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MUMC+ Award Prof. Michael Jacobs

MUMC+ Award Prof. Michael Jacobs

3 May 2024

With a symposium in the St. Janskerk and a farewell lecture in the aula, vascular surgeon and professor Michael Jacobs bid farewell last Friday. From board chairman Helen Mertens, he received the MUMC+ Award, the highest distinction within the MUMC+, in recognition of all he has meant for Maastricht UMC+ and its patients.

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Prof. Kevin Vernooy Director HVC

Prof. Kevin Vernooy Director HVC

30 April 2024

Prof. Kevin Vernooy will become the medical director of the Heart+Vascular Center (HVC) at Maastricht UMC+.

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Carim Maastricht
Carim Maastricht

Dominik Linz

Professor

Prof Dominik Linz is a clinician-scientist who received his PhD from Maastricht University, The Netherlands, in 2013 (Prof. U. Schotten) and completed his Cardiology training in Homburg/Saar, Germany, in 2017 (Prof. M. Böhm). In 2017, he was recruited as an Associate Professor and clinical EP-fellow to Adelaide to initiate and drive a translational research programme focussing on atrial fibrillation and sleep disordered breathing at the Royal Adelaide Hospital and University of Adelaide (Prof. P. Sanders). Since 2019, Dr Dominik Linz is a Staff member and consultant clinician at the Heart+Vascular Center, Maastricht UMC+.

Over the past years Prof. Dominik Linz has developed a National and International reputation in the field of cardiac arrhythmia research. The focus of this work has been to understand the pathophysiology and mechanisms underlying atrial arrhythmias and the development of treatment approaches. This research has broadly included: (i) Work describing sleep apnoea associated electrophysiological changes in the atria increasing atrial fibrillation susceptibility. (ii) Description of antiarrhythmic effects of autonomic modulation by renal sympathetic denervation under different pathophysiological conditions. (iii) Work describing the role of the lysosomal carboxypeptidase cathepsin A in the development of an atrial arrhythmogenic substrates. Ongoing research is mainly focused on risk factor modification and preventive interventions for AF.

As of January 2024, Dominik Linz (Department of Cardiology) has been appointed as a professor at Maastricht University. The title of his position is 'Comprehensive Atrial Fibrillation Management.

Dominik-linz

Department of Cardiology

 

