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Professorship Julie Staals

Professorship Julie Staals

22 April 2024

Dr Julie Staals (Dept. of Neurology) has been appointed as professor 'Neurovascular disease' as of 1 April 2024.

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ERC Advanced Grant awarded to Prof. Andy Baker

ERC Advanced Grant awarded to Prof. Andy Baker

15 April 2024

Prof. Andy Baker (Dept of Pathology) has been awarded a European Research Council (ERC) Advanced Grant of €2,5M for his research project PolymiRize: Poly-miRNA targeting to prevent and reverse complex tissue remodelling after acute cardiovascular events'.

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Carim Maastricht
Carim Maastricht

Dominik Linz

Professor

Prof Dominik Linz is a clinician-scientist who received his PhD from Maastricht University, The Netherlands, in 2013 (Prof. U. Schotten) and completed his Cardiology training in Homburg/Saar, Germany, in 2017 (Prof. M. Böhm). In 2017, he was recruited as an Associate Professor and clinical EP-fellow to Adelaide to initiate and drive a translational research programme focussing on atrial fibrillation and sleep disordered breathing at the Royal Adelaide Hospital and University of Adelaide (Prof. P. Sanders). Since 2019, Dr Dominik Linz is a Staff member and consultant clinician at the Heart+Vascular Center, Maastricht UMC+.

Over the past years Prof. Dominik Linz has developed a National and International reputation in the field of cardiac arrhythmia research. The focus of this work has been to understand the pathophysiology and mechanisms underlying atrial arrhythmias and the development of treatment approaches. This research has broadly included: (i) Work describing sleep apnoea associated electrophysiological changes in the atria increasing atrial fibrillation susceptibility. (ii) Description of antiarrhythmic effects of autonomic modulation by renal sympathetic denervation under different pathophysiological conditions. (iii) Work describing the role of the lysosomal carboxypeptidase cathepsin A in the development of an atrial arrhythmogenic substrates. Ongoing research is mainly focused on risk factor modification and preventive interventions for AF.

As of January 2024, Dominik Linz (Department of Cardiology) has been appointed as a professor at Maastricht University. The title of his position is 'Comprehensive Atrial Fibrillation Management.

Dominik-linz

Department of Cardiology

 

