Casper Schalkwijk

Professor

Prof. Casper Schalkwijk studied chemistry at University Utrecht and graduated in biochemistry. At the same university he obtained his PhD in 1992. He did post-graduate training in endothelial cell biology at TNO-PG in Leiden. He was appointed in 1995 as assistant professor and staff member at the Department of Clinical Chemistry at the Vrije Universiteit Medical Cente in Amsterdam and from 2004 as associate professor. He has led the Vascular Unit. He moved to the Department of Internal Medicine at Maastricht University in 2005, where he is heading the Laboratory for Metabolism and Vascular Medicine (~15fte). He was appointed as Professor of Experimental Internal Medicine at the Faculty of Health, Medicine and Life Sciences (FHML) of Maastricht UMC+ in 2011.

His main research themes are obesity, insulin resistance, endothelial function and vascular complications. The importance of endothelial dysfunction for the development of diabetic complications is studied in epidemiological setting with the availability of several cohorts and with experimental ex-vivo -, animal - and cell work. He has led several clinical studies. A major aim of his programme is to deliver specific and sensitive diagnostic biomarkers for the identification of patients developing  type 2 diabetes and to identify patients with high risk of vascular complications. Robust analytical techniques for measurements of biomarkers with multi-array technology and with UPLC-MSMS are available. A second aim of his programme is to obtain insight in the pathophysiology of vascular complications in diabetes. His current studies focus mainly on the importance non-enzymatic glycation for the development of diabetes and diabetic complications. He discovered, as one of the first, the link between AGEs and vascular complications in individuals with and without diabetes. He is an (inter)nationally recognised expert in the field of glycation. His lab is one of the most renowned labs in this field.The work has been supported by several grants and is now granted by the Diabetes Fonds Nederland, EFSD, NWO, ZonMw and NVWA.

Department of Internal Medicine
Universiteitssingel 50, 6229 ER Maastricht
PO Box 616, 6200 MD Maastricht
Room number: 5.324
T: +31(0)43 388 21 86

  • 2022
    • Jin, S., Reesink, K. D., Kroon, A. A., de Galan, B., van der Kallen, C. J. H., Wesselius, A., Schalkwijk, C. G., Stehouwer, C. D. A., & van Greevenbroek, M. M. J. (2022). Complement factors D and C3 cross-sectionally associate with arterial stiffness, but not independently of metabolic risk factors: The Maastricht Study. Journal of Hypertension, 40(11), 2161-2170. https://doi.org/10.1097/HJH.0000000000003237
    • van der Heide, F. C. T., Foreman, Y. D., Franken, I. W. M., Henry, R. M. A., Kroon, A. A., Dagnelie, P. C., Eussen, S. J. P. M., Berendschot, T. T. J. M., Schouten, J. S. A. G., Webers, C. A. B., Schram, M. T., van der Kallen, C. J. H., van Greevenbroek, M. M. J., Wesselius, A., Schalkwijk, C. G., Schaper, N. C., Brouwers, M. C. G. J., & Stehouwer, C. D. A. (2022). (Pre)diabetes, glycemia, and daily glucose variability are associated with retinal nerve fiber layer thickness in The Maastricht Study. Scientific Reports, 12(1), [17750]. https://doi.org/10.1038/s41598-022-22748-2
