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Nicolaes, G. A. F., Hackeng, T. M., Segers, K., & Rosing, J. (2006). A structural model of the SHBG domain of human variant protein S Heerlen. Thrombosis and Haemostasis, 96(4), 538-540. https://doi.org/10.1160/TH06-07-0361

Spronk, H. M. H. (2006). Vitamin K epoxide reductase complex and vascular calcification: is this the important link between vitamin K and the arterial vessel wall?Circulation, 113(12), 1550-2. https://doi.org/10.1161/CIRCULATIONAHA.105.617167

Sommeijer, D. W., Hansen, H. R., van Oerle, R., Hamulyak, K., van Zanten, A. P., Meesters, E., Spronk, H. M. H., & ten Cate, H. (2006). Soluble tissue factor is a candidate marker for progression of microvascular disease in patients with Type 2 diabetes. Journal of Thrombosis and Haemostasis, 4(3), 574-80. https://doi.org/10.1111/j.1538-7836.2005.01763.x

Hackeng, TM., Sere, KM., Tans, G., & Rosing, J. (2006). Protein S stimulates inhibition of the tissue factor pathway by tissue factor pathway inhibitor. Proceedings of the National Academy of Sciences of the United States of America, 103(9), 3106-3111. https://doi.org/10.1073/pnas.0504240103

de Waard, V., Hansen, H. R., Spronk, H. H. M., Timmerman, J. J., Pannekoek, H., Florquin, S., Reitsma, P. H., & ten Cate, H. (2006). Differential expression of tissue factor mRNA and protein expression in murine sepsis. The role of the granulocyte revisited. Thrombosis and Haemostasis, 95(2), 348-53. https://doi.org/10.1160/TH05-07-0512

Dirksen, A., Hackeng, T. M., & Dawson, P. E. (2006). Nucleophilic catalysis of oxime ligation. Angewandte Chemie-International Edition, 45(45), 7581-7584. https://doi.org/10.1002/anie.200602877

Dirksen, A., Meijer, EW., Adriaens, W., & Hackeng, TM. (2006). Strategy for the synthesis of multivalent peptide-based nonsymmetric dendrimers by native chemical ligation. Chemical Communications, (15), 1667-1669. https://doi.org/10.1039/b600286b

Dielis, A. W. J. H., Smid, M., Spronk, H. M. H., Hamulyak, K., Kroon, A. A., ten Cate, H., & de Leeuw, P. W. (2005). The prothrombotic paradox of hypertension: role of the renin-angiotensin and kallikrein-kinin systems. Hypertension, 46(6), 1236-42. https://doi.org/10.1161/01.HYP.0000193538.20705.23

Denis, CV., Roberts, SJ., Hackeng, TM., & Lenting, PJ. (2005). In vivo clearance of human protein S in a mouse model - Influence of c4b-binding protein and the Heerlen polymorphism. Arteriosclerosis Thrombosis and Vascular Biology, 25(10), 2209-2215. https://doi.org/10.1161/01.ATV.0000181760.55269.6b

Hackeng, TM., Sere, KM., & Rosing, J. (2005). Misconceptions about protein-S multimers - Response. Blood, 106(5), 1884-1885. https://doi.org/10.1182/blood-2004-12-4706

Sommeijer, D. W., van Oerle, R., Reitsma, P. H., Timmerman, J. J., Meijers, J. C. M., Spronk, H. M. H., & ten Cate, H. (2005). Analysis of blood coagulation in mice: pre-analytical conditions and evaluation of a home-made assay for thrombin-antithrombin complexes. Thrombosis Journal, 3, Article 12. https://doi.org/10.1186/1477-9560-3-12

Keuren, JFW., Wielders, SJH., Ulrichts, H., Hackeng, T., Heemskerk, JWM., Deckmyn, H., Bevers, EM., & Lindhout, T. (2005). Synergistic effect of thrombin on collagen-induced platelet procoagulant activity is mediated through protease-activated receptor-1. Arteriosclerosis Thrombosis and Vascular Biology, 25(7), 1499-1505. https://doi.org/10.1161/01.ATV.0000167526.31611.f6

