Publications
- 2014
- Wildhagen, K. C. A. A., Schrijver, R., Beckers, L., ten Cate, H., Reutelingsperger, C. P. M., Lutgens, E., & Nicolaes, G. A. F. (2014). Effects of Exogenous Recombinant APC in Mouse Models of Ischemia Reperfusion Injury and of Atherosclerosis. PLOS ONE, 9(7), Article e101446. https://doi.org/10.1371/journal.pone.0101446
- Angin, Y., Schwenk, R. W., Nergiz-Unal, R., Hoebers, N., Heemskerk, J. W. M., Kuijpers, M. J., Coumans, W. A., van Zandvoort, M. A. M. J., Bonen, A., Neumann, D., Glatz, J. F. C., & Luiken, J. (2014). Calcium signaling recruits substrate transporters GLUT4 and CD36 to the sarcolemma without increasing cardiac substrate uptake. American Journal of Physiology : Endocrinology and Metabolism, 307(2), E225-E236. https://doi.org/10.1152/ajpendo.00655.2013
- Vijayan, S., Asare, Y., Grommes, J., Soehnlein, O., Lutgens, E., Shagdarsuren, G., Togtokh, A., Jacobs, M. J., Fischer, J. W., Bernhagen, J., Weber, C., Schober, A., & Shagdarsuren, E. (2014). High Expression of C5L2 Correlates with High Proinflammatory Cytokine Expression in Advanced Human Atherosclerotic Plaques. American Journal of Pathology, 184(7), 2123-2133. https://doi.org/10.1016/j.ajpath.2014.04.004
- de Witt, S. M., Swieringa, F., Cavill, R., Lamers, M. M., van Kruchten, R., Mastenbroek, T., Baaten, C., Coort, S., Pugh, N., Schulz, A., Scharrer, I., Jurk, K., Zieger, B., Clemetson, K. J., Farndale, R. W., Heemskerk, J. W., & Cosemans, J. M. (2014). Identification of platelet function defects by multi-parameter assessment of thrombus formation. Nature Communications, 5, Article 4257. https://doi.org/10.1038/ncomms5257
- Schmitt, M. M. N., Fraemohs, L., Hackeng, T. M., Weber, C., & Koenen, R. R. (2014). Atherogenic mononuclear cell recruitment is facilitated by oxidized lipoprotein-induced endothelial junctional adhesion molecule-A redistribution. Atherosclerosis, 234(2), 254-264. https://doi.org/10.1016/j.atherosclerosis.2014.03.014
- Streng, A. S., Jacobs, L. H. J., Schwenk, R. W., Cardinaels, E. P. M., Meex, S. J. R., Glatz, J. F. C., Wodzig, W. K. W. H., & van Dieijen-Visser, M. P. (2014). Cardiac troponin in ischemic cardiomyocytes: Intracellular decrease before onset of cell death. Experimental and Molecular Pathology, 96(3), 339-345. https://doi.org/10.1016/j.yexmp.2014.02.012
- Nagler, M., ten Cate, H., Kathriner, S., Casutt, M., Bachmann, L. M., & Wuillemin, W. A. (2014). Consistency of thromboelastometry analysis under scrutiny: Results of a systematic evaluation within and between analysers. Thrombosis and Haemostasis, 111(6), 1161-1166. https://doi.org/10.1160/TH13-10-0870
- Noels, H., Zhou, B., Tilstam, P. V., Theelen, W., Li, X., Pawig, L., Schmitz, C., Akhtar, S., Simsekyilmaz, S., Shagdarsuren, E., Schober, A., Adams, R. H., Bernhagen, J., Liehn, E. A., Doering, Y., & Weber, C. (2014). Deficiency of Endothelial Cxcr4 Reduces Reendothelialization and Enhances Neointimal Hyperplasia After Vascular Injury in Atherosclerosis-Prone Mice. Arteriosclerosis Thrombosis and Vascular Biology, 34(6), 1209-1220. https://doi.org/10.1161/ATVBAHA.113.302878
