Pieter Dagnelie

Professor

Prof. Pieter Dagnelie is nutritional epidemiologist. He studied human nutrition at Wageningen University and received his PhD in 1988 based on a population-based, mixed-longitudinal cohort study of the nutritional status and growth of children fed macrobiotic diets. Subsequently, he received fellowships from the Dutch Cancer Society (1989) and the Royal Netherlands Academy of Arts and Sciences (1991) to work on the etiology of weight loss in cancer patients, using magnetic resonance spectroscopy and stable isotope tracers as main research tools.

In 1997, he was appointed Associate Professor in Maastricht to lead the nutritional epidemiology research group at the department of epidemiology and to build up the collaboration on nutritional epidemiology within Maastricht UMC+. In 2012, he received a strategic professorship in nutritional epidemiology.

Prof. Dagnelie’s overall aim is to explore new paradigms in the field of health research, lifestyle and nutrition, and to integrate and implement this new knowledge in disease prevention and treatment, thus contributing to improving people’s nutritional and health status, and quality of life. He has performed and supervised numerous observational studies and randomised clinical trials on the role of nutrition and bioactive compounds in the prevention and treatment of chronic diseases and cancer, with the improvement of transmural health care. His central aim has always been to contribute to the wellbeing of healthy individuals and patients. He is former member of the Scientific Committee of  and the Medical Ethical Committee of Maastricht UMC+.

Prof. Dagnelie’s current research is focussed on The Maastricht Study (https://www.demaastrichtstudie.nl/), a large-scale study initiated in 2010 on the etiology and prognosis of diabetes and its comorbidities, with oversampling individuals with type 2 diabetes. Enrolment is still ongoing. The Maastricht Study is one of the largest studies world-wide of its kind. All participants undergo 5 half-days of intensive phenotyping. Prof. Dagnelie was involved in the Life Style collaborative group of The Maastricht Study and the development of the extensive Food Frequency Questionnaire to assess dietary intake, both in terms of nutrients, dietary patterns and processing.

Since 2012, Prof. Dagnelie has been member of the Management Team of The Maastricht Study. Within the MT, his focus is on optimising research methodology, quality, and design of projects within The Maastricht Study. He also contributes to exploring new targets for funding, and is currently coordinator for organizaing a second assessment round of this population study, including obtaining permission from the Health Council of The Netherlands.

Lately, outside The Maastricht Study, Prof. Dagnelie’s aim is to integrate population health and sustainability of the food chain, in relation with climate change, biodiversity, and fair pricing.

Department of Internal Medicine
Randwijcksingel 35, 6229 EG Maastricht
T: +31(0)43 387 66 00

  • 2015
    • Nielen, J. T. H., van den Bemt, B. J. F., Boonen, A., Dagnelie, P. C., Emans, P. J., Veldhorst, N., Lalmohamed, A., van Staa, T. P., & de Vries, F. (2015). Identification of antithrombotic drugs related to total joint replacement using anonymised free-text notes: a search strategy in the Clinical Practice Research Datalink. BMJ Open, 5(11), [e009017]. https://doi.org/10.1136/bmjopen-2015-009017
