• 2017
    • Christophersen, I. E., Magnani, J. W., Yin, X., Barnard, J., Weng, L.-C., Arking, D. E., Niemeijer, M. N., Lubitz, S. A., Avery, C. L., Duan, Q., Felix, S. B., Bis, J. C., Kerr, K. F., Isaacs, A., Mueller-Nurasyid, M., Mueller, C., North, K. E., Reiner, A. P., Tinker, L. F., ... Ellinor, P. T. (2017). Fifteen Genetic Loci Associated With the Electrocardiographic P Wave. Circulation : Cardiovascular Genetics, 10(4), Article 001667. https://doi.org/10.1161/CIRCGENETICS.116.001667
    • Sörensen, B. M., Houben, A. J. H. M., Berendschot, T. T. J. M., Schouten, J. S. A. G., Kroon, A. A., van der Kallen, C. J. H., Henry, R. M. A., Koster, A., Reesink, K. D., Dagnelie, P. C., Schaper, N. C., Schalkwijk, C. G., Schram, M. T., & Stehouwer, C. D. A. (2017). Hyperglycemia Is the Main Mediator of Prediabetes- and Type 2 Diabetes-Associated Impairment of Microvascular Function: The Maastricht Study. Diabetes Care, 40(8), e103-e105. https://doi.org/10.2337/dc17-0574
    • van der Huller, T., van Es, N., den Exter, P. L., van Es, J., Mos, I. C. M., Douma, R. A., Kruip, M. J. H. A., Hovens, M. M. C., ten Woldes, M., Nijkeuter, M., ten Cate, H., Kamphuisen, P. W., BuIler, H. R., Huisman, M. V., & Klok, F. A. (2017). Is a normal computed tomography pulmonary angiography safe to rule out acute pulmonary embolism in patients with a likely clinical probability?Thrombosis and Haemostasis, 117(8), 1622-1629. https://doi.org/10.1160/TH17-02-0076
    • Stolk, L. M., de Vries, F., Ebbelaar, C., de Boer, A., Schalekamp, T., Souverein, P., ten Cate-Hoek, A., & Burden, A. M. (2017). Risk of myocardial infarction in patients with atrial fibrillation using vitamin K antagonists, aspirin or direct acting oral anticoagulants. British Journal of Clinical Pharmacology, 83(8), 1835-1843. https://doi.org/10.1111/bcp.13264
    • Van der Velde, J. H. P. M., Koster, A., Van der Berg, J. D., Sep, S. J. S., Van der Kallen, C. J. H., Dagnelie, P. C., Schram, M. T., Henry, R. M. A., Eussen, S. J. P. M., Van Dongen, M. C. J. M., Stehouwer, C. D. A., Schaper, N. C., & Savelberg, H. H. C. M. (2017). Sedentary Behavior, Physical Activity, and Fitness-The Maastricht Study. Medicine and Science in Sports and Exercise, 49(8), 1583-1591. https://doi.org/10.1249/MSS.0000000000001262
    • de Waard, E. A. C., Driessen, J. H. M., de Jong, J. J. A., van Geel, T. A. C. M., Henry, R. M. A., van Onzenoort, H. A. W., Schram, M. T., Dagnelie, P. C., van der Kallen, C. J., Sep, S. J. S., Stehouwer, C. D. A., Schaper, N. C., Koster, A., Savelberg, H. H. C. M., Neef, C., Geusens, P. P. M. M., de Vries, F., & van den Bergh, J. P. W. (2017). The association between insulin use and volumetric bone mineral density, bone micro-architecture and bone strength of the distal radius in patients with type 2 diabetes - The Maastricht study. Bone, 101, 156-161. https://doi.org/10.1016/j.bone.2017.05.004
    • Elissen, A. M. J., Hertroijs, D. F. L., Schaper, N. C., Bosma, H., Dagnelie, P. C., Henry, R. M., van der Kallen, C. J., Koster, A., Schram, M. T., Stehouwer, C. D. A., Schouten, J. S. A. G., Berendschot, T. T. J. M., & Ruwaard, D. (2017). Differences in biopsychosocial profiles of diabetes patients by level of glycaemic control and health-related quality of life: The Maastricht Study. PLOS ONE, 12(7), Article e0182053. https://doi.org/10.1371/journal.pone.0182053
