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ERC Advanced Grant awarded to Prof. Andy Baker

ERC Advanced Grant awarded to Prof. Andy Baker

15 April 2024

Prof. Andy Baker (Dept of Pathology) has been awarded a European Research Council (ERC) Advanced Grant of €2,5M for his research project PolymiRize: Poly-miRNA targeting to prevent and reverse complex tissue remodelling after acute cardiovascular events'.

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Longer and better lives for patients with atrial fibrillation

Longer and better lives for patients with atrial fibrillation

15 April 2024

An international panel of experts published recommendations to improve management of atrial fibrillation (AF).

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Carim Maastricht
Carim Maastricht

Tammo Delhaas

Professor

Tammo Delhaas is Pediatric Cardiologist and Professor of Biomedical Engineering. He obtained his MD at the University of Groningen and received his PhD degree from Maastricht University in 1993 for a thesis on cardiac mechanics. After his training in Pediatrics in Maastricht and Utrecht, he received a Fulbright grant/ICIN-Fellowship and spent one year at the Departments of Bioengineering and Medicine from the UCSD. Thereafter, he trained in Pediatric Cardiology in Aachen and Melbourne. In 2000, he returned to Maastricht as Pediatric Cardiologist and continued his research on the crossroads of (Pediatric) Cardiology, Physiology and Biomedical Engineering. In 2009, he was appointed Professor and Chair of Biomedical Engineering at Maastricht University, where he is involved in projects related to cellular and cardiac mechanics, cardiac pacing, and mathematical modeling of the heart and circulation.

Prof. Tammo Delhaas is heading the CardioVascular System Dynamics Research Group (CVSDRG). With clinical questions regarding (congenital) heart diseases in mind, his research focusses on asynchronous electrical activation, vascular and myocardial structure-function relation, and computer model-assisted diagnosis and treatment of cardiac failure, pulmonary hypertension and congenital heart diseases. Besides standard expertise, CVSDRG uses following techniques/models in which it has expertise of extraordinary quality according to international standards: 1) CircAdapt, a lumped parameter mathematical model of the human heart and circulation that enables real-time simulation of cardiovascular system dynamics in a wide variety of physiological and pathophysiological situations (www.circadapt.org); 2) Finite Element Model of the heart with left and right ventricle, simulating local stress and strain as a function of time with emphasis on adaptation of wall anatomy to local mechanical load; 3) Pulse Wave Propagation and Computational Fluid Dynamics models that predict pressure and flow waveforms after vascular interventions, such as Arterio-Venous Fistula creation for hemodialysis. Prof. Tammo Delhaas serves as a reviewer or member of the editorial board of many journals, and has received grants from, amongst others, the Dutch Heart Foundation, Maastricht UMC+, Province of Limburg, NWO, European Research Council, and the Interuniversity Cardiology Institute of the Netherlands (ICIN).

Tammo-delhaas

Department of Biomedical Engineering
Universiteitssingel 50, 6229 ER Maastricht
PO Box 616, 6200 MD Maastricht
Room number: 3.366
T:+31(0)43 388 16 67