    • Top, W. M. C., Lehert, P., Schalkwijk, C. G., Stehouwer, C. D. A., & Kooy, A. (2022). Effect of metformin on arginine and dimethylarginines in patients with advanced type 2 diabetes: A post hoc analysis of a randomized trial. Diabetes Obesity & Metabolism, 24(10), 1983-1988. https://doi.org/10.1111/dom.14784
    • Janssen, L. E. F., Simons, N., Simons, P. I. H. G., Schaper, N. C., Feskens, E. J. M., van der Ploeg, L. M. C., Van den Eynde, M. D. G., Schalkwijk, C. G., Houben, A. J. H. M., Stehouwer, C. D. A., & Brouwers, M. C. G. J. (2022). Effects of fructose restriction on blood pressure: Secondary analysis of a double-blind randomized controlled trial. Clinical Nutrition ESPEN, 51, 97-103. https://doi.org/10.1016/j.clnesp.2022.07.009
    • Geraets, A. F. J., Schram, M. T., Jansen, J. F. A., Backes, W. H., Schalkwijk, C. G., Stehouwer, C. D. A., van Boxtel, M. P. J., Eussen, S. J. P. M., Kooman, J. P., Verhey, F. R. J., & Köhler, S. (2022). The cardiometabolic depression subtype and its association with clinical characteristics: The Maastricht Study. Journal of Affective Disorders, 313, 110-117. https://doi.org/10.1016/j.jad.2022.06.045
    • Baylan, U., Korn, A., Emmens, R. W., Schalkwijk, C. G., Niessen, H. W. M., Krijnen, P. A. J., & Simsek, S. (2022). Liraglutide treatment attenuates inflammation markers in the cardiac, cerebral and renal microvasculature in streptozotocin-induced diabetic rats. European Journal of Clinical Investigation, 52(9), [13807]. https://doi.org/10.1111/eci.13807
    • Zhang, X., Schalkwijk, C. G., & Wouters, K. (2022). Immunometabolism and the modulation of immune responses and host defense: A role for methylglyoxal?Biochimica et Biophysica Acta-Molecular Basis of Disease, 1868(8), [166425]. https://doi.org/10.1016/j.bbadis.2022.166425
    • Barutta, F., Bellini, S., Guarrera, S., Matullo, G., Schalkwijk, C., Stehouwer, C. D., Chaturvedi, N., Soedamah-Muthu, S. S., Durazzo, M., & Gruden, G. (2022). Association of Serum MicroRNA-145-5p Levels with Microvascular Complications of Type 1 Diabetes: the EURODIAB Prospective Complications Study. Diabetes Research and Clinical Practice, 190, [109987]. https://doi.org/10.1016/j.diabres.2022.109987
    • Brouwers, M. C. G. J., Simons, N., Kooi, M. E., de Ritter, R., van Dongen, M. C. J. M., Eussen, S. J. P. M., Bekers, O., Kooman, J., van Greevenbroek, M. M. J., van der Kallen, C. J. H., Schram, M. T., Schaper, N. C., Schalkwijk, C. G., & Stehouwer, C. D. A. (2022). Intrahepatic lipid content is independently associated with soluble E-selectin levels: The Maastricht study. Digestive and Liver Disease, 54(8), 1038-1043. https://doi.org/10.1016/j.dld.2022.01.130
    • Jin, S., Kusters, Y. H. A. M., Houben, A. J. H. M., Plat, J., Joris, P. J., Mensink, R. P., Schalkwijk, C. G., Stehouwer, C. D. A., & van Greevenbroek, M. M. J. (2022). A randomized diet-induced weight-loss intervention reduces plasma complement C3: Possible implication for endothelial dysfunction. Obesity, 30(7), 1401-1410. https://doi.org/10.1002/oby.23467