    • Kimenai, D. M., Martens, R. J. H., Kooman, J. P., Stehouwer, C. D. A., Tan, F. E. S., Schaper, N. C., Dagnelie, P. C., Schram, M. T., van der Kallen, C. J. H., Sep, S. J. S., van Suijlen, J. D. E., Kroon, A. A., Bekers, O., van Dieijen-Visser, M. P., Henry, R. M. A., & Meex, S. J. R. (2017). Troponin I and T in relation to cardiac injury detected with electrocardiography in a population-based cohort - The Maastricht Study. Scientific Reports, 7(1), Article 6610. https://doi.org/10.1038/s41598-017-06978-3
    • Doring, Y., Noels, H., van der Vorst, E. P. C., Neideck, C., Egea, V., Drechsler, M., Mandl, M., Pawig, L., Jansen, Y., Schroeder, K., Bidzhekov, K., Megens, R. T. A., Theelen, W., Klinkhammer, B. M., Boor, P., Schurgers, L., van Gorp, R., Ries, C., Kusters, P. J. H., ... Weber, C. (2017). Vascular CXCR4 Limits Atherosclerosis by Maintaining Arterial Integrity Evidence From Mouse and Human Studies. Circulation, 136(4), 388-403. https://doi.org/10.1161/CIRCULATIONAHA.117.027646
    • Prochaska, J. H., Frank, B., Nagler, M., Lamparter, H., Weisser, G., Schulz, A., Eggebrecht, L., Goebel, S., Arnold, N., Panova-Noeva, M., Hermanns, I., Pinto, A., Konstantinides, S., ten Cate, H., Lackner, K. J., Muenzel, T., Espinola-Klein, C., & Wild, P. S. (2017). Age-related diagnostic value of D-dimer testing and the role of inflammation in patients with suspected deep vein thrombosis. Scientific Reports, 7(1), Article 4591. https://doi.org/10.1038/s41598-017-04843-x
    • Sabrkhany, S., Kuijpers, M. J. E., van Kuijk, S. M. J., Sanders, L., Pineda, S., Damink, S. W. M. O., Dingemans, A.-M. C., Griffioen, A. W., & Egbrink, M. G. A. O. (2017). A combination of platelet features allows detection of early-stage cancer. European Journal of Cancer, 80, 5-13. https://doi.org/10.1016/j.ejca.2017.04.010
    • Orsini, S., Noris, P., Bury, L., Heller, P. G., Santoro, C., Kadir, R. A., Butta, N. C., Falcinelli, E., Cid, A. R., Fabris, F., Fouassier, M., Miyazaki, K., Luisa Lozano, M., Zuniga, P., Flaujac, C., Podda, G. M., Bermejo, N., Favier, R., Henskens, Y., ... EHA-SWG Thrombocytopenias Platelet (2017). Bleeding risk of surgery and its prevention in patients with inherited platelet disorders. Haematologica-the Hematology Journal, 102(7), 1192-1203. https://doi.org/10.3324/haematol.2016.160754
    • ten Cate, H., Hackeng, T. M., & de Frutos, P. G. (2017). Coagulation factor and protease pathways in thrombosis and cardiovascular disease. Thrombosis and Haemostasis, 117(7), 1265-1271. https://doi.org/10.1160/TH17-02-0079
    • Honickel, M., Spronk, H. M., Rossaint, R., Stoppe, C., van Ryn, J., ten Cate, H., & Grottke, O. (2017). Dose requirements for idarucizumab reversal of dabigatran in a lethal porcine trauma model with continuous bleeding. Thrombosis and Haemostasis, 117(7), 1370-1378. https://doi.org/10.1160/TH16-11-0824
    • Prochaska, J. H., Goebel, S., Keller, K., Coldewey, M., Ullmann, A., Lamparter, H., Schulz, A., Schinzel, H., Bickel, C., Lauterbach, M., Michal, M., Hardt, R., Binder, H., Espinola-Klein, C., Lackner, K. J., Ten Cate, H., Muenzel, T., & Wild, P. S. (2017). e-Health-based management of patients receiving oral anticoagulation therapy: results from the observational thrombEVAL study. Journal of Thrombosis and Haemostasis, 15(7), 1375-1385. https://doi.org/10.1111/jth.13727
