• 2025
    • Karakasis, P., Lefkou, E., Pamporis, K., Heymans, S., Filippatos, G., & Fragakis, N. (2025). Reply to the letter regarding the article 'Association of clonal haematopoiesis with heart failure incidence and outcomes: A systematic review and meta-analysis'. European journal of heart failure, 27(5), 933-934. https://doi.org/10.1002/ejhf.3660
    • Mourmans, S. G. J., Achten, A., Hermans, R., Scheepers, M. J. E., D'Alessandro, E., Swennen, G., Woudstra, J., Appelman, Y., Goor, H. V., Schalkwijk, C., Knackstedt, C., Weerts, J., Eringa, E. C., & van Empel, V. P. M. (2025). The effect of empagliflozin on peripheral microvascular dysfunction in patients with heart failure with preserved ejection fraction. Cardiovascular Diabetology, 24(1), Article 182. https://doi.org/10.1186/s12933-025-02679-8
    • Gigli, M., Stolfo, D., Barbati, G., Graw, S., Chen, S. N., Merlo, M., Medo, K., Gregorio, C., Dal Ferro, M., Paldino, A., Perotto, M., Peter van Tintelen, J., Te Riele, A. S. J. M., Baas, A. F., Wilde, A. M., Amin, A. S., Houweling, A. C., Elliott, P., Cannie, D., ... Filamin C Registry Consortium (2025). Arrhythmic Risk Stratification of Carriers of Filamin C Truncating Variants. JAMA Cardiology, 10(4), 359-369. https://doi.org/10.1001/jamacardio.2024.5543
    • Vranken, N. P. A., Li, X., Bouman, H., Mourmans, S. G. J., Achten, A., Aizpurua, A. B., Brunner-La Rocca, H.-P., Knackstedt, C., van Empel, V. P. M., & Weerts, J. (2025). Temporal prevalence and prognostic impact of diabetes mellitus and albuminuria in heart failure with preserved ejection fraction. Cardiovascular Diabetology, 24(1), Article 156. https://doi.org/10.1186/s12933-025-02708-6
    • Simons, R. B., Karkala, F., Kukk, M. M., Adams, H. H. H., Kayser, M., & Vidaki, A. (2025). Comparative performance evaluation of bisulfite- and enzyme-based DNA conversion methods. Clinical epigenetics, 17(1), Article 56. https://doi.org/10.1186/s13148-025-01855-7
    • Achten, A., Weerts, J., van Koll, J., Ghossein, M., Mourmans, S. G. J., Aizpurua, A. B., van Stipdonk, A. M. W., Vernooy, K., Prinzen, F. W., Rocca, H.-P. B.-L., Knackstedt, C., & van Empel, V. P. M. (2025). Prevalence and prognostic value of ventricular conduction delay in heart failure with preserved ejection fraction. IJC Heart and Vasculature, 57, Article 101622. https://doi.org/10.1016/j.ijcha.2025.101622
    • D'Italia, G., Schroen, B., & Cosemans, J. M. E. M. (2025). Commonalities of platelet dysfunction in heart failure with preserved ejection fraction and underlying comorbidities. Esc heart failure, 12(2), 1013-1028. Article 15090. https://doi.org/10.1002/ehf2.15090
    • Berends, E., Vangrieken, P., Amiri, N., van de Waarenburg, M. P. H., Scheijen, J. L. J. M., Hermes, D. J. H. P., Wouters, K., van Oostenbrugge, R. J., Schalkwijk, C. G., & Foulquier, S. (2025). Increased Levels of Circulating Methylglyoxal Have No Consequence for Cerebral Microvascular Integrity and Cognitive Function in Young Healthy Mice. Molecular Neurobiology, 62(4), 4190-4202. Article 101148. https://doi.org/10.1007/s12035-024-04552-3
    • Schwanbeck, J., Stahnke, M., Eberlein, A., Goeritzer, M., Schulze, A., Pernitsch, D., Kolb, D., Grabner, G. F., Bartolomaeus, T. U. P., Forslund, S. K., Gerhardt, H., Schiattarella, G. G., Ortega, L. C., Lopez-Anguita, N., Kershaw, E. E., Maatz, H., Huebner, N., Zechner, R., Foryst-Ludwig, A., & Kintscher, U. (2025). Endothelial deletion of adipose triglyceride lipase protects against heart failure with preserved ejection fraction. JCI INSIGHT, 10(5), Article e187145. https://doi.org/10.1172/jci.insight.187145