  • 2024
    • Neuen, S. M. L., Ophelders, D. R. M. G., Widowski, H., Hütten, M. C., Brokken, T., van Gorp, C., Nikkels, P. G. J., Severens-Rijvers, C. A. H., Sthijns, M. M. J. P. E., van Blitterswijk, C. A., Troost, F. J., LaPointe, V. L. S., Jolani, S., Seiler, C., Pillow, J. J., Delhaas, T., Reynaert, N. L., & Wolfs, T. G. A. M. (2024). Multipotent adult progenitor cells prevent functional impairment and improve development in inflammation driven detriment of preterm ovine lungs. Regenerative Therapy, 27, 207-217. https://doi.org/10.1016/j.reth.2024.03.014
    • van der Bruggen, M., Spronck, B., Bos, S., Heusinkveld, M. H. G., Taddei, S., Ghiadoni, L., Delhaas, T., Maria Bruno, R., & Reesink, K. D. (2024). Correction to: Pressure-Corrected Carotid Stiffness and Young's Modulus. American Journal of Hypertension, Article hpae037. https://doi.org/10.1093/ajh/hpae037
    • Arts, T., Lyon, A., Delhaas, T., Kuster, D. W. D., van der Velden, J., & Lumens, J. (2024). Translating myosin-binding protein C and titin abnormalities to whole-heart function using a novel calcium-contraction coupling model. Journal of Molecular and Cellular Cardiology, 190, 13-23. Advance online publication. https://doi.org/10.1016/j.yjmcc.2024.03.001
    • Konings, T. J. A. J., Delhaas, T., & Mees, B. M. E. (2024). Re: "Thoracic Stent Graft Numerical Models to Virtually Simulate Thoracic Endovascular Aortic Repair. European Journal of Vascular and Endovascular Surgery. Advance online publication. https://doi.org/10.1016/j.ejvs.2024.02.024
    • Ložek, M., Kovanda, J., Kubuš, P., Vrbík, M., Lhotská, L., Lumens, J., Delhaas, T., & Janoušek, J. (2024). How to assess and treat right ventricular electromechanical dyssynchrony in post-repair tetralogy of Fallot: insights from imaging, invasive studies and computational modelling. EP Europace, 26(2), Article euae024. https://doi.org/10.1093/europace/euae024
    • Koopsen, T., Gerrits, W., van Osta, N., van Loon, T., Wouters, P., Prinzen, F. W., Vernooy, K., Delhaas, T., Teske, A. J., Meine, M., Cramer, M. J., & Lumens, J. (2024). Virtual pacing of a patient’s digital twin to predict left ventricular reverse remodelling after cardiac resynchronization therapy. EP Europace, 26(1), Article euae009. https://doi.org/10.1093/europace/euae009
    • van Vliet, L. V., Delhaas, T., Mees, B. M. E., & Snoeijs, M. G. (2024). Response letter. Journal of vascular access. Advance online publication. https://doi.org/10.1177/11297298231218663
  • 2023
    • Tamargo, M., Martínez-Legazpi, P., Espinosa, M. Á., Lyon, A., Méndez, I., Gutiérrez-Ibañes, E., Fernández, A. I., Prieto-Arévalo, R., González-Mansilla, A., Arts, T., Delhaas, T., Mombiela, T., Sanz-Ruiz, R., Elízaga, J., Yotti, R., Tschöpe, C., Fernández-Avilés, F., Lumens, J., & Bermejo, J. (2023). Increased Chamber Resting Tone Is a Key Determinant of Left Ventricular Diastolic Dysfunction. Circulation-Heart Failure, 16(12), E010673. Article 010673. https://doi.org/10.1161/CIRCHEARTFAILURE.123.010673
    • Giudici, A., van der Laan, K. W. F., van der Bruggen, M. M., Parikh, S., Berends, E., Foulquier, S., Delhaas, T., Reesink, K. D., & Spronck, B. (2023). Constituent-based quasi-linear viscoelasticity: a revised quasi-linear modelling framework to capture nonlinear viscoelasticity in arteries. Biomechanics and modeling in mechanobiology, 22(5), 1607–1623. https://doi.org/10.1007/s10237-023-01711-8
