PI group Paul Volders
- 2023
- Verheul, L. M., van der Ree, M. H., Groeneveld, S. A., Mulder, B. A., Christiaans, I., Kapel, G. F. L., Alings, M., Bootsma, M., Barge-Schaapveld, D. Q. C. M., Balt, J. C., Yap, S-C., Krapels, I. P. C., Ter Bekke, R. M. A., Volders, P. G. A., van der Crabben, S. N., Postema, P. G., Wilde, A. A. M., Dooijes, D., Baas, A. F., & Hassink, R. J. (2023). The genetic basis of apparently idiopathic ventricular fibrillation: a retrospective overview. EP Europace, 25(11). https://doi.org/10.1093/europace/euad336
- Herrera, N. T., Zhang, X., Ni, H., Maleckar, M. M., Heijman, J., Dobrev, D., Grandi, E., & Morotti, S. (2023). Dual effects of the small-conductance Ca2+-activated K+ current on human atrial electrophysiology and Ca2+-driven arrhythmogenesis: an in silico study. American Journal of Physiology-heart and Circulatory Physiology, 325(4), H896-H908. https://doi.org/10.1152/ajpheart.00362.2023
- Steffens, S., Schröder, K., Krüger, M., Maack, C., Streckfuss-Bömeke, K., Backs, J., Backofen, R., Baeßler, B., Devaux, Y., Gilsbach, R., Heijman, J., Knaus, J., Kramann, R., Linz, D., Lister, A. L., Maatz, H., Maegdefessel, L., Mayr, M., Meder, B., ... Kohl, P. (2023). The challenges of research data management in cardiovascular science: a DGK and DZHK position paper-executive summary. Clinical research in cardiology. Advance online publication. https://doi.org/10.1007/s00392-023-02303-3
- Buonocunto, M., Lyon, A., Delhaas, T., Heijman, J., & Lumens, J. (2023). Electrophysiological effects of stretch-activated ion channels: a systematic computational characterization. The Journal of Physiology. Advance online publication. https://doi.org/10.1113/JP284439
- Filgueiras-Rama, D., Ramos-Prada, A., & Cluitmans, M. J. M. (2023). Arrhythmogenic vulnerability of reentrant pathways in post-infarct ventricular tachycardia assessed by advanced computational modelling. EP Europace, 25(9), Article euad258. https://doi.org/10.1093/europace/euad258
- Stevens, R. R. F., Hazelaar, C., Bogowicz, M., Ter Bekke, R. M. A., Volders, P. G. A., Verhoeven, K., de Ruysscher, D., Verhoeff, J. J. C., Fast, M. F., Mandija, S., Cvek, J., Knybel, L., Dvorak, P., Blanck, O., & van Elmpt, W. (2023). A framework for assessing the impact of cardiac and respiratory motion for STereotactic Arrhythmia Radioablation (STAR) using a digital phantom with a 17-segment model - A STOPSTORM.eu consortium study. International Journal of Radiation Oncology Biology Physics. Advance online publication. https://doi.org/10.1016/j.ijrobp.2023.08.059
- Remme, C. A., Heijman, J., Gomez, A. M., Zaza, A., & Odening, K. E. (2023). 25 years of basic and translational science in EP Europace: novel insights into arrhythmia mechanisms and therapeutic strategies. EP Europace, 25(8), 1-11. Article euad210. https://doi.org/10.1093/europace/euad210
- Heijman, J., & Christ, T. (2023). Mind the gap: Leak currents and induced pluripotent stem cell-derived cardiomyocytes in translational cardiac electrophysiology. EP Europace, 25(9), Article euad236. https://doi.org/10.1093/europace/euad236