    • Simons, P. I. H. G., Valkenburg, O., Telgenkamp, I., van der Waaij, K. M., de Groot, D. M., Veeraiah, P., Bons, J. A. P., Derks, T. G. J., Schalkwijk, C. G., Schrauwen-Hinderling, V. B., Stehouwer, C. D. A., & Brouwers, M. C. G. J. (2022). Serum sex hormone-binding globulin levels are reduced and inversely associated with intrahepatic lipid content and saturated fatty acid fraction in adult patients with glycogen storage disease type 1a. Journal of Endocrinological Investigation, 45(6), 1227-1234. https://doi.org/10.1007/s40618-022-01753-2
    • Doola, R., Deane, A. M., Barrett, H. L., Okano, S., Tolcher, D. M., Gregory, K., Coombes, J. S., Schalkwijk, C., Todd, A. S., Forbes, J. M., & Sturgess, D. J. (2022). The impact of a modified carbohydrate formula, and its constituents, on glycaemic control and inflammatory markers: A nested mechanistic sub-study. Journal of Human Nutrition and Dietetics, 35(3), 455-465. https://doi.org/10.1111/jhn.12959
    • Linkens, A. M. A., van Best, N., Niessen, P. M., Wijckmans, N. E. G., de Goei, E. E. C., Scheijen, J. L. J. M., van Dongen, M. C. J. M., van Gool, C. C. J. A. W., de Vos, W. M., Houben, A. J. H. M., Stehouwer, C. D. A., Eussen, S. J. M. P., Penders, J., & Schalkwijk, C. G. (2022). A 4-Week Diet Low or High in Advanced Glycation Endproducts Has Limited Impact on Gut Microbial Composition in Abdominally Obese Individuals: The deAGEing Trial. International journal of molecular sciences, 23(10), [5328]. https://doi.org/10.3390/ijms23105328
    • Buziau, A. M., Eussen, S. J. P. M., Kooi, M. E., van der Kallen, C. J. H., van Dongen, M. C. J. M., Schaper, N. C., Henry, R. M. A., Schram, M. T., Dagnelie, P. C., van Greevenbroek, M. M. J., Wesselius, A., Bekers, O., Meex, S. J. R., Schalkwijk, C. G., Stehouwer, C. D. A., & Brouwers, M. C. G. J. (2022). Fructose Intake From Fruit Juice and Sugar-Sweetened Beverages Is Associated With Higher Intrahepatic Lipid Content: The Maastricht Study. Diabetes Care, 45(5), 1116-1123. https://doi.org/10.2337/dc21-2123
    • Vandercappellen, E. J., Koster, A., Savelberg, H. H. C. M., Eussen, S. J. P. M., Dagnelie, P. C., Schaper, N. C., Schram, M. T., van der Kallen, C. J. H., van Greevenbroek, M. M. J., Wesselius, A., Schalkwijk, C. G., Kroon, A. A., Henry, R. M. A., & Stehouwer, C. D. A. (2022). Sedentary behaviour and physical activity are associated with biomarkers of endothelial dysfunction and low-grade inflammation-relevance for (pre)diabetes: The Maastricht Study. Diabetologia, 65(5), 777-789. https://doi.org/10.1007/s00125-022-05651-3
    • Mashnafi, S., Plat, J., Mensink, R. P., Joris, P. J., Kusters, Y. H. A. M., Houben, A. J. H. M., Stehouwer, C. D. A., Schalkwijk, C. G., & Baumgartner, S. (2022). Effects of Diet-Induced Weight Loss on Plasma Markers for Cholesterol Absorption and Synthesis: Secondary Analysis of a Randomized Trial in Abdominally Obese Men. Nutrients, 14(8), [1546]. https://doi.org/10.3390/nu14081546
    • Linkens, A. M. A., Houben, A. J., Niessen, P. M., Wijckmans, N., de Goei, E., Van den Eynde, M. D. G., Scheijen, J. L. J. M., Waarenburg, M., Mari, A., Berendschot, T. T. J. M., Streese, L., Hanssen, H., van Dongen, M. C. J. M., van Gool, C., Stehouwer, C. D. A., Eussen, S. J. P. M., & Schalkwijk, C. (2022). A 4-week high-AGE diet does not impair glucose metabolism and vascular function in obese individuals. JCI INSIGHT, 7(6), [156950]. https://doi.org/10.1172/jci.insight.156950
