Publications
- 2003
- Troost, F. J. J., Saris, W. H. M., Haenen, G. R. M. M., Bast, A., & Brummer, R. J. M. (2003). New method to study oxidative damage and antioxidants in the human small bowel: effects of iron application. American Journal of Physiology-Gastrointestinal and Liver Physiology, 285(2), G354-G359. https://doi.org/10.1152/ajpgi.00422.2002
- Hallemeesch, M. M., Janssen, B. J. A., de Jonge, W. J., Soeters, P. B., Lamers, W. H., & Deutz, N. E. P. (2003). NO production by cNOS and iNOS reflects blood pressure changes in LPS-challenged mice. American Journal of Physiology : Endocrinology and Metabolism, 285(4), E871-E875. https://doi.org/10.1152/ajpendo.00004.2002
- Boots, A. W., Haenen, G. R. M. M., & Bast, A. (2003). Oxidant metabolism in chronic obstructive pulmonary disease. European Respiratory Journal, 22(suppl 46), 14S-27S. https://doi.org/10.1183/09031936.03.00000403a
- de Kort, J., Fischer, M., Haenen, G. R. M. M., Bast, A., & Koek, G. H. (2003). Oxidative stress in patients with active HCV infection compared to healthy volunteers. Journal of Hepatology, 38, 374. https://doi.org/10.1016/S0168-8278(03)80643-8
- Boots, A. W., Knubben, N., Haenen, G. R. M. M., & Bast, A. (2003). Oxidized quercetin reacts with thiols rather than with ascorbate: implication for quercetin supplementation. Biochemical and Biophysical Research Communications, 308(3), 560-565. https://doi.org/10.1016/S0006-291X(03)01438-4
- den Hartog, G. J. M., Haenen, G. R. M. M., Vegt, E., van der Vijgh, W. J. F., & Bast, A. (2003). Superoxide dismutase: the balance between prevention and induction of oxidative damage. Chemico-Biological Interactions, 145(1), 33-39. https://doi.org/10.1016/S0009-2797(02)00160-6
- Hageman, G. J., Larik, I., Pennings, H. J., Haenen, G. R. M. M., Wouters, E. F. M., & Bast, A. (2003). Systemic poly(ADP-ribose) polymerase-1 activation, chronic inflammation, and oxidative stress in COPD patients. Free Radical Biology and Medicine, 35(2), 140-148. https://doi.org/10.1016/S0891-5849(03)00237-5
- Rezk, B. M., Haenen, G. R. M. M., van der Vijgh, W. J. F., & Bast, A. (2003). Tetrahydrofolate and 5-methyltetrahydrofolate are folates with high antioxidant activity. Identification of the antioxidant pharmacophore. Febs Letters, 555(3), 601-605. https://doi.org/10.1016/S0014-5793(03)01358-9
- Creemers, E. E. J. M., Davis, J. N., Parkhurst, A. M., Leenders, P., Dowdy, K. B., Hapke, E., Hauet, A. M., Escobar, P. G., Cleutjens, J. P. M., Smits, J. F. M., Daemen, M. J. A. P., Zile, M. R., & Spinale, F. G. (2003). Deficiency of TIMP-1 exacerbates LV remodeling after myocardial infarction in mice. American Journal of Physiology-heart and Circulatory Physiology, 284(1), H364-71. https://doi.org/10.1152/ajpheart.00511.2002
- 2002
- Stahl, W., van den Berg, H., Arthur, J., Bast, A., Dainty, J., Faulks, R. M., Gartner, C., Haenen, G. R. M. M., & et, A. (2002). Bioavailability and metabolism. Molecular Aspects of Medicine, 23(1-3), 39-100. https://doi.org/10.1016/S0098-2997(02)00016-X
- Griffiths, H. R., Moller, L., Bartosz, G., Bast, A., Bertoni-Freddari, C., Collins, A., Cooke, M., Coolen, S., Haenen, G. R. M. M., Hoberg, A. M., Loft, S., Lun, J., Olinski, R., Parry, J., Pompella, A., Poulsen, H., & Verhagen, H. (2002). Biomarkers. Molecular Aspects of Medicine, 23(1-3), 101-108. https://doi.org/10.1016/S0098-2997(02)00017-1