    • Sengupta, A., Angeli, F., Syamala, T. S., Dagnelie, P. C., & van Schayck, C. P. (2015). Overweight and obesity prevalence among Indian women by place of residence and socio-economic status: Contrasting patterns from 'underweight states' and 'overweight states' of India. Social Science & Medicine, 138, 161-169. https://doi.org/10.1016/j.socscimed.2015.06.004
    • Wijnands, J. M. A., Houben, A. J. H. M., Muris, D. M. J., Boonen, A., Schram, M. T., Sep, S. J. S., van der Kallen, C. J. H., Henry, R. M. A., Dagnelie, P. C., van der Linden, S., Schaper, N. C., Arts, I. C. W., & Stehouwer, C. D. A. (2015). Uric acid and skin microvascular function: the Maastricht study. Journal of Hypertension, 33(8), 1651-1657. https://doi.org/10.1097/HJH.0000000000000583
  • 2014
    • Muris, D. M. J., Houben, A. J. H. M., Kroon, A. A., Henry, R. M. A., van der Kallen, C. J. H., Sep, S. J. S., Koster, A., Dagnelie, P. C., Schram, M. T., & Stehouwer, C. D. A. (2014). Age, waist circumference, and blood pressure are associated with skin microvascular flow motion: The Maastricht Study. Journal of Hypertension, 32(12), 2439-2449. https://doi.org/10.1097/HJH.0000000000000348
    • Sengupta, A., Angeli, F., Syamala, T. S., van Schayck, C. P., & Dagnelie, P. (2014). State-wise Dynamics of the Double Burden of Malnutrition Among 15-49 Year-old Women in India: How Much Does the Scenario Change Considering Asian Population-specific BMI Cut-off Values?Ecology of Food and Nutrition, 53(6), 618-638. https://doi.org/10.1080/03670244.2014.891994
    • Wijnands, J. M. A., Boonen, A., Dagnelie, P. C., van Greevenbroek, M. M. J., van der Kallen, C. J. H., Ferreira, I., Schalkwijk, C. G., Feskens, E. J. M., Stehouwer, C. D. A., van der Linden, S., & Arts, I. C. W. (2014). The cross-sectional association between uric acid and atherosclerosis and the role of low-grade inflammation: the CODAM study. Rheumatology, 53(11), 2053-2062. https://doi.org/10.1093/rheumatology/keu239
    • Moltó-Puigmartí, C., van Dongen, M. C. J. M., Dagnelie, P. C., Plat, J., Mensink, R. P., Tan, F. E. S., Heinrich, J., & Thijs, C. (2014). Maternal but Not Fetal FADS Gene Variants Modify the Association between Maternal Long-Chain PUFA Intake in Pregnancy and Birth Weight. Journal of Nutrition, 144(9), 1430-1437. https://doi.org/10.3945/jn.114.194035
    • Sleddens, E. F., Kremers, S. P. J., Stafleu, A., Dagnelie, P. C., de Vries, N. K., & Thijs, C. (2014). Food parenting practices and child dietary behavior. Prospective relations and the moderating role of general parenting. Appetite, 79, 42-50. https://doi.org/10.1016/j.appet.2014.04.004
    • Schram, M. T., Sep, S. J. S., van der Kallen, C. J., Dagnelie, P. C., Koster, A., Schaper, N., Henry, R. M. A., & Stehouwer, C. D. A. (2014). The Maastricht Study: an extensive phenotyping study on determinants of type 2 diabetes, its complications and its comorbidities. European Journal of Epidemiology, 29(6), 439-451. https://doi.org/10.1007/s10654-014-9889-0
    • Simoes-Wüst, A. P., Kummeling, I., Mommers, M., Huber, M. A. S., Rist, L., van de Vijver, L. P. L., Dagnelie, P. C., & Thijs, C. (2014). Influence of alternative lifestyles on self-reported body weight and health characteristics in women. European Journal of Public Health, 24(2), 321-327. https://doi.org/10.1093/eurpub/ckt045
    • Gerards, S. M. P. L., Gubbels, J. S., Dagnelie, P. C., Kremers, S. P. J., Stafleu, A., de Vries, N. K., & Thijs, C. (2014). Parental perception of child's weight status and subsequent BMIz change: the KOALA birth cohort study. BMC Public Health, 14, [291]. https://doi.org/10.1186/1471-2458-14-291
