Hugo ten Cate

Professor

Prof. Hugo ten Cate graduated in Medicine at the University of Amsterdam in 1987. The title of his PhD thesis was 'Clinical and experimental studies with a low molecular weight heparinoid'. Hugo had his post-doctoral training at the laboratory of Prof. Robert Rosenberg and Dr Kenneth Bauer at the Beth Israel Hospital and Harvard Medical School Boston on mechanisms of inflammation associated coagulation activity (1988-1990). He completed his internal medicine training in 1996 and became a general internist in conjunction with research at Academic Medical Center (laboratory of Experimental Internal medicine, Prof. Pieter Reitsma). He received a Clinical Established Investigator grant from the Dutch Heart Foundation in 1998.

In 2002, Hugo ten Cate was appointed Professor of Clinical Thrombosis and Haemostasis at CARIM. In addition, Prof. ten Cate was appointed adjunct professor at the Center for Thrombosis and Haemostasis (CTH) at Gutenberg University Medical Center, Mainz, Germany in 2017

Since the transfer to CARIM in 2002 his research focus shifted from coagulation-inflammation research in sepsis models, to the broader field of cardiovascular (CV) disease (atherothrombosis and 'thrombo-inflammation'). A specific focus of current research is the pleiotropic actions of coagulation proteases in atherosclerosis, atherothrombosis and ischemia reperfusion injury. Clinical research is aimed at chronic thrombotic disease including peripheral artery disease, high risk patients with coronary disease on antithrombotic medication and, together with Dr Arina ten Cate-Hoek, on venous thrombosis and post thrombotic syndrome (PTS). He is workpackage leader in CVON consortia RACE-5 (coagulation and its impact on atrial fibrillation) and CONTRAST (acute ischemic stroke) and involved in the ITN consortia TAPAS and TICARDIO. His group has an ongoing target finding programme with Bayer (steered from CARIM by Dr Henri Spronk and Prof. Hugo ten Cate) as well as with 2M (on POC development).

Department of Biochemistry
Department of Internal Medicine
Universiteitssingel 50, 6229 ER Maastricht
PO Box 616, 6200 MD Maastricht
Room number: 4.344
T: +31(0)43 388 42 62

  • 2015
    • den Exter, P. L., van Es, J., Kroft, L. J. M., Erkens, P. M. G., Douma, R. A., Mos, I. C. M., Jonkers, G., Hovens, M. M. C., Durian, M. F., ten Cate, H., Beenen, L. F. M., Kamphuisen, P. W., & Huisman, M. V. (2015). Thromboembolic resolution assessed by CT pulmonary angiography after treatment for acute pulmonary embolism. Thrombosis and Haemostasis, 114(1), 26-34. https://doi.org/10.1160/TH14-10-0842
    • Grottke, O., & ten Cate, H. (2015). Reply to Faraoni D, Fenger-Eriksen C, Gillard S et al. Evaluation of dynamic parameters of thrombus formation measured on whole blood using rotational thromboelastometry in children undergoing cardiac surgery: a descriptive study. Pediatric Anesthesia, 25(6), 646-647. https://doi.org/10.1111/pan.12650
    • Hermanns, M. I., Grossmann, V., Spronk, H. M. H., Schulz, A., Juenger, C., Laubert-Reh, D., Mazur, J., Gori, T., Zeller, T., Pfeiffer, N., Beutel, M., Blankenberg, S., Muenzel, T., Lackner, K. J., Hoek - ten Cate, A. J., ten Cate, H., & Wild, P. S. (2015). Distribution, genetic and cardiovascular determinants of FVIII:c - Data from the population-based Gutenberg Health Study. International Journal of Cardiology, 187(1), 166-174. https://doi.org/10.1016/j.ijcard.2015.03.330
    • Posthuma, J. J., van der Meijden, P. E. J., ten Cate, H., & Spronk, H. M. H. (2015). Short- and Long-term exercise induced alterations in haemostasis: a review of the literature. Blood Reviews, 29(3), 171-178. https://doi.org/10.1016/j.blre.2014.10.005
    • GARFIELD-AF Investigators, & ten Cate, H. (2015). Does Sex Affect Anticoagulant Use for Stroke Prevention in Nonvalvular Atrial Fibrillation? The Prospective Global Anticoagulant Registry in the FIELD-Atrial Fibrillation. Circulation : Cardiovascular Quality and Outcomes, 8(2), S12-S20. https://doi.org/10.1161/CIRCOUTCOMES.114.001556