    • Braeken, D. C. W., Spruit, M. A., Houben-Wilke, S., Smid, D. E., Rohde, G. G. U., Wouters, E. F. M., & Franssen, F. M. E. (2017). Impact of exacerbations on adherence and outcomes of pulmonary rehabilitation in patients with COPD. Respirology, 22(5), 942-949. https://doi.org/10.1111/resp.12987
    • van der Linden, N., Streng, A. S., Bekers, O., Wodzig, W. K. W. H., Meex, S. J. R., & de Boer, D. (2017). Large Variation in Measured Cardiac Troponin T Concentrations after Standard Addition in Serum or Plasma of Different Individuals. Clinical Chemistry, 63(7), 1300-1302. https://doi.org/10.1373/clinchem.2017.272435
    • Ridger, V. C., Boulanger, C. M., Angelillo-Scherrer, A., Badimon, L., Blanc-Brude, O., Bochaton-Piallat, M.-L., Boilard, E., Buzas, E. I., Caporali, A., Dignat-George, F., Evans, P. C., Lacroix, R., Lutgens, E., Ketelhuth, D. F. J., Nieuwland, R., Toti, F., Tunon, J., Weber, C., Hoefer, I. E., ... Harrison, P. (2017). Microvesicles in vascular homeostasis and diseases Position Paper of the European Society of Cardiology (ESC) Working Group on Atherosclerosis and Vascular Biology. Thrombosis and Haemostasis, 117(7), 1296-1316. https://doi.org/10.1160/TH16-12-0943
    • Hilderink, J. M., Klinkenberg, L. J. J., Aakre, K. M., de Wit, N. C. J., Henskens, Y. M. C., van der Linden, N., Bekers, O., Rennenberg, R. J. M. W., Koopmans, R. P., & Meex, S. J. R. (2017). Within-day biological variation and hour-to-hour reference change values for hematological parameters. Clinical Chemistry and Laboratory Medicine, 55(7), 1013-1024. https://doi.org/10.1515/cclm-2016-0716
    • Schmidt, M., Toplak, A., Quaedflieg, P. J. L. M., Ippel, H., Richelle, G. J. J., Hackeng, T. M., van Maarseveen, J. H., & Nuijens, T. (2017). Omniligase-1: A Powerful Tool for Peptide Head-to-Tail Cyclization. Advanced Synthesis & Catalysis, 359(12), 2050-2055. https://doi.org/10.1002/adsc.201700314
    • van den Berg, M. E., Warren, H. R., Cabrera, C. P., Verweij, N., Mifsud, B., Haessler, J., Bihlmeyer, N. A., Fu, Y.-P., Weiss, S., Lin, H. J., Grarup, N., Li-Gao, R., Pistis, G., Shah, N., Brody, J. A., Mueller-Nurasyid, M., Lin, H., Mei, H., Smith, A. V., ... Munroe, P. B. (2017). Discovery of novel heart rate-associated loci using the Exome Chip. Human Molecular Genetics, 26(12), 2346-2363. https://doi.org/10.1093/hmg/ddx113
    • Arts, M., Soons, Z., Ellis, S. R., Pierzchalski, K. A., Balluff, B., Eijkel, G. B., Dubois, L. J., Lieuwes, N. G., Agten, S. M., Hackeng, T. M., van Loon, L. J. C., Heeren, R. M. A., & Damink, S. W. M. O. (2017). Detection of Localized Hepatocellular Amino Acid Kinetics by using Mass Spectrometry Imaging of Stable Isotopes. Angewandte Chemie-International Edition, 56(25), 7146-7150. https://doi.org/10.1002/anie.201702669
    • Putaala, J., Martinez-Majander, N., Saeed, S., Yesilot, N., Jakala, P., Nerg, O., Tsivgoulis, G., Numminen, H., Gordin, D., von Sarnowski, B., Waje-Andreassen, U., Ylikotila, P., Roine, R. O., Zedde, M., Huhtakangas, J., Fonseca, C., Redfors, P., de Leeuw, F. E., Pezzini, A., ... Tatlisumak, T. (2017). Searching for Explanations for Cryptogenic Stroke in the Young: Revealing the Triggers, Causes, and Outcome (SECRETO): Rationale and design. European Stroke Journal, 2(2), 116-125. https://doi.org/10.1177/2396987317703210
