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Wildhagen, K. C. A. A., Lutgens, E., Loubele, S. T. G. B., ten Cate, H., & Nicolaes, G. A. F. (2011). The structure-function relationship of activated protein C Lessons from natural and engineered mutations. Thrombosis and Haemostasis, 106(6), 1034-1045. https://doi.org/10.1160/TH11-08-0522

Liehn, E. A., Tuchscheerer, N., Kanzler, I., Drechsler, M., Fraemohs, L., Schuh, A., Koenen, R. R., Zander, S., Soehnlein, O., Hristov, M., Grigorescu, G., Urs, A. O., Leabu, M., Bucur, I., Merx, M. W., Zernecke, A., Ehling, J., Gremse, F., Lammers, T., ... Weber, C. (2011). Double-Edged Role of the CXCL12/CXCR4 Axis in Experimental Myocardial Infarction. Journal of the American College of Cardiology, 58(23), 2415-2423. https://doi.org/10.1016/j.jacc.2011.08.033

Winckers, K., Siegerink, B., Duckers, C., Maurissen, L. F., Tans, G., Castoldi, E., Spronk, H. M. H., Ten Cate, H., Algra, A., Hackeng, T. M., & Rosendaal, F. R. (2011). Increased tissue factor pathway inhibitor activity is associated with myocardial infarction in young women: results from the RATIO study. Journal of Thrombosis and Haemostasis, 9(11), 2243-2250. https://doi.org/10.1111/j.1538-7836.2011.04497.x

Tchaikovski, S. N., Thomassen, M. C. L. G. D., Costa, S.-D., Peeters, L. L. H., & Rosing, J. (2011). Role of protein S and tissue factor pathway inhibitor in the development of activated protein C resistance early in pregnancy in women with a history of preeclampsia. Thrombosis and Haemostasis, 106(5), 914-921. https://doi.org/10.1160/TH11-04-0244

Strijkers, R. H. W., Ten Cate-Hoek, A. J., Bukkems, S. F. F. W., & Wittens, C. H. A. (2011). Management of deep vein thrombosis and prevention of post-thrombotic syndrome. BMJ, 343, 8. https://doi.org/10.1136/bmj.d5916

Laeremans, H., Hackeng, T. M., van Zandvoort, M. A. M. J., Thijssen, V. L. J. L., Janssen, B. J. A., Ottenheijm, H. C. J., Smits, J. F. M., & Blankesteijn, W. M. (2011). Blocking of Frizzled Signaling With a Homologous Peptide Fragment of Wnt3a/Wnt5a Reduces Infarct Expansion and Prevents the Development of Heart Failure After Myocardial Infarction. Circulation, 124(15), 1626-U107. https://doi.org/10.1161/CIRCULATIONAHA.110.976969

Konings, J., Govers-Riemslag, J. W. P., Philippou, H., Mutch, N. J., Borissoff, J. I., Allan, P., Mohan, S., Tans, G., ten Cate, H., & Ariens, R. A. S. (2011). Factor XIIa regulates the structure of the fibrin clot independently of thrombin generation through direct interaction with fibrin. Blood, 118(14), 3942-3951. https://doi.org/10.1182/blood-2011-03-339572

International Consortium for Blood Pressure Genome-Wide Association Studies (2011). Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature, 478(7367), 103-109. https://doi.org/10.1038/nature10405

Soehnlein, O., Wantha, S., Simsekyilmaz, S., Doering, Y., Megens, R. T. A., Mause, S. F., Drechsler, M., Smeets, R., Weinandy, S., Schreiber, F., Gries, T., Jockenhoevel, S., Moeller, M., Vijayan, S., van Zandvoort, M. A. M. J., Agerberth, B., Pham, C. C. T. N., Gallo, R. L., Hackeng, T. M., ... Weber, C. (2011). Neutrophil-Derived Cathelicidin Protects from Neointimal Hyperplasia. Science Translational Medicine, 3(103), 10. https://doi.org/10.1126/scitranslmed.3002531

Surakka, I., Isaacs, A., Karssen, L. C., Laurila, P.-P. P., Middelberg, R. P. S., Tikkanen, E., Ried, J. S., Lamina, C., Mangino, M., Igl, W., Hottenga, J.-J., Lagou, V., van der Harst, P., Mateo Leach, I., Esko, T., Kutalik, Z., Wainwright, N. W., Struchalin, M. V., Sarin, A.-P., ... ENGAGE Consortium (2011). A genome-wide screen for interactions reveals a new locus on 4p15 modifying the effect of waist-to-hip ratio on total cholesterol. Plos Genetics, 7(10), e1002333. https://doi.org/10.1371/journal.pgen.1002333

