Section Leon Schurgers
- 2026
- van Loo, C., Stevens, K. A., Sigaeva, T., Giudici, A., Schurgers, L. J., Delhaas, T., Au, J. S., & Spronck, B. (2026). Biaxial biomechanics of aged human carotid arteries. Journal of the Mechanical Behavior of Biomedical Materials, 182, Article 107529. https://doi.org/10.1016/j.jmbbm.2026.107529
- van Doorn, D. P. C., van Paassen, P., & Timmermans, S. A. M. E. G. (2026). In Reply to "Placental Versus Complement Biology in Postpartum Thrombotic Microangiopathy Attribution". American Journal of Kidney Diseases, 88(4), 643-644. https://doi.org/10.1053/j.ajkd.2026.07.004
- Namba, H. F., de Jong, E. A. M., Boerhout, C. K. M., Mechroubi, A., Nijkamp, T., Damman, P., Dimitriu-Leen, A. C., Meuwissen, M., Heestermans, T. A. C. M., den Haan, M. C., Beijk, M. A. M., Vos, N. S., Escaned, J., den Ruijter, H. M., Appelman, Y., Eringa, E. C., Delewi, R., Piek, J. J., & van de Hoef, T. P. (2026). Rationale and design of the vericiguat in vasospastic angina (ViVA) trial: A double-blind placebo-controlled randomized cross-over study. American Heart Journal, 299, Article 107451. https://doi.org/10.1016/j.ahj.2026.107451
- Toonen, S. M. R. L., de Raat, F. M., van Loo, C., van Knippenberg, L., van Houte, J., Delhaas, T., Schurgers, L. J., Jeroncic, A., Mischi, M., Arthur Bouwman, R., Montenij, L. J., & Spronck, B. (2026). Vasoactive response of the thoracic aorta to phenylephrine infusion during cardiac surgery. Journal of Applied Physiology, 141(3), 863-872. https://doi.org/10.1152/japplphysiol.00996.2025
- Spanjersberg, T. C. F., Hulsman, A. H., Grinwis, G. C. M., Janssen, B., van der Wilt, C. N., Veltrop, R. J. A., Blok, C. J. B. S., Rozendom, C., Besseling, P. J., van der Velden, J., van der Harst, P., Harakalova, M., & van Steenbeek, F. G. (2026). Phenotypic patterns in feline heart failure: A natural model for understanding variable disease severity in humans. iScience, 29(8), Article 116685. https://doi.org/10.1016/j.isci.2026.116685
- Barrera-Chimal, J., Lopez-Ramirez, J., Henley, N., Gao, P., Ma, Y., Desjardins-Lecavalier, N., Costantino, S., Royal, V., Agten, S. M., Borras, T., Pichette, V., Yuen, D. A., Schurgers, L. J., & Gerarduzzi, C. (2026). Matrix Gla Protein is a novel regulator of TGFβ–dependent fibroblast activation and kidney fibrosis. Molecular Biomedicine, 7(1), Article 127. https://doi.org/10.1186/s43556-026-00518-0
- Back, M., Wilhelm, M., Marcin, T., Machado, F. V. C., Sandberg, A., Buccheri, S., Castro Conde, A., Czapla, M., De Rosa, S., Gibson, I., Gombosova, A., Korzh, O., La Rovere, M. T., Locati, E. T., Masip, J., Norekval, T. M., Novo, G., Pedretti, R. F. E., Semb, A. G., ... ESC Guidelines Advisory Group (2026). 2026 ESC Guidelines on cardiac rehabilitation Developed by the task force on cardiac rehabilitation of the European Society of Cardiology (ESC)Endorsed by the European Society of Physical and Rehabilitation Medicine (ESPRM) and World Organization of Family Doctors (WONCA). European Heart Journal. https://doi.org/10.1093/eurheartj/ehag099