Langereis, S., Dirksen, A., De Waal, BFM., Van Genderen, MHP., De Lussanet, QG., Hackeng, TM., & Meijer, EW. (2005). Solid-phase synthesis of a cyclic NGR-functionalized Gd(III)DTPA complex. European Journal of Organic Chemistry, 2005(12), 2534-2538. https://doi.org/10.1002/ejoc.200500045

Koenen, RR., Thomassen, MCLGD., Tans, G., Rosing, J., & Hackeng, TM. (2005). Effect of oral contraceptives on the anticoagulant activity of protein S in plasma. Thrombosis and Haemostasis, 93(5), 853-859. https://doi.org/10.1160/TH04-11-0762

Ravassa, S., Bennaghmouch, A., Kenis, H., Lindhout, T., Hackeng, T., Narula, J., Hofstra, L., & Reutelingsperger, C. (2005). Annexin A5 down-regulates surface expression of tissue factor. Journal of Biological Chemistry, 280(7), 6028-6035. https://doi.org/10.1074/jbc.M411710200

von Hundelshausen, P., Koenen, RR., Sack, M., Mause, SF., Adriaens, W., Proudfoot, AEI., Hackeng, TM., & Weber, C. (2005). Heterophilic interactions of platelet factor 4 and RANTES promote monocyte arrest on endothelium. Blood, 105(3), 924-930. https://doi.org/10.1182/blood-2004-06-2475

Fischer, M. A. J. G., Gransier, T. J., Beckers, L. M., Bekers, O., Bast, A., & Haenen, G. R. (2005). Determination of the antioxidant capacity in blood. Clinical Chemistry and Laboratory Medicine, 43(7), 735-740. https://doi.org/10.1515/CCLM.2005.125

op den Buijsch, R. A., de Vries, J. E., Loots, W. J., Landt, O., Wijnen, P. A. H. M., van Dieijen-Visser, M. P., & Bekers, O. (2005). Genotyping of the PXR A11156C polymorphism with locked nucleic acid containing fluorogenic probes. Pharmacogenomics, 5(2), 72-74. https://doi.org/10.1038/sj.tpj.6500299

Hackeng, TM. (2005). Gla glances at proteins. Blood, 105(1), 1-2. https://doi.org/10.1182/blood-2004-10-3874

Slofstra, S. H., van 't Veer, C., Buurman, W. A., Reitsma, P. H., ten Cate, H., & Spek, C. A. (2005). Low molecular weight heparin attenuates multiple organ failure in a murine model of disseminated intravascular coagulation. Critical Care Medicine, 33(6), 1365-1370. https://doi.org/10.1097/01.CCM.0000166370.94927.B6

Henry, R. M. A., Kamp, O., Kostense, P. J., Spijkerman, A. M., Dekker, J. M., Nijpels, G., Heine, R. J., Bouter, L. M., & Stehouwer, C. D. A. (2005). Mild renal insufficiency is associated with increased left ventricular mass in men but not in women an arterial-stiffness-related phenomenon - The Hoorn Study. Kidney International, 68, 673-679. https://doi.org/10.1111/j.1523-1755.2005.00445.x

van der Meijden, P. E. J., Feijge, M. A. H., Giesen, P. L. A., Huijberts, M. S. P., van Raak, L. P., & Heemskerk, J. W. (2005). Platelet P2Y12 receptors enhance signalling towards procoagulant activity and thrombin generation. A study with healthy subjects and patients at thrombotic risk. Thrombosis and Haemostasis, 93(6), 1128-1136. https://doi.org/10.1160/TH04-09-0597