  • 2023
    • Hereijgers, M. J. M., van der Velden, R. M. J., Simons, S., & Linz, D. (2023). Respiratory Function Assessment in Patients With Atrial Fibrillation: A Needed Extension of Combined Comorbidity Management?Canadian Journal of Cardiology, 39(5), 623-624. https://doi.org/10.1016/j.cjca.2023.02.006
    • Baumert, M., Immanuel, S., McKane, S., & Linz, D. (2023). Transvenous phrenic nerve stimulation for the treatment of central sleep apnea reduces episodic hypoxemic burden. International Journal of Cardiology, 378(1), 89-95. https://doi.org/10.1016/j.ijcard.2023.02.041
    • Leao, S., Luermans, J., Vernooy, K., ter Bekke, R., den Uijl, D., Linz, D., & Chaldoupi, S.-M. (2023). The great deceiver: a case series of 'double fire' atrioventricular nodal response. European Heart Journal - Case Reports, 7(4), Article ytad162. https://doi.org/10.1093/ehjcr/ytad162
    • Arita, V. A., Van de Lande, M. E., Ekrami, N. K., Nguyen, B. O., Van Melle, J. M., Geelhoed, B., De With, R. R., Weberndorfer, V., Erkuner, O., Hillege, H., Linz, D., Ten Cate, H., Spronk, H. M. H., Koldenhof, T., Tieleman, R. G., Schotten, U., Crijns, H. J. G. M., Van Gelder, I. C., & Rienstra, M. (2023). Clinical utility of the 4S-AF scheme in predicting progression of atrial fibrillation: data from the RACE V study. EP Europace, 25(4), 1323-1331. https://doi.org/10.1093/europace/euac268
    • Hermans, A. N. L., Betz, K., Verhaert, D. V. M., den Uijl, D. W., Clerx, K., Debie, L., Lahaije, M., Vernooy, K., Linz, D., & Weijs, B. (2023). 360° Virtual reality to improve patient education and reduce anxiety towards atrial fibrillation ablation. EP Europace, 25(3), 855-862. https://doi.org/10.1093/europace/euac246
    • Hermans, A. N. L., Isaksen, J. L., Gawalko, M., Pluymaekers, N. A. H. A., van der Velden, R. M. J., Snippe, H., Evens, S., De Witte, G., Luermans, J. G. L. M., Manninger, M., Lumens, J., Kanters, J. K., & Linz, D. (2023). Accuracy of continuous photoplethysmography-based 1 min mean heart rate assessment during atrial fibrillation. EP Europace, 25(3), 835-844. https://doi.org/10.1093/europace/euad011
    • Hertel, J. N., Jerltorp, K., Hansen, M. E. H., Isaksen, J. L., Sattler, S. M., Linz, B., Chaldoupi, S. M., Jespersen, T., Saljic, A., Gang, U. F., Manninger, M., & Linz, D. (2023). 3D-electroanatomical mapping of the left atrium and catheter-based pulmonary vein isolation in pigs: A practical guide. Frontiers in Cardiovascular Medicine, 10(1), Article 1139364. https://doi.org/10.3389/fcvm.2023.1139364
    • Rahm, A. K., Linz, D., & Gang, U. J. O. (2023). Imaging approaches for pulmonary vein isolation in patients after lobectomy or pneumonectomy: a case series. European Heart Journal - Case Reports, 7(3), Article ytad117. https://doi.org/10.1093/ehjcr/ytad117
    • Linz, D., & Chaldoupi, S. M. (2023). Alcohol Abstinence Around Atrial Fibrillation Ablation: Breaking Common Habits. Canadian Journal of Cardiology, 39(3), 274-276. https://doi.org/10.1016/j.cjca.2023.01.006
    • Hillmann, H. A. K., Betz, K., Linz, D., & Duncker, D. (2023). How to: Antiarrhythmika in der klinischen Anwendung. Herzschrittmachertherapie und Elektrophysiologie, 34(1), 82-90. https://doi.org/10.1007/s00399-022-00919-y
    • Gawalko, M., Saljic, A., Li, N., Abu-Taha, I., Jespersen, T., Linz, D., Nattel, S., Heijman, J., Fender, A., & Dobrev, D. (2023). Adiposity-associated atrial fibrillation: molecular determinants, mechanisms, and clinical significance. Cardiovascular Research, 119(3), 614-630. https://doi.org/10.1093/cvr/cvac093
