Pieter Dagnelie


Prof. Pieter Dagnelie is nutritional epidemiologist. He studied human nutrition at Wageningen University and received his PhD in 1988 based on a population-based, mixed-longitudinal cohort study of the nutritional status and growth of children fed macrobiotic diets. Subsequently, he received fellowships from the Dutch Cancer Society (1989) and the Royal Netherlands Academy of Arts and Sciences (1991) to work on the etiology of weight loss in cancer patients, using magnetic resonance spectroscopy and stable isotope tracers as main research tools.

In 1997, he was appointed Associate Professor in Maastricht to lead the nutritional epidemiology research group at the department of epidemiology and to build up the collaboration on nutritional epidemiology within Maastricht UMC+. In 2012, he received a strategic professorship in nutritional epidemiology.

Prof. Dagnelie’s overall aim is to explore new paradigms in the field of health research, lifestyle and nutrition, and to integrate and implement this new knowledge in disease prevention and treatment, thus contributing to improving people’s nutritional and health status, and quality of life. He has performed and supervised numerous observational studies and randomised clinical trials on the role of nutrition and bioactive compounds in the prevention and treatment of chronic diseases and cancer, with the improvement of transmural health care. His central aim has always been to contribute to the wellbeing of healthy individuals and patients. He is former member of the Scientific Committee of  and the Medical Ethical Committee of Maastricht UMC+.

Prof. Dagnelie’s current research is focussed on The Maastricht Study (https://www.demaastrichtstudie.nl/), a large-scale study initiated in 2010 on the etiology and prognosis of diabetes and its comorbidities, with oversampling individuals with type 2 diabetes. Enrolment is still ongoing. The Maastricht Study is one of the largest studies world-wide of its kind. All participants undergo 5 half-days of intensive phenotyping. Prof. Dagnelie was involved in the Life Style collaborative group of The Maastricht Study and the development of the extensive Food Frequency Questionnaire to assess dietary intake, both in terms of nutrients, dietary patterns and processing.

Since 2012, Prof. Dagnelie has been member of the Management Team of The Maastricht Study. Within the MT, his focus is on optimising research methodology, quality, and design of projects within The Maastricht Study. He also contributes to exploring new targets for funding, and is currently coordinator for organizaing a second assessment round of this population study, including obtaining permission from the Health Council of The Netherlands.

Lately, outside The Maastricht Study, Prof. Dagnelie’s aim is to integrate population health and sustainability of the food chain, in relation with climate change, biodiversity, and fair pricing.

Department of Internal Medicine
Randwijcksingel 35, 6229 EG Maastricht
T: +31(0)43 387 66 00