- Saljic, A., Heijman, J., & Dobrev, D. (2023). Recent Advances in Antiarrhythmic Drug Therapy. Drugs. https://doi.org/10.1007/s40265-023-01923-3
- Bergeman, A. T. J., Hoeksema, W. F. N., van der Ree, M. H., Boersma, L. V. A., Yap, S-C., Verheul, L. M. G., Hassink, R. J., van der Crabben, S. N., Volders, P. G. A., van der Werf, C., Wilde, A. A. M. G., Postema, P. G., & European Reference Network for rare, low prevalence and complex diseases of the heart: ERN GUARD-Heart (2023). Outcomes in Dutch DPP6 risk haplotype for familial idiopathic ventricular fibrillation: a focused update. Netherlands Heart Journal, 31(7-8), 309-314. https://doi.org/10.1007/s12471-023-01792-1
- Heijman, J., & Dobrev, D. (2023). Determinants and therapeutic potential of calcium handling abnormalities in atrial fibrillation: What can we learn from computer models?The Journal of Physiology, 601(13), 2545-2546. https://doi.org/10.1113/jp283817
- Meier, S., Grundland, A., Dobrev, D., Volders, P. G. A., & Heijman, J. (2023). In silico analysis of the dynamic regulation of cardiac electrophysiology by K(v)11.1 ion-channel trafficking. The Journal of Physiology, 601(13), 2711-2731. https://doi.org/10.1113/JP283976
- Wang, X., Song, J., Yuan, Y., Li, L., Abu-Taha, I., Heijman, J., Sun, L., Dobrev, S., Kamler, M., Xie, L., Wehrens, X. H. T., Horrigan, F. T., Dobrev, D., & Li, N. (2023). Downregulation of FKBP5 Promotes Atrial Arrhythmogenesis. Circulation Research, 133(1), E1-E16. https://doi.org/10.1161/CIRCRESAHA.122.322213
- Cluitmans, M., Walton, R., & Plank, G. (2023). Editorial: Computational methods in cardiac electrophysiology. Frontiers in physiology, 14, Article 1231342. https://doi.org/10.3389/fphys.2023.1231342
- ter Bekke, R. M. A., de Schouwer, K., Conti, S., Claes, G. R. F., Vanoevelen, J., Gommers, S., Helderman-van den Enden, A. T. J. M., & Brunner-LaRocca, H-P. (2023). Juvenile-onset multifocal atrial arrhythmias, atrial standstill and compound heterozygosity of genetic variants in TAF1A: sentinel event for evolving dilated cardiomyopathy-a case report. European Heart Journal - Case Reports, 7(6), Article ytad255. https://doi.org/10.1093/ehjcr/ytad255
- Rijks, J. H. J., Lankveld, T., Manusama, R., Broers, B., van Stipdonk, A. M. W., Chaldoupi, S. M., ter Bekke, R. M. A., Schotten, U., Linz, D., Luermans, J. G. L. M., & Vernooy, K. (2023). Left Bundle Branch Area Pacing and Atrioventricular Node Ablation in a Single-Procedure Approach for Elderly Patients with Symptomatic Atrial Fibrillation. Journal of Clinical Medicine, 12(12), Article 4028. https://doi.org/10.3390/jcm12124028
- Nies, H. M. J. M., Martens, B., Gommers, S., Bijvoet, G. P., Wildberger, J. E., Ter Bekke, R. M. A., Holtackers, R. J., & Mihl, C. (2023). Myocardial Scar Detection Using High-Resolution Free-Breathing 3D Dark-Blood and Standard Breath-Holding 2D Bright-Blood Late Gadolinium Enhancement MRI: A Comparison of Observer Confidence. Topics in Magnetic Resonance Imaging, 32(3), 27-32. https://doi.org/10.1097/RMR.0000000000000304
