Hugo ten Cate

Professor

Prof. Hugo ten Cate graduated in Medicine at the University of Amsterdam in 1987. The title of his PhD thesis was 'Clinical and experimental studies with a low molecular weight heparinoid'. Hugo had his post-doctoral training at the laboratory of Prof. Robert Rosenberg and Dr Kenneth Bauer at the Beth Israel Hospital and Harvard Medical School Boston on mechanisms of inflammation associated coagulation activity (1988-1990). He completed his internal medicine training in 1996 and became a general internist in conjunction with research at Academic Medical Center (laboratory of Experimental Internal medicine, Prof. Pieter Reitsma). He received a Clinical Established Investigator grant from the Dutch Heart Foundation in 1998.

In 2002, Hugo ten Cate was appointed Professor of Clinical Thrombosis and Haemostasis at CARIM. In addition, Prof. ten Cate was appointed adjunct professor at the Center for Thrombosis and Haemostasis (CTH) at Gutenberg University Medical Center, Mainz, Germany in 2017

Since the transfer to CARIM in 2002 his research focus shifted from coagulation-inflammation research in sepsis models, to the broader field of cardiovascular (CV) disease (atherothrombosis and 'thrombo-inflammation'). A specific focus of current research is the pleiotropic actions of coagulation proteases in atherosclerosis, atherothrombosis and ischemia reperfusion injury. Clinical research is aimed at chronic thrombotic disease including peripheral artery disease, high risk patients with coronary disease on antithrombotic medication and, together with Dr Arina ten Cate-Hoek, on venous thrombosis and post thrombotic syndrome (PTS). He is workpackage leader in CVON consortia RACE-5 (coagulation and its impact on atrial fibrillation) and CONTRAST (acute ischemic stroke) and involved in the ITN consortia TAPAS and TICARDIO. His group has an ongoing target finding programme with Bayer (steered from CARIM by Dr Henri Spronk and Prof. Hugo ten Cate) as well as with 2M (on POC development).

Department of Biochemistry
Department of Internal Medicine
Universiteitssingel 50, 6229 ER Maastricht
PO Box 616, 6200 MD Maastricht
Room number: 4.344
T: +31(0)43 388 42 62

  • 2022
    • Willems, L. H., Nagy, M., Ten Cate, H., Spronk, H. M. H., Groh, L. A., Leentjens, J., Janssen, N. A. F., Netea, M. G., Thijssen, D. H. J., Hannink, G., van Petersen, A. S., & Warle, M. C. (2022). Sustained inflammation, coagulation activation and elevated endothelin-1 levels without macrovascular dysfunction at 3 months after COVID-19. Thrombosis Research, 209, 106-114. https://doi.org/10.1016/j.thromres.2021.11.027
    • Vignoli, A., Gamba, S., van der Meijden, P. E. J., Marchetti, M., Russo, L., Tessarolo, S., Giaccherini, C., Swieringa, F., Cate, H. T., Finazzi, G., Heemskerk, J. W. M., & Falanga, A. (2022). Increased platelet thrombus formation under flow conditions in whole blood from polycythaemia vera patients. Blood Transfusion, 20(2), 143-151. https://doi.org/10.2450/2021.0456-20
  • 2021
    • Hulshof, A.-M., Olie, R. H., Vries, M. J. A., Verhezen, P. W. M., van der Meijden, P. E. J., Ten Cate, H., & Henskens, Y. M. C. (2021). Rotational Thromboelastometry in High-Risk Patients on Dual Antithrombotic Therapy After Percutaneous Coronary Intervention. Frontiers in Cardiovascular Medicine, 8, Article 788137. https://doi.org/10.3389/fcvm.2021.788137
