• 2016
    • Linz, D., Hohl, M., Dhein, S., Ruf, S., Reil, J.-C., Kabiri, M., Wohlfart, P., Verheule, S., Boehm, M., Sadowski, T., & Schotten, U. (2016). Cathepsin A mediates susceptibility to atrial tachyarrhythmia and impairment of atrial emptying function in Zucker diabetic fatty rats. Cardiovascular Research, 110(3), 371-380. https://doi.org/10.1093/cvr/cvw071
    • Zwanenburg, A., Hermans, B. J. M., Andriessen, P., Niemarkt, H. J., Jellema, R. K., Ophelders, D. R. M. G., Vullings, R., Wolfs, T. G. A. M., Kramer, B. W., & Delhaas, T. (2016). Comparison of ECG-based physiological markers for hypoxia in a preterm ovine model. Pediatric Research, 79(6), 907-915. https://doi.org/10.1038/pr.2016.21
    • Ophelders, D. R. M. G., Wolfs, T. G. A. M., Jellema, R. K., Zwanenburg, A., Andriessen, P., Delhaas, T., Ludwig, A.-K., Radtke, S., Peters, V., Janssen, L., Giebel, B., & Kramer, B. W. (2016). Mesenchymal Stromal Cell-Derived Extracellular Vesicles Protect the Fetal Brain After Hypoxia-Ischemia. Stem Cells Translational Medicine, 5(6), 754-763. https://doi.org/10.5966/sctm.2015-0197
    • Baumert, M., Porta, A., Vos, M. A., Malik, M., Couderc, J.-P., Laguna, P., Piccirillo, G., Smith, G. L., Tereshchenko, L. G., & Volders, P. G. A. (2016). QT interval variability in body surface ECG: measurement, physiological basis, and clinical value: position statement and consensus guidance endorsed by the European Heart Rhythm Association jointly with the ESC Working Group on Cardiac Cellular Electrophysiology. EP Europace, 18(6), 925-944. https://doi.org/10.1093/europace/euv405
    • Reilly, S. N., Liu, X., Carnicer, R., Recalde, A., Muszkiewicz, A., Jayaram, R., Carena, M. C., Wijesurendra, R., Stefanini, M., Surdo, N. C., Lomas, O., Ratnatunga, C., Sayeed, R., Krasopoulos, G., Rajakumar, T., Bueno-Orovio, A., Verheule, S., Fulga, T. A., Rodriguez, B., ... Casadei, B. (2016). Up-regulation of miR-31 in human atrial fibrillation begets the arrhythmia by depleting dystrophin and neuronal nitric oxide synthase. Science Translational Medicine, 8(340), Article 340ra74. https://doi.org/10.1126/scitranslmed.aac4296
    • Lau, D. H., Schotten, U., Mahajan, R., Antic, N. A., Hatem, S. N., Pathak, R. K., Hendriks, J. M. L., Kalman, J. M., & Sanders, P. (2016). Novel mechanisms in the pathogenesis of atrial fibrillation: practical applications. European Heart Journal, 37(20), 1573–1581. https://doi.org/10.1093/eurheartj/ehv375
    • Wellens, H., Lindemans, F. W., Houben, R. P., Gorgels, A., Volders, P. G., ter Bekke, R. M. A., & Crijns, H. J. (2016). Improving survival after out-of-hospital cardiac arrest requires new tools. European Heart Journal, 37(19), 1499-1503. https://doi.org/10.1093/eurheartj/ehv485
    • Heijman, J., & Dobrev, D. (2016). Challenges to the translation of basic science findings to atrial fibrillation therapies. Future Cardiology, 12(3), 251-254. https://doi.org/10.2217/fca-2016-0007
    • Schotten, U., Dobrev, D., Platonov, P. G., Kottkamp, H., & Hindricks, G. (2016). Current controversies in determining the main mechanisms of atrial fibrillation. Journal of Internal Medicine, 279(5), 428-438. https://doi.org/10.1111/joim.12492