- Isaacs, A., Barysenka, A., ter Bekke, R. M. A., den Enden, A. T. J. M. H., van den Wijngaard, A., Volders, P. G. A., & Stoll, M. (2023). Standing genetic variation affects phenotypic heterogeneity in an SCN5A-mutation founder population with excess sudden cardiac death. Heart Rhythm, 20(5), 720-727. https://doi.org/10.1016/j.hrthm.2023.02.004
- Heijman, J., Zhou, X., Morotti, S., Molina, C. E., Abu-Taha, I. H., Tekook, M., Jespersen, T., Zhang, Y., Dobrev, S., Milting, H., Gummert, J., Karck, M., Kamler, M., El-Armouche, A., Saljic, A., Grandi, E., Nattel, S., & Dobrev, D. (2023). Enhanced Ca2+-Dependent SK-Channel Gating and Membrane Trafficking in Human Atrial Fibrillation. Circulation Research, 132(9), E116-E133. https://doi.org/10.1161/CIRCRESAHA.122.321858
- Cluitmans, M. J. M., Bayer, J., Bear, L. R., Ter Bekke, R. M. A., Heijman, J., Coronel, R., & Volders, P. G. A. (2023). The circle of reentry: Characteristics of trigger-substrate interaction leading to sudden cardiac arrest. Frontiers in cardiovascular medicine, 10, Article 1121517. https://doi.org/10.3389/fcvm.2023.1121517
- Grehn, M., Mandija, S., Miszczyk, M., Krug, D., Tomasik, B., Stickney, K. E., Alcantara, P., Alongi, F., Anselmino, M., Aranda, R. S., Balgobind, B. V., Boda-Heggemann, J., Boldt, L. H., Bottoni, N., Cvek, J., Elicin, O., De Ferrari, G. M., Hassink, R. J., Hazelaar, C., ... Verhoeff, J. (2023). STereotactic Arrhythmia Radioablation (STAR): the Standardized Treatment and Outcome Platform for Stereotactic Therapy Of Re-entrant tachycardia by a Multidisciplinary consortium (STOPSTORM.eu) and review of current patterns of STAR practice in Europe. EP Europace, 25, 1284-1295. https://doi.org/10.1093/europace/euac238
- Leao, S., Luermans, J., Vernooy, K., ter Bekke, R., den Uijl, D., Linz, D., & Chaldoupi, S-M. (2023). The great deceiver: a case series of 'double fire' atrioventricular nodal response. European Heart Journal - Case Reports, 7(4), Article ytad162. https://doi.org/10.1093/ehjcr/ytad162
- Stoks, J., Bear, L. R., Vijgen, J., Dendale, P., Peeters, R., Volders, P. G. A., & Cluitmans, M. J. M. (2023). Understanding repolarization in the intracardiac unipolar electrogram: A long-lasting controversy revisited. Frontiers in physiology, 14, Article 1158003. https://doi.org/10.3389/fphys.2023.1158003
- Seibertz, F., Sutanto, H., Dulk, R., Pronto, J. R. D., Springer, R., Rapedius, M., Liutkute, A., Ritter, M., Jung, P. L., Stelzer, L., Husgen, L. M., Klopp, M., Rubio, T., Fakuade, F. E., Mason, F. E., Hartmann, N., Pabel, S., Streckfuss-Bomeke, K., Cyganek, L., ... Voigt, N. (2023). Electrophysiological and calcium-handling development during long-term culture of human-induced pluripotent stem cell-derived cardiomyocytes. Basic Research in Cardiology, 118(1), Article 14. https://doi.org/10.1007/s00395-022-00973-0
- Gawalko, M., Saljic, A., Li, N., Abu-Taha, I., Jespersen, T., Linz, D., Nattel, S., Heijman, J., Fender, A., & Dobrev, D. (2023). Adiposity-associated atrial fibrillation: molecular determinants, mechanisms, and clinical significance. Cardiovascular Research, 119(3), 614-630. https://doi.org/10.1093/cvr/cvac093