    • Willems, L. H., Nagy, M., Ten Cate, H., Spronk, H. M. H., Jacobs, L. M. C., Kranendonk, J., van Leeuwen, M., Meijer, D., Middeldorp, S., Groh, L. A., & Warle, M. C. (2021). ChAdOx1 vaccination, blood coagulation, and inflammation: No effect on coagulation but increased interleukin-6. Research and practice in thrombosis and haemostasis, 5(8), Article e12630. https://doi.org/10.1002/rth2.12630
    • Sun, S. Y., Urbanus, R. T., ten Cate, H., de Groot, P. G., de Laat, B., Heemskerk, J. W. M., & Roest, M. (2021). Platelet Activation Mechanisms and Consequences of Immune Thrombocytopenia. Cells, 10(12), Article 3386. https://doi.org/10.3390/cells10123386
    • van Haaps, T. F. V., Collard, D., van Osch, F. H. M. V., Middeldorp, S., Coppens, M., de Kruif, M. D., Vlot, E. A., Douma, R. A., ten Cate, H., Juffermans, N. P., Gritters, N., Vlaar, A. P., Reidinga, A. C., Heuvelmans, M. A., Oudkerk, M., Buller, H. R., van den Bergh, J. P. W. V., Maas, A., Ten Wolde, M., ... Dutch COVID & Thrombosis Coalition (2021). Pre-admission anticoagulant therapy and mortality in hospitalized COVID-19 patients: A retrospective cohort study. Thrombosis Research, 208, 35-38. https://doi.org/10.1016/j.thromres.2021.10.006
    • D'Alessandro, E., Scaf, B., van Oerle, R., van Nieuwenhoven, F. A., van Hunnik, A., Verheule, S., Schotten, U., Ten Cate, H., & Spronk, H. M. H. (2021). Thrombin generation by calibrated automated thrombography in goat plasma: Optimization of an assay. Research and practice in thrombosis and haemostasis, 5(8), Article e12620. https://doi.org/10.1002/rth2.12620
    • van der Bruggen, M. M., Kremers, B., van Oerle, R., van Oostenbrugge, R. J., & ten Cate, H. (2021). Potential value of the calibrated automated thrombogram in patients after a cerebral venous sinus thrombosis; an exploratory study. Thrombosis Journal, 19(1), Article 81. https://doi.org/10.1186/s12959-021-00335-1
    • D'Alessandro, E., Scaf, B., Munts, C., van Hunnik, A., Trevelyan, C. J., Verheule, S., Spronk, H. M. H., Turner, N. A., ten Cate, H., Schotten, U., & van Nieuwenhoven, F. A. (2021). Coagulation Factor Xa Induces Proinflammatory Responses in Cardiac Fibroblasts via Activation of Protease-Activated Receptor-1. Cells, 10(11), Article 2958. https://doi.org/10.3390/cells10112958
    • Bruggemann, R. A. G., Alnima, T., Brouns, S. H. A., Hanssen, N. M. J., Schols, J. M. G. A., ten Cate, H., Spaetgens, B., & ten Cate-Hoek, A. J. (2021). A known unknown? Pharmacological prevention of venous thromboembolism in nursing home residents. Journal of the American Geriatrics Society, 69(11), 3338-3343. https://doi.org/10.1111/jgs.17422
    • Jiritano, F., Fina, D., Lorusso, R., ten Cate, H., Kowalewski, M., Matteucci, M., Serra, R., Mastroroberto, P., & Serraino, G. F. (2021). Systematic review and meta-analysis of the clinical effectiveness of point-of-care testing for anticoagulation management during ECMO. Journal of Clinical Anesthesia, 73, Article 110330. https://doi.org/10.1016/j.jclinane.2021.110330
    • Schreurs, R. H. P., Joore, M. A., ten Cate, H., & ten Cate-Hoek, A. J. (2021). Using the Functional Resonance Analysis Method to explore how elastic compression therapy is organised and could be improved from a multistakeholder perspective. BMJ Open, 11(10), Article e048331. https://doi.org/10.1136/bmjopen-2020-048331