- Haenen, G. R. M. M., Borm, P. J. A., Knaapen, A. M., Albrecht, C., Becker, A., Hohr, D., Winzer, A., & Schins, R. P. F. (2002). DNA damage in lung epithelial cells isolated from rats exposed to quartz: role of surface reactivity and neutrophilic inflammation. Carcinogenesis, 23(7), 1111-1120. https://doi.org/10.1093/carcin/23.7.1111
- van Schooten, F. J., Besarati Nia, A., de Flora, S., D'Agostini, F., Izzotti, A., Camoirano, A., Balm, A. J. M., Dallinga, J. W., Bast, A., Haenen, G. R. M. M., & et, A. (2002). Effects of oral administration of N-acetyl-L-cysteine: a multi-biomarker study in smokers. Cancer Epidemiology Biomarkers & Prevention, 11(2), 167-175. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11867504&dopt=Abstract
- den Hartog, G. J. M., Haenen, G. R. M. M., Vegt, E., van der Vijgh, W. J. F., & Bast, A. (2002). Efficacy of HOCl scavenging by sulfur-containing compounds: antioxidant activity of glutathione disulfide?Biological Chemistry, 383(3-4), 709-713. https://doi.org/10.1515/BC.2002.073
- den Hartog, G. J. M., Vegt, E., van der Vijgh, W. J. F., Haenen, G. R. M. M., & Bast, A. (2002). Hypochlorous acid is a potent inhibitor of acetylcholinesterase. Toxicology and Applied Pharmacology, 181(3), 228-232. https://doi.org/10.1006/taap.2002.9419
- Arts, M. J. T. J., Haenen, G. R. M. M., Wilms, L. C., Beetstra, S., Beerens - Heijnen, C. G. M., Voss, H. P., & Bast, A. (2002). Interactions between flavonoids and proteins: effect on the total antioxidant capacity. Journal of Agricultural and Food Chemistry, 50(5), 1184-1187. https://doi.org/10.1021/jf010855a
- Boots, A. W., Haenen, G. R. M. M., den Hartog, G. J. M., & Bast, A. (2002). Oxidative damage shifts from lipid peroxidation to thiol arylation by catechol-containing antioxidants. Biochimica et Biophysica Acta-Molecular and Cell Biology of Lipids, 1583(3), 279-284. https://doi.org/10.1016/S1388-1981(02)00247-0
- de Kort, J., Haenen, G. R. M. M., Bast, A., Koek, G. H., & Barnes , E. (2002). Oxidative stress in patients with active HCV infection. Hepatology, 36(4), 743. https://doi.org/10.1053/jhep.2002.35344
- Beerens - Heijnen, C. G. M., Haenen, G. R. M. M., Oostveen, R. M., Stalpers, E. M., & Bast, A. (2002). Protection of flavonoids against lipid peroxidation: the structure activity relationship revisited. Free Radical Research, 36(5), 575-581. https://doi.org/10.1080/10715760290025951
- Rezk, B. M., Haenen, G. R. M. M., van der Vijgh, W. J. F., & Bast, A. (2002). The antioxidant activity of phloretin: the disclosure of a new antioxidant pharmacophore in flavonoids. Biochemical and Biophysical Research Communications, 295(1), 9-13. https://doi.org/10.1016/S0006-291X(02)00618-6
- Dallinga, J. W., Haenen, G. R. M. M., Bast, A., & van Schooten, F. J. (2002). The effect of the trolox equivalent antioxidant capacity (TEAC) in plasma on the formation of 4-aminobiphenylhaemoglobin adducts in smokers. Biomarkers, 7(4), 291-298. https://doi.org/10.1080/13547500210148306
- Bast, A., & Haenen, G. R. M. M. (2002). The toxicity of antioxidants and their metabolites. Environmental Toxicology and Pharmacology, 11, 251-258. https://doi.org/10.1016/S1382-6689(01)00118-1
- Haenen, G. R. M. M., & Bast, A. (2002). The use of vitamin supplements in self-medication. Therapie, 57(2), 119-122. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12185958&dopt=Abstract
- van Haaften, R. I. M., Haenen, G. R. M. M., Evelo, C. T. A., & Bast, A. (2002). Tocotrienols inhibit human glutathione S-transferase P1-1. Iubmb Life, 54(2), 81-84. https://doi.org/10.1080/15216540214315
- 2001
