Pieter Dagnelie


Prof. Pieter Dagnelie is nutritional epidemiologist. He studied human nutrition at Wageningen University and received his PhD in 1988 based on a population-based, mixed-longitudinal cohort study of the nutritional status and growth of children fed macrobiotic diets. Subsequently, he received fellowships from the Dutch Cancer Society (1989) and the Royal Netherlands Academy of Arts and Sciences (1991) to work on the etiology of weight loss in cancer patients, using magnetic resonance spectroscopy and stable isotope tracers as main research tools.

In 1997, he was appointed Associate Professor in Maastricht to lead the nutritional epidemiology research group at the department of epidemiology and to build up the collaboration on nutritional epidemiology within Maastricht UMC+. In 2012, he received a strategic professorship in nutritional epidemiology.

Prof. Dagnelie’s overall aim is to explore new paradigms in the field of health research, lifestyle and nutrition, and to integrate and implement this new knowledge in disease prevention and treatment, thus contributing to improving people’s nutritional and health status, and quality of life. He has performed and supervised numerous observational studies and randomised clinical trials on the role of nutrition and bioactive compounds in the prevention and treatment of chronic diseases and cancer, with the improvement of transmural health care. His central aim has always been to contribute to the wellbeing of healthy individuals and patients. He is former member of the Scientific Committee of  and the Medical Ethical Committee of Maastricht UMC+.

Prof. Dagnelie’s current research is focussed on The Maastricht Study (https://www.demaastrichtstudie.nl/), a large-scale study initiated in 2010 on the etiology and prognosis of diabetes and its comorbidities, with oversampling individuals with type 2 diabetes. Enrolment is still ongoing. The Maastricht Study is one of the largest studies world-wide of its kind. All participants undergo 5 half-days of intensive phenotyping. Prof. Dagnelie was involved in the Life Style collaborative group of The Maastricht Study and the development of the extensive Food Frequency Questionnaire to assess dietary intake, both in terms of nutrients, dietary patterns and processing.

Since 2012, Prof. Dagnelie has been member of the Management Team of The Maastricht Study. Within the MT, his focus is on optimising research methodology, quality, and design of projects within The Maastricht Study. He also contributes to exploring new targets for funding, and is currently coordinator for organizaing a second assessment round of this population study, including obtaining permission from the Health Council of The Netherlands.

Lately, outside The Maastricht Study, Prof. Dagnelie’s aim is to integrate population health and sustainability of the food chain, in relation with climate change, biodiversity, and fair pricing.

Department of Internal Medicine
Randwijcksingel 35, 6229 EG Maastricht
T: +31(0)43 387 66 00

  • 2010
    • Swennen, E. L. R., Ummels, V., Buss, I., Jaehde, U., Bast, A., & Dagnelie, P. C. (2010). ATP sensitizes H460 lung carcinoma cells to cisplatin-induced apoptosis. Chemico-Biological Interactions, 184(3), 338-345. https://doi.org/10.1016/j.cbi.2010.02.011
    • Gubbels, J. S., Kremers, S. P., Stafleu, A., Dagnelie, P. C., de Vries, N. K., & Thijs, C. T. (2010). Child-care environment and dietary intake of 2- and 3-year-old children.Journal of Human Nutrition and Dietetics, 23(1), 97-101. https://doi.org/10.1111/j.1365-277X.2009.01022.x