- Sperandio, O., Wildhagen, K. C. A. A., Schrijver, R., Wielders, S., Villoutreix, B. O., & Nicolaes, G. A. F. (2014). Identification of novel small molecule inhibitors of activated protein C. Thrombosis Research, 133(6), 1105-1114. https://doi.org/10.1016/j.thromres.2014.01.026
- Shadid, N. H., van der Velden, S. K., van Oerle, R., ten Cate, H., Sommer, A., & Nelemans, P. (2014). In vivo effects of foam sclerotherapy on coagulation. Phlebology: The Journal of Venous Disease, 29(5), 287-292. https://doi.org/10.1177/0268355513479590
- Posthuma, J. J., Loeffen, R., van Oerle, R., Henskens, Y. M. C., ten Cate, H., Spronk, H. M. H., & van der Meijden, P. E. J. (2014). Long-term strenuous exercise induces a hypercoagulable state through contact activation. Thrombosis and Haemostasis, 111(6), 1197-1199. https://doi.org/10.1160/TH13-11-0963
- Kuijpers, M. J. E., de Witt, S., Nergiz-Unal, R., van Kruchten, R., Korporaal, S. J. A., Verhamme, P., Febbraio, M., Tjwa, M., Voshol, P. J., Hoylaerts, M. F., Cosemans, J. M. E. M., & Heemskerk, J. W. M. (2014). Supporting Roles of Platelet Thrombospondin-1 and CD36 in Thrombus Formation on Collagen. Arteriosclerosis Thrombosis and Vascular Biology, 34(6), 1187-1192. https://doi.org/10.1161/ATVBAHA.113.302917
- van Sloten, T. T., Schram, M. T., van den Hurk, K., Dekker, J. M., Nijpels, G., Henry, R. M. A., & Stehouwer, C. D. A. (2014). Local Stiffness of the Carotid and Femoral Artery Is Associated With Incident Cardiovascular Events and All-Cause Mortality The Hoorn Study. Journal of the American College of Cardiology, 63(17), 1739-1747. https://doi.org/10.1016/j.jacc.2013.12.041
- Projahn, D., Simsekyilmaz, S., Singh, S., Kanzler, I., Kramp, B. K., Langer, M., Burlacu, A., Bernhagen, J., Klee, D., Zernecke, A., Hackeng, T. M., Groll, J., Weber, C., Liehn, E. A., & Koenen, R. R. (2014). Controlled intramyocardial release of engineered chemokines by biodegradable hydrogels as a treatment approach of myocardial infarction. Journal of Cellular and Molecular Medicine, 18(5), 790-800. https://doi.org/10.1111/jcmm.12225
- Spronk, H. M. H., ten Cate, H., & van der Meijden, P. E. J. (2014). Differential roles of Tissue Factor and Phosphatidylserine in activation of coagulation. Thrombosis Research, 133(SUPPL. 1), S54-S56. https://doi.org/10.1016/j.thromres.2014.03.022
- van Sloten, T. T., Schram, M. T., Adriaanse, M. C., Dekker, J. M., Nijpels, G., Teerlink, T., Scheffer, P. G., Pouwer, F., Schalkwijk, C. G., Stehouwer, C. D. A., & Henry, R. M. A. (2014). Endothelial dysfunction is associated with a greater depressive symptom score in a general elderly population: the Hoorn Study. Psychological Medicine, 44(7), 1403-1416. https://doi.org/10.1017/S0033291713002043
- de Witt, S. M., Verdoold, R., Cosemans, J. M. E. M., & Heemskerk, J. W. M. (2014). Insights into platelet-based control of coagulation. Thrombosis Research, 133(SUPPL. 2), S139-S148. https://doi.org/10.1016/S0049-3848(14)50024-2