    • Vajen, T., Benedikter, B. J., Heinzmann, A. C. A., Vasina, E. M., Henskens, Y., Parsons, M., Maguire, P. B., Stassen, F. R., Heemskerk, J. W. M., Schurgers, L. J., & Koenen, R. R. (2017). Platelet extracellular vesicles induce a pro-inflammatory smooth muscle cell phenotype. Journal of Extracellular Vesicles, 6(1), Article 1322454. https://doi.org/10.1080/20013078.2017.1322454
    • Oshagbemi, O. A., Burden, A. M., Braeken, D. C. W., Henskens, Y., Wouters, E. F. M., Driessen, J. H. M., Maitland-van der Zee, A. H., de Vries, F., & Franssen, F. M. E. (2017). Stability of Blood Eosinophils in Patients with Chronic Obstructive Pulmonary Disease and in Control Subjects, and the Impact of Sex, Age, Smoking, and Baseline Counts. American Journal of Respiratory and Critical Care Medicine, 195(10), 1402-1404. https://doi.org/10.1164/rccm.201701-0009LE
    • Aarts, S. A. B. M., Seijkens, T. T. P., Kusters, P. J. H., van der Pol, S. M. A., Zarzycka, B., Heijnen, P. D. A. M., Beckers, L., den Toom, M., Gijbels, M. J. J., Boon, L., Weber, C., de Vries, H. E., Nicolaes, G. A. F., Dijkstra, C. D., Kooij, G., & Lutgens, E. (2017). Inhibition of CD40-TRAF6 interactions by the small molecule inhibitor 6877002 reduces neuroinflammation. Journal of Neuroinflammation, 14(1), Article 105. https://doi.org/10.1186/s12974-017-0875-9
    • Sohail, M., Vakhrusheva, O. A., Sul, J. H., Pulit, S. L., Francioli, L. C., van den Berg, L. H., Veldink, J. H., de Bakker, P. I. W., Bazykin, G. A., Kondrashov, A. S., Sunyaev, S. R., Genome of the Netherlands Consortium, & Isaacs, A. (2017). Negative selection in humans and fruit flies involves synergistic epistasis. Science, 356(6337), 539-542. https://doi.org/10.1126/science.aah5238
    • Van Der Linden, N., Streng, A. S., Wodzig, W. K. W. H., Bekers, O., & Meex, S. J. R. (2017). Better, higher, lower, faster: increasingly rapid clinical decision making using high-sensitivity cardiac troponin assays. Journal of Laboratory and Precision Medicine, 2, Article 14. https://doi.org/10.21037/jlpm.2017.04.03
    • Kremers, R. M. W., Kleinegris, M.-C., Ninivaggi, M., de Laat, B., ten Cate, H., Koek, G. H., Wagenvoord, R. J., & Hemker, H. C. (2017). Decreased prothrombin conversion and reduced thrombin inactivation explain rebalanced thrombin generation in liver cirrhosis. PLOS ONE, 12(5), Article 0177020. https://doi.org/10.1371/journal.pone.0177020
    • Bloemen, S., Zwaveling, S., ten Cate, H., ten Cate-Hoek, A., & de Laat, B. (2017). Prediction of bleeding risk in patients taking vitamin K antagonists using thrombin generation testing. PLOS ONE, 12(5), Article e0176967. https://doi.org/10.1371/journal.pone.0176967
    • Westhoff, C. L., Pike, M. C., Cremers, S., Eisenberger, A., Thomassen, S., & Rosing, J. (2017). Endogenous thrombin potential changes during the first cycle of oral contraceptive use. Contraception, 95(5), 456-463. https://doi.org/10.1016/j.contraception.2017.01.001
    • Geijselaers, S. L. C., Sep, S. J. S., Schram, M. T., van Boxtel, M. P. J., Henry, R. M. A., Verhey, F. R. J., Kroon, A. A., Schaper, N. C., Dagnelie, P. C., Kallen, C. J. H. V. D., Stehouwer, C. D. A., & Biessels, G. J. (2017). Insulin resistance and cognitive performance in type 2 diabetes - The Maastricht study. Journal of Diabetes and Its Complications, 31(5), 824-830. https://doi.org/10.1016/j.jdiacomp.2017.01.020