    • Buonocunto, M., Lyon, A., Delhaas, T., Heijman, J., & Lumens, J. (2023). Electrophysiological effects of stretch-activated ion channels: a systematic computational characterization. The Journal of Physiology. Advance online publication. https://doi.org/10.1113/JP284439
    • Westphal, P., Luo, H., Shahmohammadi, M., Prinzen, F. W., Delhaas, T., & Cornelussen, R. N. (2023). Machine learning–powered, device-embedded heart sound measurement can optimize AV delay in patients with CRT. Heart Rhythm, 20(9), 1316-1324. https://doi.org/10.1016/j.hrthm.2023.05.025
    • Munneke, A. G., Lumens, J., Arts, T., Prinzen, F. W., & Delhaas, T. (2023). Myocardial perfusion and flow reserve in the asynchronous heart: mechanistic insight from a computational model. Journal of Applied Physiology, 135(3), 489-499. https://doi.org/10.1152/japplphysiol.00181.2023
    • Kirkels, F. P., van Osta, N., Rootwelt-Norberg, C., Chivulescu, M., van Loon, T., Aabel, E. W., Castrini, A. I., Lie, Ø. H., Asselbergs, F. W., Delhaas, T., Cramer, M. J., Teske, A. J., Haugaa, K. H., & Lumens, J. (2023). Monitoring of Myocardial Involvement in Early Arrhythmogenic Right Ventricular Cardiomyopathy Across the Age Spectrum. Journal of the American College of Cardiology, 82(9), 785-797. https://doi.org/10.1016/j.jacc.2023.05.065
    • Neumann, B., Vink, A. S., Hermans, B. J. M., Lieve, K. V. V., Cömert, D., Beckmann, B.-M., Clur, S.-A. B., Blom, N. A., Delhaas, T., Wilde, A. A. M., Kääb, S., Postema, P. G., & Sinner, M. F. (2023). Manual vs. automatic assessment of the QT-interval and corrected QT. EP Europace, 25(9), 1-12. Article euad213. https://doi.org/10.1093/europace/euad213
    • Debeij, G. P., Parikh, S., Delhaas, T., Bidar, E., & Reesink, K. D. (2023). Evidence in Clinical Studies for the Role of Wall Thickness in Ascending Thoracic Aortic Aneurysms: A Scoping Review. Bioengineering, 10(8), Article 882. https://doi.org/10.3390/bioengineering10080882
    • Ganizada, B. H., Reesink, K. D., Parikh, S., Ramaekers, M. J. F. G., Akbulut, A. C., Saraber, P. J. M. H., Debeij, G. P., Jaminon, A. M., Natour, E., Lorusso, R., Wildberger, J. E., Mees, B., Schurink, G. W., Jacobs, M. J., Cleutjens, J., Krapels, I., Gombert, A., Maessen, J. G., Accord, R., ... MUMC TAA Student Team (2023). The Maastricht Acquisition Platform for Studying Mechanisms of Cell-Matrix Crosstalk (MAPEX): An Interdisciplinary and Systems Approach towards Understanding Thoracic Aortic Disease. Biomedicines, 11(8), Article 2095. https://doi.org/10.3390/biomedicines11082095
    • Beela, A. S., Manetti, C. A., Lyon, A., Prinzen, F. W., Delhaas, T., Herbots, L., & Lumens, J. (2023). Impact of Estimated Left Atrial Pressure on Cardiac Resynchronization Therapy Outcome. Journal of Clinical Medicine, 12(15), Article 4908. https://doi.org/10.3390/jcm12154908
    • Vink, A. S., Hermans, B. J. M., Hooglugt, J. L. Q., Peltenburg, P. J., Meijborg, V. M. F., Hofman, N., Clur, S. A. B., Blom, N. A., Delhaas, T., Wilde, A. A. M., & Postema, P. G. (2023). Diagnostic Accuracy of the Standing Test in Adults Suspected for Congenital Long-QT Syndrome. Journal of the American Heart Association, 12(14), Article e026419. https://doi.org/10.1161/JAHA.122.026419