Honickel, M., Rieg, A. D., Rossaint, R., Braunschweig, T., Spronk, H. M. H., ten Cate, H., van Oerle, R., Tolba, R., & Grottke, O. (2011). Prothrombin complex concentrate reduces blood loss and enhances thrombin generation in a pig model with blunt liver injury under severe hypothermia. Thrombosis and Haemostasis, 106(4), 724-733. https://doi.org/10.1160/TH11-02-0101

Bis, J. C., Kavousi, M., Franceschini, N., Isaacs, A., Abecasis, G. R., Schminke, U., Post, W. S., Smith, A. V., Cupples, L. A., Markus, H. S., Schmidt, R., Huffman, J. E., Lehtimäki, T., Baumert, J., Münzel, T., Heckbert, S. R., Dehghan, A., North, K., Oostra, B., ... CARDIoGRAM Consortium (2011). Meta-analysis of genome-wide association studies from the CHARGE consortium identifies common variants associated with carotid intima media thickness and plaque. Nature Genetics, 43(10), 940-7. https://doi.org/10.1038/ng.920

Panova-Noeva, M., Marchetti, M., Buoro, S., Russo, L., Leuzzi, A., Finazzi, G., Rambaldi, A., Ottomano, C., ten Cate, H., & Falanga, A. (2011). JAK2V617F mutation and hydroxyurea treatment as determinants of immature platelet parameters in essential thrombocythemia and polycythemia vera patients. Blood, 118(9), 2599-2601. https://doi.org/10.1182/blood-2011-02-339655

Schuur, M., Ikram, M. A., van Swieten, J. C., Isaacs, A., Vergeer-Drop, J. M., Hofman, A., Oostra, B. A., Breteler, M. M. B., & van Duijn, C. M. (2011). Cathepsin D gene and the risk of Alzheimer's disease: a population-based study and meta-analysis. Neurobiology of Aging, 32(9), 1607-14. https://doi.org/10.1016/j.neurobiolaging.2009.10.011

Panizzi, P., Nahrendorf, M., Figueiredo, J.-L., Panizzi, J., Marinelli, B., Iwamoto, Y., Keliher, E., Maddur, A. A., Waterman, P., Kroh, H. K., Leuschner, F., Aikawa, E., Swirski, F. K., Pittet, M. J., Hackeng, T. M., Fuentes-Prior, P., Schneewind, O., Bock, P. E., & Weissleder, R. (2011). In vivo detection of Staphylococcus aureus endocarditis by targeting pathogen-specific prothrombin activation. Nature Medicine, 17(9), 1142-U153. https://doi.org/10.1038/nm.2423

Vasina, E. M., Cauwenberghs, S., Feijge, M. A. H., Heemskerk, J. W. M., Weber, C., & Koenen, R. R. (2011). Microparticles from apoptotic platelets promote resident macrophage differentiation. Cell Death & Disease, 2, 10. Article e211. https://doi.org/10.1038/cddis.2011.94

Nergiz-Unal, R., Lamers, M. M. E., Van Kruchten, R., Luiken, J. J., Cosemans, J. M. E. M., Glatz, J. F. C., Kuijpers, M. J. E., & Heemskerk, J. W. M. (2011). Signaling role of CD36 in platelet activation and thrombus formation on immobilized thrombospondin or oxidized low-density lipoprotein. Journal of Thrombosis and Haemostasis, 9(9), 1835-1846. https://doi.org/10.1111/j.1538-7836.2011.04416.x

Kornfeld, J.-W., Isaacs, A., Vitart, V., Pospisilik, J. A., Meitinger, T., Gyllensten, U., Wilson, J. F., Rudan, I., Campbell, H., Penninger, J. M., Sexl, V., Moriggl, R., van Duijn, C., Pramstaller, P. P., & Hicks, A. A. (2011). Variants in STAT5B associate with serum TC and LDL-C levels. Journal of Clinical Endocrinology & Metabolism, 96(9), E1496-501. https://doi.org/10.1210/jc.2011-0322

