Dominik Linz

Academic Staff

Dr Dominik Linz is a clinician-scientist who received his PhD from Maastricht University, The Netherlands, in 2013 (Prof. U. Schotten) and completed his Cardiology training in Homburg/Saar, Germany, in 2017 (Prof. M. Böhm). In 2017, he was recruited as an Associate Professor and clinical EP-fellow to Adelaide to initiate and drive a translational research programme focussing on atrial fibrillation and sleep disordered breathing at the Royal Adelaide Hospital and University of Adelaide (Prof. P. Sanders). Since 2019, Dr Dominik Linz is a Staff member and consultant clinician at the Haart en Vaatcentrum, Maastricht UMC+.

Over the past years Dr Dominik Linz has developed a National and International reputation in the field of cardiac arrhythmia research. The focus of this work has been to understand the pathophysiology and mechanisms underlying atrial arrhythmias and the development of treatment approaches. This research has broadly included: (i) Work describing sleep apnoea associated electrophysiological changes in the atria increasing atrial fibrillation susceptibility. (ii) Description of antiarrhythmic effects of autonomic modulation by renal sympathetic denervation under different pathophysiological conditions. (iii) Work describing the role of the lysosomal carboxypeptidase cathepsin A in the development of an atrial arrhythmogenic substrates. Ongoing research is mainly focused on risk factor modification and preventive interventions for AF.

Department of Cardiology

 

  • 2020
    • Hohl, M., Mayr, M., Lang, L., Nickel, A. G., Barallobre-Barreiro, J., Yin, X., Speer, T., Selejan, S-R., Goettsch, C., Erb, K., Fecher-Trost, C., Reil, J-C., Linz, B., Ruf, S., Huebschle, T., Maack, C., Boehm, M., Sadowski, T., & Linz, D. (2020). Cathepsin A contributes to left ventricular remodeling by degrading extracellular superoxide dismutase in mice. Journal of Biological Chemistry, 295(36), 12605-12617. https://doi.org/10.1074/jbc.RA120.013488
    • Linz, B., Saljic, A., Hohl, M., Gawalko, M., Jespersen, T., Sanders, P., Bohm, M., & Linz, D. (2020). Inhibition of sodium-proton-exchanger subtype 3-mediated sodium absorption in the gut: A new antihypertensive concept. IJC Heart & Vasculature, 29, [100591]. https://doi.org/10.1016/j.ijcha.2020.100591
    • Gawalko, M., Jespersen, T., Dobrev, D., & Linz, D. (2020). The gut microbial-derived metabolite trimethylamine N-oxide: A missing link between lifestyle-components and atrial fibrillation?IJC Heart & Vasculature, 29, [100581]. https://doi.org/10.1016/j.ijcha.2020.100581
    • Khan, A., Hasan, F., Bandorski, D., Lemke, B., Linz, D., Zarse, M., Bimpong-Buta, N-Y., & Bogossian, H. (2020). Transaortic pulmonary vein isolation in the presence of situs inversus and total venous anomaly; technical capabilities for 3D reconstruction and considerations of adequate choice of ablation catheters. IJC Heart & Vasculature, 29, [100577]. https://doi.org/10.1016/j.ijcha.2020.100577
    • Linz, D., Pluymaekers, N. A. H. A., Hendriks, J. M., & TeleCheck-AF investigators (2020). TeleCheck-AF for COVID-19. European Heart Journal, 41(21), 1954-1955. https://doi.org/10.1093/eurheartj/ehaa404