    • Monzo, L., Kobayashi, M., Ferreira, J. P., Lamiral, Z., Delles, C., Clark, A. L., Edelmann, F., González, A., Heymans, S., Pellicori, P., Petutschnigg, J., Verdonschot, J. A. J., Rossignol, P., Cleland, J. G. F., Zannad, F., Girerd, N., & HOMAGE “Heart Omics in AGEing” Trial Committees and Investigators (2025). Echocardiographic and biomarker characteristics in diabetes, coronary artery disease or both: insights from HOMAGE trial. Cardiovascular Diabetology, 24(1), Article 111. https://doi.org/10.1186/s12933-025-02609-8
    • Timmer, L. T., den Hertog, E., Versteeg, D., Post, H., Verdonschot, J. A. J., Monshouwer-Kloots, J., Kyriakopoulou, E., Perini, I., Koopmans, T., van der Kraak, P., Zentilin, L., Heymans, S. R. B., Vink, A., Giacca, M., Heck, A. J. R., & van Rooij, E. (2025). Cardiomyocyte SORBS2 expression increases in heart failure and regulates integrin interactions and extracellular matrix composition. Cardiovascular Research, 121(4), 585-600. Article cvaf021. https://doi.org/10.1093/cvr/cvaf021
    • Gingele, A. J., Amin, H., De Wit, K., Jacobsen, M., Hageman, A., van der Mierden, K., Brandts, J., Weerts, J., Barrett, M., Dixon, L. J., Hill, L., Knackstedt, C., & Brunner-La Rocca, H.-P. (2025). Developing an artificial intelligence-based decision engine for disease-modifying therapy in heart failure: a pilot study. European Heart Journal - Digital Health, 6(2), 285-288. https://doi.org/10.1093/ehjdh/ztad075
    • Schoonvelde, S. A. C., Wiethoff, I., Zwetsloot, P. P., Hirsch, A., Knackstedt, C., Germans, T., Sikking, M., Schinkel, A. F. L., van Slegtenhorst, M. A., Verhagen, J. M. A., de Boer, R. A., Evers, S. M. A. A., Hiligsmann, M., & Michels, M. (2025). Loss of quality of life and increased societal costs in patients with hypertrophic cardiomyopathy: the AFFECT-HCM study. European heart journal - Quality of care & clinical outcomes, 11(2), 174-185. https://doi.org/10.1093/ehjqcco/qcae092
    • Eijgen, J. V., Winckel, L. V., Hanssen, H., Kotliar, K., Vanassche, T., Craenenbroeck, E. V., Cornelissen, V., Craenenbroeck, A. V., Jones, E., & Stalmans, I. (2025). Retinal vessel analysis to assess microvascular function in the healthy eye: A systematic review on the response to acute physiological and pathological stressors. Survey of Ophthalmology, 70(2), 200-214. https://doi.org/10.1016/j.survophthal.2024.11.008
    • Simons, R. B., Adams, H. H. H., Kayser, M., & Vidaki, A. (2025). Investigating Single-Molecule Molecular Inversion Probes for Medium-Scale Targeted DNA Methylation Analysis. Epigenomes, 9(1), Article 8. https://doi.org/10.3390/epigenomes9010008
    • Verdonschot, J. A. J., Paulussen, A. D. C., Lakdawala, N. K., de Die-Smulders, C. E. M., Ware, J. S., & Ingles, J. (2025). Reproductive options and genetic testing for patients with an inherited cardiac disease. Nature Reviews Cardiology, 22(3), 199-211. Article e000067. https://doi.org/10.1038/s41569-024-01073-3
    • Maatz, H., Lindberg, E. L., Adami, E., Lopez-Anguita, N., Perdomo-Sabogal, A., Cocera Ortega, L., Patone, G., Reichart, D., Myronova, A., Schmidt, S., Elsanhoury, A., Klein, O., Kuehl, U., Wyler, E., Landthaler, M., Yousefian, S., Haas, S., Kurth, F., Teichmann, S. A., ... Tschoepe, C. (2025). The cellular and molecular cardiac tissue responses in human inflammatory cardiomyopathies after SARS-CoV-2 infection and COVID-19 vaccination. Nature cardiovascular research, 4(3), 330-345. https://doi.org/10.1038/s44161-025-00612-6
    • Vangrieken, P., Scheijen, J. L. J. M., Schiffers, P. M. H., van de Waarenburg, M. P. H., Foulquier, S., & Schalkwijk, C. C. G. (2025). Modelling the effects of elevated methylglyoxal levels on vascular and metabolic complications. Scientific Reports, 15(1), Article 6025. https://doi.org/10.1038/s41598-025-90661-5