Grottke, O., Braunschweig, T., Spronk, H. M. H., Esch, S., Rieg, A. D., van Oerle, R., ten Cate, H., Fitzner, C., Tolba, R., & Rossaint, R. (2011). Increasing concentrations of prothrombin complex concentrate induce disseminated intravascular coagulation in a pig model of coagulopathy with blunt liver injury. Blood, 118(7), 1943-1951. https://doi.org/10.1182/blood-2011-03-343046

Schiepers, O. J. G., van Boxtel, M. P. J., de Groot, R. H. M., Jolles, J., Bekers, O., Kok, F. J., Verhoef, P., & Durga, J. (2011). Genetic variation in folate metabolism is not associated with cognitive functioning or mood in healthy adults. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 35(7), 1682-1688. https://doi.org/10.1016/j.pnpbp.2011.06.008

Ninivaggi, M., Dargaud, Y., Van Oerle, R., De Laat, B., Hemker, H. C., & Lindhout, T. (2011). Thrombin generation assay using factor IXa as a trigger to quantify accurately factor VIII levels in haemophilia A. Journal of Thrombosis and Haemostasis, 9(8), 1549-1555. https://doi.org/10.1111/j.1538-7836.2011.04358.x

Bouman, H. J., Harmsze, A. M., van Werkum, J. W., Breet, N. J., Bergmeijer, T. O., ten Cate, H., Hackeng, C. M., Deneer, V. H. M., & Ten Berg, J. M. (2011). Variability in on-treatment platelet reactivity explained by CYP2C19*2 genotype is modest in clopidogrel pretreated patients undergoing coronary stenting. Heart, 97(15), 1239-1244. https://doi.org/10.1136/hrt.2010.220509

Konopatskaya, O., Matthews, S. A., Harper, M. T., Gilio, K., Cosemans, J. M. E. M., Williams, C. M., Navarro, M. N., Carter, D. A., Heemskerk, J. W. M., Leitges, M., Cantrell, D., & Poole, A. W. (2011). Protein kinase C mediates platelet secretion and thrombus formation through protein kinase D2. Blood, 118(2), 416-424. https://doi.org/10.1182/blood-2010-10-312199

Kilinc, E., Van Oerle, R., Borissoff, J. I., Oschatz, C., Gerlofs Nijland, M. E., Janssen, N. A., Cassee, F. R., Sandstrom, T., Renne, T., Ten Cate, H., & Spronk, H. M. H. (2011). Factor XII activation is essential to sustain the procoagulant effects of particulate matter. Journal of Thrombosis and Haemostasis, 9(7), 1359-1367. https://doi.org/10.1111/j.1538-7836.2011.04280.x

Demirkan, A., Amin, N., Isaacs, A., Jarvelin, M.-R., Whitfield, J. B., Wichmann, H.-E., Kyvik, K. O. H. M., Rudan, I., Gieger, C., Hicks, A. A., Johansson, Å., Hottenga, J.-J., Smith, J. J., Wild, S. H., Pedersen, N. L., Willemsen, G., Mangino, M., Hayward, C., Uitterlinden, A. G., ... ENGAGE Consortium (2011). Genetic architecture of circulating lipid levels. European Journal of Human Genetics, 19(7), 813-9. https://doi.org/10.1038/ejhg.2011.21

Heemskerk, J. W. M., Harper, M. T., Cosemans, J. M. E. M., & Poole, A. W. (2011). Unravelling the different functions of protein kinase C isoforms in platelets. Febs Letters, 585(12), 1711-1716. https://doi.org/10.1016/j.febslet.2011.05.017

Douma, R. A., Mos, I. C. M., Erkens, P. M. G., Nizet, T. A. C., Durian, M. F., Hovens, M. M. C., van Houten, A., Hofstee, H. M. A., Klok, F. A., ten Cate, H., Ullmann, E. F., Buller, H. R., Kamphuisen, P. W., & Huisman, M. V. (2011). Performance of 4 Clinical Decision Rules in the Diagnostic Management of Acute Pulmonary Embolism A Prospective Cohort Study. Annals of Internal Medicine, 154(11), 14-718. https://doi.org/10.7326/0003-4819-154-11-201106070-00002

Maas, A. H. E. M., van der Schouw, Y. T., Regitz-Zagrosek, V., Swahn, E., Appelman, Y. E., Pasterkamp, G., ten Cate, H., Nilsson, P. M., Huisman, M. V., Stam, H. C. G., Eizema, K., & Stramba-Badiale, M. (2011). Red alert for women's heart: the urgent need for more research and knowledge on cardiovascular disease in women. European Heart Journal, 32(11), 1362-U89. https://doi.org/10.1093/eurheartj/ehr048

