Dominik Linz

Academic Staff

Dr Dominik Linz is a clinician-scientist who received his PhD from Maastricht University, The Netherlands, in 2013 (Prof. U. Schotten) and completed his Cardiology training in Homburg/Saar, Germany, in 2017 (Prof. M. Böhm). In 2017, he was recruited as an Associate Professor and clinical EP-fellow to Adelaide to initiate and drive a translational research programme focussing on atrial fibrillation and sleep disordered breathing at the Royal Adelaide Hospital and University of Adelaide (Prof. P. Sanders). Since 2019, Dr Dominik Linz is a Staff member and consultant clinician at the Haart en Vaatcentrum, Maastricht UMC+.

Over the past years Dr Dominik Linz has developed a National and International reputation in the field of cardiac arrhythmia research. The focus of this work has been to understand the pathophysiology and mechanisms underlying atrial arrhythmias and the development of treatment approaches. This research has broadly included: (i) Work describing sleep apnoea associated electrophysiological changes in the atria increasing atrial fibrillation susceptibility. (ii) Description of antiarrhythmic effects of autonomic modulation by renal sympathetic denervation under different pathophysiological conditions. (iii) Work describing the role of the lysosomal carboxypeptidase cathepsin A in the development of an atrial arrhythmogenic substrates. Ongoing research is mainly focused on risk factor modification and preventive interventions for AF.

Department of Cardiology

 

  • 2021
    • Mueller, P., Weijs, B., Bemelmans, N. M. A. A., Muegge, A., Eckardt, L., Crijns, H. J. G. M., Bax, J. J., Linz, D., & den Uijl, D. W. (2021). Echocardiography-derived total atrial conduction time (PA-TDI duration): risk stratification and guidance in atrial fibrillation management. Clinical research in cardiology, 110(11), 1734-1742. https://doi.org/10.1007/s00392-021-01917-9
    • Starczynski, M., Krzowski, B., Gawalko, M., Linz-, D., & Lodzinski, P. (2021). Impact of photoplethysmography on therapeutic decisions in atrial fibrillation. Kardiologia Polska, 79(10), 1155-1156. https://doi.org/10.33963/KP.a2021.0076
    • Elliott, A. D., Middeldorp, M. E., & Linz, D. K. (2021). The ins and outs of physical activity monitoring: implications for atrial fibrillation management. European Heart Journal, 42(38), 3989-3991. https://doi.org/10.1093/eurheartj/ehab520
    • Hermans, A. N. L., Pluymaekers, N. A. H. A., Lankveld, T. A. R., van Mourik, M. J. W., Zeemering, S., Dinh, T., den Uijl, D. W., Luermans, J. G. L. M., Vernooy, K., Crijns, H. J. G. M., Schotten, U., & Linz, D. (2021). Clinical utility of rhythm control by electrical cardioversion to assess the association between self-reported symptoms and rhythm status in patients with persistent atrial fibrillation. IJC Heart and Vasculature, 36, [100870]. https://doi.org/10.1016/j.ijcha.2021.100870
    • Chaldoupi, S. M., Luermans, J., Vernooy, K., & Linz, D. (2021). High-power short-duration ablation: The new standard for pulmonary vein isolation?IJC Heart and Vasculature, 36, [100865]. https://doi.org/10.1016/j.ijcha.2021.100865
    • Desteghe, L., Hendriks, J. M. L., Heidbuchel, H., Potpara, T. S., Lee, G. A., & Linz, D. (2021). Obstructive sleep apnoea testing and management in atrial fibrillation patients: a joint survey by the European Heart Rhythm Association (EHRA) and the Association of Cardiovascular Nurses and Allied Professions (ACNAP). EP Europace, 23(10), 1677-1684. https://doi.org/10.1093/europace/euab109