- Dobrev, D., Heijman, J., Hiram, R., Li, N., & Nattel, S. (2023). Inflammatory signalling in atrial cardiomyocytes: a novel unifying principle in atrial fibrillation pathophysiology. Nature Reviews Cardiology, 20(3), 145-167. https://doi.org/10.1038/s41569-022-00759-w
- Groeneveld, S. A., Verheul, L. M., van der Ree, M. H., Mulder, B. A., Scholten, M. F., Alings, M., van der Voort, P., Bootsma, M., Evertz, R., Balt, J. C., Yap, S-C., Doevendans, P. A. F. M., Postema, P. G., Wilde, A. A. M., Volders, P. G. A., & Hassink, R. J. (2023). The Importance of Systematic Diagnostic Testing in Idiopathic Ventricular Fibrillation: Results From the Dutch iVF-Registry. JACC: Clinical Electrophysiology, 9(3), 345-355. https://doi.org/10.1016/j.jacep.2022.10.003
- Cachorro, E., Guenscht, M., Schubert, M., Sadek, M. S., Siegert, J., Dutt, F., Bauermeister, C., Quickert, S., Berning, H., Nowakowski, F., Laemmle, S., Firneburg, R., Luo, X. J., Kunzel, S. R., Klapproth, E., Mirtschink, P., Mayr, M., Dewenter, M., Vettel, C., ... Kammerer, S. (2023). CNP Promotes Antiarrhythmic Effects via Phosphodiesterase 2. Circulation Research, 132(4), 400-414. https://doi.org/10.1161/CIRCRESAHA.122.322031
- Stoks, J., Hermans, B. M., Boukens, B. J. D., Holtackers, R. J., Gommers, S., Kaya, Y. S., Vernooy, K., Cluitmans, M. J. M., Volders, P. G. A., & ter Bekke, R. M. A. (2023). High-resolution structural-functional substrate-trigger characterization: Future roadmap for catheter ablation of ventricular tachycardia. Frontiers in cardiovascular medicine, 10, Article 1112980. https://doi.org/10.3389/fcvm.2023.1112980
- Hoorntje, E. T., Burns, C., Marsili, L., Corden, B., Parikh, V. N., Te Meerman, G. J., Gray, B., Adiyaman, A., Bagnall, R. D., Barge-Schaapveld, D. Q. C. M., van den Berg, M. P., Bootsma, M., Bosman, L. P., Correnti, G., Duflou, J., Eppinga, R. N., Fatkin, D., Fietz, M., Haan, E., ... Ingles, J. (2023). Variant Location Is a Novel Risk Factor for Individuals With Arrhythmogenic Cardiomyopathy Due to a Desmoplakin (DSP) Truncating Variant. Circulation: Genomic and Precision Medicine, 16(1), 69-79. https://doi.org/10.1161/CIRCGEN.121.003672
- 2022
- Xenakis, M. N., Kapetis, D., Yang, Y., Heijman, J., Waxman, S. G., Lauria, G., Faber, C. G., Smeets, H. J., Lindsey, P. J., & Westra, R. L. (2022). Correction to: Non-extensitivity and criticality of atomic hydropathicity around a voltage-gated sodium channel's pore: a modeling study. Journal of Biological Physics, 48(4), 477-478. https://doi.org/10.1007/s10867-022-09616-w
- Scheurlen, C., van den Bruck, J-H., Filipovic, K., Wörmann, J., Arica, Z., Erlhöfer, S., Dittrich, S., Heijman, J., Lüker, J., Steven, D., & Sultan, A. (2022). Procedural and outcome impact of obesity in cryoballoon versus radiofrequency pulmonary vein isolation in atrial fibrillation patients. Journal of Interventional Cardiac Electrophysiology, 65(2), 403-410. https://doi.org/10.1007/s10840-022-01210-3
- van der Waal, J., Bear, L., Meijborg, V., Dubois, R., Cluitmans, M., & Coronel, R. (2022). Steep repolarization time gradients in pig hearts cause distinct changes in composite electrocardiographic T-wave parameters. Annals of Noninvasive Electrocardiology, 27(6), Article 12994. https://doi.org/10.1111/anec.12994
