• 2024
    • Becher, N., Toennis, T., Bertaglia, E., Blomström-Lundqvist, C., Brandes, A., Cabanelas, N., Calvert, M., Camm, A. J., Chlouverakis, G., Dan, G.-A., Dichtl, W., Diener, H. C., Fierenz, A., Goette, A., de Groot, J. R., Hermans, A. N. L., Lip, G. Y. H., Lubinski, A., Marijon, E., ... NOAH-AFNET 6 investigators (2024). Anticoagulation with edoxaban in patients with long atrial high-rate episodes ≥24 h. European Heart Journal, 45(10), 837-849. Article ehad771. https://doi.org/10.1093/eurheartj/ehad771
    • Aydeniz, E., van Rosmalen, F., de Kok, J., Martens, B., Mingels, A. M. A., Canakci, M. E., Mihl, C., Vernooy, K., Prinzen, F. W., Wildberger, J. E., van der Horst, I. C. C., van Bussel, B. C. T., & Driessen, R. G. H. (2024). The association between coronary artery calcification and vectorcardiography in mechanically ventilated COVID-19 patients: the Maastricht Intensive Care COVID cohort. Intensive Care Medicine Experimental, 12(1), 26. https://doi.org/10.1186/s40635-024-00611-0
    • Leinveber, P., Halamek, J., Curila, K., Prinzen, F., Lipoldova, J., Matejkova, M., Smisek, R., Plesinger, F., Nagy, A., Novak, M., Viscor, I., Vondra, V., & Jurak, P. (2024). Ultra-high-frequency ECG volumetric and negative derivative epicardial ventricular electrical activation pattern. Scientific Reports, 14(1), Article 5681. https://doi.org/10.1038/s41598-024-55789-w
    • Dib, M.-J., Levin, M. G., Zhao, L., Diab, A., Wang, Z., Ebert, C., Salman, O., Azzo, J. D., Gan, S., Zamani, P., Cohen, J. B., Gill, D., Burgess, S., Zagkos, L., van Empel, V., Richards, A. M., Doughty, R., Rietzschel, E. R., Kammerhoff, K., ... Chirinos, J. A. (2024). Proteomic Associations of Adverse Outcomes in Human Heart Failure. Journal of the American Heart Association, 13(5), Article e031154. https://doi.org/10.1161/JAHA.123.031154
    • Tubben, A., Tingen, H. S. A., Prakken, N. H. J., van Empel, V. P. M., Gorter, T. M., Meems, L. M. G., Manintveld, O. C., Rienstra, M., Tieleman, R. G., Glaudemans, A. W. J. M., van Veldhuisen, D. J., Slart, R. H. J. A., Nienhuis, H. L. A., & van der Meer, P. (2024). Prevalence of wild-type transthyretin amyloidosis in a prospective heart failure cohort with preserved and mildly reduced ejection fraction: Results of the Amylo-VIP-HF study. European journal of heart failure. Advance online publication. https://doi.org/10.1002/ejhf.3186
    • Edgar, R., Scholte, N. T. B., Ebrahimkheil, K., Brouwer, M. A., Beukema, R. J., Mafi-Rad, M., Vernooy, K., Yap, S. C., Ronner, E., van Mieghem, N., Boersma, E., Stas, P. C., van Royen, N., & Bonnes, J. L. (2024). Automated cardiac arrest detection using a photoplethysmography wristband: algorithm development and validation in patients with induced circulatory arrest in the DETECT-1 study. The Lancet Digital Health, 6(3), e201-e210. https://doi.org/10.1016/S2589-7500(23)00249-2
    • Gawalko, M., Betz, K., Hendriks, V., Hermans, A. N. L., van der Velden, R. M. J., Manninger, M., Chaldoupi, S.-M., Hoogervorst, H., Martens, H., Pluymaekers, N. A. H. A., Spreeuwenberg, M. D., Hendriks, J., & Linz, D. (2024). Changes in healthcare utilisation during implementation of remote atrial fibrillation management: TeleCheck-AF project. Netherlands Heart Journal, 32(3), 130-139. https://doi.org/10.1007/s12471-023-01836-6
    • Heijman, J., & Madreiter-Sokolowski, C. T. (2024). Is ageing a modifiable risk factor for atrial fibrillation?Cardiovascular Research. Advance online publication. https://doi.org/10.1093/cvr/cvae040