  • 2006
    • Swennen, E. L. R., Bast, A., & Dagnelie, P. C. (2006). Purinergic receptors involved in the immunomodulatory effects of ATP in human blood. Biochemical and Biophysical Research Communications, 348(3), 1194-1199. https://doi.org/10.1016/j.bbrc.2006.07.177
  • 2005
    • Skrabanja, A. T. P., Bouman, E. A., & Dagnelie, P. C. (2005). Additional use for adenosine in anaesthesia and surgery.British Journal of Anaesthesia, 95, 836-837. https://doi.org/10.1093/bja/aei612
    • Kranse, R., Dagnelie, P. C., van Kemenade, M. C., de Jong, F. H., Blom, J. H., Tijburg, L. B. M., Weststrate, J. A., & Schroder, F. H. (2005). Dietary intervention in prostate cancer patients: PSA response in a randomized double-blind placebo-controlled study. International Journal of Cancer, 113(5), 835-840. https://doi.org/10.1002/ijc.20653
    • Hoenjet, K. M., Dagnelie, P. C., Delaere, K. P., Wijckmans-Duijsens, N. E., Zambon, J. V., & Oosterhof, G. O. N. (2005). Effect of a nutritional supplement containing vitamin E, selenium, vitamin c and coenzyme Q10 on serum PSA in patients with hormonally untreated carcinoma of the prostate: a randomised placebo-controlled study. European Urology, 47(4), 433-439. https://doi.org/10.1016/j.eururo.2004.11.017
    • Kummeling, I., Thijs, C., Penders, J., Snijders, B. E. P., Stelma, F. F., Reimerink, J., Koopmans, M., Dagnelie, P. C., Huber, M., Jansen, M. C. J. F., de Bie, R. A., & van den Brandt, P. A. (2005). Etiology of atopy in infancy: the KOALA Birth Cohort Study.Pediatric Allergy and Immunology, 16(8), 679-684. https://doi.org/10.1111/j.1399-3038.2005.00333.x
    • Pijls-Johannesma, M. C. G., Pijpe, A., Kempen, G. I. J. M., Lambin, P., & Dagnelie, P. C. (2005). Health related quality of life assessment instruments: a prospective study on preference and acceptability among cancer patients referred for radiotherapy. European Journal of Cancer, 41(15), 2250-2256. https://doi.org/10.1016/j.ejca.2005.06.019
    • Swennen, E. L. R., Bast, A., & Dagnelie, P. C. (2005). Immunoregulatory effects of adenosine 5'-triphosphate on cytokine release from stimulated whole blood. European Journal of Immunology, 35(3), 852-858. https://doi.org/10.1002/eji.200425423
    • Koebnick, C., Garcia, A., Dagnelie, P. C., Strassner, C., Lindemans, J., Katz, N., Leitzmann, C., & Hoffmann, I. (2005). Long-term consumption of a raw food diet is associated with favorable serum LDL cholesterol and triglycerides but also with elevated plasma homocysteine and low serum HDL cholesterol in humans. Journal of Nutrition, 135(10), 2372-2378. https://doi.org/10.1093/jn/135.10.2372
    • Skrabanja, A. T., Bouman, E. A., & Dagnelie, P. C. (2005). Potential value of adenosine 5'-triphosphate (ATP) and adenosine in anaesthesia and intensive care medicine. British Journal of Anaesthesia, 94(5), 556-562. https://doi.org/10.1093/bja/aei093
    • Dean, S. C., Harper, C. E., Cappuccio, F. P., Rink, E., Dirckx, C., Arnout, J., Zito, F., Iacoviello, L., Europ. Collaborative Group, I., van Dongen, M. C. J. M., & Dagnelie, P. C. (2005). The challenges of cross-national research in primary health care across Europe. Family Practice, 22(3), 341-346. https://doi.org/10.1093/fampra/cmi008
  • 2004
    • van Gool, C. J. A. W., Thijs, C. T. M., Dagnelie, P. C., Henquet, C. E. C., van Houwelingen, A. C., Schrander, J. J. P., Menheere, P. P., & van den Brandt, P. A. (2004). Determinants of neonatal IgE level: parity, maternal age, birth season and perinatal essential fatty acid status in infants of atopic mothers. Allergy, 59(9), 961-968. https://doi.org/10.1111/j.1398-9995.2004.00528.x
    • Dagnelie, P. C., Schuurman, A. G., Goldbohm, R. A., & van den Brandt, P. A. (2004). Diet, anthropometric measures and prostate cancer risk: a review of prospective cohort and intervention studies. BJU International, 93(8), 1139-50. https://doi.org/10.1111/j.1464-410X.2004.04795.x
    • Bogers, R. P., Brug, J., van Assema, P. T., & Dagnelie, P. C. (2004). Explaining fruit and vegetable consumption: the theory of planned behaviour and misconception of personal intake levels. Appetite, 42(2), 157-166. https://doi.org/10.1016/j.appet.2003.08.015
    • Koebnick, C., Hoffmann, I., Dagnelie, P. C., Heins, U. A., Wickramasinghe, S. N., Ratnayaka, I. D., Gruendel, S., Lindemans, J., & Leitzmann, C. (2004). Long-term ovo-lacto vegetarian diet impairs vitamin B-12 status in pregnant women. Journal of Nutrition, 134(12), 3319-3326. https://doi.org/10.1093/jn/134.12.3319
    • Bogers, R. P., van Assema, P. T., Kester, A. D. M., Westerterp, K. R., & Dagnelie, P. C. (2004). Reproducibility, validity, and responsiveness to change of a short questionnaire for measuring fruit and vegetable intake. American Journal of Epidemiology, 159(9), 900-909. https://doi.org/10.1093/aje/kwh123
