Publications
- 2005
- Dielis, A. W. J. H., Smid, M., Spronk, H. M. H., Hamulyak, K., Kroon, A. A., ten Cate, H., & de Leeuw, P. W. (2005). The prothrombotic paradox of hypertension: role of the renin-angiotensin and kallikrein-kinin systems. Hypertension, 46(6), 1236-42. https://doi.org/10.1161/01.HYP.0000193538.20705.23
- Denis, CV., Roberts, SJ., Hackeng, TM., & Lenting, PJ. (2005). In vivo clearance of human protein S in a mouse model - Influence of c4b-binding protein and the Heerlen polymorphism. Arteriosclerosis Thrombosis and Vascular Biology, 25(10), 2209-2215. https://doi.org/10.1161/01.ATV.0000181760.55269.6b
- Hackeng, TM., Sere, KM., & Rosing, J. (2005). Misconceptions about protein-S multimers - Response. Blood, 106(5), 1884-1885. https://doi.org/10.1182/blood-2004-12-4706
- Sommeijer, D. W., van Oerle, R., Reitsma, P. H., Timmerman, J. J., Meijers, J. C. M., Spronk, H. M. H., & ten Cate, H. (2005). Analysis of blood coagulation in mice: pre-analytical conditions and evaluation of a home-made assay for thrombin-antithrombin complexes. Thrombosis Journal, 3, Article 12. https://doi.org/10.1186/1477-9560-3-12
- Keuren, JFW., Wielders, SJH., Ulrichts, H., Hackeng, T., Heemskerk, JWM., Deckmyn, H., Bevers, EM., & Lindhout, T. (2005). Synergistic effect of thrombin on collagen-induced platelet procoagulant activity is mediated through protease-activated receptor-1. Arteriosclerosis Thrombosis and Vascular Biology, 25(7), 1499-1505. https://doi.org/10.1161/01.ATV.0000167526.31611.f6
- Langereis, S., Dirksen, A., De Waal, BFM., Van Genderen, MHP., De Lussanet, QG., Hackeng, TM., & Meijer, EW. (2005). Solid-phase synthesis of a cyclic NGR-functionalized Gd(III)DTPA complex. European Journal of Organic Chemistry, 2005(12), 2534-2538. https://doi.org/10.1002/ejoc.200500045
- Koenen, RR., Thomassen, MCLGD., Tans, G., Rosing, J., & Hackeng, TM. (2005). Effect of oral contraceptives on the anticoagulant activity of protein S in plasma. Thrombosis and Haemostasis, 93(5), 853-859. https://doi.org/10.1160/TH04-11-0762
- Ravassa, S., Bennaghmouch, A., Kenis, H., Lindhout, T., Hackeng, T., Narula, J., Hofstra, L., & Reutelingsperger, C. (2005). Annexin A5 down-regulates surface expression of tissue factor. Journal of Biological Chemistry, 280(7), 6028-6035. https://doi.org/10.1074/jbc.M411710200
- von Hundelshausen, P., Koenen, RR., Sack, M., Mause, SF., Adriaens, W., Proudfoot, AEI., Hackeng, TM., & Weber, C. (2005). Heterophilic interactions of platelet factor 4 and RANTES promote monocyte arrest on endothelium. Blood, 105(3), 924-930. https://doi.org/10.1182/blood-2004-06-2475
- Fischer, M. A. J. G., Gransier, T. J., Beckers, L. M., Bekers, O., Bast, A., & Haenen, G. R. (2005). Determination of the antioxidant capacity in blood. Clinical Chemistry and Laboratory Medicine, 43(7), 735-740. https://doi.org/10.1515/CCLM.2005.125
- op den Buijsch, R. A., de Vries, J. E., Loots, W. J., Landt, O., Wijnen, P. A. H. M., van Dieijen-Visser, M. P., & Bekers, O. (2005). Genotyping of the PXR A11156C polymorphism with locked nucleic acid containing fluorogenic probes. Pharmacogenomics, 5(2), 72-74. https://doi.org/10.1038/sj.tpj.6500299
- Hackeng, TM. (2005). Gla glances at proteins. Blood, 105(1), 1-2. https://doi.org/10.1182/blood-2004-10-3874
- Slofstra, S. H., van 't Veer, C., Buurman, W. A., Reitsma, P. H., ten Cate, H., & Spek, C. A. (2005). Low molecular weight heparin attenuates multiple organ failure in a murine model of disseminated intravascular coagulation. Critical Care Medicine, 33(6), 1365-1370. https://doi.org/10.1097/01.CCM.0000166370.94927.B6