    • Nguyên, U. C., Rijks, J. H. J., Plesinger, F., Rademakers, L. M., Luermans, J., Smits, K. C., van Stipdonk, A. M. W., Prinzen, F. W., Vernooy, K., Halamek, J., Curila, K., & Jurak, P. (2024). Ultra-High-Frequency ECG in Cardiac Pacing and Cardiac Resynchronization Therapy: From Technical Concept to Clinical Application. Journal of Cardiovascular Development and Disease, 11(3), Article 76. https://doi.org/10.3390/jcdd11030076
    • Azzo, J. D., Dib, M.-J., Zagkos, L., Zhao, L., Wang, Z., Chang, C.-P., Ebert, C., Salman, O., Gan, S., Zamani, P., Cohen, J. B., van Empel, V., Richards, A. M., Javaheri, A., Mann, D. L., Rietzschel, E. R., Schafer, P. H., Seiffert, D. A., Gill, D., ... Chirinos, J. A. (2024). Proteomic Associations of NT-proBNP (N-Terminal Pro-B-Type Natriuretic Peptide) in Heart Failure With Preserved Ejection Fraction. Circulation-Heart Failure, 17(2), Article e011146. https://doi.org/10.1161/CIRCHEARTFAILURE.123.011146
    • Clephas, P. R. D., Malgie, J., Schaap, J., Koudstaal, S., Emans, M., Linssen, G. C. M., de Boer, G. A., van Heerebeek, L., Borleffs, C. J. W., Manintveld, O. C., van Empel, V., van Wijk, S., van den Heuvel, M., da Fonseca, C., Damman, K., van Ramshorst, J., van Kimmenade, R., van de Ven, A. R. T., Tio, R. A., ... Brugts, J. J. (2024). Guideline implementation, drug sequencing, and quality of care in heart failure: design and rationale of TITRATE-HF. Esc heart failure, 11(1), 550-559. https://doi.org/10.1002/ehf2.14604
    • Mullens, W., Dauw, J., Gustafsson, F., Mebazaa, A., Steffel, J., Witte, K. K., Delgado, V., Linde, C., Vernooy, K., Anker, S. D., Chioncel, O., Milicic, D., Hasenfuß, G., Ponikowski, P., Stephan von Bardeleben, R., Koehler, F., Ruschitzka, F., Damman, K., Schwammenthal, E., ... Rosano, G. M. C. (2024). Integration of implantable device therapy in patients with heart failure. A clinical consensus statement from the Heart Failure Association (HFA) and European Heart Rhythm Association (EHRA) of the European Society of Cardiology (ESC). European journal of heart failure, 26(2), 483-501. https://doi.org/10.1002/ejhf.3150
    • Nguyên, U. C., Prinzen, F. W., & Vernooy, K. (2024). Left ventricular lead placement in cardiac resynchronization therapy: current data and potential explanations for lack of benefit. Heart Rhythm, 21(2), 197-205. https://doi.org/10.1016/j.hrthm.2023.10.003
    • Spoormans, E. M., Lemkes, J. S., Janssens, G. N., van der Hoeven, N. W., Jewbali, L. S. D., Dubois, E. A., Meuwissen, M., Rijpstra, T. A., Bosker, H. A., Blans, M. J., Bleeker, G. B., Baak, R., Vlachojannis, G. J., Eikemans, B. J. W., van der Harst, P., van der Horst, I. C. C., Voskuil, M., van der Heijden, J. J., Beishuizen, A., ... van Royen, N. (2024). The Prognostic Value of Troponin-T in Out-of-Hospital Cardiac Arrest Without ST-Segment Elevation: A COACT Substudy. Journal of the Society for Cardiovascular Angiography and Interventions, 3(2), Article 101191. https://doi.org/10.1016/j.jscai.2023.101191
    • Tjong, F. V. Y., Perrotta, L., Goette, A., Duncker, D., Vernooy, K., Boveda, S., Chun, K. R. J., & Svennberg, E. (2024). Utilization of and perceived need for simulators in clinical electrophysiology: results from an EHRA physician survey. EP Europace, 26(2), Article euae037. https://doi.org/10.1093/europace/euae037