    • van Geffen, J. P., Kleinegris, M.-C., Verdoold, R., Baaten, C. C. F. M. J., Cosemans, J. M. E. M., Clemetson, K. J., ten Cate, H., Roest, M., de Laat, B., & Heemskerk, J. W. M. (2015). Normal Platelet Activation Profile in Patients with Peripheral Arterial Disease on Aspirin. Thrombosis Research, 135(3), 513-520. https://doi.org/10.1016/j.thromres.2014.12.029
    • Eijgenraam, P., Meertens, N., van den Ham, R., ten Cate, H., & Hoek - ten Cate, A. (2015). The effect of clinical decision support on adherence to thrombosis prophylaxis guidelines in medical patients; A single center experience. Thrombosis Research, 135(3), 464-471. https://doi.org/10.1016/j.thromres.2014.12.012
    • Prochaska, J. H., Goebel, S., Keller, K., Coldewey, M., Ullmann, A., Lamparter, H., Juenger, C., Al-Bayati, Z., Baer, C., Walter, U., Bickel, C., ten Cate, H., Muenzel, T., & Wild, P. S. (2015). Quality of oral anticoagulation with phenprocoumon in regular medical care and its potential for improvement in a telemedicine-based coagulation service - results from the prospective, multi-center, observational cohort study thrombEVAL. BMC Medicine, 13(1), Article 14. https://doi.org/10.1186/s12916-015-0268-9
  • 2014
    • Loeffen, R., van Oerle, R., de Groot, P. G., Waltenberger, J., Crijns, H. J., Spronk, H. M. H., & ten Cate, H. (2014). Increased factor XIa levels in patients with a first acute myocardial infarction: The introduction of a new thrombin generation based factor XIa assay. Thrombosis Research, 134(6), 1328-1334. https://doi.org/10.1016/j.thromres.2014.09.015
    • van der Hulle, T., den Exter, P. L., Mos, I. C. M., Kamphuisen, P. W., Hovens, M. M. C., Kruip, M. J. H. A., van Es, J., ten Cate, H., Huisman, M. V., & Klok, F. A. (2014). Optimization of the diagnostic management of clinically suspected pulmonary embolism in hospitalized patients. British Journal of Haematology, 167(5), 681-686. https://doi.org/10.1111/bjh.13090
    • ten Cate, H., & Lowe, G. (2014). Coagulation proteases and cardiovascular disease. Thrombosis and Haemostasis, 112(5), 858-859. https://doi.org/10.1160/TH14-09-0781
    • Nagler, M., & ten Cate, H. (2014). Thromboelastometry changes in myeloproliferative neoplasms-surrogate for a procoagulant haemostatic imbalance or a consequence of technical reasons? Comment on A-Tripodi et al. Ann Hematol (2013) 92:1633-1639. Annals of Hematology, 93(10), 1781-1782. https://doi.org/10.1007/s00277-014-2059-3
    • Wildhagen, K. C. A. A., Schrijver, R., Beckers, L., ten Cate, H., Reutelingsperger, C. P. M., Lutgens, E., & Nicolaes, G. A. F. (2014). Effects of Exogenous Recombinant APC in Mouse Models of Ischemia Reperfusion Injury and of Atherosclerosis. PLOS ONE, 9(7), Article e101446. https://doi.org/10.1371/journal.pone.0101446
    • Nagler, M., ten Cate, H., Kathriner, S., Casutt, M., Bachmann, L. M., & Wuillemin, W. A. (2014). Consistency of thromboelastometry analysis under scrutiny: Results of a systematic evaluation within and between analysers. Thrombosis and Haemostasis, 111(6), 1161-1166. https://doi.org/10.1160/TH13-10-0870
    • Shadid, N. H., van der Velden, S. K., van Oerle, R., ten Cate, H., Sommer, A., & Nelemans, P. (2014). In vivo effects of foam sclerotherapy on coagulation. Phlebology: The Journal of Venous Disease, 29(5), 287-292. https://doi.org/10.1177/0268355513479590
    • Posthuma, J. J., Loeffen, R., van Oerle, R., Henskens, Y. M. C., ten Cate, H., Spronk, H. M. H., & van der Meijden, P. E. J. (2014). Long-term strenuous exercise induces a hypercoagulable state through contact activation. Thrombosis and Haemostasis, 111(6), 1197-1199. https://doi.org/10.1160/TH13-11-0963
    • Spronk, H. M. H., ten Cate, H., & van der Meijden, P. E. J. (2014). Differential roles of Tissue Factor and Phosphatidylserine in activation of coagulation. Thrombosis Research, 133(SUPPL. 1), S54-S56. https://doi.org/10.1016/j.thromres.2014.03.022
    • ten Cate, H., & Meade, T. (2014). The Northwick Park Heart Study: evidence from the laboratory. Journal of Thrombosis and Haemostasis, 12(5), 587-592. https://doi.org/10.1111/jth.12545
    • Eijgenraam, P., ten Cate, H., & ten Cate-Hoek, A. J. (2014). Practice of bridging anticoagulation: guideline adherence and risk factors for bleeding. Netherlands Journal of Medicine, 72(3), 157-164.
