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Professorship Julie Staals

Professorship Julie Staals

22 April 2024

Dr Julie Staals (Dept. of Neurology) has been appointed as professor 'Neurovascular disease' as of 1 April 2024.

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ERC Advanced Grant awarded to Prof. Andy Baker

ERC Advanced Grant awarded to Prof. Andy Baker

15 April 2024

Prof. Andy Baker (Dept of Pathology) has been awarded a European Research Council (ERC) Advanced Grant of €2,5M for his research project PolymiRize: Poly-miRNA targeting to prevent and reverse complex tissue remodelling after acute cardiovascular events'.

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Carim Maastricht
Carim Maastricht

Dominik Linz

Professor

Prof Dominik Linz is a clinician-scientist who received his PhD from Maastricht University, The Netherlands, in 2013 (Prof. U. Schotten) and completed his Cardiology training in Homburg/Saar, Germany, in 2017 (Prof. M. Böhm). In 2017, he was recruited as an Associate Professor and clinical EP-fellow to Adelaide to initiate and drive a translational research programme focussing on atrial fibrillation and sleep disordered breathing at the Royal Adelaide Hospital and University of Adelaide (Prof. P. Sanders). Since 2019, Dr Dominik Linz is a Staff member and consultant clinician at the Heart+Vascular Center, Maastricht UMC+.

Over the past years Prof. Dominik Linz has developed a National and International reputation in the field of cardiac arrhythmia research. The focus of this work has been to understand the pathophysiology and mechanisms underlying atrial arrhythmias and the development of treatment approaches. This research has broadly included: (i) Work describing sleep apnoea associated electrophysiological changes in the atria increasing atrial fibrillation susceptibility. (ii) Description of antiarrhythmic effects of autonomic modulation by renal sympathetic denervation under different pathophysiological conditions. (iii) Work describing the role of the lysosomal carboxypeptidase cathepsin A in the development of an atrial arrhythmogenic substrates. Ongoing research is mainly focused on risk factor modification and preventive interventions for AF.

As of January 2024, Dominik Linz (Department of Cardiology) has been appointed as a professor at Maastricht University. The title of his position is 'Comprehensive Atrial Fibrillation Management.

Dominik-linz

Department of Cardiology

 