- Evans, P. C., Davidson, S. M., Wojta, J., Bäck, M., Bollini, S., Brittan, M., Catapano, A. L., Chaudhry, B., Cluitmans, M., Gnecchi, M., Guzik, T. J., Hoefer, I., Madonna, R., Monteiro, J. P., Morawietz, H., Osto, E., Padró, T., Sluimer, J. C., Tocchetti, C. G., ... Weber, C. (2022). From novel discovery tools and biomarkers to precision medicine-basic cardiovascular science highlights of 2021/22. Cardiovascular Research, 118(13), 2754-2767. https://doi.org/10.1093/cvr/cvac114
- Heijman, J., & Dobrev, D. (2022). Molecular determinants and therapeutic potential of focal ectopic activity: more than meets the Iti. European Heart Journal, 43(40), 4208-4210. https://doi.org/10.1093/eurheartj/ehac357
- Cai, M., Schotten, U., Dobrev, D., & Heijman, J. (2022). Atrial fibrillation substrate development before, during and after cardiac surgery: Who is to blame for late post-operative atrial fibrillation?International Journal of Cardiology, 365, 44-46. https://doi.org/10.1016/j.ijcard.2022.07.027
- Dilaveris, P. E., Antoniou, C. K., Caiani, E. G., Casado-Arroyo, R., Climent, A. Μ., Cluitmans, M., Cowie, M. R., Doehner, W., Guerra, F., Jensen, M. T., Kalarus, Z., Locati, E. T., Platonov, P., Simova, I., Schnabel, R. B., Schuuring, M., Tsivgoulis, G., & Lumens, J. (2022). ESC Working Group on e-Cardiology Position Paper: accuracy and reliability of electrocardiogram monitoring in the detection of atrial fibrillation in cryptogenic stroke patients : In collaboration with the Council on Stroke, the European Heart Rhythm Association, and the Digital Health Committee. European Heart Journal - Digital Health, 3(3), 341-358. https://doi.org/10.1093/ehjdh/ztac026
- Meier, S., & Heijman, J. (2022). Commentary: EP-PINNs: Cardiac electrophysiology characterisation using physics-informed neural networks. Frontiers in cardiovascular medicine, 9, Article 1003652. https://doi.org/10.3389/fcvm.2022.1003652
- Odening, K. E., van der Linde, H. J., Ackerman, M. J., Volders, P. G. A., & Ter Bekke, R. M. A. (2022). Electromechanical reciprocity and arrhythmogenesis in long-QT syndrome and beyond. European Heart Journal, 43(32), 3018-3028. https://doi.org/10.1093/eurheartj/ehac135
- Verheul, L. M., Groeneveld, S. A., Kirkels, F. P., Volders, P. G. A., Teske, A. J., Cramer, M. J., Guglielmo, M., & Hassink, R. J. (2022). State-of-the-Art Multimodality Imaging in Sudden Cardiac Arrest with Focus on Idiopathic Ventricular Fibrillation: A Review. Journal of Clinical Medicine, 11(16), Article 4680. https://doi.org/10.3390/jcm11164680
- Cunha, P. S., Laranjo, S., Heijman, J., & Oliveira, M. M. (2022). The Atrium in Atrial Fibrillation - A Clinical Review on How to Manage Atrial Fibrotic Substrates. Frontiers in cardiovascular medicine, 9, Article 879984. https://doi.org/10.3389/fcvm.2022.879984
