• 2021
    • Cluitmans, M. J. M., Bear, L. R., Nguyên, U. C., van Rees, B., Stoks, J., Ter Bekke, R. M. A., Mihl, C., Heijman, J., Lau, K. D., Vigmond, E., Bayer, J., Belterman, C. N. W., Abell, E., Labrousse, L., Rogier, J., Bernus, O., Haïssaguerre, M., Hassink, R. J., Dubois, R., ... Volders, P. G. A. (2021). Noninvasive detection of spatiotemporal activation-repolarization interactions that prime idiopathic ventricular fibrillation. Science Translational Medicine, 13(620), [eabi9317]. https://doi.org/10.1126/scitranslmed.abi9317
    • Kruithof, E., Amirrajab, S., Cluitmans, M. J. M., Lau, K. D., & Breeuwer, M. (2021). Influence of image artifacts on image-based computer simulations of the cardiac electrophysiology. Computers in Biology and Medicine, 137, [104773]. https://doi.org/10.1016/j.compbiomed.2021.104773
    • Lyon, A., van Opbergen, C. J. M., Delmar, M., Heijman, J., & van Veen, T. A. B. (2021). In silico Identification of Disrupted Myocardial Calcium Homeostasis as Proarrhythmic Trigger in Arrhythmogenic Cardiomyopathy. Frontiers in physiology, 12, [732573]. https://doi.org/10.3389/fphys.2021.732573
    • Schwartz, P. J., Moreno, C., Kotta, M-C., Pedrazzini, M., Crotti, L., Dagradi, F., Castelletti, S., Haugaa, K. H., Denjoy, I., Shkolnikova, M. A., Brink, P. A., Heradien, M. J., Seyen, S. R. M., Spätjens, R. L. H. M. G., Spazzolini, C., & Volders, P. G. A. (2021). Mutation location and IKs regulation in the arrhythmic risk of long QT syndrome type 1: the importance of the KCNQ1 S6 region. European Heart Journal. https://doi.org/10.1093/eurheartj/ehab582
    • Sutanto, H., Dobrev, D., & Heijman, J. (2021). Angiotensin Receptor-Neprilysin Inhibitor (ARNI) and Cardiac Arrhythmias. International journal of molecular sciences, 22(16), [8994]. https://doi.org/10.3390/ijms22168994
    • Nedios, S., Lindemann, F., Heijman, J., Crijns, H. J. G. M., Bollmann, A., & Hindricks, G. (2021). Atrial remodeling and atrial fibrillation recurrence after catheter ablation: Past, present, and future developments. Herz, 46(4), 312-317. https://doi.org/10.1007/s00059-021-05050-1
    • Sultan, A., Wormann, J., Luker, J., van der Bruck, J. H., Plenge, T., Rudolph, V., Klinke, A., Heijman, J., Mollenhauer, M., Ravekes, T., Baldus, S., & Steven, D. (2021). Significance of myeloperoxidase plasma levels as a predictor for cardiac resynchronization therapy response. Clinical research in cardiology, 110(8), 1173-1180. https://doi.org/10.1007/s00392-020-01690-1
    • Heijman, J., Sutanto, H., Crijns, H. J. G. M., Nattel, S., & Trayanova, N. A. (2021). Computational models of atrial fibrillation: achievements, challenges and perspectives for improving clinical care. Cardiovascular Research, 117(7), 1682-1699. https://doi.org/10.1093/cvr/cvab138
    • Nattel, S., Sager, P. T., Huser, J., Heijman, J., & Dobrev, D. (2021). Why translation from basic discoveries to clinical applications is so difficult for atrial fibrillation and possible approaches to improving it. Cardiovascular Research, 117(7), 1616-1631. https://doi.org/10.1093/cvr/cvab093
    • Jurak, P., Bear, L. R., Nguyên, U. C., Viscor, I., Andrla, P., Plesinger, F., Halamek, J., Vondra, V., Abell, E., Cluitmans, M. J. M., Dubois, R., Curila, K., Leinveber, P., & Prinzen, F. W. (2021). 3-Dimensional ventricular electrical activation pattern assessed from a novel high-frequency electrocardiographic imaging technique: principles and clinical importance. Scientific Reports, 11(1), 11469. [11469]. https://doi.org/10.1038/s41598-021-90963-4