    • Herweg, B., Sharma, P. S., Cano, O., Ponnusamy, S. S., Zanon, F., Jastrzebski, M., Zou, J., Chelu, M. G., Vernooy, K., Whinnett, Z. I., Nair, G. M., Molina-Lerma, M., Curila, K., Zalavadia, D., Dye, C., Vipparthy, S. C., Brunetti, R., Mumtaz, M., Moskal, P., ... Vijayaraman, P. (2024). Arrhythmic Risk In Biventricular Pacing Compared with Left Bundle Branch Area Pacing: Results From The International LBBAP Collaborative Study (I-CLAS). Circulation, 149(5), 379-390. https://doi.org/10.1161/CIRCULATIONAHA.123.067465
    • Koopsen, T., Gerrits, W., van Osta, N., van Loon, T., Wouters, P., Prinzen, F. W., Vernooy, K., Delhaas, T., Teske, A. J., Meine, M., Cramer, M. J., & Lumens, J. (2024). Virtual pacing of a patient’s digital twin to predict left ventricular reverse remodelling after cardiac resynchronization therapy. EP Europace, 26(1), Article euae009. https://doi.org/10.1093/europace/euae009
    • Saljic, A., & Heijman, J. (2024). P2X7 receptors: central drivers of the neuro-cardiac link between atrial fibrillation and depression?EP Europace, 26(2), Article euae023. https://doi.org/10.1093/europace/euae023
    • Eerenberg, F., Luermans, J., Lumens, J., Nguyên, U. C., Vernooy, K., & van Stipdonk, A. (2024). Exploring QRS Area beyond Patient Selection in CRT-Can It Guide Left Ventricular Lead Placement?Journal of Cardiovascular Development and Disease, 11(1). https://doi.org/10.3390/jcdd11010018
    • van der Velden, R. M. J., Bonander, C., Crijns, H. J. G. M., Kemp-Gudmundsdottir, K., Engdahl, J., Linz, D., & Svennberg, E. (2024). Adherence to a handheld device-based atrial fibrillation screening protocol is associated with clinical outcomes. Heart. Advance online publication. https://doi.org/10.1136/heartjnl-2023-323522
    • Nebhwani, M., Chaibekava, K., Achten, A., Oerlemans, M. I. F. J., Michels, M., van der Meer, P., Nienhuis, H. L. A., Weerts, J., van Empel, V., Rocca, H. P. B. L., Wijk, S. S. V., van der Pol, J., & Knackstedt, C. (2024). Detection of cardiac amyloidosis on routine bone scintigraphy: an important gatekeeper role for the nuclear medicine physician. International Journal of Cardiovascular Imaging. Advance online publication. https://doi.org/10.1007/s10554-024-03085-z
    • Farnir, F. I. P., Luermans, J. G. L. M., Farnir, F. P. F. J. D. J., Chaldoupi, S. M., & Linz, D. (2024). Impedance drop during focal monopolar pulsed field ablation in the atrium. Journal of Interventional Cardiac Electrophysiology. Advance online publication. https://doi.org/10.1007/s10840-024-01793-z
    • Dural, M., Ghossein, M. A., Gerrits, W., Daniels, F., Meine, M., Maass, A. H., Rienstra, M., Prinzen, F. W., Vernooy, K., & van Stipdonk, A. M. W. (2024). Association of vectorcardiographic T-wave area with clinical and echocardiographic outcomes in cardiac resynchronization therapy. EP Europace, 26(1), Article euad370. https://doi.org/10.1093/europace/euad370
    • van der Velden, R. M. J., Pluymaekers, N. A. H. A., Dudink, E. A. M. P., Luermans, J. G. L. M., Meeder, J. G., Heesen, W. F., Lenderink, T., Widdershoven, J. W. M. G., Bucx, J. J. J., Rienstra, M., Kamp, O., van Opstal, J. M., Kirchhof, C. J. H. J., van Dijk, V. F., Swart, H. P., Alings, M., Van Gelder, I. C., Crijns, H. J. G. M., & Linz, D. (2024). Cardioversion strategy impacts rate control during recurrences in patients with paroxysmal atrial fibrillation: A subanalysis of the RACE 7 ACWAS trial. Clinical Cardiology, 47(1), Article e24161. https://doi.org/10.1002/clc.24161