    • Olie, R. H., van der Meijden, P. E. J., Vries, M. J. A., Veenstra, L., van't Hof, A. W. J., ten Berg, J. M., Henskens, Y. M. C., & ten Cate, H. (2021). Antithrombotic therapy in high-risk patients after percutaneous coronary intervention; study design, cohort profile and incidence of adverse events. Netherlands Heart Journal, 29(10), 525-535. https://doi.org/10.1007/s12471-021-01606-2
    • Olie, R. H., Hensgens, R. R. K., Wijnen, P. A. H. M., Veenstra, L. F., de Greef, B. T. A., Vries, M. J. A., van der Meijden, P. E. J., ten Berg, J. M., ten Cate, H., Bekers, O., & Henskens, Y. M. C. (2021). Differential Impact of Cytochrome 2C19 Allelic Variants on Three Different Platelet Function Tests in Clopidogrel-Treated Patients. Journal of Clinical Medicine, 10(17), Article 3992. https://doi.org/10.3390/jcm10173992
    • Giesen, P. L. A., Gulpen, A. J. W., van Oerle, R., ten Cate, H., Nagy, M., & Spronk, H. M. H. (2021). Calibrated automated thrombogram II: removing barriers for thrombin generation measurements. Thrombosis Journal, 19(1), Article 60. https://doi.org/10.1186/s12959-021-00312-8
    • ten Cate, H. (2021). Surviving Covid-19 with Heparin?New England Journal of Medicine, 385(9), 845-846. https://doi.org/10.1056/NEJMe2111151
    • Hulshof, A. M., Braeken, D. C. W., Ghossein-Doha, C., van Santen, S., Sels, J. W. E. M., Kuiper, G. J. A. J. M., van der Horst, I. C. C., ten Cate, H., van Bussel, B. C. T., Olie, R. H., & Henskens, Y. M. C. (2021). Hemostasis and fibrinolysis in COVID-19 survivors 6 months after intensive care unit discharge. Research and practice in thrombosis and haemostasis, 5(6), Article e12579. https://doi.org/10.1002/rth2.12579
    • Ten Cate, H., Guzik, T. J., Eikelboom, J., & Spronk, H. M. H. (2021). Pleiotropic actions of factor Xa inhibition in cardiovascular prevention - mechanistic insights and implications for anti-thrombotic treatment. Cardiovascular Research, 117(9), 2030-2044. https://doi.org/10.1093/cvr/cvaa263
    • ten Cate, H., & Lammle, B. (2021). Special Issue: "The Latest Clinical Advances in Thrombocytopenia". Journal of Clinical Medicine, 10(16), Article 3463. https://doi.org/10.3390/jcm10163463
    • Aarsetøy, R., Ten Cate, H., Spronk, H., Van Oerle, R., Aarsetøy, H., Staines, H., & Nilsen, D. W. T. (2021). Activated factor XI-antithrombin complex presenting as an independent predictor of 30-days mortality in out-of-hospital cardiac arrest patients. Thrombosis Research, 204, 1-8. https://doi.org/10.1016/j.thromres.2021.05.014
    • Livneh, N., Braeken, D., Drozdinsky, G., Gafter-Gvili, A., Seelig, J., Rozovski, U., Berger, T., Raanani, P., Falanga, A., ten Cate, H., Spectre, G., & Leader, A. (2021). Anticoagulation in patients with atrial fibrillation, thrombocytopenia and hematological malignancy. Journal of Thrombosis and Thrombolysis, 52(2), 590-596. https://doi.org/10.1007/s11239-021-02393-8
    • Dahlen, B., Schulz, A., Göbel, S., Tröbs, S.-O., Schwuchow-Thonke, S., Spronk, H. M., Prochaska, J. H., Arnold, N., Lackner, K. J., Gori, T., Ten Cate, H., Münzel, T., Wild, P. S., & Panova-Noeva, M. (2021). The impact of platelet indices on clinical outcome in heart failure: results from the MyoVasc study. Esc heart failure, 8(4), 2991-3001. https://doi.org/10.1002/ehf2.13390