  • 2003
    • Dirx, M. J. M., Zeegers, M. P. A., Dagnelie, P. C., van den Bogaard, T., & van den Brandt, P. A. (2003). Energy restriction and the risk of spontaneous mammary tumors in mice: a meta-analysis. International Journal of Cancer, 106(5), 766-770. https://doi.org/10.1002/ijc.11277
    • van Gool, C. J. A. W., Thijs, C. T. M., Henquet, C. J. M., van Houwelingen, A. C., Dagnelie, P. C., Schrander, J. J. P., Menheere, P. P. C. A., & van den Brandt, P. A. (2003). Gamma-linolenic acid supplementation for prophylaxis of atopic dermatitis--a randomized controlled trial in infants at high familial risk. American Journal of Clinical Nutrition, 77(4), 943-951. https://doi.org/10.1093/ajcn/77.4.943
    • Jellema, A., Zeegers, M. P. A., Feskens, E., Dagnelie, P. C., & Mensink, R. P. (2003). Gly972Arg variant in the insulin receptor substrate-1 gene and association with Type 2 diabetes: a meta-analysis of 27 studies. Diabetologia, 46(7), 990-995. https://doi.org/10.1007/s00125-003-1126-4
    • Agteresch, H. J., van Rooijen, M. H., van den Berg, J. W. O., Minderman-Voortman, G. J., Wilson, J. H. P., & Dagnelie, P. C. (2003). Growth inhibition of lung cancer cells by adenosine 5'-triphosphate. Drug Development Research, 60, 196-203. https://doi.org/10.1002/ddr.10296
    • Russel, M. G. V. M., Ryan, B. M., Dagnelie, P. C., de Rooij, M., Sijbrandij, J., Feleus, A., van der Hesselink-Kruijs, M. A. M., Muris, J. W. M., & Stockbrügger, R. W. (2003). Insurance problems among inflammatory bowel disease patients: results of a Dutch population based study. Gut, 52(3), 358-362. https://doi.org/10.1136/gut.52.3.358
    • Dagnelie, P. C. (2003). Nutrition and health--potential health benefits and risks of vegetarianism and limited consumption of meat in the Netherlands. Nederlands Tijdschrift voor Geneeskunde, 147(27), 1308-1313. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12868158&dopt=Abstract
    • Hulzebos, E. H. J., van Meeteren, N. L. U., de Bie, R. A., Dagnelie, P. C., & Helders, P. J. M. (2003). Prediction of postoperative pulmonary complications on the basis of preoperative risk factors in patients who had undergone coronary artery bypass graft surgery. Physical Therapy, 83(1), 8-16. https://doi.org/10.1093/ptj/83.1.8
    • Dagnelie, P. C., & Agteresch, H. J. (2003). Promising effects of adenosine triphosphate infusion on nutritional status and quality of life in advanced non-smell-cell lung cancer: a randomized clinical trial. Drug Development Research, 59, 146-151. https://doi.org/10.1002/ddr.10172
    • Agteresch, H. J., Burgers, S. A., van der Gaast, A., Wilson, J. H. P., & Dagnelie, P. C. (2003). Randomized clinical trial of adenosine 5'-triphosphate on tumor growth and survival in advanced lung cancer patients. Anti-Cancer Drugs, 14(8), 639-644. https://doi.org/10.1097/00001813-200309000-00009
    • Bogers, R. P., Dagnelie, P. C., Westerterp, K. R., Kester, A. D. M., van Klaveren, J. D., Bast, A., & van den Brandt, P. A. (2003). Using a correction factor to correct for overreporting in a food-frequency questionnaire does not improve biomarker-assessed validity of estimates for fruit and vegetable consumption. Journal of Nutrition, 133(4), 1213-1219. https://doi.org/10.1093/jn/133.4.1213
  • 2002
    • Leij-Halfwerk, S., Agteresch, H. J., Sijens, P. E., & Dagnelie, P. C. (2002). Adenosine triphosphate infusion increases liver energy status in advanced lung cancer patients: an in vivo 31P magnetic resonance spectroscopy study. Hepatology, 35(2), 421-424. https://doi.org/10.1053/jhep.2002.31318
    • Agteresch, H. J., Rietveld, T., Kerkhofs, L. G. M., van den Berg, J. W. O., Wilson, J. H. P., & Dagnelie, P. C. (2002). Beneficial effects of adenosine triphosphate on nutritional status in advanced lung cancer patients: a randomized clinical trial. Journal of Clinical Oncology, 20(2), 362-363. https://doi.org/10.1200/JCO.2002.20.2.371
    • Zuijdgeest-van Leeuwen, S. D., van der Heijden, M. S., Rietveld, T., van den Berg, J. W. O., Tilanus, H. W., Burgers, J. A., Wilson, J. H. P., & Dagnelie, P. C. (2002). Fatty acid composition of plasma lipids in patients with pancreatic, lung and oesophageal cancer in comparison with healthy subjects. Clinical Nutrition, 21(3), 225-230. https://doi.org/10.1054/clnu.2001.0530