    • Meani, P., Gelsomino, S., Natour, E., Johnson, D. M., Rocca, H.-P. B. L., Pappalardo, F., Bidar, E., Makhoul, M., Raffa, G., Heuts, S., Lozekoot, P., Kats, S., Sluijpers, N., Schreurs, R., Delnoij, T., Montalti, A., Sels, J. W., van de Poll, M., Roekaerts, P., ... Lorusso, R. (2017). Modalities and Effects of Left Ventricle Unloading on Extracorporeal Life support: a Review of the Current Literature. European journal of heart failure, 19 Suppl 2, 84-91. https://doi.org/10.1002/ejhf.850
    • Alshaikh, N. A., Rosing, J., Thomassen, M. C. L. G. D., Castoldi, E., Simioni, P., & Hackeng, T. M. (2017). New functional assays to selectively quantify the activated protein C- and tissue factor pathway inhibitor-cofactor activities of protein S in plasma. Journal of Thrombosis and Haemostasis, 15(5), 950-960. https://doi.org/10.1111/jth.13657
    • Veugen, M. G. J., Henry, R. M. A., van Sloten, T. T., Hermeling, E., Brunner-La Rocca, H.-P., Schram, M. T., Dagnelie, P. C., Schalkwijk, C. G., Kroon, A. A., Stehouwer, C. D. A., & Reesink, K. D. (2017). The systolic-diastolic difference in carotid stiffness is increased in type 2 diabetes: The Maastricht Study. Journal of Hypertension, 35(5), 1052-1060. https://doi.org/10.1097/HJH.0000000000001298
    • van der Velde, J. H. P. M., Savelberg, H. H. C. M., van der Berg, J. D., Sep, S. J. S., van der Kallen, C. J. H., Dagnelie, P. C., Schram, M. T., Henry, R. M. A., Reijven, P. L. M., van Geel, T. A. C. M., Stehouwer, C. D. A., Koster, A., & Schaper, N. C. (2017). Sedentary Behavior Is Only Marginally Associated with Physical Function in Adults Aged 40-75 Years - the Maastricht Study. Frontiers in physiology, 8(APR), Article 242. https://doi.org/10.3389/fphys.2017.00242
    • Kleinegris, M.-C. F., Konings, J., Daemen, J. W., Henskens, Y., de Laat, B., Spronk, H. M. H., ten Cate-Hoek, A. J., & ten Cate, H. (2017). Increased Clot Formation in the Absence of Increased Thrombin Generation in Patients with Peripheral Arterial Disease: A Case-Control Study. Frontiers in Cardiovascular Medicine, 4, Article 23. https://doi.org/10.3389/fcvm.2017.00023
    • Hobbelt, A. H., Spronk, H. M., Crijns, H. J. G. M., Ten Cate, H., Rienstra, M., & Van Gelder, I. C. (2017). Prethrombotic State in Young Very Low- Risk Patients With Atrial Fibrillation. Journal of the American College of Cardiology, 69(15), 1990-1992. https://doi.org/10.1016/j.jacc.2017.01.057
    • von Hundelshausen, P., Agten, S. M., Eckardt, V., Blanchet, X., Schmitt, M. M., Ippel, H., Neideck, C., Bidzhekov, K., Leberzammer, J., Wichapong, K., Faussner, A., Drechsler, M., Grommes, J., van Geffen, J. P., Li, H., Ortega-Gomez, A., Megens, R. T. A., Naumann, R., Dijkgraaf, I., ... Weber, C. (2017). Chemokine interactome mapping enables tailored intervention in acute and chronic inflammation. Science Translational Medicine, 9(384), Article eaah6650. https://doi.org/10.1126/scitranslmed.aah6650
    • van Smaalen, T. C., Beurskens, D. M. H., Hoogland, E. R. P., Winkens, B., Christiaans, M. H. L., Reutelingsperger, C. P., van Heurn, L. W. E., & Nicolaes, G. A. F. (2017). Presence of Cytotoxic Extracellular Histones in Machine Perfusate of Donation After Circulatory Death Kidneys. Transplantation, 101(4), e93-e101. https://doi.org/10.1097/TP.0000000000001590