  • 2021
    • Linz, D., Malfertheiner, M. V., Werner, N., Lerzer, C., Gfullner, F., Linz, B., Zeman, F., McEvoy, R. D., Arzt, M., & Baumert, M. (2021). Nocturnal hypoxemic burden during positive airway pressure treatment across different central sleep apnea etiologies. Sleep Medicine, 79, 62-70. https://doi.org/10.1016/j.sleep.2021.01.007
    • Lyon, A., van Mourik, M., Cruts, L., Heijman, J., Bekkers, S. C. A. M., Schotten, U., Crijns, H. J. G. M., Linz, D., & Lumens, J. (2021). Both beat-to-beat changes in RR-interval and left ventricular filling time determine ventricular function during atrial fibrillation. EP Europace, 23, I21-I28. https://doi.org/10.1093/europace/euaa387
    • Pluymaekers, N. A. H. A., Hermans, A. N. L., van der Velden, R. M. J., Gawalko, M., den Uijl, D. W., Buskes, S., Vernooy, K., Crijns, H. J. G. M., Hendriks, J. M., & Linz, D. (2021). Implementation of an on-demand app-based heart rate and rhythm monitoring infrastructure for the management of atrial fibrillation through teleconsultation: TeleCheck-AF. EP Europace, 23(3), 345-352. https://doi.org/10.1093/europace/euaa201
    • Vaas, V., Fisser, C., Tafelmeier, M., Linz, D., & Arzt, M. (2021). Interaktionen schlafbezogener Atmungsstörungen mit Vorhofflimmern. Somnologie, 25(1), 38-44. https://doi.org/10.1007/s11818-020-00271-8
    • Linz, B., Hohl, M., Lang, L., Wong, D. W. L., Nickel, A. G., De La Torre, C., Sticht, C., Wirth, K., Boor, P., Maack, C., Speer, T., Jespersen, T., Schotten, U., Sanders, P., Bohm, M., & Linz, D. (2021). Repeated exposure to transient obstructive sleep apnea-related conditions causes an atrial fibrillation substrate in a chronic rat model. Heart Rhythm, 18(3), 455-464. https://doi.org/10.1016/j.hrthm.2020.10.011
    • Heijman, J., Luermans, J. G. L. M., Linz, D., van Gelder, I. C., & Crijns, H. J. G. M. (2021). Risk Factors for Atrial Fibrillation Progression. Cardiac Electrophysiology Clinics, 13(1), 201-209. https://doi.org/10.1016/j.ccep.2020.10.011
    • Linz, D., Nattel, S., Kalman, J. M., & Sanders, P. (2021). Sleep Apnea and Atrial Fibrillation. Cardiac Electrophysiology Clinics, 13(1), 87-94. https://doi.org/10.1016/j.ccep.2020.10.003
    • Heijman, J., Linz, D., & Schotten, U. (2021). Dynamics of Atrial Fibrillation Mechanisms and Comorbidities. Annual Review of Physiology, 83, 83-106. https://doi.org/10.1146/annurev-physiol-031720-085307
    • Hermans, B. J. M., & Linz, D. (2021). Abnormal electrograms during sinus rhythm for VT ablation: Beware of Fata Morganas. Journal of Cardiovascular Electrophysiology, 32(2), 389-390. https://doi.org/10.1111/jce.14855
    • Simons, S. O., Elliott, A., Sastry, M., Hendriks, J. M., Arzt, M., Rienstra, M., Kalman, J. M., Heidbuchel, H., Nattel, S., Wesseling, G., Schotten, U., van Gelder, I. C., Franssen, F. M. E., Sanders, P., Crijns, H. J. G. M., & Linz, D. (2021). Chronic obstructive pulmonary disease and atrial fibrillation an interdisciplinary perspective. European Heart Journal, 42(5), 532-540. https://doi.org/10.1093/eurheartj/ehaa822
  • 2020
    • Hendriks, J. M., & Linz, D. (2020). Screening for obstructive sleep apnoea in patients with atrial fibrillation: Much more than a screening tool alone. IJC Heart and Vasculature, 31, Article 100655. https://doi.org/10.1016/j.ijcha.2020.100655
    • Linz, D., & Dobrev, D. (2020). Sleep apnea and atrial fibrillation: Update 2020. IJC Heart and Vasculature, 31, Article 100681. https://doi.org/10.1016/j.ijcha.2020.100681
    • Hermans, A. N. L., Andrade, J. G., & Linz, D. (2020). Arterial Stiffness Association With Symptom Burden in Patients With Atrial Fibrillation: Direct Cause or Marker of Concomitant Risk Factors?Canadian Journal of Cardiology, 36(12), 1843-1846. https://doi.org/10.1016/j.cjca.2020.08.003