    • Pluymaekers, N. A. H. A., Hermans, A. N. L., van der Velden, R. M. J., den Uijl, D. W., Vorstermans, B., Buskes, S., Hendriks, J. M., Vernooy, K., Crijns, H. J. G. M., & Linz, D. (2020). On-demand app-based rate and rhythm monitoring to manage atrial fibrillation through teleconsultations during COVID-19. IJC Heart & Vasculature, 28, [100533]. https://doi.org/10.1016/j.ijcha.2020.100533
    • Linz, B., Hohl, M., Mishima, R., Saljic, A., Lau, D. H., Jespersen, T., Schotten, U., Sanders, P., & Linz, D. (2020). Pharmacological inhibition of sodium-proton-exchanger subtype 3-mediated sodium absorption in the gut reduces atrial fibrillation susceptibility in obese spontaneously hypertensive rats. IJC Heart & Vasculature, 28, [100534]. https://doi.org/10.1016/j.ijcha.2020.100534
    • Linz, D., Linz, B., & Heijman, J. (2020). Sleep Apnea, Intermittent Hypoxemia, and Effects on Ischemic Myocardial Damage: Friend or Foe?Canadian Journal of Cardiology, 36(6), 809-812. https://doi.org/10.1016/j.cjca.2020.02.075
    • Gawalko, M., Elliott, A., Kadhim, K., Sanders, P., & Linz, D. (2020). A call for a more objective and longitudinal reporting of lifestyle components in cardiovascular research. IJC Heart & Vasculature, 27, [100506]. https://doi.org/10.1016/j.ijcha.2020.100506
    • Scheenstra, B., van't Hof, A., Spreeuwenberg, M., & Linz, D. (2020). From calculating cardiovascular risk factors in Honduras towards a universal cardiovascular risk model. IJC Heart & Vasculature, 27, [100485]. https://doi.org/10.1016/j.ijcha.2020.100485
  • 2019
    • Pluymaekers, N. A. H. A., Hermans, A. N. L., Middeldorp, M. E., Kadhim, K., Crijns, H. J. G. M., Sanders, P., & Linz, D. (2019). Gender differences and daily variation in atrial fibrillation risk factor profiles: Considerations for risk factor management. IJC Heart and Vasculature, 25, [100442]. https://doi.org/10.1016/j.ijcha.2019.100442
    • Linz, D., Ammirati, E., Dan, G-A., Heijman, J., & Dobrev, D. (2019). Highlights from the International Journal of Cardiology Heart & Vasculature: Heart failure, atrial fibrillation, coronary artery disease and myocardial infarction. IJC Heart and Vasculature, 25, [100443]. https://doi.org/10.1016/j.ijcha.2019.100443
    • Hendriks, J. M. L., Gallagher, C., Astley, C., Linz, D., & Gallagher, R. (2019). Cardiac rehabilitation services: A global perspective on performance and barriers. IJC Heart and Vasculature, 24, [100410]. https://doi.org/10.1016/j.ijcha.2019.100410
    • Lankveld, T. A. R., Vernooy, K., Crijns, H. J. G. M., & Linz, D. (2019). How to make catheter ablation available world-wide?IJC Heart and Vasculature, 24, [100411]. https://doi.org/10.1016/j.ijcha.2019.100411
    • den Uijl, D. W., Crijns, H. J. G. M., Vernooy, K., & Linz, D. (2019). Hypnotic communication during atrial fibrillation ablation: Another clinical application of hypnotherapy?IJC Heart and Vasculature, 24, [100408]. https://doi.org/10.1016/j.ijcha.2019.100408
    • Linz, D., Baumert, M., Desteghe, L., Kadhim, K., Vernooy, K., Kalman, J. M., Dobrev, D., Arzt, M., Sastry, M., Crijns, H. J. G. M., Schotten, U., Cowie, M. R., McEvoy, R. D., Heidbuchel, H., Hendriks, J., Sanders, P., & Lau, D. H. (2019). Nightly sleep apnea severity in patients with atrial fibrillation: Potential applications of long-term sleep apnea monitoring. IJC Heart and Vasculature, 24, 1-7. [100424]. https://doi.org/10.1016/j.ijcha.2019.100424