    • Bours, M. J. L., Peeters, R. H., Landewé, R. B. M., Beijer- van Eck, S., Arts, I. C. W., & Dagnelie, P. C. (2010). Adenosine 5'-triphosphate infusions reduced disease activity and inflammation in a patient with active rheumatoid arthritis.Rheumatology, 49(11), 2223-2225. https://doi.org/10.1093/rheumatology/keq177
    • Gubbels, J. S., Kremers, S. P., Stafleu, A., Dagnelie, P. C., de Vries, N. K., van Buuren, S., & Thijs, C. T. M. (2010). Child-care use and the association with body mass index and overweight in children from 7 months to 2 years of age.International Journal of Obesity, 34(10), 1480-1486. https://doi.org/10.1038/ijo.2010.100
    • Bartholomé, R., Haenen, G. R. M. M., Hollman, C. H., Bast, A., Dagnelie, P. C., Roos, D., Keijer, J., Kroon, P. A., Needs, P. W., & Arts, C. W. (2010). Deconjugation Kinetics of Glucuronidated Phase II Flavonoid Metabolites by beta-glucuronidase from Neutrophils. Drug metabolism and pharmacokinetics, 25(4), 379-87. https://doi.org/10.2133/dmpk.DMPK-10-RG-002
    • Romberg-Camps, M., Bol, Y., Dagnelie, P. C., van der Hesselink-Kruijs, M. A. M., Kester, A. D., Engels, L. G. B., van Deursen, C., Hameeteman, W. H., Pierik, M. J., Wolters, F., Russel, M. G., & Stockbrügger, R. W. (2010). Fatigue and health-related quality of life in inflammatory bowel disease: Results from a population-based study in the Netherlands: The IBD-South Limburg cohort.Inflammatory Bowel Diseases, 16(12), 2137-2147. https://doi.org/10.1002/ibd.21285
    • Romberg-Camps, M., Kuiper, E., Schouten, L. J., Kester, A., van der Hesselink-Kruijs, M. A. M., Limonard, C., Bos, R., Goedhard, J., Hameeteman, W., Wolters, F., Russel, M., Stockbrugger, R., & Dagnelie, P. (2010). Mortality in inflammatory bowel disease in the Netherlands 1991-2002: results of a population-based study: the IBD South-Limburg cohort.Inflammatory Bowel Diseases, 16(8), 1397-1410. https://doi.org/10.1002/ibd.21189
    • Beijer- van Eck, S., Hupperets, P. S., van den Borne, B. E., Wijckmans, N. E., Spreeuwenberg, C., van den Brandt, P. A., & Dagnelie, P. C. (2010). Randomized clinical trial on the effects of adenosine 5'-triphosphate infusions on quality of life, functional status, and fatigue in preterminal cancer patients. Journal of Pain and Symptom Management, 40(4), 520-30. https://doi.org/10.1016/j.jpainsymman.2010.01.023
    • Molag, M. L., de Vries, J. H., Duif, N., Ocke, M. C., Dagnelie, P. C., Bausch-Goldbohm, R. A., & van 't Veer, P. (2010). Selecting informative food items for compiling food-frequency questionnaires: comparison of procedures.British Journal of Nutrition, 104(3), 446-456. https://doi.org/10.1017/S0007114510000401
    • van den Boogaard, M., Peters, S. A., van der Hoeven, J. G., Dagnelie, P. C., Leffers, P., Pickkers, P., & Schoonhoven, L. (2010). The impact of delirium on the prediction of in-hospital mortality in intensive care patients.Critical Care, 14(4), R146. [146]. https://doi.org/10.1186/cc9214
    • Rzehak, P., Thijs, C., Standl, M., Mommers, M., Glaser, C., Jansen, E., Klopp, N., Koppelman, G. H., Singmann, P., Postma, D. S., Sausenthaler, S., Dagnelie, P. C., van den Brandt, P. A., Koletzko, B., & Heinrich, J. (2010). Variants of the FADS1 FADS2 gene cluster, blood levels of polyunsaturated fatty acids and eczema in children within the first 2 years of life. PLOS ONE, 5(10), [e13261]. https://doi.org/10.1371/journal.pone.0013261
  • 2009
    • Gubbels, J. S., Kremers, S. P., Stafleu, A., Dagnelie, P. C., de Vries, S. I., de Vries, N. K., & Thijs, C. (2009). Clustering of dietary intake and sedentary behavior in 2-year-old children.Journal of Pediatrics, 155(2), 194-198. https://doi.org/10.1016/j.jpeds.2009.02.027