- ter Steeg, L., Bouwmeester, R. N., ter Avest, M., Bemelman, F. J., Bouts, A. H. M., Bredewold, O. W., Dorresteijn, E., Eijgelsheim, M., Engels, F. A. P. T., Gracchi, V., ter Heine, R., Keijzer-Veen, M. G., van de Logt, A.-E., Meijden, W. A. G. V. D., van Rooij, R. W. G., Severs, D., Timmermans, S. A. M. E. G., van Zuilen, A. D., Michels, M. A. H. M., ... van de Kar, N. C. A. J. (2026). Atypical Hemolytic Uremic Syndrome in Children and Adults With the Hot Spot C3 Gene Variant p.Arg161Trp. Kidney International Reports, 11(8), Article 106599. https://doi.org/10.1016/j.ekir.2026.106599
- Heuts, S., de Keijzer, A. R., Adriaans, B. P., Notenboom, M. L., Mihl, C., Wildberger, J. E., Vos, R. J., Post, M. C., Rylski, B., Czerny, M., Reesink, K. D., Takkenberg, J. J. M., Veen, K. M., Arabkhani, B., Schalla, S. S., Schurgers, L. J., Lorusso, R., Hjortnaes, J., & Bidar, E. (2026). Rethinking Aortic Risk: The Potential Impact of Novel, Adjusted, and Combined Aortic Measures in the Prediction of Aortic Dissection. The Canadian journal of cardiology, 42(7), 1686-1696. https://doi.org/10.1016/j.cjca.2026.01.023
- Spanjersberg, T. C. F., Klaassen, A., Wubbolts, R., van Dijk, C. G. M., van der Velden, J., Veltrop, R. J. A., van der Harst, P., Harakalova, M., & van Steenbeek, F. G. (2026). Protocol for fibrin-based endothelial-cardiomyocyte co-culture in a microfluidic device. STAR protocols, 7(2), Article 104562. https://doi.org/10.1016/j.xpro.2026.104562
- Lotfalla, A., Heuts, S., Schreurs, R., Maessen, J. G., Schurgers, L., Korver, E., Verheule, S., Lorusso, R., Jacobs, M., & Bidar, E. (2026). A Comprehensive Total Body Perfusion Strategy vs Conventional Techniques in Elective Aortic Arch Surgery: A Comparative Analysis. Interdisciplinary CardioVascular and Thoracic Surgery, 41(6), Article ivag145. https://doi.org/10.1093/icvts/ivag145
- Lambrichts, S. M. P., van der Taelen, L., Pastor, I., Leenders, P., Bitsch, N., Majcher, D., Hermes, D., Simmonds, S. J., van Herwijnen, M., Kamps, R., Weltjens, E., Jessen, P. J. J., Steinbusch, H. P., Arentz, F., Wiesmann, M., Kiliaan, A. J., Caiment, F., Kutmon, M., Jones, E. A., ... Foulquier, S. (2026). Downregulation of Trpv4 and Klf2 in brain microvessels is associated with the progression of neurovascular dysfunction and cognitive impairment in a model of heart failure with preserved ejection fraction. Journal of Cerebral Blood Flow and Metabolism. Advance online publication. https://doi.org/10.1177/0271678X261462714
- Vossen, L. M., de Leeuw, P. W., Schurgers, L. J., Heuts, S., Adriaans, B. P., de Haan, C., van Varik, B. J., & Kroon, A. A. (2026). Two Years of Menaquinone-7 Supplementation and Coronary Artery Calcification A Randomized Clinical Trial. JAMA Cardiology. Advance online publication. https://doi.org/10.1001/jamacardio.2026.1279
- van Doorn, D. P. C., van Paassen, P., & Timmermans, S. A. M. E. G. (2026). Whole-exome sequencing in hypertensive emergency with kidney disease. Kidney International, 109(6), 1326-1327. https://doi.org/10.1016/j.kint.2026.03.006
- Potjewijd, J., Tobal, R., van Doorn, D. P. C., Schurgers, L. J., Heeringa, P., Damoiseaux, J. G. M. C., & van Paassen, P. (2026). Soluble immune checkpoints reflect immune activation and treatment response in high-risk systemic sclerosis patients treated with plasma exchange. Journal of Translational Autoimmunity, 12, Article 100361. https://doi.org/10.1016/j.jtauto.2026.100361