    • Spronk, H. M. H., de Jong, A. M., Crijns, H. J., Schotten, U., Van Gelder, I. C., & ten Cate, H. (2014). Pleiotropic effects of factor Xa and thrombin: what to expect from novel anticoagulants. Cardiovascular Research, 101(3), 344-351. https://doi.org/10.1093/cvr/cvt343
    • Ninivaggi, M., Feijge, M. A. H., Baaten, C. C. F. M. J., Kuiper, G. J. A. J. M., Marcus, M. A. E., ten Cate, H., Lance, M. D., Heemskerk, J. W. M., & van der Meijden, P. E. J. (2014). Additive roles of platelets and fibrinogen in whole-blood fibrin clot formation upon dilution as assessed by thromboelastometry. Thrombosis and Haemostasis, 111(3), 447-457. https://doi.org/10.1160/TH13-06-0493
    • Bosch, Y. P. J., al Dieri, R., ten Cate, H., Nelemans, P. J., Bloemen, S., de Laat, B., Hemker, C., Weerwind, P. W., Maessen, J. G., & Mochtar, B. (2014). Measurement of thrombin generation intra-operatively and its association with bleeding tendency after cardiac surgery. Thrombosis Research, 133(3), 488-494. https://doi.org/10.1016/j.thromres.2013.12.017
    • Kamphuisen, P. W., & ten Cate, H. (2014). Cardiovascular risk in patients with hemophilia. Blood, 123(9), 1297-1301. https://doi.org/10.1182/blood-2013-11-453159
    • Vaidya, A., Joore, M. A., Hoek - ten Cate, A. J., ten Cate, H., & Severens, J. L. (2014). Screen or not to screen for peripheral arterial disease: guidance from a decision model. BMC Public Health, 14(1), Article 89. https://doi.org/10.1186/1471-2458-14-89
    • Erkens, P. M. G., Lucassen, W. A. M., Geersing, G. J., van Weert, H. C. P. M., Kuijs-Augustijn, M., van Heugten, M., Rietjens, L., ten Cate, H., Prins, M. H., Büller, H. R., Hoes, A. W., Moons, K. G. M., Oudega, R., & Stoffers, H. E. J. H. (2014). Alternative diagnoses in patients in whom the GP considered the diagnosis of pulmonary embolism. Family Practice, (6). https://doi.org/10.1093/fampra/cmu055
    • Vaidya, A., Joore, M. A., ten Cate-Hoek, A. J., Kleinegris, M. C., ten Cate, H., & Severens, J. L. (2014). A systematic review of model-based economic evaluations of diagnostic and therapeutic strategies for lower extremity artery disease. Thrombosis and Haemostasis, 111(1), 19-28. https://doi.org/10.1160/TH13-06-0498
    • Vaidya, A., Joore, M. A., ten Cate-Hoek, A. J., ten Cate, H., & Severens, J. L. (2014). Cost-effectiveness of risk assessment and tailored treatment for peripheral arterial disease patients. Biomarkers in Medicine, 8(8), 989-999. https://doi.org/10.2217/BMM.14.45
    • Kalz, J., ten Cate, H., & Spronk, H. M. H. (2014). Thrombin generation and atherosclerosis. Journal of Thrombosis and Thrombolysis, 37(1), 45-55. https://doi.org/10.1007/s11239-013-1026-5
    • Cornelis, T., Broers, N. J. H., Titulaer, D. C. L. M., Henskens, Y. M., van Oerle, R., van der Sande, F. M., Spronk, H. M., Vink, H., Leunissen, K. M., ten Cate, H., & Kooman, J. P. (2014). Effects of Ultrapure Hemodialysis and Low Molecular Weight Heparin on the Endothelial Surface Layer. Blood Purification, 38(3-4), 203-210. https://doi.org/10.1159/000369055
  • 2013
    • Hilhorst, M., Winckers, K., Wilde, B., van Oerle, R., ten Cate, H., & Tervaert, J. W. C. (2013). Patients with Antineutrophil Cytoplasmic Antibodies Associated Vasculitis in Remission Are Hypercoagulable. Journal of Rheumatology, 40(12), 2042-2046. https://doi.org/10.3899/jrheum.130200