    • Gubbels, J. S., Kremers, S. P., Stafleu, A., Dagnelie, P. C., Goldbohm, R. A., de Vries, N. K., & Thijs, C. (2009). Diet-related restrictive parenting practices. Impact on dietary intake of 2-year-old children and interactions with child characteristics.Appetite, 52(2), 423-429. https://doi.org/10.1016/j.appet.2008.12.002
    • Beijer, S., Hupperets, P. S. G. J., van den Borne, B. E., Eussen, S. R., van Henten, A. M., van den Beuken Everdingen, M., de Graeff, A., Ambergen, T. A., van den Brandt, P. A., & Dagnelie, P. C. (2009). Effect of adenosine 5'-triphosphate infusions on the nutritional status and survival of preterminal cancer patients.Anti-Cancer Drugs, 20(7), 625-633. https://doi.org/10.1097/CAD.0b013e32832d4f22
    • Romberg-Camps, M., Hesselink-van d Kruijs, MAM., Schouten, L. J., Dagnelie, P. C., Limonard, C., Kester, A. D. M., Bos, L. J., Goedhard, J., & Hameeteman, W. (2009). Inflammatory Bowel Disease in South Limburg (the Netherlands) 1991-2002: Incidence, diagnostic delay, and seasonal variations in onset of symptoms. Journal of Crohn's & Colitis, 3, 115-124. https://doi.org/10.1016/j.crohns.2008.12.002
    • Romberg-Camps, M., Dagnelie, P. C., Kester, A. D., van der Hesselink-Kruijs, M. A. M., Cilissen, M., Engels, L. G., van Deursen, C., Hameeteman, W., Wolters, F. L., Russel, M. G., & Stockbrugger, R. W. (2009). Influence of phenotype at diagnosis and of other potential prognostic factors on the course of inflammatory bowel disease. American Journal of Gastroenterology, 104(2), 371-83. https://doi.org/10.1038/ajg.2008.38
    • Gubbels, J. S., Kremers, S. P. J., Dagnelie, P. C., de Vries, N. E., Thijs, C. T. M., Stafleu, A., & Goldbohm, R. A. (2009). Invloeden van restrictieve voedingsregels op de consumptie van 2-jarige kinderen. Voeding Nu, 11(6), 10-13.
  • 2008
    • Kummeling, I., Thijs, C. T., Huber, M., van de Vijver, L. P. L., Snijders, B. E., Penders, J., Stelma, F., Van Ree, R., van den Brandt, P. A., & Dagnelie, P. C. (2008). Consumption of organic foods and risk of atopic disease during the first 2 years of life in the Netherlands. British Journal of Nutrition, 99(3), 598-605. https://doi.org/10.1017/S0007114507815844
    • Beijer, S., Kempen, G. I. J. M., Pijls Johannesma, M. C., de Graeff, A., & Dagnelie, P. C. (2008). Determinants of overall quality of life in preterminal cancer patients.International Journal of Cancer, 123(1), 232-235. https://doi.org/10.1002/ijc.23497
    • Kroeze, W., Oenema, A., Dagnelie, P. C., & Brug, J. (2008). Examining the minimal required elements of a computer-tailored intervention aimed at dietary fat reduction: results of a randomized controlled dismantling study.Health Education Research, 23(5), 880-891. https://doi.org/10.1093/her/cym075
    • Hughes, L. A. E., Arts, I. C., Ambergen, T., Brants, H. A., Dagnelie, P. C., Goldbohm, R. A., van den Brandt, P. A., & Weijenberg, M. P. (2008). Higher dietary flavone, flavonol, and catechin intakes are associated with less of an increase in BMI over time in women: a longitudinal analysis from the Netherlands Cohort Study. American Journal of Clinical Nutrition, 88(5), 1341-1352. https://doi.org/10.3945/ajcn.2008.26058
    • Garcia, A., Koebnick, C., Dagnelie, P. C., Strassner, C., Elmadfa, I., Katz, N., Leitzmann, C., & Hoffmann, I. (2008). Long-term strict raw food diet is associated with favourable plasma beta-carotene and low plasma lycopene concentrations in Germans.British Journal of Nutrition, 99(6), 1293-1300. https://doi.org/10.1017/S0007114507868486