    • Wiedmann, F., Beyersdorf, C., Zhou, X-B., Kraft, M., Paasche, A., Jávorszky, N., Rinné, S., Sutanto, H., Büscher, A., Foerster, K. I., Blank, A., El-Battrawy, I., Li, X., Lang, S., Tochtermann, U., Kremer, J., Arif, R., Karck, M., Decher, N., ... Schmidt, C. (2021). Treatment of atrial fibrillation with doxapram: TASK-1 potassium channel inhibition as a novel pharmacological strategy. Cardiovascular Research. https://doi.org/10.1093/cvr/cvab177
    • Bear, L. R., Cluitmans, M., Abell, E., Rogier, J., Labrousse, L., Cheng, L. K., LeGrice, I., Lever, N., Sands, G. B., Smaill, B., Haïssaguerre, M., Bernus, O., Coronel, R., & Dubois, R. (2021). Electrocardiographic Imaging of Repolarization Abnormalities. Journal of the American Heart Association, 10(9), [e020153]. https://doi.org/10.1161/JAHA.120.020153
    • Wagner, M., Sadek, M. S., Dybkova, N., Mason, F. E., Klehr, J., Firneburg, R., Cachorro, E., Richter, K., Klapproth, E., Kuenzel, S. R., Lorenz, K., Heijman, J., Dobrev, D., El-Armouche, A., Sossalla, S., & Kaemmerer, S. (2021). Cellular Mechanisms of the Anti-Arrhythmic Effect of Cardiac PDE2 Overexpression. International journal of molecular sciences, 22(9), [4816]. https://doi.org/10.3390/ijms22094816
    • Pluymaekers, N. A. H. A., Dudink, E. A. M. P., Weijs, B., Vernooy, K., Hartgerink, D. E. J., Jacobs, J. S., Erkuner, O., Marcks, N. G. H. M., van Cauteren, Y. J. M., Dinh, T., ter Bekke, R. M. A., Sels, J. E. M. W., Delnoij, T. S. R., Geyik, Z., Driessen, R. G. H., Linz, D. K., den Uijl, D. W., Crijns, H. J. G. M., & Luermans, J. G. L. M. (2021). Clinical determinants of early spontaneous conversion to sinus rhythm in patients with atrial fibrillation. Netherlands Heart Journal, 29(5), 255-261. https://doi.org/10.1007/s12471-020-01528-5
    • Aguilar, M., Heijman, J., Dobrev, D., & Nattel, S. (2021). One Ring to Rule Them All: Continuous Monitoring of Patients With Secondary Atrial Fibrillation Points to a Unifying Underlying Mechanism. Canadian Journal of Cardiology, 37(5), 686-689. https://doi.org/10.1016/j.cjca.2021.01.018
    • Holtackers, R. J., Gommers, S., Van De Heyning, C. M., Mihl, C., Smink, J., Higgins, D. M., Wildberger, J. E., & ter Bekke, R. M. A. (2021). Steadily Increasing Inversion Time Improves Blood Suppression for Free-Breathing 3D Late Gadolinium Enhancement MRI With Optimized Dark-Blood Contrast. Investigative Radiology, 56(5), 335-340. https://doi.org/10.1097/RLI.0000000000000747
    • Salinet, J., Molero, R., Schlindwein , F., Karel, J., Rodrigo, M., Rojo-Álvarez, J. L., Berenfeld, O., Climent, A., Zenger, B., Vanheusden, F., Paredes Jimena, G. S., MacLeod, R., Atienza, F., Guillem, M., Cluitmans, M., & Bonizzi, P. (2021). Electrocardiographic imaging for atrial fibrillation: a perspective from computer models and animal experiments to clinical value. Frontiers in physiology, 12, [653013]. https://doi.org/10.3389/fphys.2021.653013
    • Xenakis, M. N., Kapetis, D., Yang, Y., Gerrits, M. M., Heijman, J., Waxman, S. G., Lauria, G., Faber, C. G., Westra, R. L., Lindsey, P. J., & Smeets, H. J. (2021). Hydropathicity-based prediction of pain-causing NaV1.7 variants. BMC Bioinformatics, 22(1), [212]. https://doi.org/10.1186/s12859-021-04119-2
    • Vagos, M. R., Arevalo, H., Heijman, J., Schotten, U., & Sundnes, J. (2021). A Computational Study of the Effects of Tachycardia-Induced Remodeling on Calcium Wave Propagation in Rabbit Atrial Myocytes. Frontiers in physiology, 12, [651428]. https://doi.org/10.3389/fphys.2021.651428