    • Hermans, A. N. L., Gawalko, M., Dohmen, L., van der Velden, R. M. J., Betz, K., Duncker, D., Verhaert, D. V. M., Heidbuchel, H., Svennberg, E., Neubeck, L., Eckstein, J., Lane, D. A., Lip, G. Y. H., Crijns, H. J. G. M., Sanders, P., Hendriks, J. M., Pluymaekers, N. A. H. A., & Linz, D. (2021). Mobile health solutions for atrial fibrillation detection and management: a systematic review. Clinical research in cardiology. https://doi.org/10.1007/s00392-021-01941-9
    • Gruwez, H., Evens, S., Proesmans, T., Duncker, D., Linz, D., Heidbuchel, H., Manninger, M., Vandervoort, P., Haemers, P., & Pison, L. (2021). Accuracy of Physicians Interpreting Photoplethysmography and Electrocardiography Tracings to Detect Atrial Fibrillation: INTERPRET-AF. Frontiers in cardiovascular medicine, 8, [734737]. https://doi.org/10.3389/fcvm.2021.734737
    • Fox, H., Arzt, M., Bergmann, M. W., Bitter, T., Linz, D., Oldenburg, O., Penzel, T., Rillig, A., Schobel, C., Sinha, A. M., Sommer, P., Spiesshofer, J., Stadler, S., & Skobel, C. E. (2021). Positionspapier „Schlafmedizin in der Kardiologie“, Update 2021. Der Kardiologe, 15(5), 429-461. https://doi.org/10.1007/s12181-021-00506-4
    • Cowie, M. R., Linz, D., Redline, S., Somers, V. K., & Simonds, A. K. (2021). Sleep Disordered Breathing and Cardiovascular Disease: JACC State-of-the-Art Review. Journal of the American College of Cardiology, 78(6), 608-624. https://doi.org/10.1016/j.jacc.2021.05.048
    • Linz, B., Sattler, S. M., Flethoj, M., Hansen, M. E. H., Hesselkilde, E. M., Saljic, A., Wirth, K., Linz, D., Tfelt-Hansen, J., & Jespersen, T. (2021). Arrhythmogenic mechanisms of acute obstructive respiratory events in a porcine model of drug-induced long QT. Heart Rhythm, 18(8), 1384-1391. https://doi.org/10.1016/j.hrthm.2021.03.017
    • Linz, D., Garcia, R., Guerra, F., Kommata, V., Bollmann, A., & Duncker, D. (2021). Twitter for professional use in electrophysiology: practical guide for #EPeeps. EP Europace, 23(8), 1192-1199. https://doi.org/10.1093/europace/euab048
    • Guerra, F., Linz, D., Garcia, R., Kommata, V., Kosiuk, J., Chun, J. L., Boveda, S., & Duncker, D. (2021). Use and misuse of instant messaging in clinical data sharing: the EHRA-SMS survey. EP Europace, 23(8), 1326-1330. https://doi.org/10.1093/europace/euab063
    • Linz, D., Linz, B., Dobrev, D., Baumert, M., Hendriks, J. M., Pepin, J-L., & Jespersen, T. (2021). Personalized management of sleep apnea in patients with atrial fibrillation: An interdisciplinary and translational challenge. IJC Heart & Vasculature, 35, [100843]. https://doi.org/10.1016/j.ijcha.2021.100843
    • Gawalko, M., Duncker, D., Manninger, M., van der Velden, R. M. J., Hermans, A. N. L., Verhaert, D. V. M., Pison, L., Pisters, R., Hemels, M., Sultan, A., Steven, D., Gupta, D., Heidbuchel, H., Sohaib, A., Wijtvliet, P., Tieleman, R., Gruwez, H., Chun, J. L., Schmidt, B., ... TeleCheck-AF investigators (2021). The European TeleCheck-AF project on remote app-based management of atrial fibrillation during the COVID-19 pandemic: centre and patient experiences. EP Europace, 23(7), 1003-1015. https://doi.org/10.1093/europace/euab050
    • Fisser, C., Bureck, J., Gall, L., Vaas, V., Priefert, J., Fredersdorf, S., Zeman, F., Linz, D., Wohrle, H., Tamisier, R., Teschler, H., Cowie, M. R., & Arzt, M. (2021). Ventricular arrhythmia in heart failure patients with reduced ejection fraction and central sleep apnoea. ERJ Open Research, 7(3), [00147-2021]. https://doi.org/10.1183/23120541.00147-2021
    • Scott, L., Fender, A. C., Saljic, A., Li, L., Chen, X., Wang, X., Linz, D., Lang, J., Hohl, M., Twomey, D., Pham, T. T., Diaz-Lankenau, R., Chelu, M. G., Kamler, M., Entman, M. L., Taffet, G. E., Sanders, P., Dobrev, D., & Li, N. (2021). NLRP3 inflammasome is a key driver of obesity-induced atrial arrhythmias. Cardiovascular Research, 117(7), 1746-1759. https://doi.org/10.1093/cvr/cvab024