    • Gawałko, M., & Linz, D. (2023). Atrial Fibrillation Detection and Management in Hypertension. Hypertension, 80(3), 523-533. https://doi.org/10.1161/HYPERTENSIONAHA.122.19459
    • Linz, D., & Schnabel, R. B. (2023). Gut microbiota-derived metabolites in atrial fibrillation: risk markers or modifiable risk factors?Heart, 109(5), 342-343. https://doi.org/10.1136/heartjnl-2022-321806
    • Warming, P. E., Garcia, R., Hansen, C. J., Simons, S. O., Torp-Pedersen, C., Linz, D., & Tfelt-Hansen, J. (2023). The association of temporal sequence in atrial fibrillation and chronic obstructive pulmonary disease diagnosis and mortality risk: Reply. European heart journal - Quality of care & clinical outcomes, 9(2), E2-E2. https://doi.org/10.1093/ehjqcco/qcac079
    • Warming, P. E., Garcia, R., Hansen, C. J., Simons, S. O., Torp-Pedersen, C., Linz, D., & Tfelt-Hansen, J. (2023). Atrial fibrillation and chronic obstructive pulmonary disease: diagnostic sequence and mortality risk. European heart journal - Quality of care & clinical outcomes, 9(2), 128-134. Article qcac059. https://doi.org/10.1093/ehjqcco/qcac059
    • Leao, S., Linz, D., & Luermans, J. (2023). Accessory pathway ablation: microelectrodes reveal the hidden signals. EP Europace, 25(2), 432. https://doi.org/10.1093/europace/euac271
    • Nguyen, B. O., Weberndorfer, V., Crijns, H. J. G. M., Geelhoed, B., Ten Cate, H., Spronk, H., Kroon, A., De With, R., Al-Jazairi, M., Maass, A. H., Blaauw, Y., Tieleman, R. G., Hemels, M. E. W., Luermans, J., de Groot, J., Allaart, C. P., Elvan, A., De Melis, M., Scheerder, C., ... Rienstra, M. (2023). Prevalence and determinants of atrial fibrillation progression in paroxysmal atrial fibrillation. Heart, 109(3), 186-194. https://doi.org/10.1136/heartjnl-2022-321027
    • Shahrbabaki, S. S., Linz, D., Redline, S., Stone, K., Ensrud, K., & Baumert, M. (2023). Sleep Arousal-Related Ventricular Repolarization Lability Is Associated With Cardiovascular Mortality in Older Community-Dwelling Men. Chest, 163(2), 419-432. https://doi.org/10.1016/j.chest.2022.09.043
    • Luker, J., Strik, M., Andrade, J. G., Raymond-Paquin, A., Elrefai, M. H., Roberts, P. R., Perez, O. C., Kron, J., Koneru, J., Franqui-Rivera, H., Sultan, A., Ernst, A., Schmitt, J., Pott, A., Veltmann, C., Srinivasan, N. T., Collinson, J., van Stipdonk, A. M. W., Linz, D., ... Steven, D. (2023). Incidence of premature battery depletion in subcutaneous cardioverter-defibrillator patients: insights from a multicenter registry. Journal of Interventional Cardiac Electrophysiology. Advance online publication. https://doi.org/10.1007/s10840-023-01468-1
    • Betz, K., Giordano, M., Hillmann, H. A. K., Duncker, D., Dobrev, D., & Linz, D. (2023). The impact of Twitter/X promotion on visibility of research articles: Results of the #TweetTheJournal study. IJC Heart and Vasculature, 50, Article 101328. Advance online publication. https://doi.org/10.1016/j.ijcha.2023.101328
    • Schnabel, R. B., Marinelli, E. A., Arbelo, E., Boriani, G., Boveda, S., Buckley, C. M., Camm, A. J., Casadei, B., Chua, W., Dagres, N., de Melis, M., Desteghe, L., Diederichsen, S. Z., Duncker, D., Eckardt, L., Eisert, C., Engler, D., Fabritz, L., Freedman, B., ... Kirchhof, P. (2023). Early diagnosis and better rhythm management to improve outcomes in patients with atrial fibrillation: the 8th AFNET/EHRA consensus conference. EP Europace, 25(1), 6–27. https://doi.org/10.1093/europace/euac062