- ten Cate, H., & Meade, T. (2014). The Northwick Park Heart Study: evidence from the laboratory. Journal of Thrombosis and Haemostasis, 12(5), 587-592. https://doi.org/10.1111/jth.12545
- Schram, M. T., Sep, S. J. S., van der Kallen, C. J., Dagnelie, P. C., Koster, A., Schaper, N., Henry, R. M. A., & Stehouwer, C. D. A. (2014). The Maastricht Study: an extensive phenotyping study on determinants of type 2 diabetes, its complications and its comorbidities. European Journal of Epidemiology, 29(6), 439-451. https://doi.org/10.1007/s10654-014-9889-0
- Castoldi, E. (2014). FV and APC resistance: the plot thickens. Blood, 123(15), 2288-2289. https://doi.org/10.1182/blood-2014-02-557363
- Vlassaks, E., Nikiforou, M., Strackx, E., Hutten, M., Bekers, O., Gazzolo, D., Li Volti, G., Martinez-Martinez, P., Kramer, B. W., & Gavilanes, A. W. (2014). Acute and chronic immunomodulatory changes in rat liver after fetal and perinatal asphyxia. Journal of developmental origins of health and disease, 5(2), 98-108. https://doi.org/10.1017/S2040174413000561
- Koenen, R. R. (2014). CX(3)CL1, a special deputy at the intersection of platelets and the vessel wall. Thrombosis and Haemostasis, 111(4), 567-567. https://doi.org/10.1160/TH14-02-0173
- Kok, M., Mihl, C., Mingels, A. A., Kietselaer, B. L., Muhlenbruch, G., Seehofnerova, A., Wildberger, J. E., & Das, M. (2014). Influence of Contrast Media Viscosity and Temperature on Injection Pressure in Computed Tomographic Angiography A Phantom Study. Investigative Radiology, 49(4), 217-223. https://doi.org/10.1097/RLI.0000000000000019
- Schober, A., Nazari-Jahantigh, M., Wei, Y., Bidzhekov, K., Gremse, F., Grommes, J., Megens, R. T. A., Heyll, K., Noels, H., Hristov, M., Wang, S., Kiessling, F., Olson, E. N., & Weber, C. (2014). MicroRNA-126-5p promotes endothelial proliferation and limits atherosclerosis by suppressing Dlk1. Nature Medicine, 20(4), 368–376. https://doi.org/10.1038/nm.3487
- Eijgenraam, P., ten Cate, H., & ten Cate-Hoek, A. J. (2014). Practice of bridging anticoagulation: guideline adherence and risk factors for bleeding. Netherlands Journal of Medicine, 72(3), 157-164.
- Olde Engberink, R. H. G., Kuiper, G. J. A. J. M., Wetzels, R. J. H., Nelemans, P. J., Lance, M. D., Beckers, E. A. M., & Henskens, Y. M. C. (2014). Rapid and Correct Prediction of Thrombocytopenia and Hypofibrinogenemia With Rotational Thromboelastometry in Cardiac Surgery. Journal of Cardiothoracic and Vascular Anesthesia, 28(2), 210-216. https://doi.org/10.1053/j.jvca.2013.12.004
- Raps, M., Curvers, J., Helmerhorst, F. M., Ballieux, B. E. P. B., Rosing, J., Thomassen, S., Rosendaal, F. R., & van Vliet, H. A. A. M. (2014). Thyroid function, activated protein C resistance and the risk of venous thrombosis in users of hormonal contraceptives. Thrombosis Research, 133(4), 640-644. https://doi.org/10.1016/j.thromres.2013.12.041