    • Khokhar, K. B., Lau, D. H., Sanders, P., & Linz, D. (2019). Risk profiling in atrial fibrillation: Value of assessment of vascular blush. IJC Heart and Vasculature, 24, [100399]. https://doi.org/10.1016/j.ijcha.2019.100399
    • Linz, D., Elliott, A. D., Hohl, M., Malik, V., Schotten, U., Dobrev, D., Nattel, S., Boehm, M., Floras, J., Lau, D. H., & Sanders, P. (2019). Role of autonomic nervous system in atrial fibrillation. International Journal of Cardiology, 287, 181-188. https://doi.org/10.1016/j.ijcard.2018.11.091
    • Hohl, M., Erb, K., Lang, L., Ruf, S., Hübschle, T., Dhein, S., Linz, W., Elliott, A. D., Sanders, P., Zamyatkin, O., Böhm, M., Schotten, U., Sadowski, T., & Linz, D. (2019). Cathepsin A Mediates Ventricular Remote Remodeling and Atrial Cardiomyopathy in Rats With Ventricular Ischemia/Reperfusion. JACC: Basic to Translational Science, 4(3), 332-344. https://doi.org/10.1016/j.jacbts.2019.01.008
  • 2017
    • Hohl, M., Lau, D. H., Mueller, A., Elliott, A. D., Linz, B., Mahajan, R., Hendriks, J. M. L., Boehn, M., Schotten, U., Sanders, P., & Linz, D. (2017). Concomitant Obesity and Metabolic Syndrome Add to the Atrial Arrhythmogenic Phenotype in Male Hypertensive Rats. Journal of the American Heart Association, 6(9), [006717]. https://doi.org/10.1161/JAHA.117.006717
    • Lau, D. H., Linz, D., Schotten, U., Mahajan, R., Sanders, P., & Kalman, J. M. (2017). Pathophysiology of Paroxysmal and Persistent Atrial Fibrillation: Rotors, Foci and Fibrosis. Heart Lung and Circulation, 26(9), 887-893. https://doi.org/10.1016/j.hlc.2017.05.119
    • Spronk, H. M. H., De Jong, A. M., Verheule, S., De Boer, H. C., Maass, A. H., Lau, D. H., Rienstra, M., van Hunnik, A., Kuiper, M., Lumeij, S., Zeemering, S., Linz, D., Kamphuisen, P. W., ten Cate, H., Crijns, H. J., Van Gelder, I. C., van Zonneveld, A. J., & Schotten, U. (2017). Hypercoagulability causes atrial fibrosis and promotes atrial fibrillation. European Heart Journal, 38(1), 38-50. https://doi.org/10.1093/eurheartj/ehw119
  • 2016
    • Linz, D., Hohl, M., Dhein, S., Ruf, S., Reil, J-C., Kabiri, M., Wohlfart, P., Verheule, S., Boehm, M., Sadowski, T., & Schotten, U. (2016). Cathepsin A mediates susceptibility to atrial tachyarrhythmia and impairment of atrial emptying function in Zucker diabetic fatty rats. Cardiovascular Research, 110(3), 371-380. https://doi.org/10.1093/cvr/cvw071
  • 2015
    • Linz, D., van Hunnik, A., Hohl, M., Mahfoud, F., Wolf, M., Neuberger, H-R., Casadei, B., Reilly, S. N., Verheule, S., Boehm, M., & Schotten, U. (2015). Catheter-Based Renal Denervation Reduces Atrial Nerve Sprouting and Complexity of Atrial Fibrillation in Goats. Circulation-Arrhythmia and Electrophysiology, 8(2), 466-U294. https://doi.org/10.1161/CIRCEP.114.002453
  • 2014
    • Linz, D., Hunnik, A. V., Ukena, C., Mahfoud, F., Ewen, S., Verheule, S., Böhm, M., & Schotten, U. (2014). Effects of renal denervation on atrial arrhythmogenesis. Future Cardiology, 10(6), 813-22. https://doi.org/10.2217/fca.14.43
    • Linz, D., van Hunnik, A., Ukena, C., Ewen, S., Mahfoud, F., Schirmer, S. H., Lenski, M., Neuberger, H-R., Schotten, U., & Boehm, M. (2014). Renal denervation: effects on atrial electrophysiology and arrhythmias. Clinical research in cardiology, 103(10), 765-774. https://doi.org/10.1007/s00392-014-0695-1