- van Eickels, M., Grohé, C., Cleutjens, J. P., Janssen, B. J., Wellens, H. J., & Doevendans, P. A. (2001). 17beta-estradiol attenuates the development of pressure-overload hypertrophy. Circulation, 104(12), 1419-23. https://doi.org/10.1161/hc3601.095577
- Blankesteijn, W. M., Creemers, E., Lutgens, E., Cleutjens, J. P., Daemen, M. J., & Smits, J. F. (2001). Dynamics of cardiac wound healing following myocardial infarction: observations in genetically altered mice. Acta Physiologica Scandinavica, 173(1), 75-82. https://doi.org/10.1046/j.1365-201X.2001.00887.x
- van Gijn, M. E., Snel, F., Cleutjens, J. P., Smits, J. F., & Blankesteijn, W. M. (2001). Overexpression of components of the Frizzled-Dishevelled cascade results in apoptotic cell death, mediated by beta-catenin. Experimental Cell Research, 265(1), 46-53. https://doi.org/10.1006/excr.2001.5174
- van Haaften, R. I. M., Evelo, C. T. A., Haenen, G. R. M. M., & Bast, A. (2001). alpha-Tocopherol inhibits human glutathione S-transferase pi.Biochemical and Biophysical Research Communications, 280, 631-633. https://doi.org/10.1006/bbrc.2000.4174
- Nia, A. B., van Schooten, F. J., Schilderman-Houba, P. A. E. L., de Kok, T. M. C. M., Haenen, G. R. M. M., van Herwijnen, M. H. M., van Agen, E., Pachen, D. M. F. A., & Kleinjans, J. C. S. (2001). A multi-biomarker approach to study the effects of smoking on oxidative DNA damage and repair and antioxidative defense mechanisms.Carcinogenesis, 22, 395-401. https://doi.org/10.1093/carcin/22.3.395
- van den Berg, R., van Vliet, T., Broekmans, W. M. R., Cnubben, N. H. P., Vaes, W. H. J., Roza, L., Haenen, G. R. M. M., Bast, A., & van den Berg, H. (2001). A vegetable/fruit concentrate with high antioxidant capacity has no effect on biomarkers of antioxidant status in male smokers.Journal of Nutrition, 131, 1714-1722. https://doi.org/10.1093/jn/131.6.1714
- Beerens - Heijnen, C. G. M., Haenen, G. R. M. M., van Acker, F. A. A., van der Vijgh, W. J. F., & Bast, A. (2001). Flavonoids as peroxynitrite scavengers: the role of the hydroxyl groups.Toxicology in Vitro, 15, 3-6. https://doi.org/10.1016/S0887-2333(00)00053-9
- van Haaften, R. I. M., den Hartog, G. J. M., Evelo, C. T. A., Haenen, G. R. M. M., & Bast, A. (2001). Hypochlorous acid is a potent inhibitor of GST P1-1.Chemico-Biological Interactions, 138, 77-83. https://doi.org/10.1016/S0009-2797(01)00262-9
- van Haaften, R. I. M., Evelo, C. T. A., Penders, J., Eijnwachter, M., Haenen, G. R. M. M., & Bast, A. (2001). Inhibition of human glutathione S-transferase P1-1 by tocopherols and alpha-tocopherol derivatives.Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, 1548, 23-28. https://doi.org/10.1016/S0167-4838(01)00211-4
- Arts, M. J. T. J., Haenen, G. R. M. M., Voss, H. P., & Bast, A. (2001). Masking of antioxidant capacity by the interaction of flavonoids with protein.Food and Chemical Toxicology, 39, 787-791. https://doi.org/10.1016/S0278-6915(01)00020-5
- van Acker, F. A. A., Hulshof, J., Haenen, G. R. M. M., Menge, W. M. P. B., van der Vijgh, W. J. F., & Bast, A. (2001). New synthetic flavonoids as potent protectors against doxorubicin-induced cardiotoxicity.Free Radical Biology and Medicine, 31, 31-37. https://doi.org/10.1016/S0891-5849(01)00546-9
- Drent, M., van den Berg, R., Haenen, G. R. M. M., van den Berg, H., Wouters, E. F. M., & Bast, A. (2001). NF-kappaB activation in sarcoidosis.Sarcoidosis Vasculitis and Diffuse Lung Diseases, 18(1), 50-56. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11354547&dopt=Abstract
