• 2013
    • Do, R., Willer, C. J., Schmidt, E. M., Sengupta, S., Gao, C., Peloso, G. M., Gustafsson, S., Kanoni, S., Ganna, A., Chen, J., Buchkovich, M. L., Mora, S., Beckmann, J. S., Bragg-Gresham, J. L., Chang, H.-Y., Demirkan, A., Den Hertog, H. M., Donnelly, L. A., Ehret, G. B., ... Author collaboration (2013). Common variants associated with plasma triglycerides and risk for coronary artery disease. Nature Genetics, 45(11), 1345-1352. https://doi.org/10.1038/ng.2795
    • Willer, C. J., Schmidt, E. M., Sengupta, S., Peloso, G. M., Gustafsson, S., Kanoni, S., Ganna, A., Chen, J., Buchkovich, M. L., Mora, S., Beckmann, J. S., Bragg-Gresham, J. L., Chang, H.-Y., Demirkan, A., Den Hertog, H. M., Do, R., Donnelly, L. A., Ehret, G. B., Esko, T., ... Global Lipids Genetics Consortium (2013). Discovery and refinement of loci associated with lipid levels. Nature Genetics, 45(11), 1274-1283. https://doi.org/10.1038/ng.2797
    • Spronk, H. M. H., Borissoff, J. I., & ten Cate, H. (2013). New Insights into Modulation of Thrombin Formation. Current Atherosclerosis Reports, 15(11), Article 363. https://doi.org/10.1007/s11883-013-0363-3
    • Brouwers, M. C. G. J., Konrad, R. J., van Himbergen, T. M., Isaacs, A., Otokozawa, S., Troutt, J. S., Schaefer, E. J., van Greevenbroek, M. M. J., Stalenhoef, A. F. H., & de Graaf, J. (2013). Plasma proprotein convertase subtilisin kexin type 9 levels are related to markers of cholesterol synthesis in familial combined hyperlipidemia. Nutrition Metabolism and Cardiovascular Diseases, 23(11), 1115-1121. https://doi.org/10.1016/j.numecd.2012.11.008
    • Van der Hulle, T., Den Exter, P. L., Erkens, P. G. M., Van Es, J., Mos, I. C. M., Ten Cate, H., Kamphuisen, P. W., Hovens, M. M. C., Buller, H. R., Klok, F. A., & Huisman, M. V. (2013). Variable D-dimer thresholds for diagnosis of clinically suspected acute pulmonary embolism. Journal of Thrombosis and Haemostasis, 11(11), 1986-1992. https://doi.org/10.1111/jth.12394
    • Kramp, B. K., Megens, R. T. A., Sarabi, A., Winkler, S., Projahn, D., Weber, C., Koenen, R. R., & von Hundelshausen, P. (2013). Exchange of extracellular domains of CCR1 and CCR5 reveals confined functions in CCL5-mediated cell recruitment. Thrombosis and Haemostasis, 110(4), 795-806. https://doi.org/10.1160/TH13-05-0420
    • Broer, L., Codd, V., Nyholt, D. R., Deelen, J., Mangino, M., Willemsen, G., Albrecht, E., Amin, N., Beekman, M., de Geus, E. J. C., Henders, A., Nelson, C. P., Steves, C. J., Wright, M. J., de Craen, A. J. M., Isaacs, A., Matthews, M., Moayyeri, A., Montgomery, G. W., ... Boomsma, D. I. (2013). Meta-analysis of telomere length in 19,713 subjects reveals high heritability, stronger maternal inheritance and a paternal age effect. European Journal of Human Genetics, 21(10), 1163-8. https://doi.org/10.1038/ejhg.2012.303
    • Omarova, F., De Willige, S. U., Ariens, R. A. S., Rosing, J., Bertina, R. M., & Castoldi, E. (2013). Inhibition of thrombin-mediated factor V activation contributes to the anticoagulant activity of fibrinogen gamma '. Journal of Thrombosis and Haemostasis, 11(9), 1669-1678. https://doi.org/10.1111/jth.12354
    • Isaacs, A., Willems, S. M., Bos, D., Dehghan, A., Hofman, A., Ikram, M. A., Uitterlinden, A. G., Oostra, B. A., Franco, O. H., Witteman, J. C., & van Duijn, C. M. (2013). Risk scores of common genetic variants for lipid levels influence atherosclerosis and incident coronary heart disease. Arteriosclerosis Thrombosis and Vascular Biology, 33(9), 2233-9. https://doi.org/10.1161/ATVBAHA.113.301236
