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Weerts, J., Barandiarán Aizpurua, A., Henkens, M. T. H. M., Lyon, A., van Mourik, M. J. W., van Gemert, M. R. A. A., Raafs, A., Sanders-van Wijk, S., Bayés-Genís, A., Heymans, S. R. B., Crijns, H. J. G. M., Brunner-La Rocca, H.-P., Lumens, J., van Empel, V. P. M., & Knackstedt, C. (2022). The prognostic impact of mechanical atrial dysfunction and atrial fibrillation in heart failure with preserved ejection fraction. European Heart Journal Cardiovascular Imaging, 23(1), 74-84. https://doi.org/10.1093/ehjci/jeab222

Tobal, R., Potjewijd, J., van Empel, V. P. M., Ysermans, R., Schurgers, L. J., Reutelingsperger, C. P., Damoiseaux, J. G. M. C., & van Paassen, P. (2021). Vascular Remodeling in Pulmonary Arterial Hypertension: The Potential Involvement of Innate and Adaptive Immunity. Frontiers in medicine, 8, Article 806899. https://doi.org/10.3389/fmed.2021.806899

Gadde, S. G. K., Kshirsagar, A., Anegondi, N., Mochi, T. B., Heymans, S., Ghosh, A., & Roy, A. S. (2021). Correlation of Volume of Macular Edema with Retinal Tomography Features in Diabetic Retinopathy Eyes. Journal of Personalized Medicine, 11(12), Article 1337. https://doi.org/10.3390/jpm11121337

Ferreira, J. P., Girerd, N., Brunner-La Rocca, H. P., Pellicori, P., Cleland, J. G., Rossignol, P., & Zannad, F. (2021). No influence of spironolactone on plasma concentrations of angiotensin-converting enzyme 2: Findings from the HOMAGE randomized trial. Archives of Cardiovascular Diseases, 114(12), 814-817. https://doi.org/10.1016/j.acvd.2021.10.003

Scherrenberg, M., Storms, V., van der Velde, A. E., Boyne, J., Bruins, W., Vranken, J., Leenen, J. P. L., Brunner-La Rocca, H.-P., De Kluiver, E. P., & Dendale, P. (2021). A Home Hospitalisation Strategy for Patients with an Acute Episode of Heart Failure Using a Digital Health-Supported Platform: A Multicentre Feasibility Study - A Rationale and Study Design. Cardiology, 146(6), 793-800. https://doi.org/10.1159/000519085

Gentile, P., Merlo, M., Peretto, G., Ammirati, E., Sala, S., Della Bella, P., Aquaro, G. D., Imazio, M., Potena, L., Campodonico, J., Foa, A., Raafs, A., Hazebroek, M., Brambatti, M., Cercek, A. C., Nucifora, G., Shrivastava, S., Huang, F., Schmidt, M., ... Sinagra, G. (2021). Post-discharge arrhythmic risk stratification of patients with acute myocarditis and life-threatening ventricular tachyarrhythmias. European journal of heart failure, 23(12), 2045-2054. https://doi.org/10.1002/ejhf.2288

Lumbers, R. T., Shah, S., Lin, H. H., Czuba, T., Henry, A., Swerdlow, D. I., Malarstig, A., Andersson, C., Verweij, N., Holmes, M. V., Arnlov, J., Svensson, P., Hemingway, H., Sallah, N., Almgren, P., Aragam, K. G., Asselin, G., Backman, J. D., Biggs, M. L., ... Regeneron Genetics Ctr (2021). The genomics of heart failure: design and rationale of the HERMES consortium. Esc heart failure, 8(6), 5531–5541. https://doi.org/10.1002/ehf2.13517

Gandhi, S., Witten, A., De Majo, F., Gilbers, M., Maessen, J., Schotten, U., de Windt, L. J., & Stoll, M. (2021). Evolutionarily conserved transcriptional landscape of the heart defining the chamber specific physiology. Genomics, 113(6), 3782-3792. https://doi.org/10.1016/j.ygeno.2021.09.002