    • van Greevenbroek, M. M. J., Arts, I. C. W., van der Kallen, C. J. H., Dagnelie, P. C., Ferreira, I., Jansen, E., Schalkwijk, C. G., Feskens, E. J. M., & Stehouwer, C. D. A. (2014). Complement C3 Is Inversely Associated with Habitual Intake of Provitamin A but Not with Dietary Fat, Fatty Acids, or Vitamin E in Middle-Aged to Older White Adults and Positively Associated with Intake of Retinol in Middle-Aged to Older White Women. Journal of Nutrition, 144(1), 61-67. https://doi.org/10.3945/jn.113.181628
  • 2013
    • Gilsing, A. M. J., Weijenberg, M. P., Goldbohm, R. A. S., Dagnelie, P. C., van den Brandt, P. A., & Schouten, L. J. (2013). The Netherlands Cohort Study - Meat Investigation Cohort; a population-based cohort over-represented with vegetarians, pescetarians and low meat consumers. Nutrition Journal, 12, [156]. https://doi.org/10.1186/1475-2891-12-156
    • Versteylen, M. O., Kietselaer, B. L., Dagnelie, P. C., Joosen, I. A., Dedic, A., Raaijmakers, R. H., Wildberger, J. E., Nieman, K., Crijns, H. J., Niessen, W. J., Daemen, M. J., & Hofstra, L. (2013). Additive Value of Semiautomated Quantification of Coronary Artery Disease Using Cardiac Computed Tomographic Angiography to Predict Future Acute Coronary Syndrome. Journal of the American College of Cardiology, 61(22), 2296-2305. https://doi.org/10.1016/j.jacc.2013.02.065
    • Wesselius, A., Bours, M. J. L., Henriksen, Z., Syberg, S., Petersen, S., Schwarz, P., Jorgensen, N. R., van Helden, S., & Dagnelie, P. C. (2013). Association of P2X(7) receptor polymorphisms with bone mineral density and osteoporosis risk in a cohort of Dutch fracture patients. Osteoporosis International, 24(4), 1235-1246. https://doi.org/10.1007/s00198-012-2059-x
    • van Vught, A. J. A. H., Dagnelie, P. C., Arts, I. C. W., Froberg, K., Andersen, L. B., El-Naaman, B., Bugge, A., Nielsen, B. M., & Heitman, B. L. (2013). Dietary arginine and linear growth: the Copenhagen School Child Intervention Study. British Journal of Nutrition, 109(6), 1031-1039. https://doi.org/10.1017/S0007114512002942
    • Wesselius, A., Bours, M. J. L., Henriksen, Z., Syberg, S., Petersen, S., Schwarz, P., Jorgensen, N. R., van Helden, S., & Dagnelie, P. C. (2013). Association of P2Y(2) receptor SNPs with bone mineral density and osteoporosis risk in a cohort of Dutch fracture patients. Purinergic Signalling, 9(1), 41-49. https://doi.org/10.1007/s11302-012-9326-3
    • Wesselius, A., Bours, M. J. L., Jorgensen, N. R., Wiley, J., Gu, B., van Helden, S., van Rhijn, L., & Dagnelie, P. C. (2013). Non-synonymous polymorphisms in the P2RX (4) are related to bone mineral density and osteoporosis risk in a cohort of Dutch fracture patients. Purinergic Signalling, 9(1), 123-130. https://doi.org/10.1007/s11302-012-9337-0
    • Wyers, C. E., Reijven, P. L. M., Evers, S. M. A. A., Willems, P. C., Heyligers, I. C., Verburg, A. D., van Helden, S. H., & Dagnelie, P. C. (2013). Cost-effectiveness of nutritional intervention in elderly subjects after hip fracture: A randomized controlled trial. Osteoporosis International, 24(1), 151-162. https://doi.org/10.1007/s00198-012-2009-7
    • Touwslager, R. N., Gielen, M., Mulder, A. L. M., Gerver, W. J. M., Zimmermann, L. J., Dagnelie, P. C., Houben, A. J. H. M., Stehouwer, C. D. A., Derom, C., Vlietinck, R., Loos, R. J. F., & Zeegers, M. P. (2013). Genetic and environmental factors in associations between infant growth and adult cardiometabolic risk profile in twins. American Journal of Clinical Nutrition, 98(4), 994-1001. https://doi.org/10.3945/ajcn.112.039131