    • Parikh, S., Moerman, K. M., Ramaekers, M. J. F. G., Schalla, S., Bidar, E., Delhaas, T., Reesink, K., & Huberts, W. (2023). Biomechanical Characterisation of Thoracic Ascending Aorta with Preserved Pre-Stresses. Bioengineering, 10(7), Article 846. https://doi.org/10.3390/bioengineering10070846
    • Meiburg, R., Rijks, J. H. J., Beela, A. S., Bressi, E., Grieco, D., Delhaas, T., Luermans, J. G. L. M., Prinzen, F. W., Vernooy, K., & Lumens, J. (2023). Comparison of novel ventricular pacing strategies using an electro-mechanical simulation platform. EP Europace, 25(6), 1-11. Article euad144. https://doi.org/10.1093/europace/euad144
    • van Vliet, L. V., Zonnebeld, N., Tordoir, J. H., Huberts, W., Bouwman, L. H., Cuypers, P. W., Heinen, S. G., Huisman, L. C., Lemson, S., Mees, B. M. E., Schlosser, F. J., de Smet, A. A., Toorop, R. J., Delhaas, T., & Snoeijs, M. G. (2023). Guideline recommendations on minimal blood vessel diameters and arteriovenous fistula outcomes. Journal of vascular access. Advance online publication. https://doi.org/10.1177/11297298231180627
    • van Vliet, L. V., Zonnebeld, N., Tordoir, J. H., Huberts, W., Delhaas, T., & Snoeijs, M. G. (2023). Arteriovenous Fistulas Created with the Help of Personalised Blood Flow Simulations: Clinical Outcomes of a Randomised Controlled Trial. European Journal of Vascular and Endovascular Surgery, 65(6), 907-908. https://doi.org/10.1016/j.ejvs.2023.02.072
    • Luo, H., Westphal, P., Shahmohammadi, M., Heckman, L. I. B., Kuiper, M., Cornelussen, R. N., Delhaas, T., & Prinzen, F. W. (2023). Heart sound-derived systolic time intervals for atrioventricular delay optimization in cardiac resynchronization therapy. Heart Rhythm, 20(4), 572-579. https://doi.org/10.1016/j.hrthm.2022.12.031
    • Luo, H., Weerts, J., Bekkers, A., Achten, A., Lievens, S., Smeets, K., van Empel, V., Delhaas, T., & Prinzen, F. W. (2023). Association between phonocardiography and echocardiography in heart failure patients with preserved ejection fraction. European Heart Journal - Digital Health, 4(1), 4-11. https://doi.org/10.1093/ehjdh/ztac073
    • Malik, A. E. F., Giudici, A., van der Laan, K. W. F., Op 't Roodt, J., Mess, W. H., Delhaas, T., Spronck, B., & Reesink, K. D. (2023). Detectable Bias between Vascular Ultrasound Echo-Tracking Systems: Relevance Depends on Application. Journal of Clinical Medicine, 12(1), Article 69. https://doi.org/10.3390/jcm12010069
  • 2022
    • Bol, M. E., Huckriede, J. B., van de Pas, K. G. H., Delhaas, T., Lorusso, R., Nicolaes, G. A. F., Sels, J. E. M., & van de Poll, M. C. G. (2022). Multimodal measurement of glycocalyx degradation during coronary artery bypass grafting. Frontiers in medicine, 9, 1045728. https://doi.org/10.3389/fmed.2022.1045728
    • Bol, M. E., Broddin, B. E. K., Delhaas, T., Sels, J. E. M., & van de Poll, M. C. G. (2022). Variability of microcirculatory measurements in healthy volunteers. Scientific Reports, 12(1), Article 19887. https://doi.org/10.1038/s41598-022-22947-x
    • Shahmohammadi, M., Huberts, W., Luo, H. X., Westphal, P., Cornelussen, R. N., Prinzen, F. W., & Delhaas, T. (2022). Hemodynamics-driven mathematical model of third heart sound generation. Frontiers in physiology, 13, Article 847164. https://doi.org/10.3389/fphys.2022.847164