    • Heijman, J., Hohnloser, S. H., & Camm, A. J. (2021). Antiarrhythmic drugs for atrial fibrillation: lessons from the past and opportunities for the future. EP Europace, 23, 14-22. https://doi.org/10.1093/europace/euaa426
    • Nedios, S., Sanatkhani, S., Oladosu, M., Seewoester, T., Richter, S., Arya, A., Heijman, J., Crijns, H. J. G. M., Hindricks, G., Bollmann, A., & Menon, P. G. (2021). Association of low-voltage areas with the regional wall deformation and the left atrial shape in patients with atrial fibrillation: A proof of concept study. IJC Heart & Vasculature, 33, [100730]. https://doi.org/10.1016/j.ijcha.2021.100730
    • Heijman, J., Vernooy, K., & C van Gelder, I. (2021). The road goes ever on: innovations and paradigm shifts in atrial fibrillation management. EP Europace, 23, 1-3. https://doi.org/10.1093/europace/euab061
    • Coronel, R., Potse, M., Haïssaguerre, M., Derval, N., Rivaud, M. R., Meijborg, V. M. F., Cluitmans, M., Hocini, M., & Boukens, B. J. (2021). Why Ablation of Sites With Purkinje Activation Is Antiarrhythmic: The Interplay Between Fast Activation and Arrhythmogenesis. Frontiers in physiology, 12, [648396]. https://doi.org/10.3389/fphys.2021.648396
    • van Cauteren, Y. J. M., Smulders, M. W., Theunissen, R. A. L. J., Gerretsen, S. C., Adriaans, B. P., Bijvoet, G. P., Mingels, A. M. A., van Kuijk, S. M. J., Schalla, S., Crijns, H. J. G. M., Kim, R. J., Wildberger, J. E., Heijman, J., & Bekkers, S. C. A. M. (2021). Cardiovascular magnetic resonance accurately detects obstructive coronary artery disease in suspected non-ST elevation myocardial infarction: a sub-analysis of the CARMENTA Trial. Journal of Cardiovascular Magnetic Resonance, 23(1), [40]. https://doi.org/10.1186/s12968-021-00723-6
    • Peper, J., Kownatzki-Danger, D., Weninger, G., Seibertz, F., Pronto, J. R., Sutanto, H., Pacheu Grau, D., Hindmarsh, R., Brandenburg, S., Kohl, T., Hasenfuβ, G., Gotthardt, M., Rog-Zielinska, E. A., Wollnik, B., Rehling, P., Urlaub, H., Wegener, J. W., Heijman, J., Voigt, N., ... Lehnart, S. E. (2021). Caveolin3 Stabilizes McT1-Mediated Lactate/Proton Transport in Cardiomyocytes. Circulation Research, 128(6), e102–e120. https://doi.org/10.1161/CIRCRESAHA.119.316547
    • Qi, X-Y., Hassani, F. V., Hoffmann, D., Xiao, J., Xiong, F., Villeneuve, L. R., Ljubojevic-Holzer, S., Kamler, M., Abu-Taha, I., Heijman, J., Bers, D. M., Dobrev, D., & Nattel, S. (2021). Inositol Trisphosphate Receptors and Nuclear Calcium in Atrial Fibrillation. Circulation Research, 128(5), 619-635. https://doi.org/10.1161/circresaha.120.317768
    • Mellor, G. J., Blom, L. J., Groeneveld, S. A., Winkel, B. G., Ensam, B., Bargehr, J., van Rees, B., Scrocco, C., Krapels, I. P. C., Volders, P. G. A., Tfelt-Hansen, J., Krahn, A. D., Hassink, R. J., & Behr, E. R. (2021). Familial Evaluation in Idiopathic Ventricular Fibrillation: Diagnostic Yield and Significance of J Wave Syndromes. Circulation-Arrhythmia and Electrophysiology, 14(3), 296-305. https://doi.org/10.1161/CIRCEP.120.009089
    • Lyon, A., van Mourik, M., Cruts, L., Heijman, J., Bekkers, S. C. A. M., Schotten, U., Crijns, H. J. G. M., Linz, D., & Lumens, J. (2021). Both beat-to-beat changes in RR-interval and left ventricular filling time determine ventricular function during atrial fibrillation. EP Europace, 23, I21-I28. https://doi.org/10.1093/europace/euaa387