    • Gerards, S. M., Hummel, K., Dagnelie, P. C., de Vries, N. K., & Kremers, S. P. (2013). Parental self-efficacy in childhood overweight: validation of the Lifestyle Behavior Checklist in the Netherlands. International Journal of Behavioral Nutrition and Physical Activity, 10(1), [7]. https://doi.org/10.1186/1479-5868-10-7
    • Smulders, M. W., Kietselaer, B. L. J. H., Das, M., Wildberger, J. E., Crijns, H. J. G. M., Veenstra, L., Brunner La Rocca, H. P., van Dieijen-Visser, M. P., Mingels, A. M. A., Dagnelie, P. C., Post, M. J., Gorgels, A. P. M., van Asselt, A. D. I., Vogel, G., Schalla, S., Kim, R. J., & Bekkers, S. C. A. M. (2013). The role of cardiovascular magnetic resonance imaging and computed tomography angiography in suspected non-ST-elevation myocardial infarction patients: Design and rationale of the CARdiovascular Magnetic rEsoNance imaging and computed Tomography Angiography (CARMENTA) trial. American Heart Journal, 166(6), 968-975. https://doi.org/10.1016/j.ahj.2013.09.012
  • 2012
    • Wesselius, A., Bours, M. J. L., Arts, I. C. W., Theunisz, E. H. E., Geusens, P., & Dagnelie, P. C. (2012). The P2X(7) loss-of-function Glu496Ala polymorphism affects ex vivo cytokine release and protects against the cytotoxic effects of high ATP-levels. BMC IMMUNOLOGY, 13, 64. https://doi.org/10.1186/1471-2172-13-64
    • Rosenkotter, N., van Dongen, M. C. J. M., Hellmeier, W., Simon, K., & Dagnelie, P. C. (2012). The influence of migratory background and parental education on health care utilisation of children. European Journal of Pediatrics, 171(10), 1533-1540. https://doi.org/10.1007/s00431-012-1774-9
    • Gerards, S. M. P. L., Dagnelie, P. C., Jansen, M. W. J., van der Goot, L. O. H. M., de Vries, N. K., Sanders, M. R., & Kremers, S. P. J. (2012). Lifestyle Triple P: a parenting intervention for childhood obesity. BMC Public Health, 12, 267. [267]. https://doi.org/10.1186/1471-2458-12-267
    • Breedveld-Peters, J. J. L., Reijven, P. L. M., Wyers, C. E., van Helden, S., Arts, J. J. C., Meesters, B., Prins, M. H., van der Weijden, T., & Dagnelie, P. C. (2012). Integrated nutritional intervention in the elderly after hip fracture. A process evaluation. Clinical Nutrition, 31(2), 199-205. https://doi.org/10.1016/j.clnu.2011.10.004
    • Gilsing, A. M. J., Weijenberg, M. P., Hughes, L. A. E., Ambergen, T., Dagnelie, P. C., Goldbohm, R. A., van den Brandt, P. A., & Schouten, L. J. (2012). Longitudinal Changes in BMI in Older Adults Are Associated with Meat Consumption Differentially, by Type of Meat Consumed. Journal of Nutrition, 142(2), 340-349. https://doi.org/10.3945/jn.111.146258
    • Arts, I. C. W., Coolen, E., Bours, M. J. L., Huyghebaert, N., Stuart, M. A. C., Bast, A., & Dagnelie, P. C. (2012). Adenosine 5' -triphosphate (ATP) supplements are not orally bioavailable: a randomized, placebocontrolled cross-over trial in healthy humans. Journal of the International Society of Sports Nutrition, 9(1), 16. https://doi.org/10.1186/1550-2783-9-16
    • Breedveld-Peters, J. J. L., Reijven, P. L. M., Wyers, C. E., Hendrikx, A. A., Verburg, A. D., Schols, J. M. G. A., Prins, M. H., van der Weijden, T. D., & Dagnelie, P. C. (2012). Barriers and facilitators of nutritional intervention after hip fracture in integrated care as perceived by the different health care professionals: a qualitative interview study. e - SPEN Journal: the European e-journal of clinical nutrition and metabolism, 7, e182-e188.