    • Achten, A., Muller, S. A., Zwetsloot, P.-P., Michels, M., van der Meer, P., Nienhuis, H. L. A., van der Meer, M. G., van Empel, V. P. M., Oerlemans, M. I. F. J., & Knackstedt, C. (2025). Is transthyretin amyloid cardiomyopathy heading towards losing its rare disease classification?Expert review of cardiovascular therapy, 23(1-2), 1-4. https://doi.org/10.1080/14779072.2025.2463333
    • Grootaert, M. O. J., Pasut, A., Raman, J., Simmonds, S. J., Callewaert, B., Col, Ü., Dewerchin, M., Carmeliet, P., Heymans, S., & Jones, E. A. V. (2025). Mural cell dysfunction contributes to diastolic heart failure by promoting endothelial dysfunction and vessel remodelling. Cardiovascular Diabetology, 24(1), Article 62. https://doi.org/10.1186/s12933-025-02623-w
    • Stroeks, S. L. V. M., Muller, S., Beelen, N. J., Venner, M. F. G. H. M., Baas, A. F., van Empel, V. P. M., Krapels, I. P. C., Hazebroek, M. R., Te Riele, A. S. J. M., & Verdonschot, J. A. J. (2025). Family Screening in Patients With Dilated and Arrhythmogenic Cardiomyopathy: The Road Toward Gene-Specific Recommendations. Circulation: Genomic and Precision Medicine, 18(1), Article e004778. https://doi.org/10.1161/CIRCGEN.124.004778
    • Heuts, S., Kawczynski, M. J., Leus, A., Godinas, L., Belge, C., van Empel, V., Meyns, B., Maessen, J. G., Delcroix, M., & Verbelen, T. (2025). The volume-outcome relationship for pulmonary endarterectomy in chronic thromboembolic pulmonary hypertension. European Respiratory Journal, 65(2), Article 2401865. https://doi.org/10.1183/13993003.01865-2024
    • Mourmans, S. G. J., Weerts, J., Baumert, M., Aizpurua, A. B., Achten, A., Knackstedt, C., Linz, D., & van Empel, V. P. M. (2025). Prognostic value of hypoxaemic burden from overnight oximetry in heart failure with preserved ejection fraction. Esc heart failure, 12(1), 622-630. https://doi.org/10.1002/ehf2.15116
    • Gan, S., Azzo, J. D., Zhao, L., Pourmussa, B., Dib, M. J., Salman, O., Erten, O., Ebert, C., Richards, A. M., Javaheri, A., Mann, D. L., Rietzschel, E., Zamani, P., van Empel, V., Cappola, T. P., & Chirinos, J. A. (2025). Transferrin Saturation, Serum Iron, and Ferritin in Heart Failure: Prognostic Significance and Proteomic Associations. Circulation-Heart Failure, 18(2), Article e011728. https://doi.org/10.1161/CIRCHEARTFAILURE.124.011728
    • Baker, M. B., Hazell, G., van Rijt, S., Blankesteijn, W. M., Welting, T., den Akker, G. V., & Bauer, J. (2025). Teaching Chemistry in the New Bachelor “Regenerative Medicine and Technology”. Croatica Chemica Acta, 98(2), 157-166. https://doi.org/10.5562/cca4185
    • Manukjan, N., Fulton, D., Ahmed, Z., Blankesteijn, W. M., & Foulquier, S. (2025). Vascular endothelial growth factor: a double-edged sword in the development of white matter lesions. Neural Regeneration Research, 20(1), 191-192. https://doi.org/10.4103/NRR.NRR-D-23-01843
    • Gingele, A. J., Beckers, F., Boyne, J. J., & Brunner-La Rocca, H.-P. (2025). Fluid status assessment in heart failure patients: pilot validation of the Maastricht Decompensation Questionnaire. Netherlands Heart Journal, 33(1), 7-13. https://doi.org/10.1007/s12471-024-01921-4
    • Stroeks, S. L. V. M., Henkens, M. T. H. M., Dominguez, F., Merlo, M., Hellebrekers, D. M. E. I., Gonzalez-Lopez, E., Dal Ferro, M., Ochoa, J. P., Venturelli, F., Claes, G. R. F., Venner, M. F. G. H. M., Krapels, I. P. C., Vanhoutte, E. K., van Paassen, P., van den Wijngaard, A., Sikking, M. A., van Leeuwen, R., Abdul Hamid, M., Li, X., ... Verdonschot, J. A. J. (2025). Genetic Landscape of Patients With Dilated Cardiomyopathy and a Systemic Immune-Mediated Disease. JACC: Heart Failure, 13(1), 133-145. https://doi.org/10.1016/j.jchf.2024.08.011