Ciccarelli, M., Dawson, D., Falcao-Pires, I., Giacca, M., Hamdani, N., Heymans, S., Hooghiemstra, A., Leeuwis, A., Hermkens, D., Tocchetti, C. G., van der Velden, J., Zacchigna, S., & Thum, T. (2021). Reciprocal organ interactions during heart failure: a position paper from the ESC Working Group on Myocardial Function. Cardiovascular Research, 117(12), 2416-2433. https://doi.org/10.1093/cvr/cvab009

Wang, S. J., Schianchi, F., Neumann, D., Wong, L. Y., Sun, A. M., van Nieuwenhoven, F. A., Zeegers, M. P., Strzelecka, A., Col, U., Glatz, J. F. C., Nabben, M., & Luiken, J. J. F. P. (2021). Specific amino acid supplementation rescues the heart from lipid overload-induced insulin resistance and contractile dysfunction by targeting the endosomal mTOR-v-ATPase axis. Molecular Metabolism, 53, Article 101293. https://doi.org/10.1016/j.molmet.2021.101293

Stroeks, S. L. V. M., Hellebrekers, D. M. E. I., Claes, G. R. F., Tayal, U., Krapels, I. P. C., Vanhoutte, E. K., van den Wijngaard, A., Henkens, M. T. H. M., Ware, J. S., Heymans, S. R. B., Brunner, H. G., & Verdonschot, J. A. J. (2021). Clinical impact of re-evaluating genes and variants implicated in dilated cardiomyopathy. Genetics in Medicine, 23(11), 2186-2193. https://doi.org/10.1038/s41436-021-01255-1

Remmelzwaal, S., Beulens, J. W. J., Elders, P. J. M., Stehouwer, C. D. A., Handoko, M. L., Appelman, Y., van Empel, V., Heymans, S. R. B., & van Ballegooijen, A. J. (2021). Sex-specific associations of body composition measures with cardiac function and structure after 8 years of follow-up. Scientific Reports, 11(1), Article 21046. https://doi.org/10.1038/s41598-021-00541-x

Anker, S. D., Butler, J., Filippatos, G., Ferreira, J. P., Bocchi, E., Bohm, M., Brunner-La Rocca, H. P., Choi, D. J., Chopra, V., Chuquiure-Valenzuela, E., Giannetti, N., Gomez-Mesa, J. E., Janssens, S., Januzzi, J. L., Gonzalez-Juanatey, J. R., Merkely, B., Nicholls, S. J., Perrone, S. V., Pina, I. L., ... EMPEROR-Preserved Trial Investigators (2021). Empagliflozin in Heart Failure with a Preserved Ejection Fraction. New England Journal of Medicine, 385(16), 1451-1461. https://doi.org/10.1056/NEJMoa2107038

Sacchetto, C., Mohseni, Z., Colpaert, R. M. W., Vitiello, L., De Bortoli, M., Vonhogen, I. G. C., Xiao, K., Poloni, G., Lorenzon, A., Romualdi, C., Bariani, R., Mazzotti, E., Daliento, L., Bauce, B., Corrado, D., Thum, T., Rampazzo, A., de Windt, L. J., & Calore, M. (2021). Circulating miR-185-5p as a Potential Biomarker for Arrhythmogenic Right Ventricular Cardiomyopathy. Cells, 10(10), Article 2578. https://doi.org/10.3390/cells10102578

Schreurs, J., Sacchetto, C., Colpaert, R. M. W., Vitiello, L., Rampazzo, A., & Calore, M. (2021). Recent Advances in CRISPR/Cas9-Based Genome Editing Tools for Cardiac Diseases. International Journal of Molecular Sciences, 22(20), Article 10985. https://doi.org/10.3390/ijms222010985

Verdonschot, J. A. J., Henkens, M. T. H. M., Wang, P., Schummers, G., Raafs, A. G., Krapels, I. P. C., van Empel, V., Heymans, S. R. B., Brunner-La Rocca, H.-P., & Knackstedt, C. (2021). A global longitudinal strain cut-off value to predict adverse outcomes in individuals with a normal ejection fraction. Esc heart failure, 8(5), 4343-4345. https://doi.org/10.1002/ehf2.13465