    • Verheule, S., Eckstein, J., Linz, D., Maesen, B., Bidar, E., Gharaviri, A., & Schotten, U. (2014). Role of endo-epicardial dissociation of electrical activity and transmural conduction in the development of persistent atrial fibrillation. Progress in Biophysics & Molecular Biology, 115(2-3), 173-185. https://doi.org/10.1016/j.pbiomolbio.2014.07.007
    • Hohl, M., Ardehali, H., Azuaje, F. J., Breckenridge, R. A., Doehner, W., Eaton, P., Ehret, G. B., Fujita, T., Gaetani, R., Giacca, M., Hasenfuss, G., Heymans, S., Leite-Moreira, A. F., Linke, W. A., Linz, D., Lyon, A., Mamas, M. A., Oresic, M., Papp, Z., ... Maack, C. (2014). Meeting highlights from the 2013 European Society of Cardiology Heart Failure Association Winter Meeting on Translational Heart Failure Research. European journal of heart failure, 16(1), 6-14. https://doi.org/10.1002/ejhf.10
  • 2013
    • Linz, D., Mahfoud, F., Schotten, U., Ukena, C., Neuberger, H-R., Wirth, K., & Boehm, M. (2013). Effects of Electrical Stimulation of Carotid Baroreflex and Renal Denervation on Atrial Electrophysiology. Journal of Cardiovascular Electrophysiology, 24(9), 1028-1033. https://doi.org/10.1111/jce.12171
    • Eckstein, J., Zeemering, S., Linz, D., Maesen, B., Verheule, S., van Hunnik, A., Crijns, H., Allessie, M. A., & Schotten, U. (2013). Transmural Conduction Is the Predominant Mechanism of Breakthrough During Atrial Fibrillation Evidence From Simultaneous Endo-Epicardial High-Density Activation Mapping. Circulation-Arrhythmia and Electrophysiology, 6(2), 334-341. https://doi.org/10.1161/CIRCEP.113.000342
    • Linz, D., Mahfoud, F., Schotten, U., Ukena, C., Hohl, M., Neuberger, H-R., Wirth, K., & Bohm, M. (2013). Renal Sympathetic Denervation Provides Ventricular Rate Control But Does Not Prevent Atrial Electrical Remodeling During Atrial Fibrillation. Hypertension, 61(1), 225-231. https://doi.org/10.1161/HYPERTENSIONAHA.111.00182
  • 2012
    • Linz, D., Mahfoud, F., Schotten, U., Ukena, C., Neuberger, H-R., Wirth, K., & Boehm, M. (2012). Renal Sympathetic Denervation Suppresses Postapneic Blood Pressure Rises and Atrial Fibrillation in a Model for Sleep Apnea. Hypertension, 60(1), 172-178. https://doi.org/10.1161/HYPERTENSIONAHA.112.191965
    • Daniels, A., Linz, D., van Bilsen, M., Ruetten, H., Sadowski, T., Ruf, S., Juretschke, H-P., Neumann-Haefelin, C., Munts, C., van der Vusse, G. J., & van Nieuwenhoven, F. A. (2012). Long-term severe diabetes only leads to mild cardiac diastolic dysfunction in Zucker diabetic fatty rats. European journal of heart failure, 14(2), 193-201. https://doi.org/10.1093/eurjhf/hfr166
  • 2011
    • Linz, D., Schotten, U., Neuberger, H-R., Boehm, M., & Wirth, K. (2011). Combined blockade of early and late activated atrial potassium currents suppresses atrial fibrillation in a pig model of obstructive apnea. Heart Rhythm, 8(12), 1933-1939. https://doi.org/10.1016/j.hrthm.2011.07.018
    • Linz, D., Schotten, U., Neuberger, H-R., Boehm, M., & Wirth, K. (2011). Negative tracheal pressure during obstructive respiratory events promotes atrial fibrillation by vagal activation. Heart Rhythm, 8(9), 1436-1443. https://doi.org/10.1016/j.hrthm.2011.03.053
    • Eckstein, J., Maesen, B., Linz, D., Zeemering, S., van Hunnik, A., Verheule, S., Allessie, M., & Schotten, U. (2011). Time course and mechanisms of endo-epicardial electrical dissociation during atrial fibrillation in the goat. Cardiovascular Research, 89(4), 816-824. https://doi.org/10.1093/cvr/cvq336