    • Fabritz, L., Crijns, H. J. G. M., Guasch, E., Goette, A., Häusler, K. G., Kotecha, D., Lewalter, T., Meyer, C., Potpara, T. S., Rienstra, M., Schnabel, R. B., Willems, S., Breithardt, G., Camm, A. J., Chan, A., Chua, W., de Melis, M., Dimopoulou, C., Dobrev, D., ... Kirchhof, P. (2021). Dynamic risk assessment to improve quality of care in patients with atrial fibrillation: the 7th AFNET/EHRA Consensus Conference. EP Europace, 23(3), 329-344. https://doi.org/10.1093/europace/euaa279
    • Xenakis, M. N., Kapetis, D., Yang, Y., Heijman, J., Waxman, S. G., Lauria, G., Faber, C. G., Smeets, H. J., Lindsey, P. J., & Westra, R. L. (2021). Non-extensitivity and criticality of atomic hydropathicity around a voltage-gated sodium channel's pore: a modeling study. Journal of Biological Physics, 47(1), 61-77. https://doi.org/10.1007/s10867-021-09565-w
    • Rivaud, M. R., Bayer, J. D., Cluitmans, M., van der Waal, J., Bear, L. R., Boukens, B. J., Belterman, C., Gottlieb, L., Vaillant, F., Abell, E., Dubois, R., Meijborg, V. M. F., & Coronel, R. (2021). Critical repolarization gradients determine the induction of reentry-based torsades de pointes arrhythmia in models of long QT syndrome. Heart Rhythm, 18(2), 278-287. https://doi.org/10.1016/j.hrthm.2020.09.020
    • Heijman, J., Linz, D., & Schotten, U. (2021). Dynamics of Atrial Fibrillation Mechanisms and Comorbidities. Annual Review of Physiology, 83, 83-106. https://doi.org/10.1146/annurev-physiol-031720-085307
    • Holtackers, R. J., Ter Bekke, R. M. A., Bijvoet, G. P., Gommers, S., Chiribiri, A., & Lorusso, R. (2021). A Boolean Dilemma: True or False Aneurysm?JACC. Case reports, 3(1), 112-116. https://doi.org/10.1016/j.jaccas.2020.09.055
    • Walsh, R., Lahrouchi, N., Tadros, R., Kyndt, F., Glinge, C., Postema, P. G., Amin, A. S., Nannenberg, E. A., Ware, J. S., Whiffin, N., Mazzarotto, F., Skoric-Milosavljevic, D., Krijger, C., Arbelo, E., Babuty, D., Barajas-Martinez, H., Beckmann, B. M., Bezieau, S., Bos, J. M., ... Nantes Referral Center for inherited cardiac arrhythmia (2021). Enhancing rare variant interpretation in inherited arrhythmias through quantitative analysis of consortium disease cohorts and population controls. Genetics in Medicine, 23(1), 47-58. https://doi.org/10.1038/s41436-020-00946-5
    • Nedios, S., Loebe, S., Knopp, H., Seewoester, T., Heijman, J., Crijns, H. J. G. M., Arya, A., Bollmann, A., Hindricks, G., & Dinov, B. (2021). Left atrial activation and asymmetric anatomical remodeling in patients with atrial fibrillation: The relation between anatomy and function. Clinical Cardiology, 44(1), 116-122. [23515]. https://doi.org/10.1002/clc.23515
  • 2020
    • Stoks, J., Chau Nguyen, U., Peeters, R., Volders, P., & Cluitmans, M. (2020). An Open-Source Algorithm for Standardized Bullseye Visualization of High-Resolution Cardiac Ventricular Data: UNISYS. Computing in Cardiology, 47, 1-4. [160]. https://doi.org/10.22489/CinC.2020.160
    • Stoks, J., Van Rees, B., Groeneveld, S., Schipaanboord, D., Blom, L., Hassink, R., Cluitmans, M., Peeters, R., & Volders, P. (2020). Variability of Electrocardiographic Imaging Within and Between Leadsets. Computing in Cardiology, 47, 1-4. [097]. https://doi.org/10.22489/CinC.2020.097
    • Gomez, A. M., Heijman, J., & Remme, C. A. (2020). The ESCWorking Group Cardiac Cellular Electrophysiology. European Heart Journal, 41(46), 4374-4376. https://doi.org/10.1093/eurheartj/ehaa646
    • Haanschoten, D. M., Vernooy, K., Beukema, R. J., Szili-Torok, T., ter Bekke, R. M. A., Khan, M., de Jong, J. S. S. G., Otten, A. M., Adiyaman, A., Smit, J. J. J., Delnoy, P. P. H. M., Misier, A. R. R., & Elvan, A. (2020). Elimination of Benign Ventricular Premature Beats or Ventricular Tachycardia with Catheter Ablation versus Two Different Optimal Antiarrhythmic Drug Treatment Regimens (Sotalol or Verapamil/Flecainide). Cardiology, 145(12), 795-801. https://doi.org/10.1159/000509661