  • 2022
    • Hermans, A. N. L., Gawalko, M., Dohmen, L., van der Velden, R. M. J., Betz, K., Duncker, D., Verhaert, D. V. M., Heidbuchel, H., Svennberg, E., Neubeck, L., Eckstein, J., Lane, D. A., Lip, G. Y. H., Crijns, H. J. G. M., Sanders, P., Hendriks, J. M., Pluymaekers, N. A. H. A., & Linz, D. (2022). Mobile health solutions for atrial fibrillation detection and management: a systematic review. Clinical research in cardiology, 111(5), 479-491. https://doi.org/10.1007/s00392-021-01941-9
    • Linz, D., & Stavrakis, S. (2022). Cardioneuroablation for vasovagal syncope: How to move beyond "learning by burning"?Journal of Interventional Cardiac Electrophysiology. Advance online publication. https://doi.org/10.1007/s10840-022-01232-x
    • Verhaert, D. V. M., Betz, K., Gawałko, M., Hermans, A. N. L., Pluymaekers, N. A. H. A., van der Velden, R. M. J., Philippens, S., Vorstermans, B., Simons, S. O., den Uijl, D. W., Chaldoupi, S.-M., Luermans, J. G. L. M., Westra, S. W., Lankveld, T., Kadhim, K., Pepin, J.-L., van Steenwijk, R. P., Hol, B., Schotten, U., ... Linz, D. (2022). A VIRTUAL Sleep Apnoea management pathway For the work-up of Atrial fibrillation patients in a digital Remote Infrastructure: VIRTUAL-SAFARI. EP Europace, 24(4), 565-575. https://doi.org/10.1093/europace/euab229
    • Guerra, F., Linz, D., Garcia, R., Kommata, V., Kosiuk, J., Chun, J., Boveda, S., & Duncker, D. (2022). The use of social media for professional purposes by healthcare professionals: the #intEHRAct survey. EP Europace, 24(4), 691-696. https://doi.org/10.1093/europace/euab244
    • de Groot, J. R., & Linz, D. (2022). Arterial stiffness and atrial fibrillation recurrence: another risk marker or a call for better management of concomitant disease? Comment. Netherlands Heart Journal, 30(4), 187-189. https://doi.org/10.1007/s12471-022-01678-8
    • Krist, D., Linz, D., Schotten, U., Zeemering, S., & Leenen, D. (2022). A Novel Laser Energy Ablation Catheter for Endocardial Cavo-Tricuspid Isthmus Ablation and Epicardial Ventricular Lesion Formation: An in vivo Proof-of-Concept Study. Frontiers in Medical Technology, 4, Article 834856. https://doi.org/10.3389/fmedt.2022.834856
    • Hohl, M., Selejan, S.-R., Wintrich, J., Lehnert, U., Speer, T., Schneider, C., Mauz, M., Markwirth, P., Wong, D. W. L., Boor, P., Kazakov, A., Mollenhauer, M., Linz, B., Klinkhammer, B. M., Hübner, U., Ukena, C., Moellmann, J., Lehrke, M., Wagenpfeil, S., ... Böhm, M. (2022). Renal Denervation Prevents Atrial Arrhythmogenic Substrate Development in CKD. Circulation Research, 130(6), 814-828. https://doi.org/10.1161/circresaha.121.320104
    • Zink, M. D., Laureanti, R., Hermans, B. J. M., Pison, L., Verheule, S., Philippens, S., Pluymaekers, N., Vroomen, M., Hermans, A., van Hunnik, A., Crijns, H. J. G. M., Vernooy, K., Linz, D., Mainardi, L., Auricchio, A., Zeemering, S., & Schotten, U. (2022). Extended ECG Improves Classification of Paroxysmal and Persistent Atrial Fibrillation Based on P- and f-Waves. Frontiers in physiology, 13, Article 779826. https://doi.org/10.3389/fphys.2022.779826
    • Isaksen, J. L., Baumert, M., Hermans, A. N. L., Maleckar, M., & Linz, D. (2022). Artificial intelligence for the detection, prediction, and management of atrial fibrillation. Herzschrittmachertherapie und Elektrophysiologie, 33(1), 34-41. https://doi.org/10.1007/s00399-022-00839-x
    • Linz, B., Hertel, J. N., Hendriks, J., Saljic, A., Dobrev, D., Baumert, M., Jespersen, T., & Linz, D. (2022). Sleep apnea and atrial fibrillation: challenges in clinical and translational research. Expert review of cardiovascular therapy, 20(2), 101-109. Article 2036606. https://doi.org/10.1080/14779072.2022.2036606