- Henry, R. M. A., Kamp, O., Kostense, P. J., Spijkerman, A. M., Dekker, J. M., Nijpels, G., Heine, R. J., Bouter, L. M., & Stehouwer, C. D. A. (2005). Mild renal insufficiency is associated with increased left ventricular mass in men but not in women an arterial-stiffness-related phenomenon - The Hoorn Study. Kidney International, 68, 673-679. https://doi.org/10.1111/j.1523-1755.2005.00445.x
- van der Meijden, P. E. J., Feijge, M. A. H., Giesen, P. L. A., Huijberts, M. S. P., van Raak, L. P., & Heemskerk, J. W. (2005). Platelet P2Y12 receptors enhance signalling towards procoagulant activity and thrombin generation. A study with healthy subjects and patients at thrombotic risk. Thrombosis and Haemostasis, 93(6), 1128-1136. https://doi.org/10.1160/TH04-09-0597
- Beerenhout, C. H., Luik, A. J., Jeuken Mertens, S. G., Bekers, O., Menheere, P. P., Hover, L., Klaassen, L., van der Sande, F. M., Cheriex, E. C., Meert, N., Leunissen, K. M. L., & Kooman, J. P. (2005). Pre-dilution on-line haemofiltration vs low-flux haemodialysis: a randomized prospective study. Nephrology Dialysis Transplantation, 20(6), 1155-1163. https://doi.org/10.1093/ndt/gfh775
- op den Buijsch, R. A., Wijnen, P. A. H. M., van Dieijen-Visser, M. P., de Vries, J. E., & Bekers, O. (2005). Rapid genotyping of the OATP1B1 polymorphisms A388G and T521C with real-time PCR FRET assays. Pharmacogenomics, 6(4), 393-397. https://doi.org/10.1517/14622416.6.4.393
- Spijkerman, A. M., Smulders, Y. M., Kostense, P. J., Henry, R. M. A., Becker, A., Teerlink, T., Jakobs, C., Dekker, J. M., Nijpels, G., Heine, R. J., Bouter, L. M., & Stehouwer, C. D. (2005). S-adenosylmethionine and 5-methyltetrahydrofolate are associated with endothelial function after controlling for confounding by homocysteine: the Hoorn Study. Arteriosclerosis Thrombosis and Vascular Biology, 25(4), 778-784. https://doi.org/10.1161/01.ATV.0000157981.57694.d2
- Meex, S. J. R., van der Kallen, C. J. H., van Greevenbroek, M. M., Eurlings, P. M., El Hasnaoui, M. M., Evelo, C. T., Lindsey, P. J., Luiken, J. J. F. P., Glatz, J. F., & de Bruin, T. W. (2005). Up-regulation of CD36/FAT in preadipocytes in familial combined hyperlipidemia. Faseb Journal, 19(14), 2063-2065. https://doi.org/10.1096/fj.04-2403fje
- Dirksen, A., Langereis, S., de Waal, BFM., van Genderen, MHP., Hackeng, TM., & Meijer, EW. (2005). A supramolecular approach to multivalent target-specific MRI contrast agents for angiogenesis. Chemical Communications, (22), 2811-2813. https://doi.org/10.1039/b502347e
- van Baal, W. M., Malda, H., Synowsky, SA., van Dongen, JLJ., Hackeng, TM., Merkx, M., & Meijer, EW. (2005). Multivalent peptide and protein dendrimers using native chemical ligation. Angewandte Chemie-International Edition, 44(32), 5052-5057. https://doi.org/10.1002/anie.200500635
- 2004
- Dirksen, A., Langereis, S., de Waal, BFM., van Genderen, MHP., Meijer, EW., de Lussanet, QG., & Hackeng, TM. (2004). Design and synthesis of a bimodal target-specific contrast agent for angiogenesis. Organic Letters, 6(26), 4857-4860. https://doi.org/10.1021/ol048084u
- Spronk, H. M., van der Voort, D., & Ten Cate, H. (2004). Blood coagulation and the risk of atherothrombosis: a complex relationship. Thrombosis Journal, 2(1), 12. https://doi.org/10.1186/1477-9560-2-12
- Sere, KM., Rosing, J., & Hackeng, TM. (2004). Inhibition of thrombin generation by protein S at low procoagulant stimuli: implications for maintenance of the hemostatic balance. Blood, 104(12), 3624-3630. https://doi.org/10.1182/blood-2004-03-1146