    • Koebnick, C., Heins, U. A., Dagnelie, P. C., Wickramasinghe, S. N., Ratnayaka, I. D., Hothorn, T., Pfahlberg, A. B., Hoffmann, I., Lindemans, J., & Leitzmann, C. (2002). Longitudinal concentrations of vitamin B(12) and vitamin B(12)-binding proteins during uncomplicated pregnancy. Clinical Chemistry, 48(6 Pt 1), 928-933. http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?http://www.clinchem.org/cgi/pmidlookup?view=full&pmid=12029010
    • Boonen, A. L., Dagnelie, P. C., Feleus, A., van der Hesselink-Kruijs, M. A. M., Muris, J. W. M., Stockbrügger, R. W., & Russel, M. G. V. M. (2002). The impact of inflammatory bowel disease on labor force participation: results of a population sampled case-control study. Inflammatory Bowel Diseases, 8(6), 382-387. https://doi.org/10.1097/00054725-200211000-00002
  • 2001
    • Iacoviello, L., Arnout, J., Buntinx, F. J. V. M., Cappuccio, F. P., Dagnelie, P. C., de Lorgeril, M., Dirckx, C., Donati, M. B., Krogh, V., & Siani, A. (2001). Dietary habit profile in European communities with different risk of myocardial infarction: the impact of migration as a model of gene-environment interaction. The IMMIDIET Study. Nutrition Metabolism and Cardiovascular Diseases, 11(suppl to 4), 122-126. http://www.ncbi.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11894745&dopt=Abstract
    • Koebnick, C., Heins, U. A., Hoffmann, I., Dagnelie, P. C., & Leitzmann, C. (2001). Folate status during pregnancy in women is improved by long-term high vegetable intake compared with the average western diet.Journal of Nutrition, 131, 733-739. https://doi.org/10.1093/jn/131.3.733
  • 2000
    • Leij-Halfwerk, S., van den Berg, J. W. O., Sijens, P. E., Wilson, J. H. P., Oudkerk, M., & Dagnelie, P. C. (2000). Altered hepatic gluconeogenesis during L-alanine infusion in weight-losing lung cancer patients as observed by phosphorus magnetic resonance spectroscopy and turnover measurements. Cancer Research, 60, 618-623. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10676645&dopt=Abstract
    • Leij-Halfwerk, S., Dagnelie, P. C., Kappert, P., Oudkerk, M., & Sijens, P. E. (2000). Decreased energy and phosphorylation status in the liver of lung cancer patients with eight loss. Journal of Hepatology, 32, 887-892. https://doi.org/10.1016/S0168-8278(00)80092-6
    • Geerling, B. J., Dagnelie, P. C., Badart-Smook, J. M. T., Russel, M. G. V. M., Stockbrügger, R. W., & Brummer, R. J. M. (2000). Diet as a risk factor for the development of ulcerative colitis. American Journal of Gastroenterology, 95(4), 1008-1013. https://doi.org/10.1016/S0002-9270(00)00734-6
    • Agteresch, H. J., Leij-Halfwerk, S., van den Berg, J. W. O., Hordijk-Luijk, C. H., Wilson, J. H. P., & Dagnelie, P. C. (2000). Effects of ATP infusion on glucose turnover and gluconeogenesis in patients with advanced non-small-cell lung cancer. Clinical Science, 98(6), 689-695. https://doi.org/10.1042/cs0980689
    • van Zuijdgeest Leeuwen, S. D., Dagnelie, P. C., Wattimena, J. D. L., van den Berg, J. W. O., van der Gaast, A., Swart, G. R., & Wilson, J. H. P. (2000). Eicosapentaenoic acid ethyl ester supplementation in cachectic cancer patients and healthy subjects: effects on lipolysis and lipid oxidation. Clinical Nutrition, 19, 417-423. https://doi.org/10.1054/clnu.2000.0162
    • Leij-Halfwerk, S., Dagnelie, P. C., van den Berg, J. W. O., Wilson, J. H. P., & Sijens, P. E. (2000). Hepatic sugar phosphate levels reflect gluconeogenesis in lung cancer: simultaneous turnover measurements and 31P magnetic resonance spectroscopy in vivo. Clinical Science, 98(2), 167-174. https://doi.org/10.1042/cs0980167
    • van Zuijdgeest Leeuwen, S. D., van den Berg, J. W. O., Wattimena, J. D. L., van der Gaast, A., Swart, G. R., Wilson, J. H. P., & Dagnelie, P. C. (2000). Lipolysis and lipid oxidation in weight-losing cancer patients and healthy subjects. Metabolism-Clinical and Experimental, 49, 931-936. https://doi.org/10.1053/meta.2000.6740
    • Agteresch, H. J., Dagnelie, P. C., Rietveld, T., van den Berg, J. W. O., Danser, A. H. J., & Wilson, J. H. P. (2000). Pharmacokinetics of intravenous ATP in cancer patients. European Journal of Clinical Pharmacology, 56, 49-55. https://doi.org/10.1007/s002280050719
    • Agteresch, H. J., Dagnelie, P. C., van der Gaast, A., Stijnen, T., & Wilson, J. H. P. (2000). Randomized clinical trial of adenosine 5'-triphosphate in patients with advanced non-small-cell lung cancer. Journal of the National Cancer Institute, 92, 321-328. https://doi.org/10.1093/jnci/92.4.321
    • Leij-Halfwerk, S., Dagnelie, P. C., van den Berg, J. W. O., Wattimena, J. D. L., Hordijk-Luijk, C. H., & Wilson, J. H. P. (2000). Weight loss and elevated gluconeogenesis from alanine in lung cancer patients. American Journal of Clinical Nutrition, 71, 583-589. https://doi.org/10.1093/ajcn/71.2.583
  • 1999