    • Linz, D., Loffler, K. A., Sanders, P., Catcheside, P., Anderson, C. S., Zheng, D., Quan, W., Barnes, M., Redline, S., McEvoy, R. D., Baumert, M., & SAVE (Sleep Apnea Cardiovascular Endpoints) Investigators (2020). Low Prognostic Value of Novel Nocturnal Metrics in Patients With OSA and High Cardiovascular Event Risk Post Hoc Analyses of the SAVE Study. Chest, 158(6), 2621-2631. https://doi.org/10.1016/j.chest.2020.06.072
    • Linz, D., & Duncker, D. (2020). Twitter in der Kardiologie: Praktische Anleitung für den professionellen Gebrauch. Herzschrittmachertherapie und Elektrophysiologie, 31(4), 388-393. https://doi.org/10.1007/s00399-020-00699-3
    • Hermans, A. N. L., van der Velden, R. M. J., Gawalko, M., Verhaert, D. V. M., Desteghe, L., Duncker, D., Manninger, M., Heidbuchel, H., Pisters, R., Hemels, M., Pison, L., Sohaib, A., Sultan, A., Steven, D., Wijtvliet, P., Tieleman, R., Gupta, D., Dobrev, D., Svennberg, E., ... TeleCheck-AF investigators (2020). On-demand mobile health infrastructures to allow comprehensive remote atrial fibrillation and risk factor management through teleconsultation. Clinical Cardiology, 43(11), 1232-1239. https://doi.org/10.1002/clc.23469
    • Bejinariu, A. G., Makimoto, H., Wakili, R., Mathew, S., Kosiuk, J., Linz, D., Steinfurt, J., Dechering, D. G., Meyer, C., Veltmann, C., Kelm, M., Frommeyer, G., Eckardt, L., Deneke, T., Duncker, D., & Muller, P. (2020). One-Year Course of Periprocedural Anticoagulation in Atrial Fibrillation Ablation: Results of a German Nationwide Survey. Cardiology, 145(10), 676-681. https://doi.org/10.1159/000509399
    • Linz, D., van der Velden, R. M. J., Gawalko, M., Hermans, A. N. L., Pluymaekers, N. A. H. A., & Hendriks, J. M. (2020). Remote management and education in patients with cardiovascular conditions during COVID-19 and beyond. IJC Heart and Vasculature, 30, Article 100646. https://doi.org/10.1016/j.ijcha.2020.100646
    • Linz, D., & Hendriks, J. (2020). Central sleep apnea in atrial fibrillation: Risk factor or marker of untreated underlying disease?IJC Heart & Vasculature, 30, Article 100650. https://doi.org/10.1016/j.ijcha.2020.100650
    • Gawalko, M., Kaplon-Cieslicka, A., Hohl, M., Dobrev, D., & Linz, D. (2020). COVID-19 associated atrial fibrillation: Incidence, putative mechanisms and potential clinical implications. IJC Heart & Vasculature, 30, Article 100631. https://doi.org/10.1016/j.ijcha.2020.100631
    • Bogossian, H., Linz, D., Heijman, J., Bimpong-Buta, N.-Y., Bandorski, D., Frommeyer, G., Erkapic, D., Seyfarth, M., Zarse, M., & Crijns, H. J. (2020). QTc evaluation in patients with bundle branch block. IJC Heart & Vasculature, 30, Article 100636. https://doi.org/10.1016/j.ijcha.2020.100636
    • Pluymaekers, N. A. H. A., Linz, D. K., Rienstra, M., van Gelder, I. C., & Crijns, H. J. G. M. (2020). Emergency department cardioversion of acute atrial fibrillation. Lancet, 396(10255), 884-885. https://doi.org/10.1016/S0140-6736(20)31311-8
    • Hohl, M., Mayr, M., Lang, L., Nickel, A. G., Barallobre-Barreiro, J., Yin, X., Speer, T., Selejan, S.-R., Goettsch, C., Erb, K., Fecher-Trost, C., Reil, J.-C., Linz, B., Ruf, S., Huebschle, T., Maack, C., Boehm, M., Sadowski, T., & Linz, D. (2020). Cathepsin A contributes to left ventricular remodeling by degrading extracellular superoxide dismutase in mice. Journal of Biological Chemistry, 295(36), 12605-12617. https://doi.org/10.1074/jbc.RA120.013488
    • van der Velden, R. M. J., Hermans, A. N. L., Pluymaekers, N. A. H. A., Gawalko, M., Vorstermans, B., Martens, H., Buskes, S., Crijns, H. J. G. M., Linz, D., & Hendriks, J. M. (2020). Coordination of a remote mHealth infrastructure for atrial fibrillation management during COVID-19 and beyond: TeleCheck-AF. International Journal of Care Coordination, 23(2-3), 65-70. Article 2053434520954619. https://doi.org/10.1177/2053434520954619
    • Linz, B., Saljic, A., Hohl, M., Gawalko, M., Jespersen, T., Sanders, P., Bohm, M., & Linz, D. (2020). Inhibition of sodium-proton-exchanger subtype 3-mediated sodium absorption in the gut: A new antihypertensive concept. IJC Heart & Vasculature, 29, Article 100591. https://doi.org/10.1016/j.ijcha.2020.100591