- van Haaften, R. I. M., Evelo, C. T. A., Haenen, G. R. M. M., & Bast, A. (2001). No reduction of alpha-tocopherol quinone by glutathione in rat liver microsomes. Biochemical Pharmacology, 61, 715-719. https://doi.org/10.1016/S0006-2952(01)00545-7
- van den Berg, R., Haenen, G. R. M. M., van den Berg, H., & Bast, A. (2001). Nuclear factor-kappaB activation is higher in peripheral blood mononuclear cells of male smokers.Environmental Toxicology and Pharmacology, 9, 147-151. https://doi.org/10.1016/S1382-6689(00)00070-3
- Beerens - Heijnen, C. G. M., Haenen, G. R. M. M., Vekemans, J., & Bast, A. (2001). Peroxynitrite scavenging of flavonoids: structure activity relationship. Environmental Toxicology and Pharmacology, 10, 199-206. https://doi.org/10.1016/S1382-6689(01)00083-7
- Rhemrev, J. P. T., Vermeiden, J. P. W., Haenen, G. R. M. M., de Bruijne, J., Rekers-Mombarg, L., & Bast, A. (2001). Progressively motile human spermatozoa are well protected against in vitro lipid peroxidation imposed by induced oxidative stress.Andrologia, 33, 151-158. https://doi.org/10.1046/j.1439-0272.2001.00430.x
- Ostby, O. B., Gundersen, L. L., Rise, F., Antonson, O., Fosnes, K., Larsen, V., Bast, A., Custers, I., & Haenen, G. R. M. M. (2001). Synthesis of 5-substituted pyrrolo[1,2-b]pyridazines with antioxidant properties. Archiv der Pharmazie, 334, 21-24. https://doi.org/10.1002/1521-4184(200101)334:1<21::AID-ARDP21>3.0.CO;2-W
- Keularts, I. M. L. W., Zivelin, A., Seligsohn, U., Hemker, H. C., & Béguin, S. (2001). The role of factor XI in thrombin generation induced by low concentrations of tissue factor.Thrombosis and Haemostasis, 85, 1060-1065. https://doi.org/10.1055/s-0037-1615964
- van den Berg, R., Haenen, G. R. M. M., van den Berg, H., & Bast, A. (2001). Transcription factor NF-kappaB as a potential biomarker for oxidative stress.British Journal of Nutrition, 86 suppl 1, S121-S127. https://doi.org/10.1079/BJN2001340
- 2000
- Creemers, E., Cleutjens, J., Smits, J., Heymans, S., Moons, L., Collen, D., Daemen, M., & Carmeliet, P. (2000). Disruption of the plasminogen gene in mice abolishes wound healing after myocardial infarction. American Journal of Pathology, 156(6), 1865-73. https://doi.org/10.1016/S0002-9440(10)65060-2
- van Acker, F. A. A., van Acker, S. A. B. E., Kramer, K., Haenen, G. R. M. M., Bast, A., & van der Vijgh, W. J. F. (2000). 7-monohydroxyethylrutoside protects against chronic doxorubicin-induced cardiotoxicity when administered only once per week. Clinical Cancer Research, 6(4), 1337-1347. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10778960&dopt=Abstract
- Keularts, I. M. L. W., van Gorp Beisser, R. M. A., Feijge, M. A. H., Vuist, M. W. J., & Heemskerk, J. W. M. (2000). alpha2A-Adrenergic receptor stimulation potentiates calcium release in platelets by modulating cAMP levels. Journal of Biological Chemistry, 275(3), 1763-1772. https://doi.org/10.1074/jbc.275.3.1763
- Heunks, L. M. A., Bast, A., van Herwaarden, C. L. A., Haenen, G. R. M. M., & Dekhuijzen, P. N. R. (2000). Effects of emphysema and training on glutathione oxidation in the hamster diaphragm. Journal of Applied Physiology, 88, 2054-2061. https://doi.org/10.1152/jappl.2000.88.6.2054
- van Acker, F. A. A., Schouten, O., Haenen, G. R. M. M., van der Vijgh, W. J. F., & Bast, A. (2000). Flavonoids can replace alpha-tocopherol as an antioxidant. Febs Letters, 473, 145-148. https://doi.org/10.1016/S0014-5793(00)01517-9