Beerenhout, C. H., Luik, A. J., Jeuken Mertens, S. G., Bekers, O., Menheere, P. P., Hover, L., Klaassen, L., van der Sande, F. M., Cheriex, E. C., Meert, N., Leunissen, K. M. L., & Kooman, J. P. (2005). Pre-dilution on-line haemofiltration vs low-flux haemodialysis: a randomized prospective study. Nephrology Dialysis Transplantation, 20(6), 1155-1163. https://doi.org/10.1093/ndt/gfh775

op den Buijsch, R. A., Wijnen, P. A. H. M., van Dieijen-Visser, M. P., de Vries, J. E., & Bekers, O. (2005). Rapid genotyping of the OATP1B1 polymorphisms A388G and T521C with real-time PCR FRET assays. Pharmacogenomics, 6(4), 393-397. https://doi.org/10.1517/14622416.6.4.393

Spijkerman, A. M., Smulders, Y. M., Kostense, P. J., Henry, R. M. A., Becker, A., Teerlink, T., Jakobs, C., Dekker, J. M., Nijpels, G., Heine, R. J., Bouter, L. M., & Stehouwer, C. D. (2005). S-adenosylmethionine and 5-methyltetrahydrofolate are associated with endothelial function after controlling for confounding by homocysteine: the Hoorn Study. Arteriosclerosis Thrombosis and Vascular Biology, 25(4), 778-784. https://doi.org/10.1161/01.ATV.0000157981.57694.d2

Meex, S. J. R., van der Kallen, C. J. H., van Greevenbroek, M. M., Eurlings, P. M., El Hasnaoui, M. M., Evelo, C. T., Lindsey, P. J., Luiken, J. J. F. P., Glatz, J. F., & de Bruin, T. W. (2005). Up-regulation of CD36/FAT in preadipocytes in familial combined hyperlipidemia. Faseb Journal, 19(14), 2063-2065. https://doi.org/10.1096/fj.04-2403fje

Dirksen, A., Langereis, S., de Waal, BFM., van Genderen, MHP., Hackeng, TM., & Meijer, EW. (2005). A supramolecular approach to multivalent target-specific MRI contrast agents for angiogenesis. Chemical Communications, (22), 2811-2813. https://doi.org/10.1039/b502347e

van Baal, W. M., Malda, H., Synowsky, SA., van Dongen, JLJ., Hackeng, TM., Merkx, M., & Meijer, EW. (2005). Multivalent peptide and protein dendrimers using native chemical ligation. Angewandte Chemie-International Edition, 44(32), 5052-5057. https://doi.org/10.1002/anie.200500635

Dirksen, A., Langereis, S., de Waal, BFM., van Genderen, MHP., Meijer, EW., de Lussanet, QG., & Hackeng, TM. (2004). Design and synthesis of a bimodal target-specific contrast agent for angiogenesis. Organic Letters, 6(26), 4857-4860. https://doi.org/10.1021/ol048084u

Spronk, H. M., van der Voort, D., & Ten Cate, H. (2004). Blood coagulation and the risk of atherothrombosis: a complex relationship. Thrombosis Journal, 2(1), 12. https://doi.org/10.1186/1477-9560-2-12

Sere, KM., Rosing, J., & Hackeng, TM. (2004). Inhibition of thrombin generation by protein S at low procoagulant stimuli: implications for maintenance of the hemostatic balance. Blood, 104(12), 3624-3630. https://doi.org/10.1182/blood-2004-03-1146

Heeb, MJ., Koenen, RR., Fernandez, JA., & Hackeng, TM. (2004). Direct anticoagulant activity of protein S-C4b binding protein complex in Heerlen heterozygotes and normals. Journal of Thrombosis and Haemostasis, 2(10), 1766-1773. https://doi.org/10.1111/j.1538-7836.2004.00901.x

Koenen, RR., Gomes, L., Tans, G., Rosing, J., & Hackeng, TM. (2004). The Ser460Pro mutation in recombinant protein S Heerlen does not affect its APC-cofactor and APC-independent anticoagulant activities. Thrombosis and Haemostasis, 91(6), 1105-1114. https://doi.org/10.1160/TH04-02-0082