    • Adamo, M., Chioncel, O., Pagnesi, M., Bayes-Genis, A., Abdelhamid, M., Anker, S. D., Antohi, E.-L., Badano, L., Ben Gal, T., Böhm, M., Delgado, V., Dreyfus, J., Faletra, F. F., Farmakis, D., Filippatos, G., Grapsa, J., Gustafsson, F., Hausleiter, J., Jaarsma, T., ... Metra, M. (2024). Epidemiology, Pathophysiology, Diagnosis and Management of Chronic Right-Sided Heart Failure and Tricuspid Regurgitation. A clinical consensus statement of the Heart Failure Association (HFA) and the European Association of Percutaneous Cardiovascular Interventions (EAPCI) of the ESC. European journal of heart failure, 26(1), 18-33. https://doi.org/10.1002/ejhf.3106
    • Farnir, F., Luermans, J., Manusama, R., den Uijl, D., Chaldoupi, S. M., & Linz, D. (2024). Focal point-by-point pulsed field ablation for the treatment of atrial arrhythmias in patients with challenging anatomy where radiofrequency ablation cannot be applied: A case series. HeartRhythm Case Reports, 10(1), 21-25. https://doi.org/10.1016/j.hrcr.2023.10.012
    • HENKENS, MICHIEL. T. H. M., RAAFS, ANNE. G., VANLOON, T. I. M., VOS, JACQUELINE. L., VANDENWIJNGAARD, ARTHUR., BRUNNER, HAN. G., KRAPELS, INGRID. P. C., KNACKSTEDT, CHRISTIAN., GERRETSEN, SUZANNE., HAZEBROEK, MARK. R., VERNOOY, KEVIN., NIJVELDT, ROBIN., LUMENS, JOOST., & VERDONSCHOT, JOB. A. J. (2024). Left Atrial Function in Patients with Titin Cardiomyopathy. Journal of Cardiac Failure, 30(1), 51-60. https://doi.org/10.1016/j.cardfail.2023.05.013
    • Litwin, S. E., Komtebedde, J., Seidler, T., Borlaug, B. A., Winkler, S., Solomon, S. D., Eicher, J.-C., Mazimba, S., Khawash, R., Sverdlov, A. L., Hummel, S. L., Bugger, H., Boenner, F., Hoendermis, E., Cikes, M., Demers, C., Silva, G., van Empel, V., Starling, R., ... REDUCE LAP-HF investigators and research staff (2024). Obesity in Heart Failure with Preserved Ejection Fraction: Insights from the REDUCE LAP-HF II Trial. European journal of heart failure, 26(1), 177-189. https://doi.org/10.1002/ejhf.3092
    • Subzposh, F. A., Sharma, P. S., Cano, Ó., Ponnusamy, S. S., Herweg, B., Zanon, F., Jastrzebski, M., Zou, J., Chelu, M. G., Vernooy, K., Whinnett, Z. I., Nair, G. M., Molina-Lerma, M., Curila, K., Ellenbogen, K. A., & Vijayaraman, P. (2024). Sex-Specific Outcomes of LBBAP Versus Biventricular Pacing: Results From I-CLAS. JACC: Clinical Electrophysiology, 10(1), 96-105. https://doi.org/10.1016/j.jacep.2023.08.026
    • Farnir, F., Chaldoupi, S.-M., Farnir, F., Schotten, U., Vernooy, K., Luermans, J., & Linz, D. (2024). Focal point-by-point biphasic monopolar pulsed field ablation for posterior wall isolation. EP Europace, Article euae077. Advance online publication. https://doi.org/10.1093/europace/euae077
    • van der Heijden, C. A. J., Aerts, L., Chaldoupi, S.-M., van Cruchten, C., Kawczynski, M., Heuts, S., Bidar, E., Luermans, J. G. L. M., & Maesen, B. (2024). Hybrid atrial fibrillation ablation. Annals of Cardiothoracic Surgery, 13(1), 54-70. https://doi.org/10.21037/acs-2023-afm-0129
    • Hermans, B., Özgül, O., Wolf, M., Gonçalves Marques, V., van Hunnik, A., Verheule, S., Chaldoupi, S. M., Linz, D., El Haddad, M., Duytschaever, M., Bonizzi, P., Vernooy, K., Knecht, S., Zeemering, S., & Schotten, U. (2024). Selecting repetitive focal and rotational activation patterns with the highest probability of being a source of atrial fibrillation. Journal of Molecular and Cellular Cardiology Plus, 7, Article 100064. https://www.sciencedirect.com/science/article/pii/S2772976124000047