    • Wu, L., Baylan, U., van der Leeden, B., Schurink, B., Roos, E., Schalkwijk, C. G., Bugiani, M., van der Valk, P., van Rossum, A. C., Zeerleder, S. S., Heunks, L. M. A., Boon, R. A., de Boer, O. J., van der Wal, A. C., Niessen, H. W. M., & Krijnen, P. A. J. (2022). Cardiac inflammation and microvascular procoagulant changes are decreased in second wave compared to first wave deceased COVID-19 patients. International Journal of Cardiology, 349, 157-165. https://doi.org/10.1016/j.ijcard.2021.11.079
    • Linkens, A. M. A., Houben, A. J. H. M., Kroon, A. A., Schram, M. T., Berendschot, T. T. J. M., Webers, C. A. B., van Greevenbroek, M., Henry, R. M. A., de Galan, B., Stehouwer, C. D. A., Eussen, S. J. M. P., & Schalkwijk, C. G. (2022). Habitual intake of dietary advanced glycation end products is not associated with generalized microvascular function-the Maastricht Study. American Journal of Clinical Nutrition, 115(2), 444-455. https://doi.org/10.1093/ajcn/nqab302
    • van Dinther, M., Schram, M. T., Jansen, J. F. A., Backes, W. H., Houben, A. J. H. M., Berendschot, T. T. J. M., Schalkwijk, C. G., Stehouwer, C. D. A., van Oostenbrugge, R. J., & Staals, J. (2022). Extracerebral microvascular dysfunction is related to brain MRI markers of cerebral small vessel disease: The Maastricht Study. Geroscience, 44(1), 147-157. https://doi.org/10.1007/s11357-021-00493-0
    • Maasen, K., Eussen, S. J. P. M., Scheijen, J. L. J. M., van der Kallen, C. J. H., Dagnelie, P. C., Opperhuizen, A., Stehouwer, C. D. A., van Greevenbroek, M. M. J., & Schalkwijk, C. G. (2022). Higher habitual intake of dietary dicarbonyls is associated with higher corresponding plasma dicarbonyl concentrations and skin autofluorescence: the Maastricht Study. American Journal of Clinical Nutrition, 115(1), 34-44. https://doi.org/10.1093/ajcn/nqab329
  • 2021
    • Mao, Z., Aglago, E. K., Zhao, Z., Schalkwijk, C., Jiao, L., Freisling, H., Weiderpass, E., Hughes, D. J., Eriksen, A. K., Tjønneland, A., Severi, G., Rothwell, J., Boutron-Ruault, M-C., Katzke, V., Kaaks, R., Schulze, M. B., Birukov, A., Krogh, V., Panico, S., ... Fedirko, V. (2021). Dietary Intake of Advanced Glycation End Products (AGEs) and Mortality among Individuals with Colorectal Cancer. Nutrients, 13(12), [4435]. https://doi.org/10.3390/nu13124435
    • Kalafati, M., Kutmon, M., Evelo, C. T., van der Kallen, C. J. H., Schalkwijk, C. G., Stehouwer, C. D. A., Blaak, E. E., van Greevenbroek, M. M. J., Adriaens, M., & BIOS Consortium (2021). An interferon-related signature characterizes the whole blood transcriptome profile of insulin-resistant individuals-the CODAM study. Genes and nutrition, 16(1), [22]. https://doi.org/10.1186/s12263-021-00702-7
    • Barutta, F., Corbetta, B., Bellini, S., Guarrera, S., Matullo, G., Scandella, M., Schalkwijk, C., Stehouwer, C. D., Chaturvedi, N., Soedamah-Muthu, S. S., Durazzo, M., & Gruden, G. (2021). MicroRNA 146a is associated with diabetic complications in type 1 diabetic patients from the EURODIAB PCS. Journal of Translational Medicine, 19(1), [475]. https://doi.org/10.1186/s12967-021-03142-4