    • Pinto-Sietsma, S. J., Flossdorf, M., Buchholz, V. R., Offerhaus, J., Bleijendaal, H., Beudel, M., Volders, P. G. A., ter Bekke, R. M. A., Dormans, T., Zwetsloot, P. P., de Jager, P., Massberg, S., Ramer, P., Wendtner, C., Hoffmann, E., Rothe, K., Feihl, S., Kessler, T., Pinto, Y. M., & Schunkert, H. (2020). Antihypertensive drugs in COVID-19 infection. European Heart Journal-Cardiovascular Pharmacotherapy, 6(6), 415-416. https://doi.org/10.1093/ehjcvp/pvaa058
    • Stoks, J., Van Rees, B. D., Nguyen, U. C., Peeters, R. L. M., Dendale, P., Cluitmans, M. J. M., & Volders, P. G. A. (2020). Noninvasive assessment of dynamic cardiac electrophysiology in normal human subjects. European Heart Journal, 41(S2), 3596-3596. https://doi.org/10.1093/ehjci/ehaa946.3596
    • Sutanto, H., Lyon, A., Lumens, J., Schotten, U., Dobrev, D., & Heijman, J. (2020). Cardiomyocyte calcium handling in health and disease: Insights from in vitro and in silico studies. Progress in Biophysics & Molecular Biology, 157, 54-75. https://doi.org/10.1016/j.pbiomolbio.2020.02.008
    • Sutanto, H., & Heijman, J. (2020). Beta-Adrenergic Receptor Stimulation Modulates the Cellular Proarrhythmic Effects of Chloroquine and Azithromycin. Frontiers in physiology, 11, [587709]. https://doi.org/10.3389/fphys.2020.587709
    • Vagos, M. R., Arevalo, H., Heijman, J., Schotten, U., & Sundnes, J. (2020). A Novel Computational Model of the Rabbit Atrial Cardiomyocyte With Spatial Calcium Dynamics. Frontiers in physiology, 11, [556156]. https://doi.org/10.3389/fphys.2020.556156
    • Xenakis, M. N., Kapetis, D., Yang, Y., Heijman, J., Waxman, S. G., Lauria, G., Faber, C. G., Smeets, H. J., Westra, R. L., & Lindsey, P. J. (2020). Cumulative hydropathic topology of a voltage-gated sodium channel at atomic resolution. Proteins-structure Function and Bioinformatics, 88(10), 1319-1328. https://doi.org/10.1002/prot.25951
    • Bogossian, H., Linz, D., Heijman, J., Bimpong-Buta, N-Y., Bandorski, D., Frommeyer, G., Erkapic, D., Seyfarth, M., Zarse, M., & Crijns, H. J. (2020). QTc evaluation in patients with bundle branch block. IJC Heart & Vasculature, 30, [100636]. https://doi.org/10.1016/j.ijcha.2020.100636
    • Molenaar, M. M. D., Hesselink, T., ter Bekke, R. M. A., Scholten, M. F., Manusama, R., Pison, L., Brusse-Keizer, M., Kraaier, K., ten Haken, B., Grandjean, J. G., Timmermans, C. C., & van Opstal, J. M. (2020). Shorter RSPV cryoapplications result in less phrenic nerve injury and similar 1-year freedom from atrial fibrillation. Pacing and Clinical Electrophysiology, 43(10), 1173-1179. https://doi.org/10.1111/pace.14062
    • Heijman, J., Muna, A. P., Veleva, T., Molina, C. E., Sutanto, H., Tekook, M. A., Wang, Q., Abu-Taha, I., Gorka, M., Künzel, S., El-Armouche, A., Reichenspurner, H., Kamler, M., Nikolaev, V. O., Ravens, U., Li, N., Nattel, S., Wehrens, X. H., & Dobrev, D. (2020). Atrial Myocyte NLRP3/CaMKII Nexus Forms a Substrate for Post-Operative Atrial Fibrillation. Circulation Research, 127(8), 1036-1055. https://doi.org/10.1161/circresaha.120.316710
    • Sutanto, H., Cluitmans, M. J. M., Dobrev, D., Volders, P. G. A., Bébarová, M., & Heijman, J. (2020). Acute effects of alcohol on cardiac electrophysiology and arrhythmogenesis: Insights from multiscale in silico analyses. Journal of Molecular and Cellular Cardiology, 146, 69-83. https://doi.org/10.1016/j.yjmcc.2020.07.007