    • Spronk, H. M. H., Borissoff, J. I., & ten Cate, H. (2013). New Insights into Modulation of Thrombin Formation. Current Atherosclerosis Reports, 15(11), Article 363. https://doi.org/10.1007/s11883-013-0363-3
    • Van der Hulle, T., Den Exter, P. L., Erkens, P. G. M., Van Es, J., Mos, I. C. M., Ten Cate, H., Kamphuisen, P. W., Hovens, M. M. C., Buller, H. R., Klok, F. A., & Huisman, M. V. (2013). Variable D-dimer thresholds for diagnosis of clinically suspected acute pulmonary embolism. Journal of Thrombosis and Haemostasis, 11(11), 1986-1992. https://doi.org/10.1111/jth.12394
    • Konings, J., Cugno, M., Suffritti, C., ten Cate, H., Cicardi, M., & Govers-Riemslag, J. W. P. (2013). Ongoing Contact Activation in Patients with Hereditary Angioedema. PLOS ONE, 8(8), Article e74043. https://doi.org/10.1371/journal.pone.0074043
    • Kleinegris, M.-C. F., ten Cate, H., & ten Cate-Hoek, A. J. (2013). D-dimer as a marker for cardiovascular and arterial thrombotic events in patients with peripheral arterial disease A systematic review. Thrombosis and Haemostasis, 110(2), 233-243. https://doi.org/10.1160/TH13-01-0032
    • Borissoff, J. I., Joosen, I. A., Versteylen, M. O., Brill, A., Fuchs, T. A., Savchenko, A. S., Gallant, M., Martinod, K., ten Cate, H., Hofstra, L., Crijns, H. J., Wagner, D. D., & Kietselaer, B. L. J. H. (2013). Elevated Levels of Circulating DNA and Chromatin Are Independently Associated With Severe Coronary Atherosclerosis and a Prothrombotic State. Arteriosclerosis Thrombosis and Vascular Biology, 33(8), 2032-2040. https://doi.org/10.1161/ATVBAHA.113.301627
    • Konings, J., Govers-Riemslag, J. W. P., Spronk, H. M. H., Waltenberger, J. L., & ten Cate, H. (2013). Activation of the contact system in patients with a first acute myocardial infarction. Thrombosis Research, 132(1), 138-142. https://doi.org/10.1016/j.thromres.2013.05.016
    • Panova-Noeva, M., Marchetti, M., Russo, L., Tartari, C. J., Leuzzi, A., Finazzi, G., Rambaldi, A., ten Cate, H., & Falanga, A. (2013). ADP-induced platelet aggregation and thrombin generation are increased in Essential Thrombocythemia and Polycythemia Vera. Thrombosis Research, 132(1), 88-93. https://doi.org/10.1016/j.thromres.2013.05.003
    • Eijgenraam, P., ten Cate, H., & ten Cate-Hoek, A. (2013). Safety and Efficacy of Bridging with Low Molecular Weight Heparins: A Systematic Review and Partial Meta-Analysis. Current Pharmaceutical Design, 19(22), 4014-4023. https://doi.org/10.2174/1381612811319220010
    • Smid, M., Dielis, A. W. J. H., Spronk, H. M. H., Rumley, A., van Oerle, R., Woodward, M., ten Cate, H., & Lowe, G. (2013). Thrombin Generation in the Glasgow Myocardial Infarction Study. PLOS ONE, 8(6), Article e66977. https://doi.org/10.1371/journal.pone.0066977
    • Bosch, Y., Al Dieri, R., Ten Cate, H., Nelemans, P., Bloemen, S., Hemker, C., Weerwind, P., Maessen, J., & Mochtar, B. (2013). Preoperative thrombin generation is predictive for the risk of blood loss after cardiac surgery: a research article. Journal of Cardiothoracic Surgery, 8(1). https://doi.org/10.1186/1749-8090-8-154