- Kopytina, V., Marchant, V., Rodrigues-Diez, R., Pascual-Anton, L., Toggweiler, N., Strahl, L., Kane, J., Tejera-Munoz, A., Cortes, M., Sucunza, D., Vaquero, J. J., Vervloet, M., Piecha, D., Eringa, E. C., Ruiz-Ortega, M., Lopez-Cabrera, M., & Gonzalez-Mateo, G. T. (2026). Troxerutin is a novel osmotic agent for peritoneal dialysis with protective cardiovascular actions. Nephrology Dialysis Transplantation, 41(6), 1147-1160. Article gfaf249. https://doi.org/10.1093/ndt/gfaf249
- Bittner, R., de Vries, F., Machuron, F., Maresz, K., Gaserod, O., & Schurgers, L. (2026). Sex-Specific Effects of Menaquinone-7 (MK-7) Supplementation on Body Composition and Adiposity Markers. Nutrients, 18(11), Article 1699. https://doi.org/10.3390/nu18111699
- Roy, S., Kane, J., Grigorieva, I., Roche-Dugmore, D., Moore, S., Steadman, R., Raby, A.-C., Jakulj, L., Schurgers, L., Lutgens, E., Eringa, E. C., Vervloet, M., Fraser, D., & Meran, S. (2026). Hyaluronan Regulates Vascular Smooth Muscle Cell Osteogenic Differentiation and Vascular Calcification. Biomolecules, 16(5), Article 729. https://doi.org/10.3390/biom16050729
- Koetsier, J., Bahram Sangani, N., Gomes, A. R., Diogo, M. M., Fernandes, T. G., Bouwman, F. G., Mariman, E. C. M., Ghazvini, M., Schurgers, L. J., Gribnau, J., Curfs, L. M. G., Reutelingsperger, C. P., & Eijssen, L. M. T. (2026). Multi-omics characterization of developing forebrain organoids unravels the dynamic molecular events of Rett syndrome pathogenesis. Journal of Neurodevelopmental Disorders, 18(1), Article 33. https://doi.org/10.1186/s11689-026-09699-9
- Zagaliotis, A., Roumeliotis, A., Roumeliotis, S., Neofytou, I. E., Varouktsi, G., Leptokaridou-Mourtzila, E., Stamou, A., Sgouropoulou, V., Kocic, G., Veljkovic, A., Bittner, R., Jahnen-Dechent, W., Schurgers, L. J., & Liakopoulos, V. (2026). Red Blood Cell Distribution Width and Neutrophil-to-Lymphocyte Ratio as Markers of Cardiovascular Disease and Vascular Calcification in Chronic Kidney Disease: A Large Cohort Study. Metabolites, 16(4), Article 280. https://doi.org/10.3390/metabo16040280
- Pinckaers, N. E. T., Blankesteijn, W. M., Leenders, P., Weltjens, E., Opperhuizen, A., Van Schooten, F.-J., & Vrolijk, M. (2026). Potential Cardiovascular Risks of Phenethylamine Analogues in Food Supplements: Evidence from Vasocontraction of Rat Artery Segments. Cardiovascular Toxicology, 26(4), Article 36. https://doi.org/10.1007/s12012-026-10109-8
- Marreiros, C., Viegas, C., Nunes, S., Silva, A. P., Faisca, M., Schurgers, L., & Simes, D. C. (2026). Factors associated with Gla-rich protein serum concentrations in healthy adults. Biochemia Medica, 36(2), Article 020709. https://doi.org/10.11613/BM.2026.020709
- Atash, A., Mees, B. M. E., Cramer, M. J., Baas, A. F., Schurgers, L. J., Doevendans, P. A., & Stillitano, F. (2026). MYH11 variants in thoracic aortic aneurysm pathophysiology: From bench to bedside. European Journal of Clinical Investigation, 56(4), Article e70196. https://doi.org/10.1111/eci.70196
- Torfs, T., Veltrop, R. J. A., Lezzoche, G., Heymans, S. R. B., Verdonschot, J. A. J., & Nabben, M. (2026). Metabolic Dysregulation in Laminopathies: Implications for Heart Failure and Cardiac Health. Current Heart Failure Reports, 23(1), Article 6. https://doi.org/10.1007/s11897-025-00735-8
