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Catheter treatment is not only effective, but also cost-effective for ischemic stroke

Catheter treatment is not only effective, but also cost-effective for ischemic stroke

29 September 2026

With ischemic stroke, every minute counts. However, many patients do not seek hospital care until it is too late, for example, because symptoms are not immediately recognized or because people wake up with signs of neurological deficits. As a result, a group of patients is no longer eligible for catheter treatment. 

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Platelets: more than a band-aid

Platelets: more than a band-aid

23 September 2026

Some processes in our body might seem obvious to us. If you cut your finger, the bleeding will stop shortly and form a scab. Behind that seemingly simple process hides a sophisticated system of platelets and clotting factors. By now, we know that platelets do much more than halt bleeding: they function as information carriers and regulators of disease processes. 

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Carim Maastricht
Carim Maastricht

Publications

Section Miranda Nabben Section Vanessa van Empel Section Matthijs Blankesteijn Section Leon de Windt Section Stephane Heymans
  • 2006
    • Jones, E. A. V., le Noble, F., & Eichmann, A. (2006). What determines blood vessel structure? Genetic prespecification vs. hemodynamics. Physiology, 21, 388-95. https://doi.org/10.1152/physiol.00020.2006
    • van Haaften, R. I. M., Schroen, B. L., Janssen, B. J., van Erk, A. A., Debets, J. J., Smeets, H. J., Smits, J. F., van den Wijngaard, A., Pinto, Y. M., & Evelo, C. T. (2006). Biologically relevant effects of mRNA amplification on gene expression profiles. BMC Bioinformatics, 7, 200. https://doi.org/10.1186/1471-2105-7-200
    • van Empel, V. P. M., Bertrand, A. T., van Oort, R. J., van der Nagel, R., Engelen, M. P. K. J., van Rijen, H. V., Doevendans, P. A. F. M., Crijns, H. J. G. M., Ackerman, S. L., Sluiter, W., & de Windt, L. J. (2006). EUK-8, a superoxide dismutase and catalase mimetic, reduces cardiac oxidative stress and ameliorates pressure overload-induced heart failure in the harlequin mouse mutant. Journal of the American College of Cardiology, 48(4), 824-832. https://doi.org/10.1016/j.jacc.2006.02.075
    • Chabowski, A. M. I., Coort, S. L. M., Calles-Escandon, J. T. NN., Glatz, J. F., Luiken, J. J. F. P., & Bonen, A. (2006). Prolonged AMPK activation increases the expression of fatty acid transporters in cardiac myocytes and perfused hearts. Molecular and Cellular Biochemistry, 288, 201-212. https://doi.org/10.1007/s11010-006-9140-8
  • 2005
    • Chabowski, A., Coort, S. L. M., Calles-Escandon, J., Tandon, NN., Glatz, J. F., Luiken, J. J. F. P., & Bonen, A. (2005). The subcellular compartmentation of fatty acid transporters is regulated differently by insulin and by AICAR. Febs Letters, 579, 2428-2432. https://doi.org/10.1016/j.febslet.2004.11.118
    • Meex, S. J. R., van der Kallen, C. J. H., van Greevenbroek, M. M., Eurlings, P. M., El Hasnaoui, M. M., Evelo, C. T., Lindsey, P. J., Luiken, J. J. F. P., Glatz, J. F., & de Bruin, T. W. (2005). Up-regulation of CD36/FAT in preadipocytes in familial combined hyperlipidemia. Faseb Journal, 19(14), 2063-2065. https://doi.org/10.1096/fj.04-2403fje
  • 2004
    • Sharma, U. C., Pokharel, S., van Brakel, T. J., van Berlo, J. H., Cleutjens, J. P. M., Schroen, B., André, S., Crijns, H. J. G. M., Gabius, H.-J., Maessen, J., & Pinto, Y. M. (2004). Galectin-3 marks activated macrophages in failure-prone hypertrophied hearts and contributes to cardiac dysfunction. Circulation, 110(19), 3121-8. https://doi.org/10.1161/01.CIR.0000147181.65298.4D
    • Schroen, B., Heymans, S., Sharma, U., Blankesteijn, W. M., Pokharel, S., Cleutjens, J. P. M., Porter, J. G., Evelo, C. T. A., Duisters, R., van Leeuwen, R. E. W., Janssen, B. J. A., Debets, J. J. M., Smits, J. F. M., Daemen, M. J. A. P., Crijns, H. J. G. M., Bornstein, P., & Pinto, Y. M. (2004). Thrombospondin-2 is essential for myocardial matrix integrity: increased expression identifies failure-prone cardiac hypertrophy. Circulation Research, 95(5), 515-522. https://doi.org/10.1161/01.RES.0000141019.20332.3e