    • Theuwissen, E., Teunissen, K. J., Spronk, H. M. H., Hamulyak, K., Ten Cate, H., Shearer, M. J., Vermeer, C., & Schurgers, L. J. (2013). Effect of low-dose supplements of menaquinone-7 (vitamin K-2) on the stability of oral anticoagulant treatment: dose-response relationship in healthy volunteers. Journal of Thrombosis and Haemostasis, 11(6), 1085-1092. https://doi.org/10.1111/jth.12203
    • van der Meijden, P. E. J., Bouman, A. C., Feijge, M. A. H., van Oerle, R., Spronk, H. M. H., Hamulyak, K., ten Cate-Hoek, A. J., ten Cate, H., & Heemskerk, J. W. M. (2013). Platelet Dysfunction in Thrombosis Patients Treated with Vitamin K Antagonists and Recurrent Bleeding. PLOS ONE, 8(5). https://doi.org/10.1371/journal.pone.0064112
    • Grottke, O., Rossaint, R., Henskens, Y., van Oerle, R., ten Cate, H., & Spronk, H. H. (2013). Thrombin Generation Capacity of Prothrombin Complex Concentrate in an In Vitro Dilutional Model. PLOS ONE, 8(5), Article e64100. https://doi.org/10.1371/journal.pone.0064100
    • Winckers, K., ten Cate, H., & Hackeng, T. M. (2013). The role of tissue factor pathway inhibitor in atherosclerosis and arterial thrombosis. Blood Reviews, 27(3), 119-132. https://doi.org/10.1016/j.blre.2013.03.001
    • Ten Cate-Hoek, A. J., Prins, M. H., Wittens, C. H. A., & Cate, H. T. (2013). Postintervention duration of anticoagulation in venous surgery. Phlebology: The Journal of Venous Disease, 28(1_suppl), 105-111. https://doi.org/10.1177/0268355513476415
    • Borissoff, J. I., Otten, J. J. T., Heeneman, S., Leenders, P., van Oerle, R., Soehnlein, O., Loubele, S. T. B. G., Hamulyak, K., Hackeng, T. M., Daemen, M. J. A. P., Degen, J. L., Weiler, H., Esmon, C. T., van Ryn, J., Biessen, E. A. L., Spronk, H. M. H., & ten Cate, H. (2013). Genetic and Pharmacological Modifications of Thrombin Formation in Apolipoprotein E-deficient Mice Determine Atherosclerosis Severity and Atherothrombosis Onset in a Neutrophil-Dependent Manner. PLOS ONE, 8(2), Article e55784. https://doi.org/10.1371/journal.pone.0055784
  • 2012
    • Borissoff, J. I., Joosen, I. A., Versteylen, M. O., Spronk, H. M., ten Cate, H., & Hofstra, L. (2012). Accelerated In Vivo Thrombin Formation Independently Predicts the Presence and Severity of CT Angiographic Coronary Atherosclerosis. JACC-Cardiovascular Imaging, 5(12), 1201-1210. https://doi.org/10.1016/j.jcmg.2012.01.023
    • Dargaud, Y., Wolberg, A. S., Luddington, R., Regnault, V., Spronk, H., Baglin, T., Lecompte, T., Ten Cate, H., & Negrier, C. (2012). Evaluation of a standardized protocol for thrombin generation measurement using the calibrated automated thrombogram: An international multicentre study. Thrombosis Research, 130(6), 929-934. https://doi.org/10.1016/j.thromres.2012.07.017
    • Loeffen, R., Kleinegris, M. .-C. F., Loubele, S. T. B. G., Pluijmen, P. H. M., Fens, D., van Oerle, R., ten Cate, H., & Spronk, H. M. H. (2012). Preanalytic variables of thrombin generation: towards a standard procedure and validation of the method. Journal of Thrombosis and Haemostasis, 10(12), 2544-2554. https://doi.org/10.1111/jth.12012
    • Geenen, I. L., Post, M. J., Molin, D. G. M., Schurink, G. W. H., Maessen, J. G., van Oerle, R., ten Cate, H., & Spronk, H. M. H. (2012). Coagulation on endothelial cells: the underexposed part of Virchow's Triad. Thrombosis and Haemostasis, 108(5), 863-871. https://doi.org/10.1160/TH12-04-0269