Borissoff, J. I., Spronk, H. M. H., & ten Cate, H. (2011). MECHANISMS OF DISEASE The Hemostatic System as a Modulator of Atherosclerosis. New England Journal of Medicine, 364(18), 1746-1760. https://doi.org/10.1056/NEJMra1011670

Bastings, M. M. C., Helms, B. A., van Baal, I., Hackeng, T. M., Merkx, M. A. G., & Meijer, E. W. (2011). From Phage Display to Dendrimer Display: Insights into Multivalent Binding. Journal of the American Chemical Society, 133(17), 6636-6641. https://doi.org/10.1021/ja110700x

Bouman, H. J., van Werkum, J. W., Breet, N. J., ten Cate, H., Hackeng, C. M., & Ten Berg, J. M. (2011). A case-control study on platelet reactivity in patients with coronary stent thrombosis. Journal of Thrombosis and Haemostasis, 9(5), 909-916. https://doi.org/10.1111/j.1538-7836.2011.04255.x

Castoldi, E., Duckers, C., Radu, C. M., Spiezia, L., Rossetto, V., Tagariello, G., Rosing, J., & Simioni, P. (2011). Homozygous F5 deep-intronic splicing mutation resulting in severe factor V deficiency and undetectable thrombin generation in platelet-rich plasma. Journal of Thrombosis and Haemostasis, 9(5), 959-968. https://doi.org/10.1111/j.1538-7836.2011.04237.x

Debats, I. B., Koeneman, M. M., Booi, D. I., Bekers, O., & van der Hulst, R. R. W. J. (2011). Intravenous arginine and human skin graft donor site healing: A randomized controlled trial.Burns, 37(3), 420-426. https://doi.org/10.1016/j.burns.2010.06.003

Wijnen, P. A. H. M., Voorter, C. E., Nelemans, P. J., Verschakelen, J. A., Bekers, O., & Drent, M. (2011). Butyrophilin-like 2 in pulmonary sarcoidosis: a factor for susceptibility and progression?Human Immunology, 72(4), 342-347. https://doi.org/10.1016/j.humimm.2011.01.011

Trappenburg, M. C., van Schilfgaarde, M., Bredewold, E. O., van Aalderen, M. C., Spronk, H. M. H., ten Cate, H., Leyte, A., & Terpstra, W. E. (2011). Elevated numbers and altered subsets of procoagulant microparticles in breast cancer patients using endocrine therapy. Thrombosis Research, 127(4), 363-369. https://doi.org/10.1016/j.thromres.2010.12.015

Panova-Noeva, M., Marchetti, M., Spronk, H. M., Russo, L., Diani, E., Finazzi, G., Salmoiraghi, S., Rambaldi, A., Barbui, T., Ten Cate, H., & Falanga, A. (2011). Platelet-induced thrombin generation by the calibrated automated thrombogram assay is increased in patients with essential thrombocythemia and polycythemia vera. American Journal of Hematology, 86(4), 337-342. https://doi.org/10.1002/ajh.21974

Kilinc, E., Schulz, H., Kuiper, G. J. A. J. M., Spronk, H. M. H., ten Cate, H., Upadhyay, S., Ganguly, K., Stoeger, T., Semmler-Bhenke, M., Takenaka, S., Kreyling, W. G., Pitz, M., Reitmeir, P., Peters, A., Eickelberg, O., & Wichmann, H. E. (2011). The procoagulant effects of fine particulate matter in vivo. Particle and Fibre Toxicology, 8, 3. https://doi.org/10.1186/1743-8977-8-12

Kramp, B. K., Sarabi, A., Koenen, R. R., & Weber, C. (2011). Heterophilic chemokine receptor interactions in chemokine signaling and biology. Experimental Cell Research, 317(5), 655-663. https://doi.org/10.1016/j.yexcr.2010.11.014

Lexis, C. P. H., van der Horst, I. C. C., Rahel, B. M., Lexis, M. A. S., Kampinga, M. A., Gu, Y. L., de Smet, B. J. G. L., & Zijlstra, F. (2011). Impact of Chronic Total Occlusions on Markers of Reperfusion, Infarct Size, and Long-Term Mortality: A Substudy from the TAPAS-Trial. Catheterization and Cardiovascular interventions, 77(4), 484-491. https://doi.org/10.1002/ccd.22664