    • Bavalia, R., Bistervels, I. M., Boersma, W. G., Quere, I., Brisot, D., Falvo, N., Stephan, D., Couturaud, F., Schellong, S., Montaclair, K., Ghanima, W., ten Wolde, M., Coppens, M., Ferrari, E., Sanchez, O., Carroll, P., Kahn, S. R., Meijer, K., Birocchi, S., ... Hokusai Post-PE Study Investigator (2021). Quality of life in patients with pulmonary embolism treated with edoxaban versus warfarin. Research and practice in thrombosis and haemostasis, 5(5), Article e12566. https://doi.org/10.1002/rth2.12566
    • Stals, M. A. M., Kaptein, F. H. J., Bemelmans, R. H. H., van Bemmel, T., Boukema, I. C., Braeken, D. C. W., Braken, S. J. E., Bresser, C., Cate, H. T., Deenstra, D. D., Dooren, Y. P. A. V., Faber, L. M., Grootenboers, M. J. J. H., Haan, L. R. D., Haazer, C., Sol, A. I. D., Kelliher, S., Koster, T., Kroft, L. J. M., ... Dutch COVID & Thrombosis Coalition (DCTC) (2021). Ruling out Pulmonary Embolism in Patients with (Suspected) COVID-19-A Prospective Cohort Study. TH open : companion journal to thrombosis and haemostasis, 5(3), e387-e399. https://doi.org/10.1055/s-0041-1735155
    • Baidildinova, G., Nagy, M., Jurk, K., Wild, P. S., ten Cate, H., & van der Meijden, P. E. J. (2021). Soluble Platelet Release Factors as Biomarkers for Cardiovascular Disease. Frontiers in Cardiovascular Medicine, 8, Article 684920. https://doi.org/10.3389/fcvm.2021.684920
    • Dahlen, B., Mueller, F., Troebs, S.-O., Heidorn, M. W., Schulz, A., Arnold, N., Hermanns, M. I., Schwuchow-Thonke, S., Prochaska, J. H., Gori, T., ten Cate, H., Lackner, K. J., Muenzel, T., Wild, P. S., & Panova-Noeva, M. (2021). Sex-Specific Relationship Between Parathyroid Hormone and Platelet Indices in Phenotypes of Heart Failure - Results From the MyoVasc Study. Frontiers in Cardiovascular Medicine, 8, Article 682521. https://doi.org/10.3389/fcvm.2021.682521
    • de Breet, C. P. D. M., Zwaveling, S., Vries, M. J. A., van Oerle, R. G., Henskens, Y. M. C., Van't Hof, A. W. J., van der Meijden, P. E. J., Veenstra, L., ten Cate, H., & Olie, R. H. (2021). Thrombin Generation as a Method to Identify the Risk of Bleeding in High Clinical-Risk Patients Using Dual Antiplatelet Therapy. Frontiers in Cardiovascular Medicine, 8, Article 679934. https://doi.org/10.3389/fcvm.2021.679934
    • Notten, P., de Smet, A. A. E. A., Tick, L. W., van de Poel, M. H. W., Wikkeling, O. R. M., Vleming, L.-J., Koster, A., Jie, K.-S. G., Jacobs, E. M. G., Ebben, H. P., Coppens, M., ten Cate, H., Wittens, C. H. A., & ten Cate-Hoek, A. J. (2021). CAVA (Ultrasound-Accelerated Catheter-Directed Thrombolysis on Preventing Post-Thrombotic Syndrome) Trial: Long-Term Follow-Up Results. Journal of the American Heart Association, 10(11), Article 018973. https://doi.org/10.1161/JAHA.120.018973
    • Iding, A. F. J., Witten, A., Isaacs, A., Castoldi, E., ten Cate, H., Stoll, M., & ten Cate-Hoek, A. J. (2021). Leukocyte gene expression in post-thrombotic syndrome. Thrombosis Research, 202, 40-42. https://doi.org/10.1016/j.thromres.2021.03.007
    • Donkel, S. J., Pater, K., Leebeek, F. W. G., Dippel, D. W. J., Ten Cate, H., & de Maat, M. P. M. (2021). Thrombin generation is associated with ischemic stroke at a young age. Thrombosis Research, 202, 139-144. https://doi.org/10.1016/j.thromres.2021.03.028
    • Mulder, M. M. G., Brandts, LI., Brüggemann, R. A. G., Koelmann, M., Streng, A. S., Olie, R. H., Gietema, H. A., Spronk, H. M. H., van der Horst, I. C. C., Sels, J.-W. E. M., Wildberger, J. E., van Kuijk, S. M. J., Schnabel, R. M., Ten Cate, H., Henskens, Y. M. C., & van Bussel, B. C. T. (2021). Serial markers of coagulation and inflammation and the occurrence of clinical pulmonary thromboembolism in mechanically ventilated patients with SARS-CoV-2 infection; the prospective Maastricht intensive care COVID cohort. Thrombosis Journal, 19(1), Article 35. https://doi.org/10.1186/s12959-021-00286-7