    • Konings, J., Cugno, M., Suffritti, C., ten Cate, H., Cicardi, M., & Govers-Riemslag, J. W. P. (2013). Ongoing Contact Activation in Patients with Hereditary Angioedema. PLOS ONE, 8(8), Article e74043. https://doi.org/10.1371/journal.pone.0074043
    • Kleinegris, M.-C. F., ten Cate, H., & ten Cate-Hoek, A. J. (2013). D-dimer as a marker for cardiovascular and arterial thrombotic events in patients with peripheral arterial disease A systematic review. Thrombosis and Haemostasis, 110(2), 233-243. https://doi.org/10.1160/TH13-01-0032
    • Borissoff, J. I., Joosen, I. A., Versteylen, M. O., Brill, A., Fuchs, T. A., Savchenko, A. S., Gallant, M., Martinod, K., ten Cate, H., Hofstra, L., Crijns, H. J., Wagner, D. D., & Kietselaer, B. L. J. H. (2013). Elevated Levels of Circulating DNA and Chromatin Are Independently Associated With Severe Coronary Atherosclerosis and a Prothrombotic State. Arteriosclerosis Thrombosis and Vascular Biology, 33(8), 2032-2040. https://doi.org/10.1161/ATVBAHA.113.301627
    • Heeb, M. J., Mesters, R. M., Fernandez, J. A., Hackeng, T. M., Nakasone, R. K., & Griffin, J. H. (2013). Plasma protein S residues 37-50 mediate its binding to factor Va and inhibition of blood coagulation. Thrombosis and Haemostasis, 110(2), 275-282. https://doi.org/10.1160/TH12-12-0953
    • Amin, N., Hottenga, J.-J., Hansell, N. K., Janssens, A. C. J. W., de Moor, M. H. M., Madden, P. A. F., Zorkoltseva, I. V., Penninx, B. W., Terracciano, A., Uda, M., Tanaka, T., Esko, T., Realo, A., Ferrucci, L., Luciano, M., Davies, G., Metspalu, A., Abecasis, G. R., Deary, I. J., ... van Duijn, C. M. (2013). Refining genome-wide linkage intervals using a meta-analysis of genome-wide association studies identifies loci influencing personality dimensions. European Journal of Human Genetics, 21(8), 876-82. https://doi.org/10.1038/ejhg.2012.263
    • van Bussel, B. C. T., Soedamah Muthu, S. S., Henry, R. M., Schalkwijk, C. G., Ferreira, I., Chaturvedi, N., Toeller, M., Fuller, J. H., & Stehouwer, C. D. A. (2013). Unhealthy dietary patterns associated with inflammation and endothelial dysfunction in type 1 diabetes: The EURODIAB study. Nutrition Metabolism and Cardiovascular Diseases, 23(8), 758-764. https://doi.org/10.1016/j.numecd.2012.04.005
    • Schuijt, T. J., Bakhtiari, K., Daffre, S., DePonte, K., Wielders, S. J. H., Marquart, J. A., Hovius, J. W., van der Poll, T., Fikrig, E., Bunce, M. W., Camire, R. M., Nicolaes, G. A. F., Meijers, J. C. M., & van 't Veer, C. (2013). Factor Xa Activation of Factor V Is of Paramount Importance in Initiating the Coagulation System: Lessons From a Tick Salivary Protein. Circulation, 128(3), 254-266. https://doi.org/10.1161/CIRCULATIONAHA.113.003191
    • Cosemans, J. M. E. M., Angelillo-Scherrer, A., Mattheij, N. J. A., & Heemskerk, J. W. M. (2013). The effects of arterial flow on platelet activation, thrombus growth, and stabilization. Cardiovascular Research, 99(2), 342-352. https://doi.org/10.1093/cvr/cvt110
    • Konings, J., Govers-Riemslag, J. W. P., Spronk, H. M. H., Waltenberger, J. L., & ten Cate, H. (2013). Activation of the contact system in patients with a first acute myocardial infarction. Thrombosis Research, 132(1), 138-142. https://doi.org/10.1016/j.thromres.2013.05.016
    • Panova-Noeva, M., Marchetti, M., Russo, L., Tartari, C. J., Leuzzi, A., Finazzi, G., Rambaldi, A., ten Cate, H., & Falanga, A. (2013). ADP-induced platelet aggregation and thrombin generation are increased in Essential Thrombocythemia and Polycythemia Vera. Thrombosis Research, 132(1), 88-93. https://doi.org/10.1016/j.thromres.2013.05.003