    • Luo, H., Lamata, P., Bazin, S., Bautista, T., Barclay, N., Shahmohammadi, M., Lubrecht, J. M., Delhaas, T., & Prinzen, F. W. (2022). Smartphone as an electronic stethoscope: factors influencing heart sound quality. European Heart Journal - Digital Health, 3(3), 473-480. https://doi.org/10.1093/ehjdh/ztac044
    • Verzaal, N. J., van Deursen, C. J. M., Pezzuto, S., Wecke, L., van Everdingen, W. M., Vernooy, K., Delhaas, T., Auricchio, A., & Prinzen, F. W. (2022). Synchronization of repolarization after cardiac resynchronization therapy: A combined clinical and modeling study. Journal of Cardiovascular Electrophysiology, 33(8), 1837-1846. https://doi.org/10.1111/jce.15581
    • Quicken, S., Mees, B., Zonnebeld, N., Tordoir, J., Huberts, W., & Delhaas, T. (2022). A realistic arteriovenous dialysis graft model for hemodynamic simulations. PLOS ONE, 17(7), Article e0269825. https://doi.org/10.1371/journal.pone.0269825
    • Westphal, P., Luo, H. X., Shahmohammadi, M., Heckman, L. I. B., Kuiper, M., Prinzen, F. W., Delhaas, T., & Cornelussen, R. N. (2022). Left Ventricular Pressure Estimation Using Machine Learning-Based Heart Sound Classification. Frontiers in Cardiovascular Medicine, 9, Article 763048. https://doi.org/10.3389/fcvm.2022.763048
    • Koopsen, T., Van Osta, N., Van Loon, T., Van Nieuwenhoven, F. A., Prinzen, F. W., Van Klarenbosch, B. R., Kirkels, F. P., Teske, A. J., Vernooy, K., Delhaas, T., & Lumens, J. (2022). A Lumped Two-Compartment Model for Simulation of Ventricular Pump and Tissue Mechanics in Ischemic Heart Disease. Frontiers in physiology, 13, Article 782592. https://doi.org/10.3389/fphys.2022.782592
    • Salden, F. C. W. M., Huntjens, P. R., Schreurs, R., Willemen, E., Kuiper, M., Wouters, P., Maessen, J. G., Bordachar, P., Delhaas, T., Luermans, J., Meine, M., Allaart, C. P., van Stipdonk, A. M. W., Prinzen, F. W., Lumens, J., & Vernooy, K. (2022). Pacing therapy for atrioventricular dromotropathy: a combined computational-experimental-clinical study. EP Europace, 24(5), 784-795. https://doi.org/10.1093/europace/euab248
    • Van Steenkiste, G., Delhaas, T., Hermans, B., Vera, L., Decloedt, A., & van Loon, G. (2022). An Exploratory Study on Vectorcardiographic Identification of the Site of Origin of Focally Induced Premature Depolarizations in Horses, Part II: The Ventricles. Animals, 12(5), Article 550. https://doi.org/10.3390/ani12050550
    • Van Steenkiste, G., Delhaas, T., Hermans, B., Vera, L., Decloedt, A., & van Loon, G. (2022). An Exploratory Study on Vectorcardiographic Identification of the Site of Origin of Focally Induced Premature Depolarizations in Horses, Part I: The Atria. Animals, 12(5), Article 549. https://doi.org/10.3390/ani12050549
    • Munneke, A. G., Lumens, J., Arts, T., & Delhaas, T. (2022). A Closed-Loop Modeling Framework for Cardiac-to-Coronary Coupling. Frontiers in physiology, 13, Article 830925. https://doi.org/10.3389/fphys.2022.830925
    • van der Laan, K. W. F., Reesink, K. D., van der Bruggen, M. M., Jaminon, A. M. G., Schurgers, L. J., Megens, R. T. A., Huberts, W., Delhaas, T., & Spronck, B. (2022). Improved Quantification of Cell Density in the Arterial Wall-A Novel Nucleus Splitting Approach Applied to 3D Two-Photon Laser-Scanning Microscopy. Frontiers in physiology, 12, Article 814434. https://doi.org/10.3389/fphys.2021.814434
    • Munneke, A. G., Lumens, J., & Delhaas, T. (2022). Cardiovascular fetal-to-neonatal transition: an in silico model. Pediatric Research, 91(1), 116-128. https://doi.org/10.1038/s41390-021-01401-0