    • Upendra Walavalkar, V., Evers, E., Pujar, S., Viralam, K., Maiya, S., Frerich, S., John, C., Rao, S., Reddy, C., Spronck, B., Prinzen, F., Delhaas, T., & Vanagt, W. Y. (2016). Preoperative Sildenafil administration in children undergoing cardiac surgery: a randomized controlled preconditioning study. European Journal of Cardio-Thoracic Surgery, 49(5), 1403-1410. https://doi.org/10.1093/ejcts/ezv353
    • Lankveld, T., de Vos, C. B., Limantoro, I., Zeemering, S., Dudink, E., Crijns, H. J., & Schotten, U. (2016). Systematic analysis of ECG predictors of sinus rhythm maintenance after electrical cardioversion for persistent atrial fibrillation. Heart Rhythm, 13(5), 1020-1027. https://doi.org/10.1016/j.hrthm.2016.01.004
    • Van Gelder, I. C., Hobbelt, A. H., Marcos, E. G., Schotten, U., Cappato, R., Lewalter, T., Schwieler, J., Rienstra, M., & Boriani, G. (2016). Tailored treatment strategies: a new approach for modern management of atrial fibrillation. Journal of Internal Medicine, 279(5), 457-466. https://doi.org/10.1111/joim.12489
    • Wang, Y., Molin, D. G. M., Sevrin, C., Grandfils, C., van den Akker, N. M. S., Gagliardi, M., Knetsch, M. L., Delhaas, T., & Koole, L. (2016). In vitro and in vivo evaluation of drug-eluting microspheres designed for transarterial chemoembolization therapy. International Journal of Pharmaceutics, 503(1-2), 150-162. https://doi.org/10.1016/j.ijpharm.2016.03.002
    • Cardinaels, E. P. M., Altintas, S., Versteylen, M. O., Joosen, I. A., Jellema, L.-J. C., Wildberger, J. E., Das, M., Crijns, H. J., Bekers, O., van Dieijen-Visser, M. P., Kietselaer, B. L., & Mingels, A. M. A. (2016). High-Sensitivity Cardiac Troponin Concentrations in Patients with Chest Discomfort: Is It the Heart or the Kidneys As Well?PLOS ONE, 11(4), Article e0153300. https://doi.org/10.1371/journal.pone.0153300
    • Opacic, D., van Bragt, K. A., Nasrallah, H. M., Schotten, U., & Verheule, S. (2016). Atrial metabolism and tissue perfusion as determinants of electrical and structural remodelling in atrial fibrillation. Cardiovascular Research, 109(4), 527-541. https://doi.org/10.1093/cvr/cvw007
    • Heijman, J., Algalarrondo, V., Voigt, N., Melka, J., Wehrens, X. H. T., Dobrev, D., & Nattel, S. (2016). The value of basic research insights into atrial fibrillation mechanisms as a guide to therapeutic innovation: a critical analysis. Cardiovascular Research, 109(4), 467-479. https://doi.org/10.1093/cvr/cvv275
    • Kirchhof, P., Goette, A., Naebauer, M., & Schotten, U. (2016). 12 Jahre AFNET. Vom Forschungsnetzwerk zur Academic Research Organisation. Bundesgesundheitsblatt-Gesundheitsforschung-Gesundheitsschutz, 59(4), 514-522. https://doi.org/10.1007/s00103-016-2323-x
    • Spronck, B., Megens, R. T. A., Reesink, K. D., & Delhaas, T. (2016). A method for three-dimensional quantification of vascular smooth muscle orientation: application in viable murine carotid arteries. Biomechanics and modeling in mechanobiology, 15(2), 419-432. https://doi.org/10.1007/s10237-015-0699-4
    • van Hunnik, A., Lau, D. H., Zeemering, S., Kuiper, M., Verheule, S., & Schotten, U. (2016). Antiarrhythmic effect of vernakalant in electrically remodeled goat atria is caused by slowing of conduction and prolongation of postrepolarization refractoriness. Heart Rhythm, 13(4), 964-972. https://doi.org/10.1016/j.hrthm.2015.12.009