Raafs, A., Verdonschot, J., Ferreira, J. P., Wang, P., Collier, T., Henkens, M., Bjorkman, J., Boccanelli, A., Clark, A. L., Delles, C., Diez, J., Gonzalez, A., Girerd, N., Jukema, J. W., Pinet, F., Rossignol, P., Thum, T., Vodovar, N., de Boer, R. A., ... Heymans, S. (2021). Identification of sex-specific biomarkers predicting new-onset heart failure. Esc heart failure, 8(5), 3512-3520. https://doi.org/10.1002/ehf2.13476

Moura, B., Aimo, A., Al-Mohammad, A., Flammer, A., Barberis, V., Bayes-Genis, A., Brunner-La Rocca, H. P., Fontes-Carvalho, R., Grapsa, J., Hulsmann, M., Ibrahim, N., Knackstedt, C., Januzzi, J. L., Lapinskas, T., Sarrias, A., Matskeplishvili, S., Meijers, W. C., Messroghli, D., Mueller, C., ... Richards, A. M. (2021). Integration of imaging and circulating biomarkers in heart failure: a consensus document by the Biomarkers and Imaging Study Groups of the Heart Failure Association of the European Society of Cardiology. European journal of heart failure, 23(10), 1577-1596. https://doi.org/10.1002/ejhf.2339

McDonagh, T. A., Metra, M., Adamo, M., Gardner, R. S., Baumbach, A., Bohm, M., Burri, H., Butler, J., Celutkiene, J., Chioncel, O., Cleland, J. G. F., Coats, A. J. S., Crespo-Leiro, M. G., Farmakis, D., Gilard, M., Heymans, S., Hoes, A. W., Jaarsma, T., Jankowska, E. A., ... ESC Scientific Document Group (2021). 2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure. European Heart Journal, 42(36), 3599-3726. https://doi.org/10.1093/eurheartj/ehab368

De Majo, F., Martens, L., Hegenbarth, J. C., Ruhle, F., Hamczyk, M. R., Nevado, R. M., Andres, V., Hilbold, E., Bar, C., Thum, T., de Boer, M., Duncker, D. J., Schroen, B., Armand, A. S., Stoll, M., & De Windt, L. J. (2021). Genomic instability in the naturally and prematurely aged myocardium. Proceedings of the National Academy of Sciences of the United States of America, 118(36), Article e2022974118. https://doi.org/10.1073/pnas.2022974118

Vergaro, G., Gentile, F., Meems, L. M. G., Aimo, A., Januzzi, J. L., Richards, A. M., Lam, C. S. P., Latini, R., Staszewsky, L., Anand, I. S., Cohn, J. N., Ueland, T., Gullestad, L., Aukrust, P., Brunner-La Rocca, H. P., Bayes-Genis, A., Lupon, J., Yoshihisa, A., Takeishi, Y., ... Emdin, M. (2021). NT-proBNP for Risk Prediction in Heart Failure: Identification of Optimal Cutoffs Across Body Mass Index Categories. JACC: Heart Failure, 9(9), 653-663. https://doi.org/10.1016/j.jchf.2021.05.014

Amin, H., Weerts, J., Brunner-La Rocca, H. P., Knackstedt, C., & Sanders-van Wijk, S. (2021). Future perspective of heart failure care: benefits and bottlenecks of artificial intelligence and eHealth. Future Cardiology, 17(6), 917-921. https://doi.org/10.2217/fca-2021-0008

Veenis, E. F., Brunner-La Rocca, H. P., Linssen, G. C. M., Erol-Yilmaz, A., Pronk, A. C. B., Engelen, D. J. M., van Tooren, R. M., Koornstra-Wortel, H. J. J., de Boer, R. A., van der Meer, P., Hoes, A. W., Brugts, J. J., & CHECK-HF Investigators (2021). Impact of sex-specific target dose in chronic heart failure patients with reduced ejection fraction. European Journal of Preventive Cardiology, 28(9), 957-965. Article 2047487320923185. https://doi.org/10.1177/2047487320923185