    • De With, R. R., Erkuner, O., Rienstra, M., Nguyen, B.-O., Korver, F. W. J., Linz, D., Ten, H. C., Spronk, H., Kroon, A. A., Maass, A. H., Blaauw, Y., Tieleman, R. G., Hemels, M. E. W., de Groot, J. R., Elvan, A., de Melis, M., Scheerder, C. O. S., Al-Jazairi, M. I. H., Schotten, U., ... RACE V Investigators (2020). Temporal patterns and short-term progression of paroxysmal atrial fibrillation data from RACE V. EP Europace, 22(8), 1162-1172. https://doi.org/10.1093/europace/euaa123
    • Gawalko, M., Jespersen, T., Dobrev, D., & Linz, D. (2020). The gut microbial-derived metabolite trimethylamine N-oxide: A missing link between lifestyle-components and atrial fibrillation?IJC Heart & Vasculature, 29, Article 100581. https://doi.org/10.1016/j.ijcha.2020.100581
    • Khan, A., Hasan, F., Bandorski, D., Lemke, B., Linz, D., Zarse, M., Bimpong-Buta, N.-Y., & Bogossian, H. (2020). Transaortic pulmonary vein isolation in the presence of situs inversus and total venous anomaly; technical capabilities for 3D reconstruction and considerations of adequate choice of ablation catheters. IJC Heart & Vasculature, 29, Article 100577. https://doi.org/10.1016/j.ijcha.2020.100577
    • Desteghe, L., Linz, D., & Hendriks, J. M. (2020). Sleep Apnea Testing and Management in Patients With Atrial Fibrillation Why is it So Difficult?Journal of Cardiovascular Nursing, 35(4), 324-326. https://doi.org/10.1097/JCN.0000000000000668
    • Linz, D., Pluymaekers, N. A. H. A., Hendriks, J. M., & TeleCheck-AF investigators (2020). TeleCheck-AF for COVID-19. European Heart Journal, 41(21), 1954-1955. https://doi.org/10.1093/eurheartj/ehaa404
    • Pluymaekers, N. A. H. A., Hermans, A. N. L., van der Velden, R. M. J., den Uijl, D. W., Vorstermans, B., Buskes, S., Hendriks, J. M., Vernooy, K., Crijns, H. J. G. M., & Linz, D. (2020). On-demand app-based rate and rhythm monitoring to manage atrial fibrillation through teleconsultations during COVID-19. IJC Heart & Vasculature, 28, Article 100533. https://doi.org/10.1016/j.ijcha.2020.100533
    • Linz, B., Hohl, M., Mishima, R., Saljic, A., Lau, D. H., Jespersen, T., Schotten, U., Sanders, P., & Linz, D. (2020). Pharmacological inhibition of sodium-proton-exchanger subtype 3-mediated sodium absorption in the gut reduces atrial fibrillation susceptibility in obese spontaneously hypertensive rats. IJC Heart & Vasculature, 28, Article 100534. https://doi.org/10.1016/j.ijcha.2020.100534
    • Linz, D., Linz, B., & Heijman, J. (2020). Sleep Apnea, Intermittent Hypoxemia, and Effects on Ischemic Myocardial Damage: Friend or Foe?Canadian Journal of Cardiology, 36(6), 809-812. https://doi.org/10.1016/j.cjca.2020.02.075
    • Linz, D., & Crijns, H. J. G. M. (2020). Alcohol Abstinence in Drinkers with Atrial Fibrillation. New England Journal of Medicine, 382(18), 1768-1768. https://doi.org/10.1056/NEJMc2001512
    • Linz, D., & Stavrakis, S. (2020). Cardioneuroablation for vagally mediated bradyarrhythmia: The universal one fits all solution?International Journal of Cardiology, 304, 45-46. https://doi.org/10.1016/j.ijcard.2020.01.007
    • Gawalko, M., Elliott, A., Kadhim, K., Sanders, P., & Linz, D. (2020). A call for a more objective and longitudinal reporting of lifestyle components in cardiovascular research. IJC Heart & Vasculature, 27, Article 100506. https://doi.org/10.1016/j.ijcha.2020.100506
    • Scheenstra, B., van't Hof, A., Spreeuwenberg, M., & Linz, D. (2020). From calculating cardiovascular risk factors in Honduras towards a universal cardiovascular risk model. IJC Heart & Vasculature, 27, Article 100485. https://doi.org/10.1016/j.ijcha.2020.100485
    • Olligs, J., Linz, D., Dechering, D. G., Eckardt, L., & Müller, P. (2020). Heart rate - A complex prognostic marker in acute heart failure. IJC Heart and Vasculature, 26, Article 100456. https://doi.org/10.1016/j.ijcha.2019.100456