    • ten Sande, J. N., Postema, P. G., Boekholdt, S. M., Tan, H. L., van der Heijden, J. F., de Groot, N. M. S., Volders, P. G. A., Zeppenfeld, K., Boersma, L. V. A., Nannenberg, E. A., Christiaans, I., & Wilde, A. A. M. (2016). Detailed characterization of familial idiopathic ventricular fibrillation linked to the DPP6 locus. Heart Rhythm, 13(4), 905-912. https://doi.org/10.1016/j.hrthm.2015.12.006
    • Fabritz, L., Guasch, E., Antoniades, C., Bardinet, I., Benninger, G., Betts, T. R., Brand, E., Breithardt, G., Bucklar-Suchankova, G., Camm, A. J., Cartlidge, D., Casadei, B., Chua, W. W., Crijns, H., Deeks, J., Hatem, S., Hidden-Lucet, F., Kääb, S., Maniadakis, N., ... Kirchhof, P. (2016). Expert consensus document: Defining the major health modifiers causing atrial fibrillation: a roadmap to underpin personalized prevention and treatment. Nature Reviews Cardiology, 13(4), 230-237. https://doi.org/10.1038/nrcardio.2015.194
    • Gast, M., Schroen, B., Voigt, A., Haas, J., Kuehl, U., Lassner, D., Skurk, C., Escher, F., Wang, X., Kratzer, A., Michalik, K., Papageorgiou, A., Peters, T., Loebel, M., Wilk, S., Althof, N., Prasanth, K. V., Katus, H., Meder, B., ... Poller, W. (2016). Long noncoding RNA MALAT1-derived mascRNA is involved in cardiovascular innate immunity. Journal of Molecular Cell Biology, 8(2), 178-181. https://doi.org/10.1093/jmcb/mjw003
    • Schmidt, C., Wiedmann, F., Voigt, N., Zhou, X.-B., Heijman, J., Lang, S., Albert, V., Kallenberger, S., Ruhparwar, A., Szabo, G., Kallenbach, K., Karck, M., Borggrefe, M., Biliczki, P., Ehrlich, J. R., Baczko, I., Lugenbiel, P., Schweizer, P. A., Donner, B. C., ... Thomas, D. (2016). Response to Letter Regarding Article, "Upregulation of K 2P 3.1 K+ Current Causes Action Potential Shortening in Patients With Chronic Atrial Fibrillation". Circulation, 133(11), E440-E441. https://doi.org/10.1161/CIRCULATIONAHA.115.020662
    • Antonopoulos, A. S., Margaritis, M., Verheule, S., Recalde, A., Sanna, F., Herdman, L., Psarros, C., Nasrallah, H., Coutinho, P., Akoumianakis, I., Brewer, A. C., Sayeed, R., Krasopoulos, G., Petrou, M., Tarun, A., Tousoulis, D., Shah, A. M., Casadei, B., Channon, K. M., & Antoniades, C. (2016). Mutual Regulation of Epicardial Adipose Tissue and Myocardial Redox State by PPAR-gamma/Adiponectin Signalling. Circulation Research, 118(5), 842-855. https://doi.org/10.1161/CIRCRESAHA.115.307856
    • Spronck, B., Delhaas, T., op het Roodt, J., & Reesink, K. D. (2016). Carotid Artery Applanation Tonometry Does Not Cause Significant Baroreceptor Activation. American Journal of Hypertension, 29(3), 299-302. https://doi.org/10.1093/ajh/hpv064
    • Lozekoot, P. W. J., de Jong, M. M. J., Gelsomino, S., Parise, O., Matteucci, F., Luca, F., Kumar, N., Nijs, J., Czapla, J., Kwant, P. B., Bani, D., Gensini, G. F., Pison, L., Crijns, H. J. G. M., Maessen, J. G., & La Meir, M. (2016). Contact forces during hybrid atrial fibrillation ablation: an in vitro evaluation. Journal of Interventional Cardiac Electrophysiology, 45(2), 189-197. https://doi.org/10.1007/s10840-015-0089-y
    • Mafi-Rad, M., Luermans, J. G. L. M., Blaauw, Y., Janssen, M., Crijns, H. J., Prinzen, F. W., & Vernooy, K. (2016). Feasibility and Acute Hemodynamic Effect of Left Ventricular Septal Pacing by Transvenous Approach Through the Interventricular Septum. Circulation-Arrhythmia and Electrophysiology, 9(3), Article e003344. https://doi.org/10.1161/CIRCEP.115.003344