Houben, T., Yadati, T., De Kruijf, R., Gijbels, M. J. J., Luiken, J. J. F. P., Van Zandvoort, M., Kapsokalyvas, D., Lutjohann, D., Westerterp, M., Plat, J., Leake, D., & Shiri-Sverdlov, R. (2021). Pro-Inflammatory Implications of 2-Hydroxypropyl-β-cyclodextrin Treatment. Frontiers in Immunology, 12, Article 716357. https://doi.org/10.3389/fimmu.2021.716357

Raso, A., Dirkx, E., Sampaio-Pinto, V., el Azzouzi, H., Cubero, R. J., Sorensen, D. W., Ottaviani, L., Olieslagers, S., Huibers, M. M., de Weger, R., Siddiqi, S., Moimas, S., Torrini, C., Zentillin, L., Braga, L., Nascimento, D. S., da Costa Martins, P. A., van Berlo, J. H., Zacchigna, S., ... De Windt, L. J. (2021). A microRNA program regulates the balance between cardiomyocyte hyperplasia and hypertrophy and stimulates cardiac regeneration. Nature Communications, 12(1), Article 4808. https://doi.org/10.1038/s41467-021-25211-4

Verdonschot, J. A. J., Ferreira, J. P., Pellicori, P., Brunner-La Rocca, H. P., Clark, A. L., Cosmi, F., Cuthbert, J., Girerd, N., Mariottoni, B., Petutschnigg, J., Rossignol, P., Cleland, J. G. F., Zannad, F., Heymans, S. R. B., & HOMAGE “Heart Omics in AGEing” consortium (2021). Proteomic mechanistic profile of patients with diabetes at risk of developing heart failure: insights from the HOMAGE trial. Cardiovascular Diabetology, 20(1), Article 163. https://doi.org/10.1186/s12933-021-01357-9

Laukkanen, L., Diniz, C. R. A. F., Foulquier, S., Prickaerts, J., Castren, E., & Casarotto, P. C. (2021). Facilitation of TRKB Activation by the Angiotensin II Receptor Type-2 (AT2R) Agonist C21. Pharmaceuticals, 14(8), Article 773. https://doi.org/10.3390/ph14080773

Russcher, A., Verdonschot, J., Molenaar-de Backer, M. W. A., Heymans, S. R. B., Kroes, A. C. M., & Zaaijer, H. L. (2021). Parvovirus B19 DNA detectable in hearts of patients with dilated cardiomyopathy, but absent or inactive in blood. Esc heart failure, 8(4), 2723-2730. https://doi.org/10.1002/ehf2.13341

Restrepo-Cordoba, M. A., Wahbi, K., Florian, A. R., Jimenez-Jaimez, J., Politano, L., Arad, M., Climent-Paya, V., Garcia-Alvarez, A., Hansen, R. B., Larranaga-Moreira, J. M., Kubanek, M., Lopes, L. R., Ros, A., Jurcut, R., Rasmussen, T. B., Ruiz-Guerrero, L., Pribe-Wolferts, R., Palomino-Doza, J., Bilinska, Z., ... European Genetic Cardiomyopathies Initiative Investigators (2021). Prevalence and clinical outcomes of dystrophin-associated dilated cardiomyopathy without severe skeletal myopathy. European journal of heart failure, 23(8), 1276-1286. https://doi.org/10.1002/ejhf.2250

Simonavicius, J., Maeder, M. T., Eurlings, C. G. M. J., Aizpurua, A. B., Celutkiene, J., Barysiene, J., Toggweiler, S., Kaufmann, B. A., & Brunner-La Rocca, H.-P. (2021). Intensification of pharmacological decongestion but not the actual daily loop diuretic dose predicts worse chronic heart failure outcome: insights from TIME-CHF. Clinical research in cardiology, 110(8), 1221-1233. https://doi.org/10.1007/s00392-020-01779-7

Vangrieken, P., Al-Nasiry, S., Bast, A., Leermakers, P. A., Tulen, C. B. M., Schiffers, P. M. H., van Schooten, F. J., & Remels, A. H. V. (2021). Placental Mitochondrial Abnormalities in Preeclampsia. Reproductive Sciences, 28(8), 2186-2199. https://doi.org/10.1007/s43032-021-00464-y