    • Hulshof, A. M., Vries, M., Verhezen, P., Wetzels, R., Haartmans, M., Olie, R., Ten Cate, H., & Henskens, Y. (2021). The Influence of Prostaglandin E1 and Use of Inhibitor Percentage on the Correlation between the Multiplate and VerifyNow in Patients on Dual Antiplatelet Therapy. Platelets, 32(4), 463-468. https://doi.org/10.1080/09537104.2020.1754378
    • Nagy, M., Fazaeli, S., van Oerle, R., Ten Cate, H., Schemmann, M., Sherry, J., Kelleher, G., & Spronk, H. M. H. (2021). Evaluation of the analytical performance of the PC100 platelet counter. Thrombosis Journal, 19(1), Article 29. https://doi.org/10.1186/s12959-021-00283-w
    • ten Cate, H. (2021). Thrombosis: Grand Challenges Ahead!Frontiers in Cardiovascular Medicine, 8, Article 637005. https://doi.org/10.3389/fcvm.2021.637005
    • Bavalia, R., Veenhuizen, J. E., Hengeveld, R. C. C., Braeken, D., Gulpen, A. J. W., Ten Cate, H., Middeldorp, S., Henskens, Y. M. C., Hutten, B. A., Coppens, M., & Stroobants, A. K. (2021). Direct oral anticoagulant blood level monitoring in daily practice. Thrombosis Update, 3, Article 100049. https://doi.org/10.1016/j.tru.2021.100049
    • ten Cate, H. (2021). Colorectal cancer and cardiovascular disease: A thrombo-inflammatory link?European journal of internal medicine, 87, 15-17. https://doi.org/10.1016/j.ejim.2021.03.019
    • Ninivaggi, M., de Laat-Kremers, R., Tripodi, A., Wahl, D., Zuily, S., Dargaud, Y., Cate, H. T., Ignjatovic, V., Devreese, K. M. J., & de Laat, B. (2021). Recommendations for the measurement of thrombin generation: Communication from the ISTH SSC Subcommittee on Lupus Anticoagulant/Antiphospholipid Antibodies. Journal of Thrombosis and Haemostasis, 19(5), 1372-1378. https://doi.org/10.1111/jth.15287
    • van de Berg, T. W., Hulshof, A.-M. M., Nagy, M., van Oerle, R., Sels, J.-W., van Bussel, B., Ten Cate, H., Henskens, Y., Spronk, H. M. H., & Dutch Covid-19 and Thrombosis Coalition (2021). Suggestions for global coagulation assays for the assessment of COVID-19 associated hypercoagulability. Thrombosis Research, 201, 84-89. https://doi.org/10.1016/j.thromres.2021.02.026
    • Hulshof, A.-M., Brüggemann, R. A. G., Mulder, M. M. G., van de Berg, T. W., Sels, J.-W. E. M., Olie, R. H., Spaetgens, B., Streng, A. S., Verhezen, P., van der Horst, I. C. C., Ten Cate, H., Spronk, H. M. H., van Bussel, B. C. T., & Henskens, Y. M. C. (2021). Serial EXTEM, FIBTEM, and tPA Rotational Thromboelastometry Observations in the Maastricht Intensive Care COVID Cohort-Persistence of Hypercoagulability and Hypofibrinolysis Despite Anticoagulation. Frontiers in Cardiovascular Medicine, 8, Article 654174. https://doi.org/10.3389/fcvm.2021.654174
    • Nagler, M., Van Kuijk, S. M. J., Ten Cate, H., Prins, M. H., & Ten Cate-Hoek, A. J. (2021). Predicting Recurrent Venous Thromboembolism in Patients With Deep-Vein Thrombosis: Development and Internal Validation of a Potential New Prediction Model (Continu-8). Frontiers in Cardiovascular Medicine, 8, Article 655226. https://doi.org/10.3389/fcvm.2021.655226
    • ten Cate, H., & Leader, A. (2021). Management of Disseminated Intravascular Coagulation in Acute Leukemias. Hämostaseologie, 41(02), 120-126. https://doi.org/10.1055/a-1393-8302