    • Van Dijk, V. F., Liebregts, M., Luermans, J. G. L. M., & Balt, J. C. (2016). Inappropriate Shock Due to T-Wave Oversensing by a Subcutaneous ICD after Alcohol Septal Ablation for Hypertrophic Cardiomyopathy. Pacing and Clinical Electrophysiology, 39(3), 307-309. https://doi.org/10.1111/pace.12784
    • Peters, T., Beijnsberger, S., Beqqali, A., Bitsch, N., Nakagawa, S., Prasanth, K. V., de Windt, L. J., van Oort, R. J., Heymans, S., & Schroen, B. (2016). Long Non-Coding RNA Malat-1 Is Dispensable during Pressure Overload-Induced Cardiac Remodeling and Failure in Mice. PLOS ONE, 11(2), Article e0150236. https://doi.org/10.1371/journal.pone.0150236
    • Heijman, J., Abdoust, P. E., Voigt, N., Nattel, S., & Dobrev, D. (2016). Computational models of atrial cellular electrophysiology and calcium handling, and their role in atrial fibrillation. Journal of Physiology, 594(3), 537-553. https://doi.org/10.1113/JP271404
    • Walmsley, J., Huntjens, P. R., Prinzen, F. W., Delhaas, T., & Lumens, J. (2016). Septal flash and septal rebound stretch have different underlying mechanisms. American Journal of Physiology-heart and Circulatory Physiology, 310(3), H394-H403. https://doi.org/10.1152/ajpheart.00639.2015
    • Schueth, A., Spronck, B., van Zandvoort, M. A. M. J., & van Koeveringe, G. A. (2016). Age-related changes in murine bladder structure and sensory innervation: a multiphoton microscopy quantitative analysis. Age, 38(1), Article 17. https://doi.org/10.1007/s11357-016-9878-1
    • Lankveld, T., Zeemering, S., Scherr, D., Kuklik, P., Hoffmann, B. A., Willems, S., Pieske, B., Haissaguerre, M., Jais, P., Crijns, H. J., & Schotten, U. (2016). Atrial Fibrillation Complexity Parameters Derived From Surface ECGs Predict Procedural Outcome and Long-Term Follow-Up of Stepwise Catheter Ablation for Atrial Fibrillation. Circulation-Arrhythmia and Electrophysiology, 9(2), Article e003354. https://doi.org/10.1161/CIRCEP.115.003354
    • Zusterzeel, R., Selzman, K. A., Sanders, W. E., O'Callaghan, K. M., Canos, D. A., Vernooy, K., Prinzen, F. W., Gorgels, A., & Strauss, D. G. (2016). Toward Sex-Specific Guidelines for Cardiac Resynchronization Therapy?Journal of Cardiovascular Translational Research, 9(1), 12-22. https://doi.org/10.1007/s12265-015-9663-z
    • Spronck, B., Walmsley, J., Palau-Caballero, G., Reesink, K. D., & Delhaas, T. (2016). Can significance of aortic sinus vortices be assessed using the assumptions in the model of Aboelkassem et al.?Journal of Theoretical Biology, 389, 304-305. https://doi.org/10.1016/j.jtbi.2015.05.032
    • Kirchhof, P., Breithardt, G., Bax, J., Benninger, G., Blomstrom-Lundqvist, C., Boriani, G., Brandes, A., Brown, H., Brueckmann, M., Calkins, H., Calvert, M., Christoffels, V., Crijns, H., Dobrev, D., Ellinor, P., Fabritz, L., Fetsch, T., Freedman, S. B., Gerth, A., ... Camm, A. J. (2016). A roadmap to improve the quality of atrial fibrillation management: proceedings from the fifth Atrial Fibrillation Network/European Heart Rhythm Association consensus conference. EP Europace, 18(1), 37-50. https://doi.org/10.1093/europace/euv304
