meijer, K., Tick, L. W., Middeldorp, S., Mostard, G. J. M., ten Wolde, M., Van den Heiligenberg, S. M., Van Wissen, S., Van de Poel, M. H. W., Villalta, S., Serne, E. H., Otten, H-M., Klappe, E. H., Prandoni, P., & ten Cate-Hoek, A. J. (2018). Clinical and economic impact of compression in the acute phase of deep vein thrombosis. Journal of Thrombosis and Haemostasis, 16(8), 1555-1563. https://doi.org/10.1111/jth.14163
    • Crombag, G. A. J. C., Spronk, H. M., Nelemans, P., Schreuder, F. H. B. M., Truijman, M. T. B., van Dijk, A. C., de Rotte, A. A. J., Liem, M. I., Daemen, M. J. A. P., van der Steen, A. F. W., Mess, W. H., Nederkoorn, P. J., Hendrikse, J., van der Lugt, A., Wildberger, J. E., ten Cate, H., van Oostenbrugge, R. J., & Kooi, M. E. (2018). No Association between Thrombin Generation and Intra-Plaque Haemorrhage in Symptomatic Carotid Atherosclerotic Plaques: The Plaque at RISK (PARISK) Study. Thrombosis and Haemostasis, 118(8), 1461-1469. https://doi.org/10.1055/s-0038-1666858
    • Kremers, B. M. M., Ten Cate, H., & Spronk, H. M. H. (2018). Pleiotropic effects of the hemostatic system. Journal of Thrombosis and Haemostasis, 16(8), 1464-1473. https://doi.org/10.1111/jth.14161
    • D'Alessandro, E., Posma, J. J. N., Spronk, H. M. H., & ten Cate, H. (2018). Tissue factor (:Factor VIIa) in the heart and vasculature: More than an envelope. Thrombosis Research, 168, 130-137. https://doi.org/10.1016/j.thromres.2018.06.020
    • Amin, E. E., van Kuijk, S. M. J., Joore, M. A., Prandoni, P., ten Cate, H., & ten Cate-Hoek, A. J. (2018). Development and Validation of a Practical Two-Step Prediction Model and Clinical Risk Score for Post-Thrombotic Syndrome. Thrombosis and Haemostasis, 118(7), 1242-1249. https://doi.org/10.1055/s-0038-1655743
    • Vaidya, A., Kleinegris, M-C., Severens, J. L., Ramaekers, B. L., ten Cate-Hoek, A. J., ten Cate, H., & Joore, M. A. (2018). Comparison of EQ-5D and SF-36 in untreated patients with symptoms of intermittent claudication. Journal of Comparative Effectiveness Research, 7(6), 535-548. https://doi.org/10.2217/cer-2017-0029
    • Panova-Noeva, M., Schulz, A., Spronk, H. M., Beicht, A., Laubert-Reh, D., van Oerle, R., Arnold, N., Prochaska, J. H., Blettner, M., Beutel, M., Pfeiffer, N., Munzel, T., Lackner, K. J., ten Cate, H., & Wild, P. S. (2018). Clinical Determinants of Thrombin Generation Measured in Presence and Absence of Platelets-Results from the Gutenberg Health Study. Thrombosis and Haemostasis, 118(5), 873-882. https://doi.org/10.1055/s-0038-1641565
    • ten Cate, H., Olie, R. H., ten Cate-Hoek, A. J., & Henskens, Y. M. C. (2018). Direct oral anticoagulants: When to consider laboratory testing?International Journal of Laboratory Hematology, 40(S1), 30-33. https://doi.org/10.1111/ijlh.12816
    • Panova-Noeva, M., Schulz, A., Arnold, N., Hermanns, M. I., Prochaska, J. H., Laubert-Reh, D., Spronk, H. M., Blettner, M., Beutel, M., Pfeiffer, N., Munzel, T., Lackner, K. J., ten Cate, H., & Wild, P. S. (2018). Coagulation and inflammation in long-term cancer survivors: results from the adult population. Journal of Thrombosis and Haemostasis, 16(4), 699-708. https://doi.org/10.1111/jth.13975