- Verhaert, D. V. M., Linz, D., Chaldoupi, S. M., Westra, S. W., den Uijl, D. W., Philippens, S., Kerperien, M., Habibi, Z., Vorstermans, B., ter Bekke, R. M. A., Beukema, R. J., Evertz, R., Hemels, M. E. W., Luermans, J. G. L. M., Manusama, R., Lankveld, T. A. R., van der Heijden, C. A. J., Bidar, E., Hermans, B. M., ... Schotten, U. (2022). Rationale and Design of the ISOLATION Study: A Multicenter Prospective Cohort Study Identifying Predictors for Successful Atrial Fibrillation Ablation in an Integrated Clinical Care and Research Pathway. Frontiers in cardiovascular medicine, 9, Article 879139. https://doi.org/10.3389/fcvm.2022.879139
- Wiedmann, F., Beyersdorf, C., Zhou, X-B., Kraft, M., Paasche, A., Jávorszky, N., Rinné, S., Sutanto, H., Büscher, A., Foerster, K. I., Blank, A., El-Battrawy, I., Li, X., Lang, S., Tochtermann, U., Kremer, J., Arif, R., Karck, M., Decher, N., ... Schmidt, C. (2022). Treatment of atrial fibrillation with doxapram: TASK-1 potassium channel inhibition as a novel pharmacological strategy. Cardiovascular Research, 118(7), 1728-1741. https://doi.org/10.1093/cvr/cvab177
- Schuler, S., Schaufelberger, M., Bear, L. R., Bergquist, J., Cluitmans, M., Coll-Font, J., Onak, O. N., Zenger, B., Loewe, A., Macleod, R., Brooks, D. H., & Doessel, O. (2022). Reducing Line-of-block Artifacts in Cardiac Activation Maps Estimated Using ECG Imaging: A Comparison of Source Models and Estimation Methods. Ieee Transactions on Biomedical Engineering, 69(6), 2041-2052. https://doi.org/10.1109/TBME.2021.3135154
- Barc, J., Tadros, R., Glinge, C., Chiang, D. Y., Jouni, M., Simonet, F., Jurgens, S. J., Baudic, M., Nicastro, M., Potet, F., Offerhaus, J. A., Walsh, R., Choi, S. H., Verkerk, A. O., Mizusawa, Y., Anys, S., Minois, D., Arnaud, M., Duchateau, J., ... KORA-Study Group (2022). Author Correction: Genome-wide association analyses identify new Brugada syndrome risk loci and highlight a new mechanism of sodium channel regulation in disease susceptibility. Nature Genetics, 54(5), 735-735. Article 735. https://doi.org/10.1038/s41588-022-01079-y
- Saljic, A., Heijman, J., & Dobrev, D. (2022). Emerging Antiarrhythmic Drugs for Atrial Fibrillation. International Journal of Molecular Sciences, 23(8), Article 4096. https://doi.org/10.3390/ijms23084096
- Sutanto, H., & Heijman, J. (2022). Integrative Computational Modeling of Cardiomyocyte Calcium Handling and Cardiac Arrhythmias: Current Status and Future Challenges. Cells, 11(7), Article 1090. https://doi.org/10.3390/cells11071090
- Colman, M. A., Alvarez-Lacalle, E., Echebarria, B., Sato, D., Sutanto, H., & Heijman, J. (2022). Multi-Scale Computational Modeling of Spatial Calcium Handling From Nanodomain to Whole-Heart: Overview and Perspectives. Frontiers in physiology, 13, Article 836622. https://doi.org/10.3389/fphys.2022.836622
- Henkens, M. T. H. M., Raafs, A. G., Verdonschot, J. A. J., Linschoten, M., van Smeden, M., Wang, P., van der Hooft, B. H. M., Tieleman, R., Janssen, M. L. F., Ter Bekke, R. M. A., Hazebroek, M. R., van der Horst, I. C. C., Asselbergs, F. W., Magdelijns, F. J. H., Heymans, S. R. B., & CAPACITY-COVID collaborative consortium (2022). Age is the main determinant of COVID-19 related in-hospital mortality with minimal impact of pre-existing comorbidities, a retrospective cohort study. BMC Geriatrics, 22(1), Article 184. https://doi.org/10.1186/s12877-021-02673-1