    • Eijgenraam, P., ten Cate, H., & ten Cate-Hoek, A. (2013). Safety and Efficacy of Bridging with Low Molecular Weight Heparins: A Systematic Review and Partial Meta-Analysis. Current Pharmaceutical Design, 19(22), 4014-4023. https://doi.org/10.2174/1381612811319220010
    • Cardinaels, E. P. M., Mingels, A. M. A., van Rooij, T., Collinson, P. O., Prinzen, F. W., & van Dieijen-Visser, M. P. (2013). Time-Dependent Degradation Pattern of Cardiac Troponin T Following Myocardial Infarction. Clinical Chemistry, 59(7), 1083-1090. https://doi.org/10.1373/clinchem.2012.200543
    • Smid, M., Dielis, A. W. J. H., Spronk, H. M. H., Rumley, A., van Oerle, R., Woodward, M., ten Cate, H., & Lowe, G. (2013). Thrombin Generation in the Glasgow Myocardial Infarction Study. PLOS ONE, 8(6), Article e66977. https://doi.org/10.1371/journal.pone.0066977
    • Dijkgraaf, I., Van de Vijver, P., Dirksen, A., & Hackeng, T. M. (2013). Synthesis and application of cNGR-containing imaging agents for detection of angiogenesis. Bioorganic & Medicinal Chemistry, 21(12), 3555-3564. https://doi.org/10.1016/j.bmc.2013.04.002
    • Bosch, Y., Al Dieri, R., Ten Cate, H., Nelemans, P., Bloemen, S., Hemker, C., Weerwind, P., Maessen, J., & Mochtar, B. (2013). Preoperative thrombin generation is predictive for the risk of blood loss after cardiac surgery: a research article. Journal of Cardiothoracic Surgery, 8. https://doi.org/10.1186/1749-8090-8-154
    • Theuwissen, E., Teunissen, K. J., Spronk, H. M. H., Hamulyak, K., Ten Cate, H., Shearer, M. J., Vermeer, C., & Schurgers, L. J. (2013). Effect of low-dose supplements of menaquinone-7 (vitamin K-2) on the stability of oral anticoagulant treatment: dose-response relationship in healthy volunteers. Journal of Thrombosis and Haemostasis, 11(6), 1085-1092. https://doi.org/10.1111/jth.12203
    • den Hoed, M., Eijgelsheim, M., Esko, T., Brundel, B. J. J. M., Peal, D. S., Evans, D. M., Nolte, I. M., Segrè, A. V., Holm, H., Handsaker, R. E., Westra, H.-J., Johnson, T., Isaacs, A., Yang, J., Lundby, A., Zhao, J. H., Kim, Y. J., Go, M. J., Almgren, P., ... Loos, R. J. F. (2013). Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders. Nature Genetics, 45(6), 621-31. https://doi.org/10.1038/ng.2610
    • van der Meijden, P. E. J., Bouman, A. C., Feijge, M. A. H., van Oerle, R., Spronk, H. M. H., Hamulyak, K., ten Cate-Hoek, A. J., ten Cate, H., & Heemskerk, J. W. M. (2013). Platelet Dysfunction in Thrombosis Patients Treated with Vitamin K Antagonists and Recurrent Bleeding. PLOS ONE, 8(5). https://doi.org/10.1371/journal.pone.0064112
    • Grottke, O., Rossaint, R., Henskens, Y., van Oerle, R., ten Cate, H., & Spronk, H. H. (2013). Thrombin Generation Capacity of Prothrombin Complex Concentrate in an In Vitro Dilutional Model. PLOS ONE, 8(5), Article e64100. https://doi.org/10.1371/journal.pone.0064100
    • Mattheij, N. J. A., Gilio, K., van Kruchten, R., Jobe, S. M., Wieschhaus, A. J., Chishti, A. H., Collins, P., Heemskerk, J. W. M., & Cosemans, J. M. E. M. (2013). Dual Mechanism of Integrin alpha(IIb)beta(3) Closure in Procoagulant Platelets. Journal of Biological Chemistry, 288(19), 13325-13336. https://doi.org/10.1074/jbc.M112.428359
    • Strak, M., Hoek, G., Steenhof, M., Kilinc, E., Godri, K. J., Gosens, I., Mudway, I. S., van Oerle, R., Spronk, H. M. H., Cassee, F. R., Kelly, F. J., Harrison, R. M., Brunekreef, B., Lebret, E., & Janssen, N. A. H. (2013). Components of ambient air pollution affect thrombin generation in healthy humans: the RAPTES project. Occupational and Environmental Medicine, 70(5), 332-340. https://doi.org/10.1136/oemed-2012-100992