    • Costanzo, S., di Castelnuovo, A., Zito, F., Krogh, V., Siani, A., Arnout, J., Cappuccio, F. P., Miller, M. A., van Dongen, M., de Lorgeril, M., de Gaetano, G., Donati, M. B., Iacoviello, L., European Collaborative Group of the IMMIDIET Project, T., & Dagnelie, P. C. (2008). Prevalence, awareness, treatment and control of hypertension in healthy unrelated male-female pairs of European regions: the dietary habit profile in European communities with different risk of myocardial infarction--the impact of migration as a model of gene-environment interaction project. Journal of Hypertension, 26(12), 2303-11. https://doi.org/10.1097/HJH.0b013e328311ce04
    • Swennen, E. L., Dagnelie, P. C., van den Beucken, A. M., & Bast, A. (2008). Radioprotective effects of ATP in human blood ex vivo.Biochemical and Biophysical Research Communications, 367(2), 383-387. https://doi.org/10.1016/j.bbrc.2007.12.125
    • Coolen, E. J., Arts, I. C., Swennen, E. L., Bast, A., Stuart, M. A., & Dagnelie, P. C. (2008). Simultaneous determination of adenosine triphosphate and its metabolites in human whole blood by RP-HPLC and UV-detection. Journal of Chromatography B, 864(1-2), 43-51. https://doi.org/10.1016/j.jchromb.2008.01.033
    • Swennen, E. L., Coolen, E. J., Arts, I. C., Bast, A., & Dagnelie, P. C. (2008). Time-dependent effects of ATP and its degradation products on inflammatory markers in human blood ex vivo. Immunobiology, 213(5), 389-97. https://doi.org/10.1016/j.imbio.2007.10.007
    • Beijer, S., Wijckmans, N. E., van Rossum, E., Spreeuwenberg, C., Winkens, R. A., Ars, L., & Dagnelie, P. C. (2008). Treatment adherence and patients' acceptance of home infusions with adenosine 5'-triphosphate (ATP) in palliative home care.Supportive Care in Cancer, 16(12), 1419-1422. https://doi.org/10.1007/s00520-008-0504-3
  • 2007
    • Beijer- van Eck, S., van Rossum, E., Hupperets, P. S. G. J., Spreeuwenberg, C., van den Beuken, M., Winkens, R. A. G., Ars, L., van den Borne, B. E., de Graeff, A., & Dagnelie, P. C. (2007). Application of adenosine 5'-triphosphate (ATP) infusions in palliative home care: design of a randomized clinical trial. BMC Public Health, 7, 4. https://doi.org/10.1186/1471-2458-7-4
    • Snijders, B. E., Thijs, C., Dagnelie, P. C., Stelma, F. F., Mommers, M., Kummeling, I., Penders, J., Van Ree, R., & van den Brandt, P. A. (2007). Breast-feeding duration and infant atopic manifestations, by maternal allergic status, in the first 2 years of life (KOALA study).Journal of Pediatrics, 151(4), 347-351. https://doi.org/10.1016/j.jpeds.2007.03.022
    • Molag, M. L., de Vries, J. H., Ocke, M. C., Dagnelie, P. C., van den Brandt, P. A., Jansen, M. C., van Staveren, W. A., & van 't Veer, P. (2007). Design characteristics of food frequency questionnaires in relation to their validity.American Journal of Epidemiology, 166(12), 1468-1478. https://doi.org/10.1093/aje/kwm236
    • Kummeling, I., Thijs, C., Stelma, F., Huber, M., van den Brandt, P. A., & Dagnelie, P. C. (2007). Diphtheria, Pertussis, Poliomyelitis, Tetanus, and Haemophilus influenzae Type b Vaccinations and Risk of Eczema and Recurrent Wheeze in the First Year of Life: The KOALA Birth Cohort Study. Pediatrics, 119(2), e367-373. https://doi.org/10.1542/peds.2006-1479
    • Kummeling, I., Stelma, F. F., Dagnelie, P. C., Snijders, B. E., Penders, J., Huber, M., Van Ree, R., van den Brandt, P. A., & Thijs, C. (2007). Early life exposure to antibiotics and the subsequent development of eczema, wheeze, and allergic sensitization in the first 2 years of life: the KOALA Birth Cohort Study. Pediatrics, 119(1), e225-231. https://doi.org/10.1542/peds.2006-0896
    • Bogers, R. P., Dagnelie, P. C., Bast, A., van Leeuwen, M., van Klaveren, J. D., & van den Brandt, P. A. (2007). Effect of increased vegetable and fruit consumption on plasma folate and homocysteine concentrations. Nutrition, 23(2), 97-102. https://doi.org/10.1016/j.nut.2006.11.002