Brugts, J. J., Isaacs, A., de Maat, M. P., Boersma, E., van Duijn, C. M., Akkerhuis, K. M., Uitterlinden, A. G., Witteman, J. C., Cambien, F., Ceconi, C., Remme, W., Bertrand, M., Ninomiya, T., Harrap, S., Chalmers, J., Macmahon, S., Fox, K., Ferrari, R., Simoons, M. L., & Danser, A. J. (2011). A pharmacogenetic analysis of determinants of hypertension and blood pressure response to angiotensin-converting enzyme inhibitor therapy in patients with vascular disease and healthy individuals. Journal of Hypertension, 29(3), 509-19. https://doi.org/10.1097/HJH.0b013e328341d117

Obermann-Borst, S. A., Isaacs, A., Younes, Z., van Schaik, R. H. N., van der Heiden, I. P., van Duyn, C. M., Steegers, E. A. P., & Steegers-Theunissen, R. P. M. (2011). General maternal medication use, folic acid, the MDR1 C3435T polymorphism, and the risk of a child with a congenital heart defect. American Journal of Obstetrics and Gynecology, 204(3), 236.e1-8. https://doi.org/10.1016/j.ajog.2010.10.911

Smid, M., Dielis, A. W. J. H., Winkens, M. H. M., Spronk, H. M. H., van Oerle, R., Hamulyak, K., Prins, M. H., Rosing, J., Waltenberger, J. L., & ten Cate, H. (2011). Thrombin generation in patients with a first acute myocardial infarction. Journal of Thrombosis and Haemostasis, 9(3), 450-456. https://doi.org/10.1111/j.1538-7836.2010.04162.x

de Jager, S. C. A., Bermudez, B., Bot, I., Koenen, R. R., Bot, M., Kavelaars, A., de Waard, V., Heijnen, C. J., Muriana, F. J. G., Weber, C., van Berkel, T. J. C., Kuiper, J., Lee, S.-J., Abia, R., & Biessen, E. A. L. (2011). Growth differentiation factor 15 deficiency protects against atherosclerosis by attenuating CCR2-mediated macrophage chemotaxis. Journal of Experimental Medicine, 208(2), 217-225. https://doi.org/10.1084/jem.20100370

Coolen, E. J., Arts, I. C., Bekers, O., Vervaet, C., Bast, A., & Dagnelie, P. C. (2011). Oral bioavailability of ATP after prolonged administration.British Journal of Nutrition, 105(3), 357-366. https://doi.org/10.1017/S0007114510003570

Castoldi, E., & Rosing, J. (2011). Thrombin generation tests. Thrombosis Research, 127, S21-S25. https://doi.org/10.1016/S0049-3848(11)70007-X

van Schie, M. C., de Maat, M. P. M., Isaacs, A., van Duijn, C. M., Deckers, J. W., Dippel, D. W. J., & Leebeek, F. W. G. (2011). Variation in the von Willebrand factor gene is associated with von Willebrand factor levels and with the risk for cardiovascular disease. Blood, 117(4), 1393-9. https://doi.org/10.1182/blood-2010-03-273961

Ungethum, L., Kenis, H., Nicolaes, G. A., Autin, L., Stoilova-McPhie, S., & Reutelingsperger, C. P. M. (2011). Engineered Annexin A5 Variants Have Impaired Cell Entry for Molecular Imaging of Apoptosis Using Pretargeting Strategies. Journal of Biological Chemistry, 286(3), 1903-1910. https://doi.org/10.1074/jbc.M110.163527

Cosemans, J. M. E. M., Schols, S. E. M., Stefanini, L., de Witt, S., Feijge, M. A. H., Hamulyak, K., Deckmyn, H., Bergmeier, W., & Heemskerk, J. W. M. (2011). Key role of glycoprotein Ib/V/IX and von Willebrand factor in platelet activation-dependent fibrin formation at low shear flow. Blood, 117(2), 651-660. https://doi.org/10.1182/blood-2010-01-262683

Wijnen, P. A. H. M., Bekers, O., & Drent, M. (2011). Development of Cocaine-Induced Interstitial Lung Damage in Two CYP2C and VKORC1 Variant Allele Carriers. Molecular Diagnosis & Therapy, 15(3), 177-180. https://doi.org/10.1007/BF03256408