• 2005
    • Meex, S. J. R., van der Kallen, C. J. H., van Greevenbroek, M. M., Eurlings, P. M., El Hasnaoui, M. M., Evelo, C. T., Lindsey, P. J., Luiken, J. J. F. P., Glatz, J. F., & de Bruin, T. W. (2005). Up-regulation of CD36/FAT in preadipocytes in familial combined hyperlipidemia. Faseb Journal, 19(14), 2063-2065. https://doi.org/10.1096/fj.04-2403fje
    • Dirksen, A., Langereis, S., de Waal, BFM., van Genderen, MHP., Hackeng, TM., & Meijer, EW. (2005). A supramolecular approach to multivalent target-specific MRI contrast agents for angiogenesis. Chemical Communications, (22), 2811-2813. https://doi.org/10.1039/b502347e
    • van Baal, W. M., Malda, H., Synowsky, SA., van Dongen, JLJ., Hackeng, TM., Merkx, M., & Meijer, EW. (2005). Multivalent peptide and protein dendrimers using native chemical ligation. Angewandte Chemie-International Edition, 44(32), 5052-5057. https://doi.org/10.1002/anie.200500635
  • 2004
    • Dirksen, A., Langereis, S., de Waal, BFM., van Genderen, MHP., Meijer, EW., de Lussanet, QG., & Hackeng, TM. (2004). Design and synthesis of a bimodal target-specific contrast agent for angiogenesis. Organic Letters, 6(26), 4857-4860. https://doi.org/10.1021/ol048084u
    • Spronk, H. M., van der Voort, D., & Ten Cate, H. (2004). Blood coagulation and the risk of atherothrombosis: a complex relationship. Thrombosis Journal, 2(1), 12. https://doi.org/10.1186/1477-9560-2-12
    • Sere, KM., Rosing, J., & Hackeng, TM. (2004). Inhibition of thrombin generation by protein S at low procoagulant stimuli: implications for maintenance of the hemostatic balance. Blood, 104(12), 3624-3630. https://doi.org/10.1182/blood-2004-03-1146
    • Heeb, MJ., Koenen, RR., Fernandez, JA., & Hackeng, TM. (2004). Direct anticoagulant activity of protein S-C4b binding protein complex in Heerlen heterozygotes and normals. Journal of Thrombosis and Haemostasis, 2(10), 1766-1773. https://doi.org/10.1111/j.1538-7836.2004.00901.x
    • Koenen, RR., Gomes, L., Tans, G., Rosing, J., & Hackeng, TM. (2004). The Ser460Pro mutation in recombinant protein S Heerlen does not affect its APC-cofactor and APC-independent anticoagulant activities. Thrombosis and Haemostasis, 91(6), 1105-1114. https://doi.org/10.1160/TH04-02-0082
    • Soute, B. A. M., Jin, D.-Y., Spronk, H. M. H., Mutucumarana, V. P., Lin, P.-J., Hackeng, T. M., Stafford, D. W., & Vermeer, C. (2004). Characteristics of recombinant W501S mutated human gamma-glutamyl carboxylase. Journal of Thrombosis and Haemostasis, 2(4), 597-604. https://doi.org/10.1111/j.1538-7836.2004.00686.x
    • Keuren, J. F. W., Wielders, S. J. H., Driessen, A., Verhoeven, M., Hendriks, M., & Lindhout, T. (2004). Covalently-bound heparin makes collagen thromboresistant.Arteriosclerosis Thrombosis and Vascular Biology, 24(3), 613-617. https://doi.org/10.1161/01.ATV.0000116026.18945.66
    • Scheffer, P. G., Henry, R. M. A., Wever, E. J. M., van Rooij, G. J., Bos, G. M. J., Heine, R. J., Dekker, J. M., Diamant, M., Stehouwer, C. D. A., Nijpels, G., Blankenstein, M. A., & Teerlink, T. (2004). LDL oxidative modifications in well- or moderately controlled type 2 diabetes. Diabetes-metabolism Research and Reviews, 20(4), 298-304. https://doi.org/10.1002/dmrr.461
    • Beerenhout, C., Noris, M., Kooman, J. P., Porrati, F., Binda, E., Morigi, M., Bekers, O., van der Sande, F. M., Todeschini, M., Macconi, D., Leunissen, K. M. L., & Remuzzi, F. R. C. P. (2004). Nitric oxide synthetic capacity in relation to dialysate temperature. Blood Purification, 22(2), 203-209. https://doi.org/10.1159/000076854