    • Gerards, S., Dagnelie, P. C., Jansen, M. W. J., de Vries, N. K., & Kremers, S. P. J. (2012). Barriers to successful recruitment of parents of overweight children for an obesity prevention intervention: a qualitative study among youth health care professionals. BMC Family Practice, 13, 37. https://doi.org/10.1186/1471-2296-13-37
    • Witteman, B. P. L., Strijkers, R., de Vries, E. E., Toemen, L., Conchillo, J. M., Hameeteman, W., Dagnelie, P. C., Koek, G. H., & Bouvy, N. D. (2012). Transoral incisionless fundoplication for treatment of gastroesophageal reflux disease in clinical practice.Surgical endoscopy and other interventional techniques, 26(11), 3307-3315. https://doi.org/10.1007/s00464-012-2324-2
  • 2011
    • Wesselius, A., Bours, M. J. L., Agrawal, A., Gartland, A., Dagnelie, P. C., Schwarz, P. E. H., & Jorgensen, N. R. (2011). Role of purinergic receptor polymorphisms in human bone. Frontiers in Bioscience, 16, 2572-2585. https://doi.org/10.2741/3873
    • Gerards, S. M., Sleddens, E. F., Dagnelie, P. C., de Vries, N. K., & Kremers, S. P. (2011). Interventions addressing general parenting to prevent or treat childhood obesity. International Journal of Pediatric Obesity, 6(2-2), e28-e45. https://doi.org/10.3109/17477166.2011.575147
    • van Dongen, M. C. J. M., Lentjes, M. A. H., Wijckmans-Duysens, N. E. G., Dirckx, C., Lemaitre, D., Achten, W., Celis, M., Sieri, S., Arnout, J., Buntinx, F., Siani, A., Cappuccio, F. P., de Lorgeril, M., Iacoviello, L., & Dagnelie, P. C. (2011). Validation of a food-frequency questionnaire for Flemish and Italian-native subjects in Belgium: The IMMIDIET study. Nutrition, 27(3), 302-309. https://doi.org/10.1016/j.nut.2010.02.006
    • Coolen, E. J., Arts, I. C., Bekers, O., Vervaet, C., Bast, A., & Dagnelie, P. C. (2011). Oral bioavailability of ATP after prolonged administration.British Journal of Nutrition, 105(3), 357-366. https://doi.org/10.1017/S0007114510003570
    • Gubbels, J. S., Kremers, S. P., Stafleu, A., de Vries, S. I., Goldbohm, R. A., Dagnelie, P. C., de Vries, N. K., van Buuren, S., & Thijs, C. (2011). Association between parenting practices and children's dietary intake, activity behavior and development of body mass index: the KOALA Birth Cohort Study. International Journal of Behavioral Nutrition and Physical Activity, 8, [18]. https://doi.org/10.1186/1479-5868-8-18
    • van de Kant, K. D. G., Koers, K., Rijkers, G. T., Lima Passos, V., Klaassen, E. M. M., Mommers, M., Dagnelie, P. C., van Schayck, C. P., Dompeling, E. D., & Jöbsis, Q. (2011). Can exhaled inflammatory markers predict a steroid response in wheezing preschool children?Clinical and Experimental Allergy, 41(8), 1076-1083. https://doi.org/10.1111/j.1365-2222.2011.03774.x
    • Brinkman, M. T., Buntinx, F. J. V. M., Kellen, E., van Dongen, M. C., Dagnelie, P. C., Muls, E., & Zeegers, M. P. A. (2011). Consumption of animal products, olive oil and dietary fat and results from the Belgian case-control study on bladder cancer risk.European Journal of Cancer, 47(3), 436-442. https://doi.org/10.1016/j.ejca.2010.09.027