- Chatzigeorgiou, A., Seijkens, T., Zarzycka, B., Engel, D., Poggi, M., van den Berg, S., van den Berg, S., Soehnlein, O., Winkels, H., Beckers, L., Lievens, D., Driessen, A., Kusters, P., Biessen, E., Garcia-Martin, R., Klotzsche-von Ameln, A., Gijbels, M., Noelle, R., Boon, L., ... Lutgens, E. (2014). Correction for Chatzigeorgiou et al., Blocking CD40-TRAF6 signaling is a therapeutic target in obesity-associated insulin resistance (vol 111, pg 2686, 2014). Proceedings of the National Academy of Sciences of the United States of America, 111(12), 4644-4644. https://doi.org/10.1073/pnas.1403231111
- Li, X., Zhu, M., Penfold, M. E., Koenen, R. R., Thiemann, A., Heyll, K., Akhtar, S., Koyadan, S., Wu, Z., Gremse, F., Kiessling, F., van Zandvoort, M., Schall, T. J., Weber, C., & Schober, A. (2014). Activation of CXCR7 Limits Atherosclerosis and Improves Hyperlipidemia by Increasing Cholesterol Uptake in Adipose Tissue. Circulation, 129(11), 1244-1253. https://doi.org/10.1161/CIRCULATIONAHA.113.006840
- Doering, Y., Noels, H., Mandl, M., Kramp, B., Neideck, C., Lievens, D., Drechsler, M., Megens, R. T. A., Tilstam, P. V., Langer, M., Hartwig, H., Theelen, W., Marth, J. D., Sperandio, M., Soehnlein, O., & Weber, C. (2014). Deficiency of the Sialyltransferase St3Gal4 Reduces-Ccl5Mediated Myeloid Cell Recruitment and Arrest. Circulation Research, 114(6), 976-981. https://doi.org/10.1161/CIRCRESAHA.114.302426
- Geersing, G. J., Zuithoff, N. P. A., Kearon, C., Anderson, D. R., ten Cate-Hoek, A. J., Elf, J. L., Bates, S. M., Hoes, A. W., Kraaijenhagen, R. A., Oudega, R., Schutgens, R. E. G., Stevens, S. M., Woller, S. C., Wells, P. S., & Moons, K. G. M. (2014). Exclusion of deep vein thrombosis using the Wells rule in clinically important subgroups: individual patient data meta-analysis. BMJ, 348, Article g1340. https://doi.org/10.1136/bmj.g1340
- Hoek - ten Cate, A. (2014). Elastic compression stockings-is there any benefit?Lancet, 383(9920), 851-853. https://doi.org/10.1016/S0140-6736(13)62347-8
- Tragante, V., Barnes, M. R., Ganesh, S. K., Lanktree, M. B., Guo, W., Franceschini, N., Smith, E. N., Johnson, T., Holmes, M. V., Padmanabhan, S., Karczewski, K. J., Almoguera, B., Barnard, J., Baumert, J., Chang, Y.-P. C., Elbers, C. C., Farrall, M., Fischer, M. E., Gaunt, T. R., ... Keating, B. J. (2014). Gene-centric meta-analysis in 87,736 individuals of European ancestry identifies multiple blood-pressure-related loci. American Journal of Human Genetics, 94(3), 349-60. https://doi.org/10.1016/j.ajhg.2013.12.016
- Geenen, I. L., Verbruggen, S., Molin, D. G., Spronk, H. M., Maessen, J. G., Meesters, B., Schurink, G. W., & Post, M. J. (2014). Phenotypic Fitness of Primary Endothelial Cells Cultured from Patients with High Cardiovascular Risk or Chronic Kidney Disease for Vascular Tissue Engineering. Tissue Engineering - Part A: Research advances, 20(5-6), 1049-1059. https://doi.org/10.1089/ten.tea.2013.0163
- Spronk, H. M. H., de Jong, A. M., Crijns, H. J., Schotten, U., Van Gelder, I. C., & ten Cate, H. (2014). Pleiotropic effects of factor Xa and thrombin: what to expect from novel anticoagulants. Cardiovascular Research, 101(3), 344-351. https://doi.org/10.1093/cvr/cvt343