    • de Groot, N. M. S., Shah, D., Boyle, P. M., Anter, E., Clifford, G. D., Deisenhofer, I., Deneke, T., van Dessel, P., Doessel, O., Dilaveris, P., Heinzel, F. R., Kapa, S., Lambiase, P. D., Lumens, J., Platonov, P. G., Ngarmukos, T., Martinez, J. P., Sanchez, A. O., Takahashi, Y., ... Linz, D. (2022). Critical appraisal of technologies to assess electrical activity during atrial fibrillation: a position paper from the European Heart Rhythm Association and European Society of Cardiology Working Group on eCardiology in collaboration with the Heart Rhythm Society, Asia Pacific Heart Rhythm Society, Latin American Heart Rhythm Society and Computing in Cardiology. EP Europace, 24(2), 313–330. https://doi.org/10.1093/europace/euab254
    • De With, R. R., Artola Arita, V., Nguyen, B.-O., Linz, D., Ten Cate, H., Spronk, H., Schotten, U., van Zonneveld, A. J., Erküner, Ö., Bayón, M. A., Schmidt, A. S., Luermans, J. G. L. M., Crijns, H. J. G. M., Van Gelder, I. C., & Rienstra, M. (2022). Different circulating biomarkers in women and men with paroxysmal atrial fibrillation: results from the AF-RISK and RACE V studies. EP Europace, 24(2), 193-201. https://doi.org/10.1093/europace/euab179
    • Artola Arita, V., Santema, B. T., De With, R. R., Nguyen, B.-O., Linz, D., Schotten, U., Van Gelder, I. C., Crijns, H. J., Voors, A. A., & Rienstra, M. (2022). Atrial function in paroxysmal AF patients with and without heart failure with preserved ejection fraction: Data from the AF-RISK study. American Heart Journal, 244, 36-41. https://doi.org/10.1016/j.ahj.2021.10.183
    • Linz, B., Thostrup, A. H., Saljic, A., Rombouts, K., Hertel, J. N., Hohl, M., Milnes, J., Tfelt-Hansen, J., Linz, D., & Jespersen, T. (2022). Pharmacological inhibition of acetylcholine-regulated potassium current (I K,ACh) prevents atrial arrhythmogenic changes in a rat model of repetitive obstructive respiratory events. Heart Rhythm O2, 3(1), 97-104. https://doi.org/10.1016/j.hroo.2021.11.013
    • Hermans, A. N. L., Gawalko, M., Hillmann, H. A. K., Sohaib, A., van der Velden, R. M. J., Betz, K., Verhaert, D., Scherr, D., Meier, J., Sultan, A., Steven, D., Terentieva, E., Pisters, R., Hemels, M., Voorhout, L., Lodzinski, P., Krzowski, B., Gupta, D., Kozhuharov, N., ... TeleCheck-AF investigators (2022). Self-Reported Mobile Health-Based Risk Factor and CHA(2)DS(2)-VASc-Score Assessment in Patients With Atrial Fibrillation: TeleCheck-AF Results. Frontiers in Cardiovascular Medicine, 8, Article 757587. https://doi.org/10.3389/fcvm.2021.757587
  • 2021
    • Linz, B., Linz, D., & Wagner, S. (2021). Atrial connexin dysregulation in sleep apnea patients undergoing cardiac surgery: Implications for postoperative atrial fibrillation?Heart Rhythm, 18(12), 2195-2196. https://doi.org/10.1016/j.hrthm.2021.09.030
    • Lyon, A., van Mourik, M., Cruts, L., Heijman, J., Bekkers, S. C. A. M., Schotten, U., Crijns, H. J. G. M., Linz, D., & Lumens, J. (2021). Understanding the effects of heart beat irregularity on ventricular function in human atrial fibrillation: simulation models may help to untie the knot-Authors' reply. EP Europace, 23(11), 1869-1869. https://doi.org/10.1093/europace/euab144
    • Mueller, P., Weijs, B., Bemelmans, N. M. A. A., Muegge, A., Eckardt, L., Crijns, H. J. G. M., Bax, J. J., Linz, D., & den Uijl, D. W. (2021). Echocardiography-derived total atrial conduction time (PA-TDI duration): risk stratification and guidance in atrial fibrillation management. Clinical research in cardiology, 110(11), 1734-1742. https://doi.org/10.1007/s00392-021-01917-9