    • Bours, M. J. L., Bos, H. J., Meddings, J. B., Brummer, R. J., van den Brandt, P. A., & Dagnelie, P. C. (2007). Effects of oral adenosine 5'-triphosphate and adenosine in enteric-coated capsules on indomethacin-induced permeability changes in the human small intestine: a randomized cross-over study. BMC Gastroenterology, 7(1), 23. https://doi.org/10.1186/1471-230X-7-23
    • Dagnelie, P., Pijls-Johannesma, M. C. G., Lambin, P., Beijer, S., De Ruysscher, D., & Kempen, G. I. J. M. (2007). Impact of fatigue on overall quality of life in lung and breast cancer patients selected for high-dose radiotherapy. Annals of Oncology, 18(5), 940-944. https://doi.org/10.1093/annonc/mdm057
    • Beijer, S., Gielisse, E. A., Hupperets, P. S. G. J., van den Borne, B. E., van den Beuken-van Everdingen, M. H. J., Nijziel, M. R., van Henten, A. M., & Dagnelie, P. C. (2007). Intravenous ATP infusions can be safely administered in the home setting: a study in pre-terminal cancer patients. Investigational New Drugs, 25(6), 571-579. https://doi.org/10.1007/s10637-007-9076-1
    • Bours, M. J. L., Troost, F. J., Brummer, R. J., Bast, A., & Dagnelie, P. C. (2007). Local effect of adenosine 5'-triphosphate on indomethacin-induced permeability changes in the human small intestine. European Journal of Gastroenterology & Hepatology, 19(3), 245-250. https://doi.org/10.1097/MEG.0b013e328011093c
    • Bogers, R. P., van Assema, P. T., Brug, J., Kester, A. D. M., & Dagnelie, P. C. (2007). Psychosocial Predictors of Increases in Fruit and Vegetable Consumption. American Journal of Health Behavior, 31(2), 135-145. https://doi.org/10.5993/AJHB.31.2.3
    • van Helden, S. H., Wyers, C. E., Dagnelie, P. C., van Dongen, M. C. J. M., Willems, G., Brink, P. R. G., & Geusens, P. P. (2007). Risk of falling in patients with a recent fracture. BMC Musculoskeletal Disorders, 8(1), 55. https://doi.org/10.1186/1471-2474-8-55
  • 2006
    • Bours, M. J. L., Swennen, E. L. R., Di Virgilio, F., Cronstein, B. N., & Dagnelie, P. C. (2006). Adenosine 5'-triphosphate and adenosine as endogenous signaling molecules in immunity and inflammation. Pharmacology & Therapeutics, 112(2), 358-404. https://doi.org/10.1016/j.pharmthera.2005.04.013
    • Swennen, E. L. R., Dagnelie, P. C., & Bast, A. (2006). ATP inhibits hydroxyl radical formation and the inflammatory response of stimulated whole blood even under circumstances of severe oxidative stress. Free Radical Research, 40(1), 53-8. https://doi.org/10.1080/10715760500364298
    • Kummeling, I., Thijs, C., Stelma, F. F., Huber, M., van den Brandt, P. A., & Dagnelie, P. C. (2006). Do parents with an atopic family history adopt a 'prudent' lifestyle for their infant? (KOALA Study). Clinical and Experimental Allergy, 36(4), 489-494. https://doi.org/10.1111/j.1365-2222.2006.02473.x
    • Liem, D. G., Bogers, R. P., Dagnelie, P. C., & de Graaf, C. (2006). Fruit consumption of boys (8-11 years) is related to preferences for sour taste. Appetite, 46(1), 93-96. https://doi.org/10.1016/j.appet.2005.11.002
    • Leurs, L. J., Kievit, J., Dagnelie, P. C., Nelemans, P. J., & Buth, J. (2006). Influence of infrarenal neck length on outcome of endovascular abdominal aortic aneurysm repair. Journal of Endovascular Therapy, 13(5), 640-648. https://doi.org/10.1583/06-1882.1
    • Dagnelie, P. C., Pijls-Johannesma, M. C. G., Pijpe, A., Boumans, B. J., Skrabanja, A. T., Lambin, P., & Kempen, G. I. J. M. (2006). Psychometric properties of the revised Piper Fatigue Scale in Dutch cancer patients were satisfactory. Journal of Clinical Epidemiology, 59(6), 642-649. https://doi.org/10.1016/j.jclinepi.2005.09.015