    • De Celle, T., Cleutjens, J. P., Blankesteijn, W. M., Debets, J. J., Smits, J. F., & Janssen, B. J. (2004). Long-term structural and functional consequences of cardiac ischaemia-reperfusion injury in vivo in mice. Experimental Physiology, 89(5), 605-15. https://doi.org/10.1113/expphysiol.2004.027649
    • Beguin, S., Keularts, I., Al Dieri, R., Bellucci, S., Caen, J., & Hemker, H. C. (2004). Fibrin polymerization is crucial for thrombin generation in platelet-rich plasma in a VWF-GPlb-dependent process, defective in Bernhard-Soulier syndrome. Journal of Thrombosis and Haemostasis, 2(1), 170-176. https://doi.org/10.1111/j.1538-7836.2004.00558.x
  • 2003
    • Schrauwen, P., Hoeks, J., Schaart, G., Kornips, C. F. P., Binas, B., van der Vusse, G. J., van Bilsen, M., Luiken, J. J. F. P., Coort, S. L. M., Glatz, J. F., Saris, W. H. M., & Hesselink, M. K. C. (2003). Uncoupling protein 3 as a mitochondrial fatty acid anion exporter. Faseb Journal, 17(15), 2272-2274. https://doi.org/10.1096/fj.03-0515fje
  • 2001
    • Blankesteijn, W. M., Creemers, E., Lutgens, E., Cleutjens, J. P., Daemen, M. J., & Smits, J. F. (2001). Dynamics of cardiac wound healing following myocardial infarction: observations in genetically altered mice. Acta Physiologica Scandinavica, 173(1), 75-82. https://doi.org/10.1046/j.1365-201X.2001.00887.x
    • van Gijn, M. E., Snel, F., Cleutjens, J. P., Smits, J. F., & Blankesteijn, W. M. (2001). Overexpression of components of the Frizzled-Dishevelled cascade results in apoptotic cell death, mediated by beta-catenin. Experimental Cell Research, 265(1), 46-53. https://doi.org/10.1006/excr.2001.5174
    • Keularts, I. M. L. W., Zivelin, A., Seligsohn, U., Hemker, H. C., & Béguin, S. (2001). The role of factor XI in thrombin generation induced by low concentrations of tissue factor.Thrombosis and Haemostasis, 85, 1060-1065. https://doi.org/10.1055/s-0037-1615964
  • 2000
    • Creemers, E., Cleutjens, J., Smits, J., Heymans, S., Moons, L., Collen, D., Daemen, M., & Carmeliet, P. (2000). Disruption of the plasminogen gene in mice abolishes wound healing after myocardial infarction. American Journal of Pathology, 156(6), 1865-73. https://doi.org/10.1016/S0002-9440(10)65060-2
    • Keularts, I. M. L. W., van Gorp Beisser, R. M. A., Feijge, M. A. H., Vuist, M. W. J., & Heemskerk, J. W. M. (2000). alpha2A-Adrenergic receptor stimulation potentiates calcium release in platelets by modulating cAMP levels. Journal of Biological Chemistry, 275(3), 1763-1772. https://doi.org/10.1074/jbc.275.3.1763
    • Keularts, I. M. L. W., Hamulyak, K., Hemker, H. C., & Béguin, S. (2000). The effect of DDAVP infusion On thrombin generation in platelet-rich plasma of von Willebrand type 1 and in mild haemophilia A patients. Thrombosis and Haemostasis, 84(4). https://doi.org/10.1055/s-0037-1614080
  • 1999
    • Cleutjens, J. P., Blankesteijn, W. M., Daemen, M. J., & Smits, J. F. (1999). The infarcted myocardium: simply dead tissue, or a lively target for therapeutic interventions. Cardiovascular Research, 44(2), 232-41. https://doi.org/10.1016/s0008-6363(99)00212-6
    • Heymans, S., Luttun, A., Nuyens, D., Theilmeier, G., Creemers, E., Moons, L., Dyspersin, G. D., Cleutjens, J. P., Shipley, M., Angellilo, A., Levi, M., Nübe, O., Baker, A., Keshet, E., Lupu, F., Herbert, J. M., Smits, J. F., Shapiro, S. D., Baes, M., ... Carmeliet, P. (1999). Inhibition of plasminogen activators or matrix metalloproteinases prevents cardiac rupture but impairs therapeutic angiogenesis and causes cardiac failure. Nature Medicine, 5(10), 1135-42. https://doi.org/10.1038/13459
    • Luiken, J. J., Schaap, F. G., van Nieuwenhoven, F. A., van der Vusse, G. J., Bonen, A., & Glatz, J. F. (1999). Cellular fatty acid transport in heart and skeletal muscle as facilitated by proteins. Lipids, 34 Suppl, S169-75. https://doi.org/10.1007/BF02562278
    • Beguin, S., Kumar, R., Keularts, I., Seligsohn, U., Coller, B. S., & Hemker, H. C. (1999). Fibrin-dependent platelet procoagulant activity requires GPIb receptors and von Willebrand factor. Blood, 93(2), 564-570. https://doi.org/10.1182/blood.V93.2.564
  • 1998
    • Keularts, I. M. L. W., Beguin, S., de Zwaan, C., & Hemker, H. C. (1998). Treatment with a GPIIb/IIIa antagonist inhibits thrombin generation in platelet rich plasma from patients. Thrombosis and Haemostasis, 80(3), 370-371. https://doi.org/10.1055/s-0037-1615213