- Lima, L. S., Ribeiro, M., Cardozo, L. F. M. F., Bittner, R., Ribeiro-Alves, M., Schultz, J., Rosado, A. S., Leite, P. E. C., Nakao, L. S., Schurgers, L. J., & Mafra, D. (2026). Association of poor vitamin K status with inflammation and gut microbiota in hemodialysis patients: A cross-sectional study. Journal of Nutritional Biochemistry, 148, Article 110139. https://doi.org/10.1016/j.jnutbio.2025.110139
- Vidula, M. K., Schurgers, L. J., Zhao, L., Dib, M.-J., Zhao, M., Wang, Z., Ebert, C., Salman, O., Azzo, J. D., Zamani, P., van Empel, V., Richards, A. M., Doughty, R., Javaheri, A., Mann, D. L., Rietzschell, E., Kammerhoff, K., Schafer, P., Seiffert, D. A., ... Chirinos, J. A. (2026). Dephospho-Uncarboxylated Matrix Gla-Protein Is Associated With Adverse Outcomes in Heart Failure. Circulation-Heart Failure, 19(2), 1-11. Article e012734. https://doi.org/10.1161/CIRCHEARTFAILURE.124.012734
- Stenvinkel, P., Kotanko, P., Painer-Gigler, J., Shiels, P. G., Evenepoel, P., Schurgers, L., Natterson-Horowitz, B., Kalogeropoulu, S., Schiffman, J., & Johnson, R. J. (2026). Comparative physiology and biomimetics in metabolic and environmental health: what can we learn from extreme animal phenotypes?Diabetologia, 69(2), 295-307. https://doi.org/10.1007/s00125-025-06611-3
- van Doorn, D. P. C., Al-Nasiry, S., Spaanderman, M. E. A., Damoiseaux, J. G. M. C., van Paassen, P., & Timmermans, S. A. M. E. G. (2026). Thrombotic Microangiopathy During Pregnancy: Role of Soluble Fms-like Tyrosine Kinase-1-Placental Growth Factor Ratios. American Journal of Kidney Diseases, 87(2), 278-283. https://doi.org/10.1053/j.ajkd.2025.09.017
- Doukas, P., Bassett, C., Hruschka, B., Kuzmanova, E., Wessels, I., Klump, H. J., Schurgers, L. J., Jacobs, M. J., Uhl, C., Gombert, A., & Huang, J. T. J. (2026). Plasma Desmosine Is Elevated in Thoracoabdominal Aortic Aneurysms and Is Associated with Intramural Proteolytic Activity. International Journal of Molecular Sciences, 27(3), Article 1236. https://doi.org/10.3390/ijms27031236
- Muilwijk, M., Kremers, S., Schurgers, L. J., Stolaki, M., Bakker, S. J. L., & Beulens, J. W. J. (2026). A double-blind randomised controlled trial assessing the effect of menaquinone producing probiotics on vitamin K status. Beneficial Microbes. Advance online publication. https://doi.org/10.1163/18762891-bja00117
- van der Wilt, C. N., Veltrop, R. J. A., Janssens, M. H., Bakker, I., Stillitano, F., Sluijter, J. P. G., van Laake, L. W., van der Velden, J., Villard, E., Montag, J., Denning, C., van Tintelen, J. P., Te Riele, A. S. J. M., van der Harst, P., Schurgers, L. J., van Steenbeek, F. G., & Harakalova, M. (2026). Setting the stage for cardiomyopathy gene editing trials: a systematic review of isogenic pair use in human induced pluripotent stem cell-derived cardiomyocyte research. European heart journal open, 6(1), Article oeaf161. https://doi.org/10.1093/ehjopen/oeaf161
- Beckers, C., Kraemer, S., Theissen, A., Kunze, M., Soppert, J., Schurgers, L., Veltrop, R., Doorschodt, B., Tolba, R. H., Larmann, J., & Bleilevens, C. (2026). Evaluating a Novel Cell-Free Preservation Solution for Human Cardiomyocyte Protection: A Proof-of-Concept Study. BioMed Research International, 2026(1), e7101969. Article 7101969. https://doi.org/10.1155/bmri/7101969