Soute, B. A. M., Jin, D.-Y., Spronk, H. M. H., Mutucumarana, V. P., Lin, P.-J., Hackeng, T. M., Stafford, D. W., & Vermeer, C. (2004). Characteristics of recombinant W501S mutated human gamma-glutamyl carboxylase. Journal of Thrombosis and Haemostasis, 2(4), 597-604. https://doi.org/10.1111/j.1538-7836.2004.00686.x

Keuren, J. F. W., Wielders, S. J. H., Driessen, A., Verhoeven, M., Hendriks, M., & Lindhout, T. (2004). Covalently-bound heparin makes collagen thromboresistant.Arteriosclerosis Thrombosis and Vascular Biology, 24(3), 613-617. https://doi.org/10.1161/01.ATV.0000116026.18945.66

Scheffer, P. G., Henry, R. M. A., Wever, E. J. M., van Rooij, G. J., Bos, G. M. J., Heine, R. J., Dekker, J. M., Diamant, M., Stehouwer, C. D. A., Nijpels, G., Blankenstein, M. A., & Teerlink, T. (2004). LDL oxidative modifications in well- or moderately controlled type 2 diabetes. Diabetes-metabolism Research and Reviews, 20(4), 298-304. https://doi.org/10.1002/dmrr.461

Beerenhout, C., Noris, M., Kooman, J. P., Porrati, F., Binda, E., Morigi, M., Bekers, O., van der Sande, F. M., Todeschini, M., Macconi, D., Leunissen, K. M. L., & Remuzzi, F. R. C. P. (2004). Nitric oxide synthetic capacity in relation to dialysate temperature. Blood Purification, 22(2), 203-209. https://doi.org/10.1159/000076854

Spijkerman, A. M., Henry, R. M. A., Dekker, J. M., Nijpels, G., Kostense, P. J., Kors, J. A., Ruwaard, D., Stehouwer, C. D. A., Bouter, L. M., & Heine, R. J. (2004). Prevalence of macrovascular disease amongst type 2 diabetic patients detected by targeted screening and patients newly diagnosed in general practice: the Hoorn Screening Study. Journal of Internal Medicine, 256(5), 429-436. https://doi.org/10.1111/j.1365-2796.2004.01395.x

Snijder, M. B., Henry, R. M. A., Visser, M., Dekker, J. M., Seidell, J. C., Ferreira, I., Bouter, L. M., Yudkin, J. S., Westerhof, N., & Stehouwer, C. D. A. (2004). Regional body composition as a determinant of arterial stiffness in the elderly: The Hoorn Study. Journal of Hypertension, 22(12), 2339-2347. https://doi.org/10.1097/00004872-200412000-00016

van Boxtel, M. P. J., Menheere, P. P. C. A., Bekers, O., Hogervorst, E., & Jolles, J. (2004). Thyroid function, depressed mood, and cognitive performance in older individuals: the Maastricht Aging Study. Psychoneuroendocrinology, 29(7), 891-898. https://doi.org/10.1016/j.psyneuen.2003.08.002

Spronk, H. M. H., Soute, B. A. M., Schurgers, L. J., Thijssen, H. H. W., De Mey, J. G. R., & Vermeer, C. (2003). Tissue-specific utilization of menaquinone-4 results in the prevention of arterial calcification in warfarin-treated rats. Journal of Vascular Research, 40(6), 531-7. https://doi.org/10.1159/000075344

Spronk, H. M. H., Govers-Riemslag, J. W. P., & ten Cate, H. (2003). The blood coagulation system as a molecular machine. Bioessays, 25(12), 1220-8. https://doi.org/10.1002/bies.10360

Koenen, RR., Tans, G., van Oerle, R., Hamulyak, K., Rosing, J., & Hackeng, TM. (2003). The APC-independent anticoagulant activity of protein S in plasma is decreased by elevated prothrombin levels due to the prothrombin G20210A mutation. Blood, 102(5), 1686-1692. https://doi.org/10.1182/blood-2003-02-0620