    • den Biggelaar, L. J. C. J., Eussen, S. J. P. M., Sep, S. J. S., Mari, A., Ferrannini, E., van Dongen, M. C. J. M., Denissen, K. F. M., Wijckmans, N. E. G., Schram, M. T., van der Kallen, C. J., Koster, A., Schaper, N., Henry, R. M. A., Stehouwer, C. D. A., & Dagnelie, P. C. (2017). Associations of Dietary Glucose, Fructose, and Sucrose with beta-Cell Function, Insulin Sensitivity, and Type 2 Diabetes in the Maastricht Study. Nutrients, 9(4), Article 380. https://doi.org/10.3390/nu9040380
    • Martens, R. J. H., Kimenai, D. M., Kooman, J. P., Stehouwer, C. D. A., Tan, F. E. S., Bekers, O., Dagnelie, P. C., van der Kallen, C. J. H., Kroon, A. A., Leunissen, K. M. L., van der Sande, F. M., Schaper, N. C., Sep, S. J. S., Schram, M. T., van Suijlen, J. D., van Dieijen-Visser, M. P., Meex, S. J. R., & Henry, R. M. A. (2017). Estimated Glomerular Filtration Rate and Albuminuria Are Associated with Biomarkers of Cardiac Injury in a Population-Based Cohort Study: The Maastricht Study. Clinical Chemistry, 63(4), 887-897. https://doi.org/10.1373/clinchem.2016.266031
    • Driessen, J. H. M., de Vries, F., van Onzenoort, H., Harvey, N. C., Neef, C., van den Bergh, J. P. W., Vestergaard, P., & Henry, R. M. A. (2017). The use of incretins and fractures - a meta-analysis on population-based real life data. British Journal of Clinical Pharmacology, 83(4), 923-926. https://doi.org/10.1111/bcp.13167
    • Ruhle, F., & Stoll, M. (2017). Genetic factors in pediatric venous thromboembolism. Thrombosis Research, 151, S97-S99. https://doi.org/10.1016/S0049-3848(17)30077-4
    • van Moorsel, D., Henry, R. M., Schaper, N. C., van Greevenbroek, M. M., van Rossum, E. F., 't Hart, L. M., Schalkwijk, C. G., van der Kallen, C. J., Dekker, J. M., Stehouwer, C. D., & Havekes, B. (2017). BclI Glucocorticoid Receptor Polymorphism in Relation to Arterial Stiffening and Cardiac Structure and Function: The Hoorn and CODAM Studies. American Journal of Hypertension, 30(3), 286-294. https://doi.org/10.1093/ajh/hpw196
    • Mingels, A. M. A., Cardinaels, E. P. M., Broers, N. J. H., van Sleeuwen, A., Streng, A. S., van Dieijen-Visser, M. P., Kooman, J. P., & Bekers, O. (2017). Cardiac Troponin T: Smaller Molecules in Patients with End-Stage Renal Disease than after Onset of Acute Myocardial Infarction. Clinical Chemistry, 63(3), 683-690. https://doi.org/10.1373/clinchem.2016.261644
    • Driessen, J. H. M., van den Bergh, J. P. W., van Onzenoort, H. A. W., Henry, R. M. A., Leufkens, H. G. M., & de Vries, F. (2017). Long-term use of dipeptidyl peptidase-4 inhibitors and risk of fracture: A retrospective population-based cohort study. Diabetes Obesity & Metabolism, 19(3), 421-428. https://doi.org/10.1111/dom.12843
    • Simons, N., Isaacs, A., Koek, G. H., Kuc, S., Schaper, N. C., & Brouwers, M. C. G. J. (2017). PNPLA3, TM6SF2, and MBOAT7 Genotypes and Coronary Artery Disease. Gastroenterology, 152(4), 912-913. https://doi.org/10.1053/j.gastro.2016.12.020
    • Kapustin, A. N., Schoppet, M., Schurgers, L. J., Reynolds, J. L., McNair, R., Heiss, A., Jahnen-Dechent, W., Hackeng, T. M., Schlieper, G., Harrison, P., & Shanahan, C. M. (2017). Prothrombin Loading of Vascular Smooth Muscle Cell-Derived Exosomes Regulates Coagulation and Calcification. Arteriosclerosis Thrombosis and Vascular Biology, 37(3), E22-E32. https://doi.org/10.1161/ATVBAHA.116.308886