- Heeb, MJ., Koenen, RR., Fernandez, JA., & Hackeng, TM. (2004). Direct anticoagulant activity of protein S-C4b binding protein complex in Heerlen heterozygotes and normals. Journal of Thrombosis and Haemostasis, 2(10), 1766-1773. https://doi.org/10.1111/j.1538-7836.2004.00901.x
- Koenen, RR., Gomes, L., Tans, G., Rosing, J., & Hackeng, TM. (2004). The Ser460Pro mutation in recombinant protein S Heerlen does not affect its APC-cofactor and APC-independent anticoagulant activities. Thrombosis and Haemostasis, 91(6), 1105-1114. https://doi.org/10.1160/TH04-02-0082
- Soute, B. A. M., Jin, D.-Y., Spronk, H. M. H., Mutucumarana, V. P., Lin, P.-J., Hackeng, T. M., Stafford, D. W., & Vermeer, C. (2004). Characteristics of recombinant W501S mutated human gamma-glutamyl carboxylase. Journal of Thrombosis and Haemostasis, 2(4), 597-604. https://doi.org/10.1111/j.1538-7836.2004.00686.x
- Keuren, J. F. W., Wielders, S. J. H., Driessen, A., Verhoeven, M., Hendriks, M., & Lindhout, T. (2004). Covalently-bound heparin makes collagen thromboresistant.Arteriosclerosis Thrombosis and Vascular Biology, 24(3), 613-617. https://doi.org/10.1161/01.ATV.0000116026.18945.66
- Scheffer, P. G., Henry, R. M. A., Wever, E. J. M., van Rooij, G. J., Bos, G. M. J., Heine, R. J., Dekker, J. M., Diamant, M., Stehouwer, C. D. A., Nijpels, G., Blankenstein, M. A., & Teerlink, T. (2004). LDL oxidative modifications in well- or moderately controlled type 2 diabetes. Diabetes-metabolism Research and Reviews, 20(4), 298-304. https://doi.org/10.1002/dmrr.461
- Beerenhout, C., Noris, M., Kooman, J. P., Porrati, F., Binda, E., Morigi, M., Bekers, O., van der Sande, F. M., Todeschini, M., Macconi, D., Leunissen, K. M. L., & Remuzzi, F. R. C. P. (2004). Nitric oxide synthetic capacity in relation to dialysate temperature. Blood Purification, 22(2), 203-209. https://doi.org/10.1159/000076854
- Spijkerman, A. M., Henry, R. M. A., Dekker, J. M., Nijpels, G., Kostense, P. J., Kors, J. A., Ruwaard, D., Stehouwer, C. D. A., Bouter, L. M., & Heine, R. J. (2004). Prevalence of macrovascular disease amongst type 2 diabetic patients detected by targeted screening and patients newly diagnosed in general practice: the Hoorn Screening Study. Journal of Internal Medicine, 256(5), 429-436. https://doi.org/10.1111/j.1365-2796.2004.01395.x
- Snijder, M. B., Henry, R. M. A., Visser, M., Dekker, J. M., Seidell, J. C., Ferreira, I., Bouter, L. M., Yudkin, J. S., Westerhof, N., & Stehouwer, C. D. A. (2004). Regional body composition as a determinant of arterial stiffness in the elderly: The Hoorn Study. Journal of Hypertension, 22(12), 2339-2347. https://doi.org/10.1097/00004872-200412000-00016
- van Boxtel, M. P. J., Menheere, P. P. C. A., Bekers, O., Hogervorst, E., & Jolles, J. (2004). Thyroid function, depressed mood, and cognitive performance in older individuals: the Maastricht Aging Study. Psychoneuroendocrinology, 29(7), 891-898. https://doi.org/10.1016/j.psyneuen.2003.08.002
- 2003
- Spronk, H. M. H., Soute, B. A. M., Schurgers, L. J., Thijssen, H. H. W., De Mey, J. G. R., & Vermeer, C. (2003). Tissue-specific utilization of menaquinone-4 results in the prevention of arterial calcification in warfarin-treated rats. Journal of Vascular Research, 40(6), 531-7. https://doi.org/10.1159/000075344
- Spronk, H. M. H., Govers-Riemslag, J. W. P., & ten Cate, H. (2003). The blood coagulation system as a molecular machine. Bioessays, 25(12), 1220-8. https://doi.org/10.1002/bies.10360