Marcks, N., Aimo, A., Januzzi, J. L., Vergaro, G., Clerico, A., Latini, R., Meessen, J., Anand, I. S., Cohn, J. N., Gravning, J., Ueland, T., Bayes-Genis, A., Lupón, J., de Boer, R. A., Yoshihisa, A., Takeishi, Y., Egstrup, M., Gustafsson, I., Gaggin, H. K., ... Brunner-La Rocca, H.-P. (2021). Re-appraisal of the obesity paradox in heart failure: a meta-analysis of individual data. Clinical research in cardiology, 110(8), 1280-1291. https://doi.org/10.1007/s00392-021-01822-1

Veugen, M. G. J., Linssen, P. B. C., Henry, R. M. A., Koster, A., Kroon, A. A., Stehouwer, C. D. A., & Brunner-La Rocca, H.-P. (2021). Measures of Left Ventricular Diastolic Function and Cardiorespiratory Fitness According to Glucose Metabolism Status: The Maastricht Study. Journal of the American Heart Association, 10(13), Article 020387. https://doi.org/10.1161/jaha.120.020387

Breuls, N., Giarratana, N., Yedigaryan, L., Garrido, G. M., Carai, P., Heymans, S., Ranga, A., Deroose, C., & Sampaolesi, M. (2021). Valproic acid stimulates myogenesis in pluripotent stem cell-derived mesodermal progenitors in a NOTCH-dependent manner. Cell Death & Disease, 12(7), Article 677. https://doi.org/10.1038/s41419-021-03936-w

Badimon, L., Robinson, E. L., Jusic, A., Carpusca, I., DeWindt, L. J., Emanueli, C., Ferdinandy, P., Gu, W., Gyongyosi, M., Hackl, M., Karaduzovic-Hadziabdic, K., Lustrek, M., Martelli, F., Nham, E., Potocnjak, I., Satagopam, V., Schneider, R., Thum, T., & Devaux, Y. (2021). Cardiovascular RNA markers and artificial intelligence may improve COVID-19 outcome: a position paper from the EU-CardioRNA COST Action CA17129. Cardiovascular Research, 117(8), 1823-1840. https://doi.org/10.1093/cvr/cvab094

van Woerden, G., van Veldhuisen, D. J., Gorter, T. M., van Empel, V. P. M., Hemels, M. E. W., Hazebroek, E. J., van Veldhuisen, S. L., Willems, T. P., Rienstra, M., & Westenbrink, B. D. (2021). Importance of epicardial adipose tissue localization using cardiac magnetic resonance imaging in patients with heart failure with mid-range and preserved ejection fraction. Clinical Cardiology, 44(7), 987-993. https://doi.org/10.1002/clc.23644

Uijl, A., Veenis, J. F., Brunner-La Rocca, H. P., van Empel, V., Linssen, G. C. M., Asselbergs, F. W., van der Lee, C., Eurlings, L. W. M., Kragten, H., Al-Windy, N. Y. Y., van der Spank, A., Koudstaal, S., Brugts, J. J., & Hoes, A. W. (2021). Clinical profile and contemporary management of patients with heart failure with preserved ejection fraction: results from the CHECK-HF registry. Netherlands Heart Journal, 29(7-8), 370-376. https://doi.org/10.1007/s12471-020-01534-7

Craps, S., Van Wauwe, J., De Moudt, S., De Munck, D., Leloup, A. J., Boeckx, B., Vervliet, T., Dheedene, W., Criem, N., Geeroms, C., Jones, E. A., Zwijsen, A., Lambrechts, D., Fransen, P., Beerens, M., & Luttun, A. (2021). Prdm16 Supports Arterial Flow Recovery by Maintaining Endothelial Function. Circulation Research, 129(1), 63-77. https://doi.org/10.1161/CIRCRESAHA.120.318501