    • Shahrbabaki, S. S., Linz, D., Hartmann, S., Redline, S., & Baumert, M. (2021). Sleep arousal burden is associated with long-term all-cause and cardiovascular mortality in 8001 community-dwelling older men and women. European Heart Journal, 42(21), 2088-2099. https://doi.org/10.1093/eurheartj/ehab151
    • Gawalko, M., Linz, D., & Dobrev, D. (2021). Gut-microbiota derived TMAO: A risk factor, a mediator or a bystander in the pathogenesis of atrial fibrillation?IJC Heart & Vasculature, 34, [100818]. https://doi.org/10.1016/j.ijcha.2021.100818
    • Pluymaekers, N. A. H. A., Dudink, E. A. M. P., Weijs, B., Vernooy, K., Hartgerink, D. E. J., Jacobs, J. S., Erkuner, O., Marcks, N. G. H. M., van Cauteren, Y. J. M., Dinh, T., ter Bekke, R. M. A., Sels, J. E. M. W., Delnoij, T. S. R., Geyik, Z., Driessen, R. G. H., Linz, D. K., den Uijl, D. W., Crijns, H. J. G. M., & Luermans, J. G. L. M. (2021). Clinical determinants of early spontaneous conversion to sinus rhythm in patients with atrial fibrillation. Netherlands Heart Journal, 29(5), 255-261. https://doi.org/10.1007/s12471-020-01528-5
    • Pluymaekers, N. A. H. A., van der Velden, R. M. J., Hermans, A. N. L., Gawalko, M., Buskes, S., Keijenberg, J. J. H. M. W., Vorstermans, B., Crijns, H. J. G. M., Hendriks, J. M., & Linz, D. (2021). On-Demand Mobile Health Infrastructure for Remote Rhythm Monitoring within a Wait-and-See Strategy for Recent-Onset Atrial Fibrillation: TeleWAS-AF. Cardiology, 146(3), 392-396. https://doi.org/10.1159/000514156
    • Hermans, A. N. L., Gawalko, M., Pluymaekers, N. A. H. A., Dinh, T., Weijs, B., van Mourik, M. J. W., Vorstermans, B., den Uijl, D. W., Opsteyn, L., Snippe, H., Vernooy, K., Crijns, H. J. G. M., Linz, D., & Luermans, J. G. L. M. (2021). Long-term intermittent versus short continuous heart rhythm monitoring for the detection of atrial fibrillation recurrences after catheter ablation. International Journal of Cardiology, 329, 105-112. https://doi.org/10.1016/j.ijcard.2020.12.077
    • Linz, D., Hermans, A., & Tieleman, R. G. (2021). Early atrial fibrillation detection and the transition to comprehensive management. EP Europace, 23, 46-51. https://doi.org/10.1093/europace/euaa424
    • Linz, D., Homberg, M., van der Velden, R. M. J., Bouman, E., Buhre, W., & Simons, S. O. (2021). Sleep apnea, obesity and COPD depress respiration during catheter ablation procedures: Implications for transcutaneous carbon dioxide monitoring. International Journal of Cardiology, 327, 102-104. https://doi.org/10.1016/j.ijcard.2020.10.080
    • Linz, D., Malfertheiner, M. V., Werner, N., Lerzer, C., Gfullner, F., Linz, B., Zeman, F., McEvoy, R. D., Arzt, M., & Baumert, M. (2021). Nocturnal hypoxemic burden during positive airway pressure treatment across different central sleep apnea etiologies. Sleep Medicine, 79, 62-70. https://doi.org/10.1016/j.sleep.2021.01.007
    • Lyon, A., van Mourik, M., Cruts, L., Heijman, J., Bekkers, S. C. A. M., Schotten, U., Crijns, H. J. G. M., Linz, D., & Lumens, J. (2021). Both beat-to-beat changes in RR-interval and left ventricular filling time determine ventricular function during atrial fibrillation. EP Europace, 23, I21-I28. https://doi.org/10.1093/europace/euaa387
    • Pluymaekers, N. A. H. A., Hermans, A. N. L., van der Velden, R. M. J., Gawalko, M., den Uijl, D. W., Buskes, S., Vernooy, K., Crijns, H. J. G. M., Hendriks, J. M., & Linz, D. (2021). Implementation of an on-demand app-based heart rate and rhythm monitoring infrastructure for the management of atrial fibrillation through teleconsultation: TeleCheck-AF. EP Europace, 23(3), 345-352. https://doi.org/10.1093/europace/euaa201