    • Gijs, M., Ramakers, I. H. G. B., Visser, P. J., Verhey, F. R. J., van de Waarenburg, M. P. H., Schalkwijk, C. G., Nuijts, R. M. M. A., & Webers, C. A. B. (2021). Association of tear fluid amyloid and tau levels with disease severity and neurodegeneration. Scientific Reports, 11(1), [22675]. https://doi.org/10.1038/s41598-021-01993-x
    • Korn, A., Baylan, U., Simsek, S., Schalkwijk, C. G., Niessen, H. W. M., & Krijnen, P. A. J. (2021). Myocardial infarction coincides with increased NOX2 and Nε-(carboxymethyl) lysine expression in the cerebral microvasculature. Open Heart, 8(2), [e001842]. https://doi.org/10.1136/openhrt-2021-001842
    • van der Bruggen, M. M., Spronck, B., Delhaas, T., Reesink, K. D., & Schalkwijk, C. G. (2021). The Putative Role of Methylglyoxal in Arterial Stiffening: A Review. Heart Lung and Circulation, 30(11), 1681-1693. https://doi.org/10.1016/j.hlc.2021.06.527
    • Kremers, S. H. M., Remmelzwaal, S., Schalkwijk, C. G., Elders, P. J. M., Stehouwer, C. D. A., van Ballegooijen, A. J., & Beulens, J. W. J. (2021). The role of serum and dietary advanced glycation endproducts in relation to cardiac function and structure: The Hoorn Study. Nutrition Metabolism and Cardiovascular Diseases, 31(11), 3167-3175. https://doi.org/10.1016/j.numecd.2021.07.020
    • Janssen, E. P. C. J., Köhler, S., Geraets, A. F. J., Stehouwer, C. D. A., Schaper, N. C., Sep, S. J. S., Henry, R. M. A., van der Kallen, C. J. H., Schalkwijk, C. G., Koster, A., Verhey, F. R., & Schram, M. T. (2021). Low-grade inflammation and endothelial dysfunction predict four-year risk and course of depressive symptoms: The Maastricht study. Brain Behavior and Immunity, 97, 61-67. https://doi.org/10.1016/j.bbi.2021.06.013
    • Aglago, E. K., Mayen, A. L., Knaze, V., Freisling, H., Fedirko, V., Hughes, D. J., Jiao, L., Eriksen, A. K., Tjonneland, A., Boutron-Ruault, M. C., Rothwell, J. A., Severi, G., Kaaks, R., Katzke, V., Schulze, M. B., Birukov, A., Palli, D., Sieri, S., de Magistris, M. S., ... Jenab, M. (2021). Dietary Advanced Glycation End-Products and Colorectal Cancer Risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) Study. Nutrients, 13(9), [3132]. https://doi.org/10.3390/nu13093132
    • van Dongen, K. C. W., Linkens, A. M. A., Wetzels, S. M. W., Wouters, K., Vanmierlo, T., van de Waarenburg, M. P. H., Scheijen, J. L. J. M., de Vos, W. M., Belzer, C., & Schalkwijk, C. G. (2021). Dietary advanced glycation endproducts (AGEs) increase their concentration in plasma and tissues, result in inflammation and modulate gut microbial composition in mice; evidence for reversibility. Food Research International, 147, [110547]. https://doi.org/10.1016/j.foodres.2021.110547
    • Piazza, M., Hanssen, N. M. J., Persson, F., Scheijen, J. L., van de Waarenburg, M. P. H., van Greevenbroek, M. M. J., Rossing, P., Hovind, P., Stehouwer, C. D. A., Parving, H-H., & Schalkwijk, C. G. (2021). Irbesartan treatment does not influence plasma levels of the dicarbonyls methylglyoxal, glyoxal and 3-deoxyglucosone in participants with type 2 diabetes and microalbuminuria: An IRMA2 sub-study. Diabetic Medicine, 38(9), [14405]. https://doi.org/10.1111/dme.14405