- Ninivaggi, M., Feijge, M. A. H., Baaten, C. C. F. M. J., Kuiper, G. J. A. J. M., Marcus, M. A. E., ten Cate, H., Lance, M. D., Heemskerk, J. W. M., & van der Meijden, P. E. J. (2014). Additive roles of platelets and fibrinogen in whole-blood fibrin clot formation upon dilution as assessed by thromboelastometry. Thrombosis and Haemostasis, 111(3), 447-457. https://doi.org/10.1160/TH13-06-0493
- Beijers, H. J. B. H., Ferreira, I., Bravenboer, B., Henry, R. M. A., Schalkwijk, C. G., Dekker, J. M., Nijpels, G., & Stehouwer, C. D. A. (2014). Higher central fat mass and lower peripheral lean mass are independent determinants of endothelial dysfunction in the elderly: The Hoorn study. Atherosclerosis, 233(1), 310-318. https://doi.org/10.1016/j.atherosclerosis.2013.12.002
- Segers, O., Simioni, P., Tormene, D., & Castoldi, E. (2014). Influence of single nucleotide polymorphisms on thrombin generation in factor V Leiden heterozygotes. Thrombosis and Haemostasis, 111(3), 438-446. https://doi.org/10.1160/TH13-05-0360
- Bosch, Y. P. J., al Dieri, R., ten Cate, H., Nelemans, P. J., Bloemen, S., de Laat, B., Hemker, C., Weerwind, P. W., Maessen, J. G., & Mochtar, B. (2014). Measurement of thrombin generation intra-operatively and its association with bleeding tendency after cardiac surgery. Thrombosis Research, 133(3), 488-494. https://doi.org/10.1016/j.thromres.2013.12.017
- Pop, A. S., Levenga, J., de Esch, C. E. F., Buijsen, R. A. M., Nieuwenhuizen, I. M., Li, T., Isaacs, A., Gasparini, F., Oostra, B. A., & Willemsen, R. (2014). Rescue of dendritic spine phenotype in Fmr1 KO mice with the mGluR5 antagonist AFQ056/Mavoglurant. Psychopharmacology, 231(6), 1227-35. https://doi.org/10.1007/s00213-012-2947-y
- Chevre, R., Maria Gonzalez-Granado, J., Megens, R. T. A., Sreeramkumar, V., Silvestre-Roig, C., Molina-Sanchez, P., Weber, C., Soehnlein, O., Hidalgo, A., & Andres, V. (2014). High-Resolution Imaging of Intravascular Atherogenic Inflammation in Live Mice. Circulation Research, 114(5), 770-779. https://doi.org/10.1161/CIRCRESAHA.114.302590
- Kamphuisen, P. W., & ten Cate, H. (2014). Cardiovascular risk in patients with hemophilia. Blood, 123(9), 1297-1301. https://doi.org/10.1182/blood-2013-11-453159
- Karagoz, G. E., Duarte, A. M. S., Akoury, E., Ippel, H., Biernat, J., Luengo, T. M., Radli, M., Didenko, T., Nordhues, B. A., Veprintsev, D. B., Dickey, C. A., Mandelkow, E., Zweckstetter, M., Boelens, R., Madl, T., & Rudiger, S. G. D. (2014). Hsp90-Tau Complex Reveals Molecular Basis for Specificity in Chaperone Action. Cell, 156(5), 963-974. https://doi.org/10.1016/j.cell.2014.01.037
- Chatzigeorgioua, A., Seijkens, T., Zarzycka, B., Engel, D., Poggi, M., van den Berg, S., van den Berg, S., Soehnlein, O., Winkels, H., Beckers, L., Lievens, D., Driessen, A., Kusters, P., Biessen, E., Garcia-Martin, R., Ameln, A. K., Gijbels, M., Noelle, R., Boon, L., ... Lutgens, E. (2014). Blocking CD40-TRAF6 signaling is a therapeutic target in obesity-associated insulin resistance. Proceedings of the National Academy of Sciences of the United States of America, 111(7), 2686-2691. https://doi.org/10.1073/pnas.1400419111