    • Mackman, N., Spronk, H. M. H., Stouffer, G. A., & ten Cate, H. (2018). Dual Anticoagulant and Antiplatelet Therapy for Coronary Artery Disease and Peripheral Artery Disease Patients. Arteriosclerosis Thrombosis and Vascular Biology, 38(4), 726-732. https://doi.org/10.1161/ATVBAHA.117.310048
    • Nagler, M., ten Cate, H., Prins, M. H., & ten Cate-Hoek, A. J. (2018). Risk factors for recurrence in deep vein thrombosis patients following a tailored anticoagulant treatment incorporating residual vein obstruction. Research and practice in thrombosis and haemostasis, 2(2), 299-309. https://doi.org/10.1002/rth2.12079
    • Olie, R. H., van der Meijden, P. E. J., & ten Cate, H. (2018). The coagulation system in atherothrombosis: Implications for new therapeutic strategies. Research and practice in thrombosis and haemostasis, 2(2), 188-198. https://doi.org/10.1002/rth2.12080
    • Borst, O., Munzer, P., Alnaggar, N., Geue, S., Tegtmeyer, R., Rath, D., Droppa, M., Seizer, P., Heitmeier, S., Heemskerk, J. W. M., Jennings, L. K., Storey, R. F., Angiolillo, D. J., Rocca, B., Spronk, H., Ten Cate, H., Gawaz, M., & Geisler, T. (2018). Inhibitory mechanisms of very low-dose rivaroxaban in non-ST-elevation myocardial infarction. Blood advances, 2(6), 715-730. https://doi.org/10.1182/bloodadvances.2017013573
    • Kuiper, G. J. A. J. M., Christiaans, M. H. L., Mullens, M. H. J. . M., ten Cate, H., Hamulyak, K., & Henskens, Y. M. C. (2018). Routine haemostasis testing before transplanted kidney biopsy: a cohort study. Transplant International, 31(3), 302-312. https://doi.org/10.1111/tri.13090
    • Spronk, H. M. H., Padro, T., Siland, J. E., Prochaska, J. H., Winters, J., van der Wal, A. C., Posthuma, J. J., Lowe, G., d'Alessandro, E., Wenzel, P., Coenen, D. M., Reitsma, P. H., Ruf, W., van Gorp, R. H., Koenen, R. R., Vajen, T., Alshaikh, N. A., Wolberg, A. S., Macrae, F. L., ... ten Cate, H. (2018). Atherothrombosis and Thromboembolism: Position Paper from the Second Maastricht Consensus Conference on Thrombosis. Thrombosis and Haemostasis, 118(2), 229-250. https://doi.org/10.1160/TH17-07-0492
    • Henskens, Y. M. C., Gulpen, A. J. W., van Oerle, R., Wetzels, R., Verhezen, P., Spronk, H., Schalla, S., Crijns, H. J., ten Cate, H., & ten Cate-Hoek, A. (2018). Detecting clinically relevant rivaroxaban or dabigatran levels by routine coagulation tests or thromboelastography in a cohort of patients with atrial fibrillation. Thrombosis Journal, 16, [3]. https://doi.org/10.1186/s12959-017-0160-2
    • Douxfils, J., Ageno, W., Samama, C. -M., Lessire, S., ten Cate, H., Verhamme, P., Dogne, J. -M., & Mullier, F. (2018). Laboratory testing in patients treated with direct oral anticoagulants: a practical guide for clinicians. Journal of Thrombosis and Haemostasis, 16(2), 209-219. https://doi.org/10.1111/jth.13912
    • Brekelmans, M. P. A., Abdoellakhan, R. A., Scheres, L. J. J., Biedermann, J. S., Hutten, B. A., Meijer, K., ten Cate, H., Huisman, M., Kruip, M. J. H. A., Middeldorp, S., & Coppens, M. (2018). Clinical outcome of patients with a vitamin K antagonist-associated bleeding treated with prothrombin complex concentrate. Research and practice in thrombosis and haemostasis, 2(1), 77-84. https://doi.org/10.1002/rth2.12055