    • Wouters, K., Cento, A. S., Gaens, K. H., Teunissen, M., Scheijen, J. L. J. M., Barutta, F., Chiazza, F., Collotta, D., Aragno, M., Gruden, G., Collino, M., Schalkwijk, C. G., & Mastrocola, R. (2021). Deletion of RAGE fails to prevent hepatosteatosis in obese mice due to impairment of other AGEs receptors and detoxifying systems. Scientific Reports, 11(1), [17373]. https://doi.org/10.1038/s41598-021-96859-7
    • Mayen, A-L., Aglago, E. K., Knaze, V., Cordova, R., Schalkwijk, C. G., Wagner, K-H., Aleksandrova, K., Fedirko, V., Keski-Rahkonen, P., Leitzmann, M. F., Katzke, V., Srour, B., Schulze, M. B., Masala, G., Krogh, V., Panico, S., Tumino, R., Bueno-de-Mesquita, B., Brustad, M., ... Freisling, H. (2021). Dietary intake of advanced glycation endproducts and risk of hepatobiliary cancers: A multinational cohort study. International Journal of Cancer, 149(4), 854-864. https://doi.org/10.1002/ijc.33612
    • Aragones, G., Rowan, S., Francisco, S. G., Whitcomb, E. A., Yang, W. X., Perini-Villanueva, G., Schalkwijk, C. G., Taylor, A., & Bejarano, E. (2021). The Glyoxalase System in Age-Related Diseases: Nutritional Intervention as Anti-Ageing Strategy. Cells, 10(8), [1852]. https://doi.org/10.3390/cells10081852
    • van der Heide, F. C. T., Zhou, T. L., Henry, R. M. A., Houben, A. J. H. M., Kroon, A. A., Dagnelie, P. C., van Dongen, M. C. J. M., Eussen, S. J. P. M., Berendschot, T. T. J. M., Schouten, J. S. A. G., Webers, C. A. B., Schram, M. T., van Greevenbroek, M. M. J., Wesselius, A., Schalkwijk, C. G., Koster, A., Savelberg, H. H. C. M., Schaper, N. C., Reesink, K. D., & Stehouwer, C. D. A. (2021). Carotid stiffness is associated with retinal microvascular dysfunction- The Maastricht Study. Microcirculation, 28(6), [e12702]. https://doi.org/10.1111/micc.12702
    • Linkens, A. M. A., Eussen, S. J. M. P., Houben, A. J. H. M., Kroon, A. A., Schram, M. T., Reesink, K. D., Dagnelie, P. C., Henry, R. M. A., van Greevenbroek, M., Wesselius, A., Stehouwer, C. D. A., & Schalkwijk, C. G. (2021). Habitual Intake of Dietary Advanced Glycation End Products Is Not Associated with Arterial Stiffness of the Aorta and Carotid Artery in Adults: The Maastricht Study. Journal of Nutrition, 151(7), 1886-1893. https://doi.org/10.1093/jn/nxab097
    • Simons, P. I. H. G., Valkenburg, O., Telgenkamp, I., van der Waaij, K. M., de Groot, D. M., Veeraiah, P., Bons, J. A. P., Taskinen, M. R., Boren, J., Schrauwen, P., Rutten, J. H. W., Cassiman, D., Schalkwijk, C. G., Stehouwer, C. D. A., Schrauwen-Hinderling, V. B., Hodson, L., & Brouwers, M. C. G. J. (2021). Relationship between de novo lipogenesis and serum sex hormone binding globulin in humans. Clinical Endocrinology, 95(1), 101-106. https://doi.org/10.1111/cen.14459
    • Driessen, R. G. H., Kiers, D., Schalkwijk, C. G., Scheijen, J. L. J. M., Gerretsen, J., Pickkers, P., van de Poll, M. C. G., van der Horst, I. C. C., Bergmans, D. C. J. J., Kox, M., & van Bussel, B. C. T. (2021). Systemic inflammation down-regulates glyoxalase-1 expression: an experimental study in healthy males. Bioscience Reports, 41(7), [BSR20210954]. https://doi.org/10.1042/BSR20210954