- Koenen, RR., Tans, G., van Oerle, R., Hamulyak, K., Rosing, J., & Hackeng, TM. (2003). The APC-independent anticoagulant activity of protein S in plasma is decreased by elevated prothrombin levels due to the prothrombin G20210A mutation. Blood, 102(5), 1686-1692. https://doi.org/10.1182/blood-2003-02-0620
- Rothkrantz-Kos, S., Bekers, O., Gubbels, A., Drent, M., Schmitz, M. P., & van Dieijen-Visser, M. P. (2003). Evaluation of two new high-sensitivity methods for C-reactive protein. Annals of Clinical Biochemistry, 40(Pt 4), 398-405. https://doi.org/10.1258/000456303766477057
- Briedé, J. J., Wielders, S. J. H., Heemskerk, J. W. M., Baruch, D., Hemker, H. C., & Lindhout, T. (2003). von Willebrand factor stimulates thrombin-induced exposure of procoagulant phospholipids on the surface of fibrin-adherent platelets. Thrombosis and Haemostasis, 1(3), 559-565. https://doi.org/10.1046/j.1538-7836.2003.00077.x
- 2002
- Rothkrantz-Kos, S., Schmitz, M. P. J., Bekers, O., Menheere, P. P. C. A., & van Dieijen-Visser, M. P. (2002). High-sensitivity C-reactive protein methods examined. Clinical Chemistry, 48(2), 359-362. https://doi.org/10.1093/CLINCHEM/48.2.359
- 2001
- Dhore, C. R., Cleutjens, J. P., Lutgens, E., Cleutjens, K. B., Geusens, P. P., Kitslaar, P. J., Tordoir, J. H., Spronk, H. M., Vermeer, C., & Daemen, M. J. (2001). Differential expression of bone matrix regulatory proteins in human atherosclerotic plaques. Arteriosclerosis Thrombosis and Vascular Biology, 21(12), 1998-2003. https://doi.org/10.1161/hq1201.100229
- Spronk, H. M., Soute, B. A., Schurgers, L. J., Cleutjens, J. P., Thijssen, H. H., De Mey, J. G., & Vermeer, C. (2001). Matrix Gla protein accumulates at the border of regions of calcification and normal tissue in the media of the arterial vessel wall. Biochemical and Biophysical Research Communications, 289(2), 485-90. https://doi.org/10.1006/bbrc.2001.5996
- Mousallem, M., Spronk, H. M., Sacy, R., Hakime, N., & Soute, B. A. (2001). Congenital combined deficiencies of all vitamin K-dependent coagulation factors. Thrombosis and Haemostasis, 86(5), 1334-1336. https://doi.org/10.1055/s-0037-1616072
- Farzaneh-Far, A., Davies, J. D., Braam, L. A., Spronk, H. M., Proudfoot, D., Chan, S. W., O'Shaughnessy, K. M., Weissberg, P. L., Vermeer, C., & Shanahan, C. M. (2001). A polymorphism of the human matrix gamma-carboxyglutamic acid protein promoter alters binding of an activating protein-1 complex and is associated with altered transcription and serum levels. Journal of Biological Chemistry, 276(35), 32466-73. https://doi.org/10.1074/jbc.M104909200
- Sere, KM., Janssen, MP., Willems, GM., Tans, G., Rosing, J., & Hackeng, TM. (2001). Purified protein S contains multimeric forms with increased APC-independent anticoagulant activity. Biochemistry, 40(30), 8852-8860. https://doi.org/10.1021/bi002500a
- Hackeng, T. M., Rosing, J., Spronk, H. M., & Vermeer, C. (2001). Total chemical synthesis of human matrix Gla protein. Protein Science, 10(4), 864-70. https://doi.org/10.1110/ps.44701
- Schurgers, L. J., Dissel, P. E., Spronk, H. M., Soute, B. A., Dhore, C. R., Cleutjens, J. P., & Vermeer, C. (2001). Role of vitamin K and vitamin K-dependent proteins in vascular calcification. Zeitschrift fur Kardiologie, 90 Suppl 3, 57-63. https://doi.org/10.1007/s003920170043
- 2000
- Hackeng, TM., Fernandez, JA., Dawson, PE., Kent, SBH., & Griffin, JH. (2000). Chemical synthesis and spontaneous folding of a multidomain protein: Anticoagulant microprotein S. Proceedings of the National Academy of Sciences of the United States of America, 97(26), 14074-14078. https://doi.org/10.1073/pnas.260239797