    • van der Velden, R. M. J., Pluymaekers, N. A. H. A., Dudink, E. A. M. P., Luermans, J. G. L. M., Meeder, J. G., Heesen, W. F., Lenderink, T., Widdershoven, J. W. M. G., Bucx, J. J. J., Rienstra, M., Kamp, O., van Opstal, J. M., Kirchhof, C. J. H. J., van Dijk, V. F., Swart, H. P., Alings, M., Van Gelder, I. C., Crijns, H. J. G. M., & Linz, D. (2023). Mobile health adherence for the detection of recurrent recent-onset atrial fibrillation. Heart, 109(1), 26-33. https://doi.org/10.1136/heartjnl-2022-321346
    • Linz, B., Hesselkilde, E. M., Skarsfeldt, M. A., Hertel, J. N., Sattler, S. M., Yan, Y., Tfelt-Hansen, J., Diness, J. G., Bentzen, B. H., Linz, D., & Jespersen, T. (2023). Pharmacological inhibition of SK-channels with AP14145 prevents atrial arrhythmogenic changes in a porcine model for obstructive respiratory events. Journal of Cardiovascular Electrophysiology, 34(1), 126-134. https://doi.org/10.1111/jce.15769
  • 2022
    • Baumert, M., Linz, D., & Arzt, M. (2022). Modeling sleep-disordered breathing using overnight polysomnography-opportunities for patient-oriented research and patient care. Sleep (Online), 45(12). https://doi.org/10.1093/sleep/zsac213
    • Baumert, M., Cowie, M. R., Redline, S., Mehra, R., Arzt, M., Pépin, J.-L., & Linz, D. (2022). Sleep characterization with smart wearable devices: A call for standardization and consensus recommendations. Sleep (Online), 45(12), Article zsac183. https://doi.org/10.1093/sleep/zsac183
    • Hermans, B. J. M., Weberndörfer, V., Bijvoet, G. P., Chaldoupi, S.-M., & Linz, D. (2022). New concepts in atrial fibrillation pathophysiology. Herzschrittmachertherapie und Elektrophysiologie, 33, 362-366. https://doi.org/10.1007/s00399-022-00897-1
    • Boriani, G., Svennberg, E., Guerra, F., Linz, D., Casado-Arroyo, R., Malaczynska-Rajpold, K., Duncker, D., Boveda, S., Merino, J. L., & Leclercq, C. (2022). Reimbursement practices for use of digital devices in atrial fibrillation and other arrhythmias: a European Heart Rhythm Association survey. EP Europace, 24(11), 1834-1843. https://doi.org/10.1093/europace/euac142
    • Hermans, A. N. L., Gawalko, M., Slegers, D. P. J., Andelfinger, N., Pluymaekers, N. A. H. A., Verhaert, D. V. M., van der Velden, R. M. J., Betz, K., Evens, S., Luermans, J. G. L. M., den Uijl, D. W., Baumert, M., Nguyen, H. L., Isaksen, J. L., Kanters, J. K., Rienstra, M., Vernooy, K., Van Gelder, I. C., Hendriks, J. M., & Linz, D. (2022). Mobile app-based symptom-rhythm correlation assessment in patients with persistent atrial fibrillation. International Journal of Cardiology, 367, 29-37. https://doi.org/10.1016/j.ijcard.2022.08.021
    • Levine, Y. C., Ifedili, I., & Linz, D. (2022). Atrial fibrillation during the blanking period post ablation correlates with long-term recurrence: myth vs reality. Journal of Interventional Cardiac Electrophysiology, 65(2), 351-352. https://doi.org/10.1007/s10840-022-01371-1
    • Linz, D., & McIntyre, W. F. (2022). Sinus rhythm: The sine qua non for rhythm control?European Heart Journal, 43, 4145-4147. https://doi.org/10.1093/eurheartj/ehac490
    • McIntyre, W. F., & Linz, D. (2022). Atrial fibrillation and stroke: who is low risk and what are we going to do about it?European Heart Journal, 43(37), 3539-3541. https://doi.org/10.1093/eurheartj/ehac099
    • Bijvoet, G. P., Nies, H. M. J. M., Holtackers, R. J., Linz, D., Adriaans, B. P., Nijveldt, R., Wildberger, J. E., Vernooy, K., Chaldoupi, S.-M., & Mihl, C. (2022). Correlation between Cardiac MRI and Voltage Mapping in Evaluating Atrial Fibrosis: A Systematic Review. Radiology. Cardiothoracic imaging, 4(5), Article e220061. https://doi.org/10.1148/ryct.220061