    • Starczynski, M., Krzowski, B., Gawalko, M., Linz-, D., & Lodzinski, P. (2021). Impact of photoplethysmography on therapeutic decisions in atrial fibrillation. Kardiologia Polska, 79(10), 1155-1156. https://doi.org/10.33963/KP.a2021.0076
    • Linz, D., Arzt, M., & Baumert, M. (2021). Keep your rhythm during rotational night work shifts!European Heart Journal, 42(40), 4189-4191. https://doi.org/10.1093/eurheartj/ehab623
    • Elliott, A. D., Middeldorp, M. E., & Linz, D. K. (2021). The ins and outs of physical activity monitoring: implications for atrial fibrillation management. European Heart Journal, 42(38), 3989-3991. https://doi.org/10.1093/eurheartj/ehab520
    • Hermans, A. N. L., Pluymaekers, N. A. H. A., Lankveld, T. A. R., van Mourik, M. J. W., Zeemering, S., Dinh, T., den Uijl, D. W., Luermans, J. G. L. M., Vernooy, K., Crijns, H. J. G. M., Schotten, U., & Linz, D. (2021). Clinical utility of rhythm control by electrical cardioversion to assess the association between self-reported symptoms and rhythm status in patients with persistent atrial fibrillation. IJC Heart and Vasculature, 36, Article 100870. https://doi.org/10.1016/j.ijcha.2021.100870
    • Chaldoupi, S. M., Luermans, J., Vernooy, K., & Linz, D. (2021). High-power short-duration ablation: The new standard for pulmonary vein isolation?IJC Heart and Vasculature, 36, Article 100865. https://doi.org/10.1016/j.ijcha.2021.100865
    • Hendriks, J. M., Spreeuwenberg, M. D., & Linz, D. (2021). Mobile health and cardiac arrhythmias: patient self-management in digital care pathways. European Journal of Cardiovascular Nursing, 20(7), 631-632. https://doi.org/10.1093/eurjcn/zvab075
    • Desteghe, L., Hendriks, J. M. L., Heidbuchel, H., Potpara, T. S., Lee, G. A., & Linz, D. (2021). Obstructive sleep apnoea testing and management in atrial fibrillation patients: a joint survey by the European Heart Rhythm Association (EHRA) and the Association of Cardiovascular Nurses and Allied Professions (ACNAP). EP Europace, 23(10), 1677-1684. https://doi.org/10.1093/europace/euab109
    • Van Der Velden, R. M. J., Verhaert, D. V. M., Hermans, A. N. L., Duncker, D., Manninger, M., Betz, K., Gawalko, M., Desteghe, L., Pisters, R., Hemels, M., Pison, L., Sohaib, A., Sultan, A., Steven, D., Wijtvliet, P., Gupta, D., Svennberg, E., Luermans, J. C. L. M., Chaldoupi, M., ... Linz, D. (2021). The photoplethysmography dictionary: practical guidance on signal interpretation and clinical scenarios from TeleCheck-AF. European Heart Journal - Digital Health, 2(3), 363-373. https://doi.org/10.1093/ehjdh/ztab050
    • Gruwez, H., Evens, S., Proesmans, T., Duncker, D., Linz, D., Heidbuchel, H., Manninger, M., Vandervoort, P., Haemers, P., & Pison, L. (2021). Accuracy of Physicians Interpreting Photoplethysmography and Electrocardiography Tracings to Detect Atrial Fibrillation: INTERPRET-AF. Frontiers in Cardiovascular Medicine, 8, Article 734737. https://doi.org/10.3389/fcvm.2021.734737
    • Linz, D., Gawalko, M., Sanders, P., Penders, J., Li, N., Nattel, S., & Dobrev, D. (2021). Does gut microbiota affect atrial rhythm? Causalities and speculations. European Heart Journal, 42(35), 3521-3525. https://doi.org/10.1093/eurheartj/ehab467
    • Linz, D., Verheule, S., Isaacs, A., & Schotten, U. (2021). Considerations for the Assessment of Substrates, Genetics and Risk Factors in Patients with Atrial Fibrillation. Arrhythmia & Electrophysiology Review, 10(3), 132-139. https://doi.org/10.15420/aer.2020.51