    • Raps, M., Rosendaal, F., Ballieux, B., Rosing, J., Thomassen, S., Helmerhorst, F., & Van Vliet, H. (2013). Resistance to APC and SHBG levels during use of a four-phasic oral contraceptive containing dienogest and estradiol valerate: a randomized controlled trial. Journal of Thrombosis and Haemostasis, 11(5), 855-861. https://doi.org/10.1111/jth.12172
    • Winckers, K., ten Cate, H., & Hackeng, T. M. (2013). The role of tissue factor pathway inhibitor in atherosclerosis and arterial thrombosis. Blood Reviews, 27(3), 119-132. https://doi.org/10.1016/j.blre.2013.03.001
    • CARDIOGRAM, METASTROKE, Keating, B. J., & Asselbergs, F. W. (2013). Loci influencing blood pressure identified using a cardiovascular gene-centric array. Human Molecular Genetics, 22(8), 1663-78. https://doi.org/10.1093/hmg/dds555
    • Peraramelli, S., Thomassen, S., Heinzmann, A., Rosing, J., Hackeng, T. M., Hartmann, R., Scheiflinger, F., & Dockal, M. (2013). Direct inhibition of factor VIIa by TFPI and TFPI constructs. Journal of Thrombosis and Haemostasis, 11(4), 704-714. https://doi.org/10.1111/jth.12152
    • Fuchs, B., de Witt, S., Solecka, B. A., Kroening, M., Obser, T., Cosemans, J. M. E. M., Schneppenheim, R., Heemskerk, J. W. M., & Kannicht, C. (2013). Distinct Role of von Willebrand Factor Triplet Bands in Glycoprotein Ib-Dependent Platelet Adhesion and Thrombus Formation under Flow. Seminars in Thrombosis and Hemostasis, 39(3), 306-314. https://doi.org/10.1055/s-0032-1328971
    • Seehase, M., Houthuizen, P., Jellema, R. K., Collins, J. J., Bekers, O., Breuer, J., & Kramer, B. W. (2013). Propofol administration to the fetal-maternal unit reduces cardiac injury in late-preterm lambs subjected to severe prenatal asphyxia and cardiac arrest. Pediatric Research, 73(4), 427-434. https://doi.org/10.1038/pr.2013.10
    • Strak, M., Hoek, G., Godri, K. J., Gosens, I., Mudway, I. S., van Oerle, R., Spronk, H. M. H., Cassee, F. R., Lebret, E., Kelly, F. J., Harrison, R. M., Brunekreef, B., Steenhof, M., & Janssen, N. A. H. (2013). Composition of PM Affects Acute Vascular Inflammatory and Coagulative Markers - The RAPTES Project. PLOS ONE, 8(3), Article e58944. https://doi.org/10.1371/journal.pone.0058944
    • van Bussel, B. C. T., Ferreira, I., van de Waarenburg, M. P., van Greevenbroek, M. M. J., van der Kallen, C. J. H., Henry, R. M., Feskens, E. J., Stehouwer, C. D. A., & Schalkwijk, C. G. (2013). Multiple inflammatory biomarker detection in a prospective cohort study: a cross-validation between well-established single-biomarker techniques and an electrochemiluminescense-based multi-array platform.PLOS ONE, 8(3), Article 58576. https://doi.org/10.1371/journal.pone.0058576
    • Wantha, S., Alard, J.-E., Megens, R. T. A., van der Does, A. M., Doering, Y., Drechsler, M., Pham, C. T. N., Wang, M.-W., Wang, J.-M., Gallo, R. L., von Hundelshausen, P., Lindbom, L., Hackeng, T., Weber, C., & Soehnlein, O. (2013). Neutrophil-Derived Cathelicidin Promotes Adhesion of Classical Monocytes. Circulation Research, 112(5), 792-801. https://doi.org/10.1161/CIRCRESAHA.112.300666
    • van der Kolk, J. H., Boelens, R., Halkes, S. B. A., Wijnberg, I. D., de Sain-van der Velden, M. G. M., & Ippel, J. H. (2013). Some notes on fatal acquired multiple acyl-CoA dehydrogenase deficiency (MADD) in a two-year-old warmblood stallion and European tar spot (Rhytisma acerinum). Veterinary Quarterly, 33(1), 51-55. https://doi.org/10.1080/01652176.2012.758904