  • 2021
    • Malik, A. E. F., Delhaas, T., Spronck, B., Henry, R. M. A., Joseph, J., Stehouwer, C. D. A., Mess, W. H., & Reesink, K. D. (2021). Single M-Line Is as Reliable as Multiple M-Line Ultrasound for Carotid Artery Screening. Frontiers in physiology, 12, Article 787083. https://doi.org/10.3389/fphys.2021.787083
    • Hermans, B. J. M., Zink, M. D., Rosmalen, F. V., Crijns, H. J. G. M., Vernooy, K., Postema, P., Pison, L., Schotten, U., & Delhaas, T. (2021). Corrected QT interval prolongation after ganglionated plexus ablation: myth or reality?-Authors' reply. EP Europace, 23(12), 2047-2048. https://doi.org/10.1093/europace/euab148
    • Hermans, B. J. M., Zink, M. D., Rosmalen, F. V., Crijns, H. J. G. M., Vernooy, K., Postema, P., Pison, L., Schotten, U., & Delhaas, T. (2021). Does pulmonary vein isolation prolong QT-interval?-Authors' reply. EP Europace, 23(12), 2046-2047. https://doi.org/10.1093/europace/euab153
    • Shenthar, J., Valappil, S. P., Rai, M. K., Banavalikar, B., Padmanabhan, D., & Delhaas, T. (2021). Angiography-guided mid/high septal implantation of ventricular leads in patients with congenital heart disease. Journal of Arrhythmia, 37(6), 1512-1521. https://doi.org/10.1002/joa3.12636
    • Giudici, A., Khir, A. W., Reesink, K. D., Delhaas, T., & Spronck, B. (2021). Five years of cardio-ankle vascular index (CAVI) and CAVI0: how close are we to a pressure-independent index of arterial stiffness?Journal of Hypertension, 39(11), 2128-2138. https://doi.org/10.1097/HJH.0000000000002928
    • van der Bruggen, M. M., Spronck, B., Delhaas, T., Reesink, K. D., & Schalkwijk, C. G. (2021). The Putative Role of Methylglyoxal in Arterial Stiffening: A Review. Heart Lung and Circulation, 30(11), 1681-1693. https://doi.org/10.1016/j.hlc.2021.06.527
    • Shenthar, J., Rai, M. K., Chakali, S. S., Pillai, V., & Delhaas, T. (2021). Computed tomography validated right ventricular mid-septal lead implantation using right ventricular angiography. Journal of Arrhythmia, 37(5), 1131-1138. https://doi.org/10.1002/joa3.12591
    • van Osta, N., Kirkels, F. P., van Loon, T., Koopsen, T., Lyon, A., Meiburg, R., Huberts, W., Cramer, M. J., Delhaas, T., Haugaa, K. H., Teske, A. J., & Lumens, J. (2021). Uncertainty Quantification of Regional Cardiac Tissue Properties in Arrhythmogenic Cardiomyopathy Using Adaptive Multiple Importance Sampling. Frontiers in physiology, 12, Article 738926. https://doi.org/10.3389/fphys.2021.738926
    • Widowski, H., Ophelders, D. R. M. G., van Leeuwen, A. J. C. N., Nikkels, P. G. J., Severens-Rijvers, C. A. H., LaPointe, V. L. S., Cleutjens, J. P. M., Hütten, M. C., Kemp, M. W., Payne, M. S., Saito, M., Usuda, H., Newnham, J. P., Jobe, A. H., Kramer, B. W., Delhaas, T., Wolfs, T. G. A. M., & Reynaert, N. L. (2021). Chorioamnionitis induces changes in ovine pulmonary endogenous epithelial stem/progenitor cells in utero. Pediatric Research, 90(3), 549-558. https://doi.org/10.1038/s41390-020-01204-9
    • Shahmohammadi, M., Luo, H., Westphal, P., Cornelussen, R. N., Prinzen, F. W., & Delhaas, T. (2021). Hemodynamics-driven mathematical model of first and second heart sound generation. PLoS Computational Biology, 17(9), Article e1009361. https://doi.org/10.1371/journal.pcbi.1009361
Overview