Tayal, U., Ware, J. S., Lakdawala, N. K., Heymans, S., & Prasad, S. K. (2021). Understanding the genetics of adult-onset dilated cardiomyopathy: what a clinician needs to know. European Heart Journal, 42(24), 2384-2396. https://doi.org/10.1093/eurheartj/ehab286

Uijl, A., Savarese, G., Vaartjes, I., Dahlstrom, U., Brugts, J. J., Linssen, G. C. M., van Empel, V., Brunner-La Rocca, H. P., Asselbergs, F. W., Lund, L. H., Hoes, A. W., & Koudstaal, S. (2021). Identification of distinct phenotypic clusters in heart failure with preserved ejection fraction. European journal of heart failure, 23(6), 973-982. https://doi.org/10.1002/ejhf.2169

Favere, K., Bosman, M., Klingel, K., Heymans, S., Van Linthout, S., Delputte, P. L., De Sutter, J., Heidbuchel, H., & Guns, P. J. (2021). Toll-Like Receptors: Are They Taking a Toll on the Heart in Viral Myocarditis?Viruses, 13(6), Article 1003. https://doi.org/10.3390/v13061003

Vilaca, A., Sansonetti, M., Fernandes, H., de Windt, L., & Ferreira, L. (2021). Extracellular vesicles as lncRNA-H19 carriers to the cardiovascular system. European Journal of Clinical Investigation, 51, 108-109.

Callewaert, B., Jones, E. A. V., Himmelreich, U., & Gsell, W. (2021). Non-Invasive Evaluation of Cerebral Microvasculature Using Pre-Clinical MRI: Principles, Advantages and Limitations. Diagnostics, 11(6), Article 926. https://doi.org/10.3390/diagnostics11060926

Raafs, A. G., Verdonschot, J. A. J., Henkens, M. T. H. M., Adriaans, B. P., Wang, P., Derks, K., Abdul Hamid, M. A., Knackstedt, C., van Empel, V. P. M., Diez, J., Brunner-La Rocca, H.-P., Brunner, H. G., Gonzalez, A., Bekkers, S. C. A. M., Heymans, S. R. B., & Hazebroek, M. R. (2021). The combination of carboxy-terminal propeptide of procollagen type I blood levels and late gadolinium enhancement at cardiac magnetic resonance provides additional prognostic information in idiopathic dilated cardiomyopathy - A multilevel assessment of myocardial fibrosis in dilated cardiomyopathy. European journal of heart failure, 23(6), 933-944. https://doi.org/10.1002/ejhf.2201

Roblain, Q., Louis, T., Yip, C., Baudin, L., Struman, I., Caolo, V., Lambert, V., Lecomte, J., Noel, A., & Heymans, S. (2021). Intravitreal injection of anti-miRs against miR-142-3p reduces angiogenesis and microglia activation in a mouse model of laser-induced choroidal neovascularization. Aging, 13(9), 12359-12377. https://doi.org/10.18632/aging.203035

Kapsokalyvas, D., Rosas, R., Janssen, R. W. A., Vanoevelen, J. M., Nabben, M., Strauch, M., Merhof, D., & van Zandvoort, M. A. M. J. (2021). Multiview deconvolution approximation multiphoton microscopy of tissues and zebrafish larvae. Scientific Reports, 11(1), Article 10160. https://doi.org/10.1038/s41598-021-89566-w

Glatz, J. F. C., Wang, F., Nabben, M., & Luiken, J. J. F. P. (2021). CD36 as a target for metabolic modulation therapy in cardiac disease. Expert Opinion on Therapeutic Targets, 25(5), 393-400. https://doi.org/10.1080/14728222.2021.1941865

Remmelzwaal, S., Beulens, J. W. J., Elders, P. J. M., Stehouwer, C. D. A., Zhang, Z., Handoko, M. L., Appelman, Y., van Empel, V., Heymans, S. R. B., Thijs, L., Staessen, J. A., & van Ballegooijen, A. J. (2021). Sex differences in the longitudinal relationship of low-grade inflammation and echocardiographic measures in the Hoorn and FLEMENGHO Study. PLOS ONE, 16(5), Article e0251148. https://doi.org/10.1371/journal.pone.0251148