    • Van den Eynde, M. D. G., Scheijen, J. L. J. M., Stehouwer, C. D. A., Miyata, T., & Schalkwijk, C. G. (2021). Quantification of the B6 vitamers in human plasma and urine in a study with pyridoxamine as an oral supplement; pyridoxamine as an alternative for pyridoxine. Clinical Nutrition, 40(7), 4624-4632. https://doi.org/10.1016/j.clnu.2021.05.028
    • Borg, D. J., Faridi, P., Giam, K. L., Reeves, P., Fotheringham, A. K., McCarthy, D. A., Leung, S., Ward, M. S., Harcourt, B. E., Ayala, R., Scheijen, J. L., Briskey, D., Dudek, N. L., Schalkwijk, C. G., Steptoe, R., Purcell, A. W., & Forbes, J. M. (2021). Short Duration Alagebrium Chloride Therapy Prediabetes Does Not Inhibit Progression to Autoimmune Diabetes in an Experimental Model. Metabolites, 11(7), [426]. https://doi.org/10.3390/metabo11070426
    • Mastrocola, R., Dal Bello, F., Cento, A. S., Gaens, K., Collotta, D., Aragno, M., Medana, C., Collino, M., Wouters, K., & Schalkwijk, C. G. (2021). Altered hepatic sphingolipid metabolism in insulin resistant mice: Role of advanced glycation endproducts. Free Radical Biology and Medicine, 169, 425-435. https://doi.org/10.1016/j.freeradbiomed.2021.04.028
    • Maasen, K., Scheijen, J. L. J. M., Opperhuizen, A., Stehouwer, C. D. A., Van Greevenbroek, M. M., & Schalkwijk, C. G. (2021). Corrigendum to “Quantification of dicarbonyl compounds in commonly consumed foods and drinks; presentation of a food composition database for dicarbonyls” [Food Chemistry, 339 (2020) 128063]. Food Chemistry, 344, [128578]. https://doi.org/10.1016/j.foodchem.2020.128578
    • Van den Eynde, M. D. G., Kusters, Y. H. A. M., Houben, A. J. H. M., Scheijen, J. L. J. M., van Duynhoven, J., Fazelzadeh, P., Joris, P. J., Plat, J., Mensink, R. P., Hanssen, N. M. J., Stehouwer, C. D. A., & Schalkwijk, C. G. (2021). Diet-induced weight loss reduces postprandial dicarbonyl stress in abdominally obese men: Secondary analysis of a randomized controlled trial. Clinical Nutrition, 40(5), 2654-2662. https://doi.org/10.1016/j.clnu.2021.03.042
    • Aglago, E. K., Schalkwijk, C. G., Freisling, H., Fedirko, V., Hughes, D. J., Jiao, L., Dahm, C. C., Olsen, A., Tjonneland, A., Katzke, V., Johnson, T., Schulze, M. B., Aleksandrova, K., Masala, G., Sieri, S., Simeon, V., Tumino, R., Macciotta, A., Bueno-de-Mesquita, B., ... Jenab, M. (2021). Plasma concentrations of advanced glycation end-products and colorectal cancer risk in the EPIC study. Carcinogenesis, 42(5), 705-713. https://doi.org/10.1093/carcin/bgab026
    • Top, W. M. C., Lehert, P., Schalkwijk, C. G., Stehouwer, C. D. A., & Kooy, A. (2021). Metformin and N-terminal pro B-type natriuretic peptide in type 2 diabetes patients, a post-hoc analysis of a randomized controlled trial. PLOS ONE, 16(4), [0247939]. https://doi.org/10.1371/journal.pone.0247939
    • Zhou, T. L., Kroon, A. A., Henry, R. M. A., Koster, A., Dagnelie, P. C., Bosma, H., van Greevenbroek, M. M. J., van der Kallen, C. J. H., Schalkwijk, C. G., Wesselius, A., Reesink, K. D., Köhler, S., Schram, M. T., Stehouwer, C. D. A., & van Sloten, T. T. (2021). Exercise SBP response and incident depressive symptoms: The Maastricht Study. Journal of Hypertension, 39(3), 494-502. https://doi.org/10.1097/HJH.0000000000002657
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