    • Spijkerman, A. M., Henry, R. M. A., Dekker, J. M., Nijpels, G., Kostense, P. J., Kors, J. A., Ruwaard, D., Stehouwer, C. D. A., Bouter, L. M., & Heine, R. J. (2004). Prevalence of macrovascular disease amongst type 2 diabetic patients detected by targeted screening and patients newly diagnosed in general practice: the Hoorn Screening Study. Journal of Internal Medicine, 256(5), 429-436. https://doi.org/10.1111/j.1365-2796.2004.01395.x
    • Snijder, M. B., Henry, R. M. A., Visser, M., Dekker, J. M., Seidell, J. C., Ferreira, I., Bouter, L. M., Yudkin, J. S., Westerhof, N., & Stehouwer, C. D. A. (2004). Regional body composition as a determinant of arterial stiffness in the elderly: The Hoorn Study. Journal of Hypertension, 22(12), 2339-2347. https://doi.org/10.1097/00004872-200412000-00016
    • van Boxtel, M. P. J., Menheere, P. P. C. A., Bekers, O., Hogervorst, E., & Jolles, J. (2004). Thyroid function, depressed mood, and cognitive performance in older individuals: the Maastricht Aging Study. Psychoneuroendocrinology, 29(7), 891-898. https://doi.org/10.1016/j.psyneuen.2003.08.002
  • 2003
    • Spronk, H. M. H., Soute, B. A. M., Schurgers, L. J., Thijssen, H. H. W., De Mey, J. G. R., & Vermeer, C. (2003). Tissue-specific utilization of menaquinone-4 results in the prevention of arterial calcification in warfarin-treated rats. Journal of Vascular Research, 40(6), 531-7. https://doi.org/10.1159/000075344
    • Spronk, H. M. H., Govers-Riemslag, J. W. P., & ten Cate, H. (2003). The blood coagulation system as a molecular machine. Bioessays, 25(12), 1220-8. https://doi.org/10.1002/bies.10360
    • Koenen, RR., Tans, G., van Oerle, R., Hamulyak, K., Rosing, J., & Hackeng, TM. (2003). The APC-independent anticoagulant activity of protein S in plasma is decreased by elevated prothrombin levels due to the prothrombin G20210A mutation. Blood, 102(5), 1686-1692. https://doi.org/10.1182/blood-2003-02-0620
    • Rothkrantz-Kos, S., Bekers, O., Gubbels, A., Drent, M., Schmitz, M. P., & van Dieijen-Visser, M. P. (2003). Evaluation of two new high-sensitivity methods for C-reactive protein. Annals of Clinical Biochemistry, 40(Pt 4), 398-405. https://doi.org/10.1258/000456303766477057
    • Briedé, J. J., Wielders, S. J. H., Heemskerk, J. W. M., Baruch, D., Hemker, H. C., & Lindhout, T. (2003). von Willebrand factor stimulates thrombin-induced exposure of procoagulant phospholipids on the surface of fibrin-adherent platelets. Thrombosis and Haemostasis, 1(3), 559-565. https://doi.org/10.1046/j.1538-7836.2003.00077.x
  • 2002
    • Rothkrantz-Kos, S., Schmitz, M. P. J., Bekers, O., Menheere, P. P. C. A., & van Dieijen-Visser, M. P. (2002). High-sensitivity C-reactive protein methods examined. Clinical Chemistry, 48(2), 359-362. https://doi.org/10.1093/CLINCHEM/48.2.359
  • 2001
    • Dhore, C. R., Cleutjens, J. P., Lutgens, E., Cleutjens, K. B., Geusens, P. P., Kitslaar, P. J., Tordoir, J. H., Spronk, H. M., Vermeer, C., & Daemen, M. J. (2001). Differential expression of bone matrix regulatory proteins in human atherosclerotic plaques. Arteriosclerosis Thrombosis and Vascular Biology, 21(12), 1998-2003. https://doi.org/10.1161/hq1201.100229
    • Spronk, H. M., Soute, B. A., Schurgers, L. J., Cleutjens, J. P., Thijssen, H. H., De Mey, J. G., & Vermeer, C. (2001). Matrix Gla protein accumulates at the border of regions of calcification and normal tissue in the media of the arterial vessel wall. Biochemical and Biophysical Research Communications, 289(2), 485-90. https://doi.org/10.1006/bbrc.2001.5996