    • van der Velden, R. M. J., Hermans, A. N. L., Pluymaekers, N. A. H. A., Gawalko, M., Elliott, A., Hendriks, J. M., Franssen, F. M. E., Slats, A. M., van Empel, V. P. M., Van Gelder, I. C., Thijssen, D. H. J., Eijsvogels, T. M. H., Leue, C., Crijns, H. J. G. M., Linz, D., & Simons, S. O. (2022). Dyspnea in patients with atrial fibrillation: Mechanisms, assessment and an interdisciplinary and integrated care approach. IJC Heart and Vasculature, 42, Article 101086. https://doi.org/10.1016/j.ijcha.2022.101086
    • Linz, B., Hertel, J. N., Jespersen, T., & Linz, D. (2022). Mechanisms and therapeutic opportunities in atrial fibrillation in relationship to alcohol use and abuse. Canadian Journal of Cardiology, 38(9), 1352-1363. https://doi.org/10.1016/j.cjca.2022.04.009
    • Hendriks, J. M., Lee, G., Desteghe, L., & Linz, D. (2022). Sleep apnoea management in atrial fibrillation in clinical practice: key messages for health care professionals based on a joint survey by EHRA and ACNAP. European Journal of Cardiovascular Nursing, 21(7), 641–642. https://doi.org/10.1093/eurjcn/zvab082
    • Mehra, R., Chung, M. K., Olshansky, B., Dobrev, D., Jackson, C. L., Kundel, V., Linz, D., Redeker, N. S., Redline, S., Sanders, P., Somers, V. K., Amer Heart Association Electrocardiography and Arrhythmias Committee of the Council on Clinical Cardiology, & Stroke Council (2022). Sleep-Disordered Breathing and Cardiac Arrhythmias in Adults: Mechanistic Insights and Clinical Implications: A Scientific Statement From the American Heart Association. Circulation, 146(9), E119-E136. https://doi.org/10.1161/CIR.0000000000001082
    • Gawałko, M., Agbaedeng, T. A., Saljic, A., Müller, D. N., Wilck, N., Schnabel, R., Penders, J., Rienstra, M., van Gelder, I., Jespersen, T., Schotten, U., Crijns, H. J. G. M., Kalman, J. M., Sanders, P., Nattel, S., Dobrev, D., & Linz, D. (2022). Gut microbiota, dysbiosis and atrial fibrillation. Arrhythmogenic mechanisms and potential clinical implications. Cardiovascular Research, 118(11), 2415-2427. https://doi.org/10.1093/cvr/cvab292
    • Van Mourik, M. J. W., Arita, V. A., Lyon, A., Lumens, J., De With, R. R., van Melle, J. P., Schotten, U., Bekkers, S. C. A. M., Crijns, H. J. G. M., Van Gelder, I. C., Rienstra, M., & Linz, D. K. (2022). Association between comorbidities and left and right atrial dysfunction in patients with paroxysmal atrial fibrillation: Analysis of AF-RISK. International Journal of Cardiology, 360, 29-35. https://doi.org/10.1016/j.ijcard.2022.05.044
    • Verhaert, D. V. M., Linz, D., Chaldoupi, S. M., Westra, S. W., den Uijl, D. W., Philippens, S., Kerperien, M., Habibi, Z., Vorstermans, B., ter Bekke, R. M. A., Beukema, R. J., Evertz, R., Hemels, M. E. W., Luermans, J. G. L. M., Manusama, R., Lankveld, T. A. R., van der Heijden, C. A. J., Bidar, E., Hermans, B. M., ... Schotten, U. (2022). Rationale and Design of the ISOLATION Study: A Multicenter Prospective Cohort Study Identifying Predictors for Successful Atrial Fibrillation Ablation in an Integrated Clinical Care and Research Pathway. Frontiers in Cardiovascular Medicine, 9, Article 879139. https://doi.org/10.3389/fcvm.2022.879139
    • Fisser, C., Gall, L., Bureck, J., Vaas, V., Priefert, J., Fredersdorf, S., Zeman, F., Linz, D., Woehrle, H., Tamisier, R., Teschler, H., Cowie, M. R., & Arzt, M. (2022). Effects of Adaptive Servo-Ventilation on Nocturnal Ventricular Arrhythmia in Heart Failure Patients With Reduced Ejection Fraction and Central Sleep Apnea-An Analysis From the SERVE-HF Major Substudy. Frontiers in Cardiovascular Medicine, 9, 896917. https://doi.org/10.3389/fcvm.2022.896917