    • Vaas, V., Fisser, C., Tafelmeier, M., Linz, D., & Arzt, M. (2021). Interaktionen schlafbezogener Atmungsstörungen mit Vorhofflimmern. Somnologie, 25(1), 38-44. https://doi.org/10.1007/s11818-020-00271-8
    • Linz, B., Hohl, M., Lang, L., Wong, D. W. L., Nickel, A. G., De La Torre, C., Sticht, C., Wirth, K., Boor, P., Maack, C., Speer, T., Jespersen, T., Schotten, U., Sanders, P., Bohm, M., & Linz, D. (2021). Repeated exposure to transient obstructive sleep apnea-related conditions causes an atrial fibrillation substrate in a chronic rat model. Heart Rhythm, 18(3), 455-464. https://doi.org/10.1016/j.hrthm.2020.10.011
    • Hermans, B. J. M., & Linz, D. (2021). Abnormal electrograms during sinus rhythm for VT ablation: Beware of Fata Morganas. Journal of Cardiovascular Electrophysiology, 32(2), 389-390. https://doi.org/10.1111/jce.14855
    • Simons, S. O., Elliott, A., Sastry, M., Hendriks, J. M., Arzt, M., Rienstra, M., Kalman, J. M., Heidbuchel, H., Nattel, S., Wesseling, G., Schotten, U., van Gelder, I. C., Franssen, F. M. E., Sanders, P., Crijns, H. J. G. M., & Linz, D. (2021). Chronic obstructive pulmonary disease and atrial fibrillation an interdisciplinary perspective. European Heart Journal, 42(5), 532-540. https://doi.org/10.1093/eurheartj/ehaa822
    • Heijman, J., Linz, D., & Schotten, U. (2021). Dynamics of Atrial Fibrillation Mechanisms and Comorbidities. Annual Review of Physiology, 83, 83-106. https://doi.org/10.1146/annurev-physiol-031720-085307
  • 2020
    • Hendriks, J. M., & Linz, D. (2020). Screening for obstructive sleep apnoea in patients with atrial fibrillation: Much more than a screening tool alone. IJC Heart and Vasculature, 31, [100655]. https://doi.org/10.1016/j.ijcha.2020.100655
    • Linz, D., & Dobrev, D. (2020). Sleep apnea and atrial fibrillation: Update 2020. IJC Heart and Vasculature, 31, [100681]. https://doi.org/10.1016/j.ijcha.2020.100681
    • Hermans, A. N. L., Andrade, J. G., & Linz, D. (2020). Arterial Stiffness Association With Symptom Burden in Patients With Atrial Fibrillation: Direct Cause or Marker of Concomitant Risk Factors?Canadian Journal of Cardiology, 36(12), 1843-1846. https://doi.org/10.1016/j.cjca.2020.08.003
    • Linz, D., Loffler, K. A., Sanders, P., Catcheside, P., Anderson, C. S., Zheng, D., Quan, W., Barnes, M., Redline, S., McEvoy, R. D., Baumert, M., & SAVE (Sleep Apnea Cardiovascular Endpoints) Investigators (2020). Low Prognostic Value of Novel Nocturnal Metrics in Patients With OSA and High Cardiovascular Event Risk Post Hoc Analyses of the SAVE Study. Chest, 158(6), 2621-2631. https://doi.org/10.1016/j.chest.2020.06.072
    • Linz, D., & Duncker, D. (2020). Twitter in der Kardiologie: Praktische Anleitung für den professionellen Gebrauch. Herzschrittmachertherapie und Elektrophysiologie, 31(4), 388-393. https://doi.org/10.1007/s00399-020-00699-3
    • Hermans, A. N. L., van der Velden, R. M. J., Gawalko, M., Verhaert, D. V. M., Desteghe, L., Duncker, D., Manninger, M., Heidbuchel, H., Pisters, R., Hemels, M., Pison, L., Sohaib, A., Sultan, A., Steven, D., Wijtvliet, P., Tieleman, R., Gupta, D., Dobrev, D., Svennberg, E., ... TeleCheck-AF investigators (2020). On-demand mobile health infrastructures to allow comprehensive remote atrial fibrillation and risk factor management through teleconsultation. Clinical Cardiology, 43(11), 1232-1239. https://doi.org/10.1002/clc.23469
    • Bejinariu, A. G., Makimoto, H., Wakili, R., Mathew, S., Kosiuk, J., Linz, D., Steinfurt, J., Dechering, D. G., Meyer, C., Veltmann, C., Kelm, M., Frommeyer, G., Eckardt, L., Deneke, T., Duncker, D., & Muller, P. (2020). One-Year Course of Periprocedural Anticoagulation in Atrial Fibrillation Ablation: Results of a German Nationwide Survey. Cardiology, 145(10), 676-681. https://doi.org/10.1159/000509399