- Wildhagen, K. C. A. A., Garcia de Frutos, P., Reutelingsperger, C. P., Schrijver, R., Areste, C., Ortega-Gomez, A., Deckers, N. M., Hemker, H. C., Soehnlein, O., & Nicolaes, G. A. F. (2014). Nonanticoagulant heparin prevents histone-mediated cytotoxicity in vitro and improves survival in sepsis. Blood, 123(7), 1098-1101. https://doi.org/10.1182/blood-2013-07-514984
- Peloso, G. M., Auer, P. L., Bis, J. C., Voorman, A., Morrison, A. C., Stitziel, N. O., Brody, J. A., Khetarpal, S. A., Crosby, J. R., Fornage, M., Isaacs, A., Jakobsdottir, J., Feitosa, M. F., Davies, G., Huffman, J. E., Manichaikul, A., Davis, B., Lohman, K., Joon, A. Y., ... Cupples, L. A. (2014). Association of low-frequency and rare coding-sequence variants with blood lipids and coronary heart disease in 56,000 whites and blacks. American Journal of Human Genetics, 94(2), 223-32. https://doi.org/10.1016/j.ajhg.2014.01.009
- Lange, L. A., Hu, Y., Zhang, H., Xue, C., Schmidt, E. M., Tang, Z.-Z., Bizon, C., Lange, E. M., Smith, J. D., Turner, E. H., Jun, G., Kang, H. M., Peloso, G., Auer, P., Li, K.-P., Flannick, J., Zhang, J., Fuchsberger, C., Gaulton, K., ... NHLBI Grand Opportunity Exome Sequencing Project (2014). Whole-exome sequencing identifies rare and low-frequency coding variants associated with LDL cholesterol. American Journal of Human Genetics, 94(2), 233-45. https://doi.org/10.1016/j.ajhg.2014.01.010
- Tilstam, P. V., Gijbels, M. J., Habbeddine, M., Cudejko, C., Asare, Y., Theelen, W., Zhou, B., Doering, Y., Drechsler, M., Pawig, L., Simsekyilmaz, S., Koenen, R. R., de Winther, M. P. J., Lawrence, T., Bernhagen, J., Zernecke, A., Weber, C., & Noels, H. (2014). Bone Marrow-Specific Knock-In of a Non-Activatable Ikk alpha Kinase Mutant Influences Haematopoiesis but Not Atherosclerosis in Apoe-Deficient Mice. PLOS ONE, 9(2), Article e87452. https://doi.org/10.1371/journal.pone.0087452
- Aoqui, C., Chmielewski, S., Scherer, E., Eissler, R., Sollinger, D., Heid, I., Braren, R., Schmaderer, C., Megens, R. T. A., Weber, C., Heemann, U., Tschoep, M., & Baumann, M. (2014). Microvascular dysfunction in the course of metabolic syndrome induced by high-fat diet. Cardiovascular Diabetology, 13(1), Article 31. https://doi.org/10.1186/1475-2840-13-31
- Avery, C. L., Sitlani, C. M., Arking, D. E., Arnett, D. K., Bis, J. C., Boerwinkle, E., Buckley, B. M., Ida Chen, Y.-D., de Craen, A. J. M., Eijgelsheim, M., Enquobahrie, D., Evans, D. S., Ford, I., Garcia, M. E., Gudnason, V., Harris, T. B., Heckbert, S. R., Hochner, H., Hofman, A., ... Psaty, B. M. (2014). Drug-gene interactions and the search for missing heritability: a cross-sectional pharmacogenomics study of the QT interval. Pharmacogenomics Journal, 14(1), 6-13. https://doi.org/10.1038/tpj.2013.4