  • 2023
    • Trayanova, N. A., Lyon, A., Shade, J., & Heijman, J. (2023). Computational modeling of cardiac electrophysiology and arrhythmogenesis. Physiological Reviews. Advance online publication. https://doi.org/10.1152/physrev.00017.2023
    • Garcia, J. G., Arya, A., Dinov, B., Bollmann, A., ter Bekke, R. M. A., Vernooy, K., Dagres, N., Hindricks, G., & Darma, A. (2023). Impact of repeat ablation of ventricular tachycardia in patients with structural heart disease. EP Europace, 26(1), Article euad367. https://doi.org/10.1093/europace/euad367
    • Mulder, B. A., Khalilian Ekrami, N., Van De Lande, M. E., Nguyen, B.-O., Weberndorfer, V., Crijns, H. J., Geelhoed, B., Blaauw, Y., Hemels, M. E., Tieleman, R. G., Scheerder, C. O., De Melis, M., Schotten, U., Linz, D., Van Gelder, I. C., & Rienstra, M. (2023). Women have less progression of paroxysmal atrial fibrillation: data from the RACE V study. Open Heart, 10(2), Article e002534. https://doi.org/10.1136/openhrt-2023-002534
    • Hermans, B. J. M., Bijvoet, G. P., Holtackers, R. J., Mihl, C., Luermans, J. G. L. M., Maesen, B., Vernooy, K., Linz, D., Chaldoupi, S. M., & Schotten, U. (2023). Multi-modal characterization of the left atrium by a fully automated integration of pre-procedural cardiac imaging and electro-anatomical mapping. IJC Heart and Vasculature, 49(1), Article 101276. https://doi.org/10.1016/j.ijcha.2023.101276
    • Bijvoet, G. P., Nies, H. M. J. M., Holtackers, R. J., Martens, B. M., Smink, J., Linz, D., Vernooy, K., Wildberger, J. E., Nijveldt, R., Chaldoupi, S. M., & Mihl, C. (2023). Tissue characterization of acute lesions during cardiac magnetic resonance-guided ablation of cavo-tricuspid isthmus-dependent atrial flutter: a feasibility study. European Heart Journal Cardiovascular Imaging, Article jead334. Advance online publication. https://doi.org/10.1093/ehjci/jead334
    • Knackstedt, C., Ramaekers, B., Schummers, G., Schreckenberg, M., Faessen, J., Marx, N., Becker, M., Sanders-van Wijk, S., van Empel, V., Norra, C., Kunert, H. J., Brunner-La Rocca, H.-P., & PsychEcho study group (2023). Influence of Individual Personality Traits of the Reader on Visual Assessment of Left Ventricular Ejection Fraction: Another Reason to Abandon Visual Assessment. Journal of the American Society of Echocardiography, 36(12), 1332-1335. https://doi.org/10.1016/j.echo.2023.08.015
    • Potjewijd, J., Tobal, R., Boomars, K. A., van Empel, V. V. P. M., de Vries, F., Damoiseaux, J. G. M. C., Schurgers, L. J., & van Paassen, P. (2023). Plasma Dephosphorylated-Uncarboxylated Matrix Gla-Protein in Systemic Sclerosis Patients: Biomarker Potential for Vascular Calcification and Inflammation. Diagnostics, 13(23), Article 3526. https://doi.org/10.3390/diagnostics13233526
    • Hereijgers, M. J. M., van der Velden, R. M. J., el Moussaoui, N., Verhaert, D. V. M., Habibi, Z., Luermans, J., den Uijl, D., Chaldoupi, S. M., Vernooy, K., Schotten, U., Baumert, M., Gietema, H. A., Mihl, C., Koltowski, L., Franssen, F. M. E., Simons, S. O., & Linz, D. (2023). Repurposing catheter ablation work-up to detect expiratory airflow limitation in patients with atrial fibrillation. IJC Heart and Vasculature, 49(1), Article 101305. https://doi.org/10.1016/j.ijcha.2023.101305