    • Kadhim, K., Lau, D. H., Sanders, P., & Linz, D. (2020). Sleep apnea in atrial fibrillation - Highly prevalent, highly relevant, but most patients are not somnolent!IJC Heart and Vasculature, 26, Article 100463. https://doi.org/10.1016/j.ijcha.2019.100463
    • Maesen, B., Weberndorfer, V., Bidar, E., & Linz, D. (2020). The importance of bipolar bidirectional radiofrequency in surgical AF ablation. IJC Heart and Vasculature, 26, Article 100478. https://doi.org/10.1016/j.ijcha.2020.100478
    • Pluymaekers, N. A. H. A., Hermans, A. N. L., Linz, D. K., Dudink, E. A. M. P., Luermans, J. G. L. M., Weijs, B., Vernooy, K., & Crijns, H. J. G. M. (2020). Frequency and Determinants of Spontaneous Conversion to Sinus Rhythm in Patients Presenting to the Emergency Department with Recent-onset Atrial Fibrillation: A Systematic Review. Arrhythmia & Electrophysiology Review, 9(4), 195-201. https://doi.org/10.15420/aer.2020.34
  • 2019
    • Pluymaekers, N. A. H. A., Hermans, A. N. L., Middeldorp, M. E., Kadhim, K., Crijns, H. J. G. M., Sanders, P., & Linz, D. (2019). Gender differences and daily variation in atrial fibrillation risk factor profiles: Considerations for risk factor management. IJC Heart and Vasculature, 25, Article 100442. https://doi.org/10.1016/j.ijcha.2019.100442
    • Linz, D., Ammirati, E., Dan, G.-A., Heijman, J., & Dobrev, D. (2019). Highlights from the International Journal of Cardiology Heart & Vasculature: Heart failure, atrial fibrillation, coronary artery disease and myocardial infarction. IJC Heart and Vasculature, 25, Article 100443. https://doi.org/10.1016/j.ijcha.2019.100443
    • Hendriks, J. M. L., Gallagher, C., Astley, C., Linz, D., & Gallagher, R. (2019). Cardiac rehabilitation services: A global perspective on performance and barriers. IJC Heart and Vasculature, 24, Article 100410. https://doi.org/10.1016/j.ijcha.2019.100410
    • Lankveld, T. A. R., Vernooy, K., Crijns, H. J. G. M., & Linz, D. (2019). How to make catheter ablation available world-wide?IJC Heart and Vasculature, 24, Article 100411. https://doi.org/10.1016/j.ijcha.2019.100411
    • den Uijl, D. W., Crijns, H. J. G. M., Vernooy, K., & Linz, D. (2019). Hypnotic communication during atrial fibrillation ablation: Another clinical application of hypnotherapy?IJC Heart and Vasculature, 24, Article 100408. https://doi.org/10.1016/j.ijcha.2019.100408
    • Linz, D., Baumert, M., Desteghe, L., Kadhim, K., Vernooy, K., Kalman, J. M., Dobrev, D., Arzt, M., Sastry, M., Crijns, H. J. G. M., Schotten, U., Cowie, M. R., McEvoy, R. D., Heidbuchel, H., Hendriks, J., Sanders, P., & Lau, D. H. (2019). Nightly sleep apnea severity in patients with atrial fibrillation: Potential applications of long-term sleep apnea monitoring. IJC Heart and Vasculature, 24, 1-7. Article 100424. https://doi.org/10.1016/j.ijcha.2019.100424
    • Khokhar, K. B., Lau, D. H., Sanders, P., & Linz, D. (2019). Risk profiling in atrial fibrillation: Value of assessment of vascular blush. IJC Heart and Vasculature, 24, Article 100399. https://doi.org/10.1016/j.ijcha.2019.100399
    • Linz, D., Elliott, A. D., Hohl, M., Malik, V., Schotten, U., Dobrev, D., Nattel, S., Boehm, M., Floras, J., Lau, D. H., & Sanders, P. (2019). Role of autonomic nervous system in atrial fibrillation. International Journal of Cardiology, 287, 181-188. https://doi.org/10.1016/j.ijcard.2018.11.091
    • Hohl, M., Erb, K., Lang, L., Ruf, S., Hübschle, T., Dhein, S., Linz, W., Elliott, A. D., Sanders, P., Zamyatkin, O., Böhm, M., Schotten, U., Sadowski, T., & Linz, D. (2019). Cathepsin A Mediates Ventricular Remote Remodeling and Atrial Cardiomyopathy in Rats With Ventricular Ischemia/Reperfusion. JACC: Basic to Translational Science, 4(3), 332-344. https://doi.org/10.1016/j.jacbts.2019.01.008
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