    • Mousallem, M., Spronk, H. M., Sacy, R., Hakime, N., & Soute, B. A. (2001). Congenital combined deficiencies of all vitamin K-dependent coagulation factors. Thrombosis and Haemostasis, 86(5), 1334-1336. https://doi.org/10.1055/s-0037-1616072
    • Farzaneh-Far, A., Davies, J. D., Braam, L. A., Spronk, H. M., Proudfoot, D., Chan, S. W., O'Shaughnessy, K. M., Weissberg, P. L., Vermeer, C., & Shanahan, C. M. (2001). A polymorphism of the human matrix gamma-carboxyglutamic acid protein promoter alters binding of an activating protein-1 complex and is associated with altered transcription and serum levels. Journal of Biological Chemistry, 276(35), 32466-73. https://doi.org/10.1074/jbc.M104909200
    • Sere, KM., Janssen, MP., Willems, GM., Tans, G., Rosing, J., & Hackeng, TM. (2001). Purified protein S contains multimeric forms with increased APC-independent anticoagulant activity. Biochemistry, 40(30), 8852-8860. https://doi.org/10.1021/bi002500a
    • Hackeng, T. M., Rosing, J., Spronk, H. M., & Vermeer, C. (2001). Total chemical synthesis of human matrix Gla protein. Protein Science, 10(4), 864-70. https://doi.org/10.1110/ps.44701
    • Schurgers, L. J., Dissel, P. E., Spronk, H. M., Soute, B. A., Dhore, C. R., Cleutjens, J. P., & Vermeer, C. (2001). Role of vitamin K and vitamin K-dependent proteins in vascular calcification. Zeitschrift fur Kardiologie, 90 Suppl 3, 57-63. https://doi.org/10.1007/s003920170043
  • 2000
    • Hackeng, TM., Fernandez, JA., Dawson, PE., Kent, SBH., & Griffin, JH. (2000). Chemical synthesis and spontaneous folding of a multidomain protein: Anticoagulant microprotein S. Proceedings of the National Academy of Sciences of the United States of America, 97(26), 14074-14078. https://doi.org/10.1073/pnas.260239797
    • Spronk, H. M., Farah, R. A., Buchanan, G. R., Vermeer, C., & Soute, B. A. (2000). Novel mutation in the gamma-glutamyl carboxylase gene resulting in congenital combined deficiency of all vitamin K-dependent blood coagulation factors. Blood, 96(10), 3650-3652. https://doi.org/10.1182/blood.V96.10.3650
    • Hackeng, TM., Yegneswaran, S., Johnson, AE., & Griffin, JH. (2000). Conformational changes in activated protein C caused by binding of the first epidermal growth factor-like module of protein S. Biochemical Journal, 349, 757-764. https://doi.org/10.1042/bj3490757
    • Braam, L. A., Dissel, P., Gijsbers, B. L., Spronk, H. M., Hamulyák, K., Soute, B. A., Debie, W., & Vermeer, C. (2000). Assay for human matrix gla protein in serum: potential applications in the cardiovascular field. Arteriosclerosis Thrombosis and Vascular Biology, 20(5), 1257-61. https://doi.org/10.1161/01.atv.20.5.1257
    • Marx, PF., Hackeng, TM., Dawson, PE., Griffin, JH., Meijers, JCM., & Bouma, BN. (2000). Inactivation of active thrombin-activable fibrinolysis inhibitor takes place by a process that involves conformational instability rather than proteolytic cleavage. Journal of Biological Chemistry, 275(17), 12410-12415. https://doi.org/10.1074/jbc.275.17.12410
    • Fernandez, JA., Kojima, K., Petaja, J., Hackeng, TM., & Griffin, JH. (2000). Cardiolipin enhances protein C pathway anticoagulant activity. Blood Cells Molecules and Diseases, 26(2), 115-123. https://doi.org/10.1006/bcmd.2000.0285
    • Deguchi, H., Fernandez, JA., Hackeng, TM., Banka, CL., & Griffin, JH. (2000). Cardiolipin is a normal component of human plasma lipoproteins. Proceedings of the National Academy of Sciences of the United States of America, 97(4), 1743-1748. https://doi.org/10.1073/pnas.97.4.1743