    • Linz, D., van der Velden, R. M. J., Gawalko, M., Hermans, A. N. L., Pluymaekers, N. A. H. A., & Hendriks, J. M. (2020). Remote management and education in patients with cardiovascular conditions during COVID-19 and beyond. IJC Heart and Vasculature, 30, [100646]. https://doi.org/10.1016/j.ijcha.2020.100646
    • Linz, D., & Hendriks, J. (2020). Central sleep apnea in atrial fibrillation: Risk factor or marker of untreated underlying disease?IJC Heart & Vasculature, 30, [100650]. https://doi.org/10.1016/j.ijcha.2020.100650
    • Gawalko, M., Kaplon-Cieslicka, A., Hohl, M., Dobrev, D., & Linz, D. (2020). COVID-19 associated atrial fibrillation: Incidence, putative mechanisms and potential clinical implications. IJC Heart & Vasculature, 30, [100631]. https://doi.org/10.1016/j.ijcha.2020.100631
    • Bogossian, H., Linz, D., Heijman, J., Bimpong-Buta, N-Y., Bandorski, D., Frommeyer, G., Erkapic, D., Seyfarth, M., Zarse, M., & Crijns, H. J. (2020). QTc evaluation in patients with bundle branch block. IJC Heart & Vasculature, 30, [100636]. https://doi.org/10.1016/j.ijcha.2020.100636
    • Pluymaekers, N. A. H. A., Linz, D. K., Rienstra, M., van Gelder, I. C., & Crijns, H. J. G. M. (2020). Emergency department cardioversion of acute atrial fibrillation. Lancet, 396(10255), 884-885. https://www.sciencedirect.com/science/article/pii/S0140673620313118
    • Hohl, M., Mayr, M., Lang, L., Nickel, A. G., Barallobre-Barreiro, J., Yin, X., Speer, T., Selejan, S-R., Goettsch, C., Erb, K., Fecher-Trost, C., Reil, J-C., Linz, B., Ruf, S., Huebschle, T., Maack, C., Boehm, M., Sadowski, T., & Linz, D. (2020). Cathepsin A contributes to left ventricular remodeling by degrading extracellular superoxide dismutase in mice. Journal of Biological Chemistry, 295(36), 12605-12617. https://doi.org/10.1074/jbc.RA120.013488
    • van der Velden, R. M. J., Hermans, A. N. L., Pluymaekers, N. A. H. A., Gawalko, M., Vorstermans, B., Martens, H., Buskes, S., Crijns, H. J. G. M., Linz, D., & Hendriks, J. M. (2020). Coordination of a remote mHealth infrastructure for atrial fibrillation management during COVID-19 and beyond: TeleCheck-AF. International Journal of Care Coordination, 23(2-3), 65-70. [2053434520954619]. https://doi.org/10.1177/2053434520954619
    • Linz, B., Saljic, A., Hohl, M., Gawalko, M., Jespersen, T., Sanders, P., Bohm, M., & Linz, D. (2020). Inhibition of sodium-proton-exchanger subtype 3-mediated sodium absorption in the gut: A new antihypertensive concept. IJC Heart & Vasculature, 29, [100591]. https://doi.org/10.1016/j.ijcha.2020.100591
    • De With, R. R., Erkuner, O., Rienstra, M., Nguyen, B-O., Korver, F. W. J., Linz, D., Ten, H. C., Spronk, H., Kroon, A. A., Maass, A. H., Blaauw, Y., Tieleman, R. G., Hemels, M. E. W., de Groot, J. R., Elvan, A., de Melis, M., Scheerder, C. O. S., Al-Jazairi, M. I. H., Schotten, U., ... RACE V Investigators (2020). Temporal patterns and short-term progression of paroxysmal atrial fibrillation data from RACE V. EP Europace, 22(8), 1162-1172. https://doi.org/10.1093/europace/euaa123
    • Gawalko, M., Jespersen, T., Dobrev, D., & Linz, D. (2020). The gut microbial-derived metabolite trimethylamine N-oxide: A missing link between lifestyle-components and atrial fibrillation?IJC Heart & Vasculature, 29, [100581]. https://doi.org/10.1016/j.ijcha.2020.100581
    • Khan, A., Hasan, F., Bandorski, D., Lemke, B., Linz, D., Zarse, M., Bimpong-Buta, N-Y., & Bogossian, H. (2020). Transaortic pulmonary vein isolation in the presence of situs inversus and total venous anomaly; technical capabilities for 3D reconstruction and considerations of adequate choice of ablation catheters. IJC Heart & Vasculature, 29, [100577]. https://doi.org/10.1016/j.ijcha.2020.100577