- van de Bovenkamp, A. A., Nassiri, S., de Man, F. S., Oosterveer, F. P. T., Mourmans, S. G. J., van Raalte, D. H., Dijkmans, P. A., van Heerebeek, L., van Empel, V. P. M., Eringa, E. C., Bakermans, A. J., & Handoko, M. L. (2026). Intravenous IRON supplementation in Heart Failure with Preserved Ejection Fraction and iron deficiency (IRON-HFpEF): a comprehensive phase II multicentre placebo-controlled randomized clinical trial. European journal of heart failure. Advance online publication. https://doi.org/10.1093/ejhf/xuag162
- Persson, K., Nilsson, C. U., Sjovall, J., Walther Sturesson, L., Schurgers, L., & Kander, T. (2026). Vitamin K-dependent proteins in patients undergoing head and neck free flap surgery - a prospective observational study. Scandinavian Journal of Clinical & Laboratory Investigation, 86(5), 480-488. https://doi.org/10.1080/00365513.2026.2694050
- 2025
- Meulendijks, E. R., Fabrizi, B., Bruns, S., Eringa, E. C., Hoebe, R., van den Boogert, T., Wesselink, R., Al-Shama, R. F. M., de Vries, T. A. C., Ernault, A. C., Niessen, H. W. M., van Boven, W. J. P., Driessen, A. H. G., Zbairi, I., Zappala, P., Dey, D., Isgum, I., Planken, R. N., Krul, S. P. J., & de Groot, J. R. (2025). Patients with persistent atrial fibrillation and metabolic comorbidities have an altered inflammatory state of atrial epicardial adipose tissue, which is linked to CT-attenuation. Cardiovascular Diabetology, 25(1), Article 82. https://doi.org/10.1186/s12933-025-02985-1
- Nassiri, S., Voordes, G. H. D., van Heerebeek, L., van Raalte, D. H., Verhaar, M. C., Touw, D. J., Krebber, M. M., Duncker, D. J., Eringa, E. C., Handoko, M. L., Voors, A. A., & RECONNEXT Consortium (2025). Effects of geranylgeranylacetone on diastolic and microvascular function in patients with heart failure with a preserved ejection fraction: A phase 2, randomized, placebo-controlled, crossover trial. European journal of heart failure, 27(12), 3304-3311. https://doi.org/10.1002/ejhf.3711
- Lanzer, P., Schurgers, L., Twarda-Clapa, A., Ferraresi, R., Hui, H., Kamenskiy, A., Chen, Y., Hamana, T., Fok, P.-W., Millán, Á., Virmani, R., & St Hilaire, C. (2025). Medial arterial calcification in ageing and disease: current evidence and knowledge gaps. European Heart Journal, 46(45), 4876-4900. https://doi.org/10.1093/eurheartj/ehaf341
- Al-Chalabi, S., Sinha, S., Kalra, P. A., Evans, D., Green, D., Schurgers, L., & Poulikakos, D. (2025). A Randomised Prospective Crossover Study on the Effects of Medium Cut-Off Membranes on FGF-23 and Inflammatory Mediators in Patients Receiving Regular Haemodialysis. Blood Purification, 54(11), 639-651. https://doi.org/10.1159/000545745
- Ramos, K. S., Nassiri, S., Wijdeveld, L. F. J., van der Palen, R. L., Kuipers, M. F., Hills, M. T., Slijkerman, P., van Raalte, D. H., Handoko, M. L., de Groot, N. M. S., Grewal, N., Klautz, R. J. M., Eringa, E. C., & Brundel, B. J. J. M. (2025). Geranylgeranylacetone as Prevention for Postoperative Atrial Fibrillation (GENIALITY). Cardiovascular Drugs and Therapy, 39(6), 1589-1595. https://doi.org/10.1007/s10557-025-07693-2
- Altini, N., Prunella, M., Seshan, S. V., Sciascia, S., Barreca, A., Gobbo, A. D., Porubsky, S., Nguyen, H. V., Delprete, C., Prencipe, B., Dobi, D., van Doorn, D. P. C., Timmermans, S. A. M. E. G., Paassen, P. V., Bevilacqua, V., & Becker, J. U. (2025). Multistain Multicompartment Automatic Segmentation in Renal Biopsies with Thrombotic Microangiopathies and other Vasculopathies. Computerized Medical Imaging and Graphics, 126, Article 102658. https://doi.org/10.1016/j.compmedimag.2025.102658