    • Van Linthout, S., Stellos, K., Giacca, M., Bertero, E., Cannata, A., Carrier, L., Garcia-Pavia, P., Ghigo, A., Gonzalez, A., Haugaa, K. H., Imazio, M., Lopes, L. R., Most, P., Pollesello, P., Schunkert, H., Streckfuss-Boemeke, K., Thum, T., Tocchetti, C. G., Tschoepe, C., ... Heymans, S. (2025). State of the art and perspectives of gene therapy in heart failure. A scientific statement of the Heart Failure Association of the ESC, the ESC Council on Cardiovascular Genomics and the ESC Working Group on Myocardial & Pericardial Diseases. European journal of heart failure, 27(1), 5-25. https://doi.org/10.1002/ejhf.3516
  • 2024
    • Salavati, A., van der Wilt, C. N., Calore, M., van Es, R., Rampazzo, A., van der Harst, P., van Steenbeek, F. G., van Tintelen, J. P., Harakalova, M., & Te Riele, A. S. J. M. (2024). Artificial Intelligence Advancements in Cardiomyopathies: Implications for Diagnosis and Management of Arrhythmogenic Cardiomyopathy. Current Heart Failure Reports, 22(1), Article 5. https://doi.org/10.1007/s11897-024-00688-4
    • van Loon, T., Rijks, J., van Koll, J., Wolffs, J., Cornelussen, R., van Osta, N., Luermans, J., Prinzen, F., Linz, D., van Empel, V., Delhaas, T., Vernooy, K., & Lumens, J. (2024). Accelerated atrial pacing reduces left-heart filling pressure: a combined clinical-computational study. European Heart Journal, 45(46), 4953-4964. https://doi.org/10.1093/eurheartj/ehae718
    • Sikking, M. A., Harding, D., Henkens, M. T. H. M., Stroeks, S. L. V. M., Venner, M. F. G. H. M., Nihant, B., van Leeuwen, R. E. W., Fanti, S., Li, X., van Paassen, P., Knackstedt, C., Brunner-la Rocca, H.-P., van Empel, V. P. M., Verdonschot, J. A. J., Marelli-Berg, F. M., & Heymans, S. R. B. (2024). Cytotoxic T-Cells Drive Outcome in Inflammatory Dilated Cardiomyopathy. Circulation Research, 135(12), 1193-1195. https://doi.org/10.1161/CIRCRESAHA.124.325183
    • Vencato, S., Cagnin, S., Romanato, C., Murali, K., Ferron, S., Becchi, T., Velle, A., Sales, G., Romualdi, C., Rakszewska, A., Conrad, C., Braghetta, P., Vitiello, L., Rampazzo, A., & Calore, M. (2024). Characterization of a novel transgenic mouse model for arrhythmogenic cardiomyopathy: phenotype and heart transcriptome profile. European Journal of Human Genetics, 32, 1386-1386.
    • Achten, A., Muller, S. A., Wijk, S. S., van der Meer, M. G., van der Harst, P., van Tintelen, P., Te Riele, A. S., van Empel, V., Oerlemans, M. I., & Knackstedt, C. (2024). Diversity of heart failure phenotypes in transthyretin amyloid cardiomyopathy. More than just heart failure with preserved ejection fraction. Annals of Medicine, 56(1), Article 2418965. https://doi.org/10.1080/07853890.2024.2418965
    • Léger, L., Aalders, J., Heymans, N., Van Acker-Verberckt, K., De Bleeckere, L., Coucke, P., Menten, B., Bauce, B., Vitiello, L., Rampazzo, A., Calore, M., & van Hengel, J. (2024). Generation of a human induced pluripotent stem cell line UGENTi002-A from an arrhythmogenic cardiomyopathy patient carrying the c.817C>T DSP heterozygous variant and isogenic control using CRISPR/Cas9 editing. Stem Cell Research, 81, Article 103537. https://doi.org/10.1016/j.scr.2024.103537
    • Verdonschot, J. A. J., Fuster, J. J., Walsh, K., & Heymans, S. R. B. (2024). The emerging role of clonal haematopoiesis in the pathogenesis of dilated cardiomyopathy. European Heart Journal, 45(45), 4797-4807. Article ehae682. https://doi.org/10.1093/eurheartj/ehae682