    • Linz, D. (2022). Longitudinal sleep apnea burden monitoring: Implications for future smart wearable- and implantable- devices. International Journal of Cardiology, 357, 46-47. https://doi.org/10.1016/j.ijcard.2022.03.025
    • Svennberg, E., Tjong, F., Goette, A., Akoum, N., Di Biaise, L., Bordachar, P., Boriani, G., Burri, H., Conte, G., Deharo, J.-C., Deneke, T., Drossart, I., Duncker, D., Han, J. K., Heidbuchel, H., Jais, P., de Oliviera Figueiredo, M. J., Linz, D., Lip, G. Y. H., ... Sinner, M. (2022). How to use digital devices to detect and manage arrhythmias: an EHRA practical guide. EP Europace, 24(6), 979-1005. https://doi.org/10.1093/europace/euac038
    • Chaldoupi, S.-M., Maesen, B., Linz, D., & Luermans, J. G. L. M. (2022). Left-sided atrial tachycardia ablation in an atrial-esophageal fistula survivor. HeartRhythm Case Reports, 8(6), 428-432. https://doi.org/10.1016/j.hrcr.2022.03.008
    • Benjamin Fyenbo, D., Charlotte Frederiksen, T., Linz, D., Jespersen, T., Dobrev, D., Gislason, G., Betz, K., Saljic, A., & Nielsen Holck, E. (2022). Researchers in cardiology - Why and how to get on Twitter?IJC Heart and Vasculature, 40, Article 101010. https://doi.org/10.1016/j.ijcha.2022.101010
    • Hereijgers, M. J. M., Betz, K., Simons, S. O., & Linz, D. (2022). Undiagnosed sleep apnea in patients with atrial fibrillation: An underutilized opportunity for antiarrhythmic management. IJC Heart and Vasculature, 40, Article 101050. https://doi.org/10.1016/j.ijcha.2022.101050
    • Chaldoupi, S.-M., Luermans, J., & Linz, D. (2022). Very high-power short-duration ablation for treatment of premature ventricular contractions: Truth or Dare?IJC Heart and Vasculature, 40, Article 101053. https://doi.org/10.1016/j.ijcha.2022.101053
    • Homberg, M. C., Bouman, E. A., Linz, D., van Kuijk, S. M. J., Joosten, B. A., & Buhre, W. F. (2022). High-flow nasal cannula versus standard low-flow nasal cannula during deep sedation in patients undergoing radiofrequency atrial fibrillation catheter ablation: a single-centre randomised controlled trial. Trials, 23(1), Article 378. https://doi.org/10.1186/s13063-022-06362-1
    • Hermans, A. N. L., Gawalko, M., Dohmen, L., van der Velden, R. M. J., Betz, K., Verhaert, D. V. M., Pluymaekers, N. A. H. A., Hendriks, J. M., & Linz, D. (2022). A systematic review of mobile health opportunities for atrial fibrillation detection and management. European Journal of Preventive Cardiology, 29(5), E205-E208. https://doi.org/10.1093/eurjpc/zwab158
    • Heckman, L. I. B., Luermans, J. G. L. M., Jastrzębski, M., Weijs, B., Van Stipdonk, A. M. W., Westra, S., den Uijl, D., Linz, D., Mafi-Rad, M., Prinzen, F. W., & Vernooy, K. (2022). A single-centre prospective evaluation of left bundle branch area pacemaker implantation characteristics. Netherlands Heart Journal, 30(5), 249-257. https://doi.org/10.1007/s12471-022-01679-7
    • Nissen, S. D., Weis, R., Krag-Andersen, E. K., Hesselkilde, E. M., Isaksen, J. L., Carstensen, H., Kanters, J. K., Linz, D., Sanders, P., Hopster-Iversen, C., Jespersen, T., Pehrson, S., & Buhl, R. (2022). Electrocardiographic characteristics of trained and untrained standardbred racehorses. Journal of Veterinary Internal Medicine, 36(3), 1119-1130. https://doi.org/10.1111/jvim.16427
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