    • Fox, H., Arzt, M., Bergmann, M. W., Bitter, T., Linz, D., Oldenburg, O., Penzel, T., Rillig, A., Schobel, C., Sinha, A. M., Sommer, P., Spiesshofer, J., Stadler, S., & Skobel, C. E. (2021). Positionspapier „Schlafmedizin in der Kardiologie“, Update 2021. Der Kardiologe, 15(5), 429-461. https://doi.org/10.1007/s12181-021-00506-4
    • Betz, K., van der Velden, R., Gawalko, M., Hermans, A., Pluymaekers, N., Hillmann, H. A. K., Hendriks, J., Duncker, D., & Linz, D. (2021). Interpretation der Photoplethysmographie: Schritt für Schritt. Herzschrittmachertherapie und Elektrophysiologie, 32(3), 406-411. https://doi.org/10.1007/s00399-021-00795-y
    • Cowie, M. R., Linz, D., Redline, S., Somers, V. K., & Simonds, A. K. (2021). Sleep Disordered Breathing and Cardiovascular Disease: JACC State-of-the-Art Review. Journal of the American College of Cardiology, 78(6), 608-624. https://doi.org/10.1016/j.jacc.2021.05.048
    • Linz, B., Sattler, S. M., Flethoj, M., Hansen, M. E. H., Hesselkilde, E. M., Saljic, A., Wirth, K., Linz, D., Tfelt-Hansen, J., & Jespersen, T. (2021). Arrhythmogenic mechanisms of acute obstructive respiratory events in a porcine model of drug-induced long QT. Heart Rhythm, 18(8), 1384-1391. https://doi.org/10.1016/j.hrthm.2021.03.017
    • Linz, D., Garcia, R., Guerra, F., Kommata, V., Bollmann, A., & Duncker, D. (2021). Twitter for professional use in electrophysiology: practical guide for #EPeeps. EP Europace, 23(8), 1192-1199. https://doi.org/10.1093/europace/euab048
    • Guerra, F., Linz, D., Garcia, R., Kommata, V., Kosiuk, J., Chun, J. L., Boveda, S., & Duncker, D. (2021). Use and misuse of instant messaging in clinical data sharing: the EHRA-SMS survey. EP Europace, 23(8), 1326-1330. https://doi.org/10.1093/europace/euab063
    • Linz, D., Linz, B., Dobrev, D., Baumert, M., Hendriks, J. M., Pepin, J.-L., & Jespersen, T. (2021). Personalized management of sleep apnea in patients with atrial fibrillation: An interdisciplinary and translational challenge. IJC Heart & Vasculature, 35, Article 100843. https://doi.org/10.1016/j.ijcha.2021.100843
    • Gawalko, M., Duncker, D., Manninger, M., van der Velden, R. M. J., Hermans, A. N. L., Verhaert, D. V. M., Pison, L., Pisters, R., Hemels, M., Sultan, A., Steven, D., Gupta, D., Heidbuchel, H., Sohaib, A., Wijtvliet, P., Tieleman, R., Gruwez, H., Chun, J. L., Schmidt, B., ... TeleCheck-AF investigators (2021). The European TeleCheck-AF project on remote app-based management of atrial fibrillation during the COVID-19 pandemic: centre and patient experiences. EP Europace, 23(7), 1003-1015. https://doi.org/10.1093/europace/euab050
    • Fisser, C., Bureck, J., Gall, L., Vaas, V., Priefert, J., Fredersdorf, S., Zeman, F., Linz, D., Wohrle, H., Tamisier, R., Teschler, H., Cowie, M. R., & Arzt, M. (2021). Ventricular arrhythmia in heart failure patients with reduced ejection fraction and central sleep apnoea. ERJ Open Research, 7(3), Article 00147-2021. https://doi.org/10.1183/23120541.00147-2021
    • Scott, L., Fender, A. C., Saljic, A., Li, L., Chen, X., Wang, X., Linz, D., Lang, J., Hohl, M., Twomey, D., Pham, T. T., Diaz-Lankenau, R., Chelu, M. G., Kamler, M., Entman, M. L., Taffet, G. E., Sanders, P., Dobrev, D., & Li, N. (2021). NLRP3 inflammasome is a key driver of obesity-induced atrial arrhythmias. Cardiovascular Research, 117(7), 1746-1759. https://doi.org/10.1093/cvr/cvab024