    • Willems, M. G. M., Ophelders, D. R. M. G., Nikiforou, M., Jellema, R. K., Butz, A., Delhaas, T., Kramer, B. W., & Wolfs, T. G. A. M. (2016). Systemic interleukin-2 administration improves lung function and modulates chorioamnionitis-induced pulmonary inflammation in the ovine fetus. American Journal of Physiology-Lung Cellular and Molecular Physiology, 310(1), L1-L7. https://doi.org/10.1152/ajplung.00289.2015
    • van Stipdonk, A. M. W., Rad, M. M., Luermans, J. G. L. M., Crijns, H. J., Prinzen, F. W., & Vernooy, K. (2016). Identifying delayed left ventricular lateral wall activation in patients with non-specific intraventricular conduction delay using coronary venous electroanatomical mapping. Netherlands Heart Journal, 24(1), 58-65. https://doi.org/10.1007/s12471-015-0777-3
    • Clerx, M., Collins, P., De Lange, E., & Volders, P. G. A. (2016). Myokit: A simple interface to cardiac cellular electrophysiology. Progress in Biophysics & Molecular Biology, 120(1-3), 100-114. https://doi.org/10.1016/j.pbiomolbio.2015.12.008
    • Wiegerinck, R. F., Schreurs, R., & Prinzen, F. W. (2016). Pathophysiology of dyssynchrony: of squirrels and broken bones. Netherlands Heart Journal, 24(1), 4-10. https://doi.org/10.1007/s12471-015-0765-7
    • Van Aelst, L. N. L., Summer, G., Li, S., Gupta, S. K., Heggermont, W., De Vusser, K., Carai, P., Naesens, M., Van Cleemput, J., Van de Werf, F., Vanhaecke, J., Thum, T., Waer, M., Papageorgiou, A. .-P., Schroen, B., & Heymans, S. (2016). RNA Profiling in Human and Murine Transplanted Hearts: Identification and Validation of Therapeutic Targets for Acute Cardiac and Renal Allograft Rejection. American Journal of Transplantation, 16(1), 99-110. https://doi.org/10.1111/ajt.13421
    • Rad, M. M., Wijntjens, G. W. M., Engels, E. B., Blaauw, Y., Luermans, J. G. L. M., Pison, L., Crijns, H. J., Prinzen, F. W., & Vernooy, K. (2016). Vectorcardiographic QRS area identifies delayed left ventricular lateral wall activation determined by electroanatomic mapping in candidates for cardiac resynchronization therapy. Heart Rhythm, 13(1), 217-225. https://doi.org/10.1016/j.hrthm.2015.07.033
    • Rademakers, L. M., van Hunnik, A., Kuiper, M., Vernooy, K., van Gelder, B., Bracke, F. A., & Prinzen, F. (2016). A Possible Role for Pacing the Left Ventricular Septum in Cardiac Resynchronization Therapy. JACC: Clinical Electrophysiology, 2(4), 413-422. https://doi.org/10.1016/j.jacep.2016.01.010
    • Molina, C. E., Heijman, J., & Dobrev, D. (2016). Differences in Left Versus Right Ventricular Electrophysiological Properties in Cardiac Dysfunction and Arrhythmogenesis. Arrhythmia & Electrophysiology Review, 5(1), 14-9. https://doi.org/10.15420/AER.2016.8.2
    • Potse, M., Lankveld, T. A. R., Zeemering, S., Dagnelie, P. C., Stehouwer, C. D. A., Henry, R. M., Linnenbank, A. C., Kuijpers, N. H. L., & Schotten, U. (2016). P-wave complexity in normal subjects and computer models. Journal of Electrocardiology, 49(4), 545-553. https://doi.org/10.1016/j.jelectrocard.2016.05.005
    • Lozekoot, P. W. J., de Jong, M. M. J., Parise, O., Matteucci, F., Luca, F., Kumar, N., Bani, D., Czapla, J., Pison, L., Crijns, H. J. G. M., Maessen, J. G., La Meir, M., & Gelsomino, S. (2016). The ABLA-BOX An In Vitro Module of Hybrid Atrial Fibrillation Ablation. Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery, 11(3), 201-209. https://doi.org/10.1097/IMI.0000000000000256