    • Weerts, J., Amin, H., Barandiarán Aizpurua, A., Gevaert, A. B., Handoko, M. L., Dauw, J., Tun, H. N., Rommel, K.-P., Verbrugge, F. H., Kresoja, K.-P., Sanders-van Wijk, S., Brunner-La Rocca, H.-P., Bayés-Genís, A., Lumens, J., Knackstedt, C., & van Empel, V. P. M. (2023). Webtool to enhance the accuracy of diagnostic algorithms for HFpEF: a prospective cross-over study. Esc heart failure, 10(6), 3493 - 3503. https://doi.org/10.1002/ehf2.14525
    • Winters, J., Isaacs, A., Zeemering, S., Kawczynski, M., Maesen, B., Maessen, J., Bidar, E., Boukens, B., Hermans, B., van Hunnik, A., Casadei, B., Fabritz, L., Chua, W., Sommerfeld, L., Guasch, E., Mont, L., Batlle, M., Hatem, S., Kirchhof, P., ... Schotten, U. (2023). Heart Failure, Female Sex, and Atrial Fibrillation Are the Main Drivers of Human Atrial Cardiomyopathy: Results From the CATCH ME Consortium. Journal of the American Heart Association, 12(22), Article e031220. https://doi.org/10.1161/JAHA.123.031220
    • Vernooy, K., Keene, D., Huang, W., & Vijayaraman, P. (2023). Implant, assessment, and management of conduction system pacing. European Heart Journal Supplements, 25(Suppl G), G15-G26. Article suad115. https://doi.org/10.1093/eurheartjsupp/suad115
    • Bressi, E., Luermans, J. G., Arnold, A. D., & Grieco, D. (2023). Editorial: Electrical management of heart failure. Frontiers in Cardiovascular Medicine, 10(1), Article 1325989. https://doi.org/10.3389/fcvm.2023.1325989
    • Kaya, Y. S., Stoks, J., Gommers, S., Holtackers, R. J., Duijsings, R., Vernooy, K., Volders, P., & Ter Bekke, R. (2023). Optimal pixel signal intensity threshold for the assessment of endocardial left-ventricular scar by 3D dark blood MRI compared to bipolar voltage electro-anatomical mapping. European Heart Journal, 44.
    • Vijayaraman, P., Chelu, M. G., Curila, K., Dandamudi, G., Herweg, B., Mori, S., Jastrzebski, M., Sharma, P. S., Shivkumar, K., Tung, R., Upadhyay, G., Vernooy, K., Welter-Frost, A., Whinnett, Z., Zanon, F., & Ellenbogen, K. A. (2023). Cardiac Conduction System Pacing: A Comprehensive Update. JACC: Clinical Electrophysiology, 9(11), 2358-2387. https://doi.org/10.1016/j.jacep.2023.06.005
    • Herrera, N. T., Zhang, X., Ni, H., Maleckar, M. M., Heijman, J., Dobrev, D., Grandi, E., & Morotti, S. (2023). Dual effects of the small-conductance Ca2+-activated K+ current on human atrial electrophysiology and Ca2+-driven arrhythmogenesis: an in silico study. American Journal of Physiology-heart and Circulatory Physiology, 325(4), H896-H908. https://doi.org/10.1152/ajpheart.00362.2023
    • Steffens, S., Schröder, K., Krüger, M., Maack, C., Streckfuss-Bömeke, K., Backs, J., Backofen, R., Baeßler, B., Devaux, Y., Gilsbach, R., Heijman, J., Knaus, J., Kramann, R., Linz, D., Lister, A. L., Maatz, H., Maegdefessel, L., Mayr, M., Meder, B., ... Kohl, P. (2023). The challenges of research data management in cardiovascular science: a DGK and DZHK position paper-executive summary. Clinical research in cardiology. Advance online publication. https://doi.org/10.1007/s00392-023-02303-3
    • Chua, W., Cardoso, V. R., Guasch, E., Sinner, M. F., Al-Taie, C., Brady, P., Casadei, B., Crijns, H. J. G. M., Dudink, E. A. M. P., Hatem, S. N., Kääb, S., Kastner, P., Mont, L., Nehaj, F., Purmah, Y., Reyat, J. S., Schotten, U., Sommerfeld, L. C., Zeemering, S., ... Fabritz, L. (2023). An angiopoietin 2, FGF23, and BMP10 biomarker signature differentiates atrial fibrillation from other concomitant cardiovascular conditions. Scientific Reports, 13(1), Article 16743. https://doi.org/10.1038/s41598-023-42331-7