    • Soehnlein, O., Drechsler, M., Doering, Y., Lievens, D., Hartwig, H., Kemmerich, K., Ortega-Gomez, A., Mandl, M., Vijayan, S., Projahn, D., Garlichs, C. D., Koenen, R. R., Hristov, M., Lutgens, E., Zernecke, A., & Weber, C. (2013). Distinct functions of chemokine receptor axes in the atherogenic mobilization and recruitment of classical monocytes. EMBO Molecular Medicine, 5(3), 471-481. https://doi.org/10.1002/emmm.201201717
    • Demirkan, A., Isaacs, A., Ugocsai, P., Liebisch, G., Struchalin, M., Rudan, I., Wilson, J. F., Pramstaller, P. P., Gyllensten, U., Campbell, H., Schmitz, G., Oostra, B. A., & van Duijn, C. M. (2013). Plasma phosphatidylcholine and sphingomyelin concentrations are associated with depression and anxiety symptoms in a Dutch family-based lipidomics study. Journal of Psychiatric Research, 47(3), 357-62. https://doi.org/10.1016/j.jpsychires.2012.11.001
    • Ten Cate-Hoek, A. J., Prins, M. H., Wittens, C. H. A., & Cate, H. T. (2013). Postintervention duration of anticoagulation in venous surgery. Phlebology: The Journal of Venous Disease, 28, 105-111. https://doi.org/10.1177/0268355513476415
    • Kumar, N., Ippel, H., Weber, C., Hackeng, T., & Mayo, K. H. (2013). Protein lysine-N zeta alkylation and O-phosphorylation mediated by DTT-generated reactive oxygen species. Protein Science, 22(3), 327-346. https://doi.org/10.1002/pro.2214
    • Borissoff, J. I., Otten, J. J. T., Heeneman, S., Leenders, P., van Oerle, R., Soehnlein, O., Loubele, S. T. B. G., Hamulyak, K., Hackeng, T. M., Daemen, M. J. A. P., Degen, J. L., Weiler, H., Esmon, C. T., van Ryn, J., Biessen, E. A. L., Spronk, H. M. H., & ten Cate, H. (2013). Genetic and Pharmacological Modifications of Thrombin Formation in Apolipoprotein E-deficient Mice Determine Atherosclerosis Severity and Atherothrombosis Onset in a Neutrophil-Dependent Manner. PLOS ONE, 8(2), Article e55784. https://doi.org/10.1371/journal.pone.0055784
    • Wijnen, P. A. H. M., Verschakelen, J. A., Bast, A., Bekers, O., & Drent, M. (2013). Diffuse alveolar hemorrhage in coumarin users: a fibrosing interstitial pneumonia trigger?Lung, 191(1), 53-59. https://doi.org/10.1007/s00408-012-9436-2
    • Bos, D., Ikram, M. A., Isaacs, A., Verhaaren, B. F. J., Hofman, A., van Duijn, C. M., Witteman, J. C. M., van der Lugt, A., & Vernooij, M. W. (2013). Genetic loci for coronary calcification and serum lipids relate to aortic and carotid calcification. Circulation : Cardiovascular Genetics, 6(1), 47-53. https://doi.org/10.1161/CIRCGENETICS.112.963934
    • Köttgen, A., Albrecht, E., Teumer, A., Vitart, V., Krumsiek, J., Hundertmark, C., Pistis, G., Ruggiero, D., O'Seaghdha, C. M., Haller, T., Yang, Q., Tanaka, T., Johnson, A. D., Kutalik, Z., Smith, A. V., Shi, J., Struchalin, M., Middelberg, R. P. S., Brown, M. J., ... LifeLines Cohort Study (2013). Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. Nature Genetics, 45(2), 145-54. https://doi.org/10.1038/ng.2500
    • Rademakers, T., Douma, K., Hackeng, T. M., Post, M. J., Sluimer, J. C., Daemen, M. J. A. P., Biessen, E. A. L., Heeneman, S., & van Zandvoort, M. A. M. J. (2013). Plaque-Associated Vasa Vasorum in Aged Apolipoprotein E-Deficient Mice Exhibit Proatherogenic Functional Features In Vivo. Arteriosclerosis Thrombosis and Vascular Biology, 33(2), 249–256. https://doi.org/10.1161/ATVBAHA.112.300087
    • Westein, E., van der Meer, A. D., Kuijpers, M. J. E., Frimat, J.-P., van den Berg, A., & Heemskerk, J. W. M. (2013). Atherosclerotic geometries exacerbate pathological thrombus formation poststenosis in a von Willebrand factor-dependent manner. Proceedings of the National Academy of Sciences of the United States of America, 110(4), 1357-1362. https://doi.org/10.1073/pnas.1209905110