    • Brinkman, M. T., Buntinx, F. J. V. M., Kellen, E., Dagnelie, P. C., van Dongen, M. C., Muls, E., & Zeegers, M. P. A. (2011). Dietary intake of micronutrients and the risk of developing bladder cancer: results from the Belgian case-control study on bladder cancer risk. Cancer Causes & Control, 22(3), 469-478. https://doi.org/10.1007/s10552-010-9718-z
    • Schreinemacher, M. H. F., Vijgen, G. H. E. J., Dagnelie, P. C., Bloemen, J. G., Huizinga, B. F., & Bouvy, N. D. (2011). Incisional hernias in temporary stoma wounds: a cohort study. Archives of Surgery, 146(1), 94-99. https://doi.org/10.1001/archsurg.2010.281
    • Gubbels, J. S., Kremers, S. P., van Kann, D. H., Stafleu, A., Candel, M. J., Dagnelie, P. C., Thijs, C., & de Vries, N. K. (2011). Interaction between physical environment, social environment, and child characteristics in determining physical activity at child care.Health Psychology, 30(1), 84-90. https://doi.org/10.1037/a0021586
    • Wijnands, J. M. A., Boonen, A., Arts, I. C., Dagnelie, P. C., Stehouwer, C. D. A., & van der Linden, S. (2011). Large epidemiologic studies of gout: challenges in diagnosis and diagnostic criteria. Current Rheumatology Reports, 13(2), 167-174. https://doi.org/10.1007/s11926-010-0157-3
    • Brinkman, M. T., Kellen, E., Zeegers, M. P. A., van Dongen, M. C., Dagnelie, P. C., Muls, E., & Buntinx, F. J. V. M. (2011). Validation of the immidiet food frequency questionnaire in an adult Belgian population: a report from the Belgian case-control study on bladder cancer risk. Acta Clinica Belgica, 66(1), 18-25. https://doi.org/10.2143/ACB.66.1.2062509
    • Thijs, C., Mueller, A., Rist, L., Kummeling, I., Snijders, B. E. P., Huber, M., Van Ree, R., Simoes-Wuest, A. P., Dagnelie, P. C., & van den Brandt, P. A. (2011). Fatty acids in breast milk and development of atopic eczema and allergic sensitisation in infancy. Allergy, 66(1), 58-67. https://doi.org/10.1111/j.1398-9995.2010.02445.x
    • Kroeze, W., Dagnelie, P. C., Heymans, M. W., Oenema, A., & Brug, J. (2011). Biomarker Evaluation Does Not Confirm Efficacy of Computer-tailored Nutrition Education. Journal of Nutrition Education and Behavior, 43(5), 323-330. https://doi.org/10.1016/j.jneb.2010.09.009
  • 2010
    • Gubbels, J. S., Kremers, S. P., Stafleu, A., Dagnelie, P. C., de Vries, N. K., & Thijs, C. T. (2010). Letters to the Editor. Journal of Human Nutrition and Dietetics, 23(4), 427-428. https://doi.org/10.1111/j.1365-277X.2010.01085.x
    • Wouters, E. J., Larsen, J. K., Kremers, S. P. J., Dagnelie, P. C., & van Geenen, R. (2010). Peer influence on snacking behavior in adolescence.Appetite, 55(1), 11-17. https://doi.org/10.1016/j.appet.2010.03.002
    • Wyers, C. E., Breedveld-Peters, J. J., Reijven, P. L. M., van Helden, S. H., Guldemond, N. A., Severens, J. L., Verburg, A. D., Meesters, B., van Rhijn, L. W., & Dagnelie, P. C. (2010). Efficacy and cost-effectiveness of nutritional intervention in elderly after hip fracture: design of a randomized controlled trial. BMC Public Health, 10(1), 212. [212]. https://doi.org/10.1186/1471-2458-10-212
    • Dagnelie, P. C., & Halfwerk, S. (2010). Magnetic resonance spectroscopy to study hepatic metabolism in diffuse liver diseases, diabetes and cancer. World Journal of Gastroenterology, 16(13), 1577-1586. https://doi.org/10.3748/wjg.v16.i13.1577