  • 1999
    • Hackeng, TM., Griffin, JH., & Dawson, PE. (1999). Protein synthesis by native chemical ligation: Expanded scope by using straightforward methodology. Proceedings of the National Academy of Sciences of the United States of America, 96(18), 10068-10073. https://doi.org/10.1073/pnas.96.18.10068
    • Curvers, J., Christella, M., Thomassen, L. G. D., Nicolaes, G. A. F., van Oerle, R., Hamulyak, K., Hemker, H. C., Tans, G., & Rosing, J. (1999). Acquired APC resistance and oral contraceptives: Differences between two functional tests. British Journal of Haematology, 105(1), 88-94. https://doi.org/10.1111/j.1365-2141.1999.01302.x
  • 1997
    • Wang, LL., Zoppe, M., Hackeng, TM., Griffin, JH., Lee, K.-F., & Verma, IM. (1997). A factor IX-deficient mouse model for hemophilia B gene therapy. Proceedings of the National Academy of Sciences of the United States of America, 94(21), 11563-11566. https://doi.org/10.1073/pnas.94.21.11563
    • Wielders, S., Mukherjee, M., Michiels, J., Rijkers, D. T. S., Cambus, J.-P., Knebel, R. W. C., Kakkar, V., Hemker, H. C., & Beguin, S. (1997). The routine determination of the endogenous thrombin potential, first results in different forms of hyper- and hypocoagulability. Thrombosis and Haemostasis, 77(4), 629-636. https://doi.org/10.1055/s-0038-1656024
    • Rosing, J., Tans, G., Nicolaes, G. A. F., Thomassen, M. C. G. L. D., van Oerle, R., van der Ploeg, P. M. E. N., Heijnen, P., Hamulyak, K., & Hemker, H. C. (1997). Oral contraceptives and venous thrombosis: Different sensitives to activated protein C in women using second-and third-generation oral contraceptives. British Journal of Haematology, 97(1), 233-238. https://doi.org/10.1046/j.1365-2141.1997.192707.x
  • 1995
    • KOPPELMAN, SJ., HACKENG, TM., SIXMA, JJ., & BOUMA, BN. (1995). INHIBITION OF THE INTRINSIC-FACTOR-X ACTIVATING COMPLEX BY PROTEIN-S - EVIDENCE FOR A SPECIFIC BINDING OF PROTEIN-S TO FACTOR-VIII. Blood, 86(3), 1062-1071. https://doi.org/10.1182/blood.V86.3.1062.1062
    • VANTVEER, C., HACKENG, TM., BIESBROECK, D., SIXMA, JJ., & BOUMA, BN. (1995). INCREASED PROTHROMBIN ACTIVATION IN PROTEIN S-DEFICIENT PLASMA UNDER FLOW CONDITIONS ON ENDOTHELIAL-CELL MATRIX - AN INDEPENDENT ANTICOAGULANT FUNCTION OF PROTEIN-S IN PLASMA. Blood, 85(7), 1815-1821. https://doi.org/10.1182/blood.V85.7.1815.bloodjournal8571815
  • 1994
    • VANTVEER, C., HACKENG, TM., DELAHAYE, C., SIXMA, JJ., & BOUMA, BN. (1994). ACTIVATED FACTOR-X AND THROMBIN FORMATION TRIGGERED BY TISSUE FACTOR ON ENDOTHELIAL-CELL MATRIX IN A FLOW MODEL - EFFECT OF THE TISSUE FACTOR PATHWAY INHIBITOR. Blood, 84(4), 1132-1142. https://doi.org/10.1182/blood.V84.4.1132.1132
  • 1993
    • Hemker, H. C., Wielders, S., Kessels, H., & Beguin, S. (1993). Continuous registration of thrombin generation in plasma: Its use for the determination of the thrombin potential. Thrombosis and Haemostasis, 70(4), 617-624. https://doi.org/10.1055/s-0038-1649638
  • 1992
    • Beguin, S., Wielders, S., Lormeau, J. C., & Hemker, H. C. (1992). The Mode of Action of CY216 and CY222 in Plasma. Thrombosis and Haemostasis, 67(1), 33-41. https://doi.org/10.1055/s-0038-1648375
  • 1991
    • Hemker, H. C., Beguin, S., Bendetowicz, A. V., & Wielders, S. (1991). Determination of the levels of unfractionated and low-molecular-weight heparins in plasma: Their effect on thrombin-mediated feedback reactions in vivo. Haemostasis, 21(4), 258-272. https://doi.org/10.1159/000216235