- Niederau, C., Maas, S. L., van der Vorst, E. P. C., Schurgers, L. J., Shi, Y., Holzle, F., Wolf, M., & Craveiro, R. B. (2025). Jaw-specific differential kinase activity profiles in human periodontal ligament stem cells under mechanical compression. Stem Cell Research & Therapy, 16(1), Article 624. https://doi.org/10.1186/s13287-025-04778-5
- Morelle, J., Caravaca-Fontan, F., Fakhouri, F., Frangou, E., Bruchfeld, A., Floege, J., Mirioglu, S., Moran, S. M., Steiger, S., Stevens, K. I., Teng, O. Y. K., Aydin, S., Java, A., Timmermans, S. A. M. E. G., & Kronbichler, A. (2025). Complement activation in secondary thrombotic microangiopathies. Nephrology Dialysis Transplantation, 40(11), 2193-2206. https://doi.org/10.1093/ndt/gfaf091
- Willemsen, M., Abdul-Hamid, M., van Gelder, M., van Paassen, P., & Timmermans, S. A. (2025). Cryoglobulinemic vasculitis flare after daratumumab. Annals of Hematology, 104(9), 4883-4885. https://doi.org/10.1007/s00277-025-06316-y
- Heuschkel, M. A., Jaminon, A., Gräber, S., Artati, A., Adamski, J., Jankowski, J., Schurgers, L., Marx, N., Jahnen-Dechent, W., & Goettsch, C. (2025). Hypotaurine Reduces Glucose-Mediated Vascular Calcification. Acta Physiologica, 241(8), Article e70075. https://doi.org/10.1111/apha.70075
- Ganizada, B. H., Reesink, K. D., Parikh, S., Saraber, P. J. M. H., Cleutjens, J. P., Isabella, A., Krebbekx, M. Q. E., Jaminon, A. M., Maassen, C. F. M., Ramaekers, M. J. F. G., Spronck, B., van der Laan, K., Koenen, R. R., Lorusso, R., Maessen, J. G., Bidar, E., & Schurgers, L. J. (2025). Loss of wall stress homeostasis in ascending thoracic aortic aneurysm: histomorphometric insights into patient variants. The Journal of Physiology, 603(14), 3899-3922. https://doi.org/10.1113/JP288734
- Pencheva, M. G., Berends, E., van der Laan, K. W. F., Giudici, A., Niessen, P., Scheijen, J. L. J. M., Vangrieken, P., Leenders, P., Delhaas, T., Caiment, F., Kutmon, M., Trujillo, F. M., Wouters, K., Foulquier, S., Spronck, B., Reesink, K. D., & Schalkwijk, C. G. (2025). Glyoxalase-1 overexpression attenuates arterial wall stiffening in diabetic mice. Cardiovascular Diabetology, 24(1), Article 283. https://doi.org/10.1186/s12933-025-02823-4
- Timmermans, S. A. M. E. G., van Doorn, D. P. C., & van Paassen, P. (2025). Toward a Revised Definition of Thrombotic Microangiopathy. Kidney International Reports, 10(6), 1625-1627. https://doi.org/10.1016/j.ekir.2025.04.051
- Janssen-Telders, C., Eringa, E. C., de Groot, J. R., de Man, F. S., & Handoko, M. L. (2025). The role of epicardial adipose tissue remodelling in heart failure with preserved ejection fraction. Cardiovascular Research, 121(6), 860-870. https://doi.org/10.1093/cvr/cvaf056
- Suthahar, N., Mourmans, S. G. J., Achten, A., Aboumsallem, J. P., Meijers, W. C., Bomer, N., Kardys, I., Gansevoort, R. T., Bakker, S. J. L., Weerts, J., Eringa, E. C., Damman, K., van Empel, V., & de Boer, R. A. (2025). Peroxiredoxin-4, a marker of systemic oxidative stress, is associated with incident heart failure. European journal of heart failure, 27(5), 905-911. Article 3653. https://doi.org/10.1002/ejhf.3653