    • ten Cate-Hoek, A. J., Amin, E. E., Bouman, A. C., Meijer, K., Tick, L. W., Middeldorp, S., Mostard, G. J. M., ten Wolde, M., van den Heiligenberg, S. M., van Wissen, S., van de Poel, M. H. W., Villalta, S., Serne, E. H., Otten, H-M., Klappe, E. H., Bistervels, I. M., Lauw, M. N., Piersma-Wichers, M., Prandoni, P., ... IDEAL DVT Investigators (2018). Individualised versus standard duration of elastic compression therapy for prevention of post-thrombotic syndrome (IDEAL DVT): a multicentre, randomised, single-blind, allocation-concealed, non-inferiority trial. The Lancet Haematology , 5(1), 25-33. https://doi.org/10.1016/S2352-3026(17)30227-2
  • 2017
    • ten Cate, H., Henskens, Y. M. C., & Lance, M. D. (2017). Practical guidance on the use of laboratory testing in the management of bleeding in patients receiving direct oral anticoagulants. Vascular health and risk management, 13, 457-467. https://doi.org/10.2147/VHRM.S126265
    • Leers, M. P. G., Stockem, C., Ackermans, D., Loeffen, R., ten Cate, H., Kragten, J. A., & Jie, K-S. G. (2017). Intermediate and Nonclassical Monocytes Show Heterogeneity in Patients with Different Types of Acute Coronary Syndrome. Cytometry Part A, 91A(11), 1059-1067. https://doi.org/10.1002/cyto.a.23263
    • Baaten, C. C. F. M. J., ten Cate, H., van der Meijden, P. E. J., & Heemskerk, J. W. M. (2017). Platelet populations and priming in hematological diseases. Blood Reviews, 31(6), 389-399. https://doi.org/10.1016/j.blre.2017.07.004
    • Honickel, M., Braunschweig, T., Rossaint, R., Stoppe, C., ten Cate, H., & Grottke, O. (2017). Reversing Dabigatran Anticoagulation with Prothrombin Complex Concentrate versus Idarucizumab as Part of Multimodal Hemostatic Intervention in an Animal Model of Polytrauma. Anesthesiology, 127(5), 852-861. https://doi.org/10.1097/ALN.0000000000001856
    • Olie, R. H., Meertens, N. E. L., Henskens, Y. M. C., & ten Cate, H. (2017). Empirically Reduced Dosages of Tinzaparin in Patients with Moderate-to-Severe Renal Insufficiency Lead to Inadequate Anti-Xa Levels. The Nephron Journals, 137(2), 113-123. https://doi.org/10.1159/000477474
    • van der Huller, T., van Es, N., den Exter, P. L., van Es, J., Mos, I. C. M., Douma, R. A., Kruip, M. J. H. A., Hovens, M. M. C., ten Woldes, M., Nijkeuter, M., ten Cate, H., Kamphuisen, P. W., BuIler, H. R., Huisman, M. V., & Klok, F. A. (2017). Is a normal computed tomography pulmonary angiography safe to rule out acute pulmonary embolism in patients with a likely clinical probability?Thrombosis and Haemostasis, 117(8), 1622-1629. https://doi.org/10.1160/TH17-02-0076
    • Prochaska, J. H., Frank, B., Nagler, M., Lamparter, H., Weisser, G., Schulz, A., Eggebrecht, L., Goebel, S., Arnold, N., Panova-Noeva, M., Hermanns, I., Pinto, A., Konstantinides, S., ten Cate, H., Lackner, K. J., Muenzel, T., Espinola-Klein, C., & Wild, P. S. (2017). Age-related diagnostic value of D-dimer testing and the role of inflammation in patients with suspected deep vein thrombosis. Scientific Reports, 7, [4591]. https://doi.org/10.1038/s41598-017-04843-x
    • ten Cate, H., Hackeng, T. M., & de Frutos, P. G. (2017). Coagulation factor and protease pathways in thrombosis and cardiovascular disease. Thrombosis and Haemostasis, 117(7), 1265-1271. https://doi.org/10.1160/TH17-02-0079