    • Hulshof, A.-M., Hemker, H. C., Spronk, H. M. H., Henskens, Y. M. C., & Ten Cate, H. (2021). Thrombin-Fibrin(ogen) Interactions, Host Defense and Risk of Thrombosis. International journal of molecular sciences, 22(5), Article 2590. https://doi.org/10.3390/ijms22052590
    • Kaptein, F. H. J., Stals, M. A. M., Grootenboers, M., Braken, S. J. E., Burggraaf, J. L. I., van Bussel, B. C. T., Cannegieter, S. C., Ten Cate, H., Endeman, H., Gommers, D. A. M. P. J., van Guldener, C., de Jonge, E., Juffermans, N. P., Kant, K. M., Kevenaar, M. E., Koster, S., Kroft, L. J. M., Kruip, M. J. H. A., Leentjens, J., ... Dutch COVID & Thrombosis Coalition (2021). Incidence of thrombotic complications and overall survival in hospitalized patients with COVID-19 in the second and first wave. Thrombosis Research, 199, 143-148. https://doi.org/10.1016/j.thromres.2020.12.019
    • Notten, P., ten Cate, H., & ten Cate-Hoek, A. J. (2021). Postinterventional antithrombotic management after venous stenting of the iliofemoral tract in acute and chronic thrombosis: A systematic review. Journal of Thrombosis and Haemostasis, 19(3), 753-796. https://doi.org/10.1111/jth.15197
    • Kruip, M. J. H. A., Cannegieter, S. C., ten Cate, H., van Gorp, E. C. M., Juffermans, N. P., Klok, F. A., Maas, C., Vonk-Noordegraaf, A., & Dutch & COVID Thrombosis Coalition study group (2021). Caging the dragon: Research approach to COVID-19-related thrombosis. Research and practice in thrombosis and haemostasis, 5(2), 278-291. https://doi.org/10.1002/rth2.12470
    • Squiccimarro, E., Jiritano, F., Serraino, G. F., ten Cate, H., Paparella, D., & Lorusso, R. (2021). Quantitative and Qualitative Platelet Derangements in Cardiac Surgery and Extracorporeal Life Support. Journal of Clinical Medicine, 10(4), Article 615. https://doi.org/10.3390/jcm10040615
    • van Paridon, P. C. S., Panova-Noeva, M., van Oerle, R., Schulz, A., Prochaska, J. H., Arnold, N., Schmidtmann, I., Beutel, M., Pfeiffer, N., Muenzel, T., Lackner, K. J., Hackeng, T. M., ten Cate, H., Wild, P. S., & Spronk, H. M. H. (2021). Relation between Tissue Factor Pathway Inhibitor Activity and Cardiovascular Risk Factors and Diseases in a Large Population Sample. Thrombosis and Haemostasis, 121(02), 174-181. https://doi.org/10.1055/s-0040-1715897
    • Eggebrecht, L., Ludolph, P., Gobel, S., Panova-Noeva, M., Arnold, N., Nagler, M., Bickel, C., Lauterbach, M., Hardt, R., Ten Cate, H., Lackner, K. J., Espinola-Klein, C., Munzel, T., Prochaska, J. H., & Wild, P. S. (2021). Cost saving analysis of specialized, eHealth-based management of patients receiving oral anticoagulation therapy: Results from the thrombEVAL study. Scientific Reports, 11(1), Article 2577. https://doi.org/10.1038/s41598-021-82076-9
  • 2020
    • Seelig, J., Hemels, M. E. W., Xhaet, O., Bongaerts, M. C. M., de Wolf, A., Groenemeijer, B. E., Heyse, A., Hoogslag, P., Voet, J., Herrman, J.-P. R., Vervoort, G., Hermans, W., Wollaert, B., Boersma, L. V. A., Hermans, K., Lucassen, A., Verstraete, S., Adriaansen, H. J., Mairesse, G. H., ... GARFIELD-AF Investigators (2020). Impact of different anticoagulation management strategies on outcomes in atrial fibrillation: Dutch and Belgian results from the GARFIELD-AF registry. Journal of Thrombosis and Haemostasis, 18(12), 3280-3288. https://doi.org/10.1111/jth.15081