    • Shahrbabaki, S. S., Linz, D., Hartmann, S., Redline, S., & Baumert, M. (2021). Sleep arousal burden is associated with long-term all-cause and cardiovascular mortality in 8001 community-dwelling older men and women. European Heart Journal, 42(21), 2088-2099. https://doi.org/10.1093/eurheartj/ehab151
    • Gawalko, M., Linz, D., & Dobrev, D. (2021). Gut-microbiota derived TMAO: A risk factor, a mediator or a bystander in the pathogenesis of atrial fibrillation?IJC Heart & Vasculature, 34, Article 100818. https://doi.org/10.1016/j.ijcha.2021.100818
    • Pluymaekers, N. A. H. A., Dudink, E. A. M. P., Weijs, B., Vernooy, K., Hartgerink, D. E. J., Jacobs, J. S., Erkuner, O., Marcks, N. G. H. M., van Cauteren, Y. J. M., Dinh, T., ter Bekke, R. M. A., Sels, J. E. M. W., Delnoij, T. S. R., Geyik, Z., Driessen, R. G. H., Linz, D. K., den Uijl, D. W., Crijns, H. J. G. M., & Luermans, J. G. L. M. (2021). Clinical determinants of early spontaneous conversion to sinus rhythm in patients with atrial fibrillation. Netherlands Heart Journal, 29(5), 255-261. https://doi.org/10.1007/s12471-020-01528-5
    • Pluymaekers, N. A. H. A., van der Velden, R. M. J., Hermans, A. N. L., Gawalko, M., Buskes, S., Keijenberg, J. J. H. M. W., Vorstermans, B., Crijns, H. J. G. M., Hendriks, J. M., & Linz, D. (2021). On-Demand Mobile Health Infrastructure for Remote Rhythm Monitoring within a Wait-and-See Strategy for Recent-Onset Atrial Fibrillation: TeleWAS-AF. Cardiology, 146(3), 392-396. https://doi.org/10.1159/000514156
    • Hermans, A. N. L., Gawalko, M., Pluymaekers, N. A. H. A., Dinh, T., Weijs, B., van Mourik, M. J. W., Vorstermans, B., den Uijl, D. W., Opsteyn, L., Snippe, H., Vernooy, K., Crijns, H. J. G. M., Linz, D., & Luermans, J. G. L. M. (2021). Long-term intermittent versus short continuous heart rhythm monitoring for the detection of atrial fibrillation recurrences after catheter ablation. International Journal of Cardiology, 329, 105-112. https://doi.org/10.1016/j.ijcard.2020.12.077
    • Linz, D., & Dobrev, D. (2021). A disproportional rise in the growing submission rate to International Journal of Cardiology Heart & Vasculature during the COVID‑19 pandemic. IJC Heart and Vasculature, 33, Article 100749. https://doi.org/10.1016/j.ijcha.2021.100749
    • Linz, D., Hermans, A., & Tieleman, R. G. (2021). Early atrial fibrillation detection and the transition to comprehensive management. EP Europace, 23, II46-II51. https://doi.org/10.1093/europace/euaa424
    • Linz, D., Linz, B., Homberg, M., Bouman, E., Dobrev, D., Hendriks, J. M., & Simons, S. O. (2021). Obstructive respiratory events during procedural sedation and analgesia: Another WHY to routinely screen for sleep apnea before catheter ablation of atrial fibrillation. IJC Heart and Vasculature, 33, Article 100783. https://doi.org/10.1016/j.ijcha.2021.100783
    • Betz, K., Knuf, F., Duncker, D., Giordano, M., Dobrev, D., & Linz, D. (2021). The impact of Twitter promotion on future citation rates: The #TweetTheJournal study. IJC Heart and Vasculature, 33, Article 100776. https://doi.org/10.1016/j.ijcha.2021.100776
    • Heijman, J., Ghossein, M. A., Vernooy, K., & Linz, D. (2021). The walk of life: Remote monitoring provides insights into physical activity during a pandemic. IJC Heart and Vasculature, 33, Article 100772. https://doi.org/10.1016/j.ijcha.2021.100772
    • Linz, D., Homberg, M., van der Velden, R. M. J., Bouman, E., Buhre, W., & Simons, S. O. (2021). Sleep apnea, obesity and COPD depress respiration during catheter ablation procedures: Implications for transcutaneous carbon dioxide monitoring. International Journal of Cardiology, 327, 102-104. https://doi.org/10.1016/j.ijcard.2020.10.080
Overview