    • Hoen, M., Hofman, D. E., Hompes, B. H. A., Peeters, L. E. E., Langenveld, B., van Kimmenade, R. R. J., Frenken, L. A. M., Lenderink, T., Brunner-La Rocca, H. P., & Sanders-Van Wijk, S. (2024). The role of urine sodium in acutely decompensated heart failure. IJC Heart and Vasculature, 55, Article 101509. https://doi.org/10.1016/j.ijcha.2024.101509
    • Wei, F.-F., Mariottoni, B., An, D.-W., Pellicori, P., Yu, Y.-L., Verdonschot, J. A. J., Liu, C., Ahmed, F. Z., Petutschnigg, J., Rossignol, P., Heymans, S., Cuthbert, J., Girerd, N., Li, Y., Clark, A. L., Nawrot, T. S., Ferreira, J. P., Zannad, F., Cleland, J. G. F., ... HOMAGE investigators (2024). Heart rate reactivity, recovery, and endurance of the incremental shuttle walk test in patients prone to heart failure. Esc heart failure, 11(6), 4116-4126. https://doi.org/10.1002/ehf2.15000
    • Berends, E., Pencheva, M. G., van de Waarenburg, M. P. H., Scheijen, J. L. J. M., Hermes, D. J. H. P., Wouters, K., van Oostenbrugge, R. J., Foulquier, S., & Schalkwijk, C. G. (2024). Glyoxalase 1 overexpression improves neurovascular coupling and limits development of mild cognitive impairment in a mouse model of type 1 diabetes. Journal of Physiology, 602(22), 6209-6223. https://doi.org/10.1113/JP286723
    • Tobal, R., Potjewijd, J., de Vries, F., van Doorn, D. P. C., Jaminon, A., Bittner, R., Akbulut, C., van Empel, V., Heeringa, P., Damoiseaux, J., Schurgers, L., & van Paassen, P. (2024). Dephosphorylated uncarboxylated Matrix-Gla-Protein as candidate biomarker for immune-mediated vascular remodeling and prognosis in pulmonary hypertension. Scientific Reports, 14(1), Article 26633. https://doi.org/10.1038/s41598-024-77000-w
    • Daems, M., Ponomarev, L. C., Simoes-Faria, R., Nobis, M., Scheele, C. L. G. J., Luttun, A., Ghesquière, B., Zwijsen, A., & Jones, E. A. V. (2024). Smad1/5 is acetylated in the dorsal aortae of the mouse embryo before the onset of blood flow, driving early arterial gene expression. Cardiovascular Research, 120(16), 2078-2091. Article cvae201. https://doi.org/10.1093/cvr/cvae201
    • Wei, F.-F., Pellicori, P., Ferreira, J. P., González, A., Mariottoni, B., An, D.-W., Verdonschot, J. A. J., Liu, C., Ahmed, F. Z., Petutschnigg, J., Rossignol, P., Heymans, S., Cuthbert, J., Girerd, N., Clark, A. L., Li, Y., Nawrot, T. S., Díez, J., Zannad, F., ... HOMAGE investigators (2024). Effects of spironolactone on exercise blood pressure in patients at increased risk of developing heart failure: report from the HOMAGE trial. Hypertension Research, 47(11), 3225-3236. https://doi.org/10.1038/s41440-024-01843-z
    • Poggiali, B., Dupont, M. E., Jacobsen, S. B., Smerup, M. H., Christiansen, S. N. N., Tfelt-Hansen, J., Vidaki, A., Morling, N., & Andersen, J. D. (2024). DNA methylation stability in cardiac tissues kept at different temperatures and time intervals. Scientific Reports, 14(1), 25170. Article 25170. https://doi.org/10.1038/s41598-024-76027-3
    • Callewaert, B., Gsell, W., Lox, M., Himmelreich, U., & Jones, E. A. V. (2024). A timeline study on vascular co-morbidity induced cerebral endothelial dysfunction assessed by perfusion MRI. Neurobiology of Disease, 202, Article 106709. https://doi.org/10.1016/j.nbd.2024.106709
    • Woudstra, J., Mourmans, S. G. J., Vink, C. E. M., Marques, K. M. J., de Jong, E., Haddad, R. Y. R., van de Hoef, T. P., Chamuleau, S. A. J., Damman, P., Beijk, M. A. M., van Empel, V., Serné, E. H., Appelman, Y., & Eringa, E. C. (2024). Relationship between peripheral and intracoronary blood flow in patients with angina and non-obstructive coronary arteries. American Journal of Physiology-heart and Circulatory Physiology, 327(4), H1086-H1097. https://doi.org/10.1152/ajpheart.00335.2024
    • Achten, A., van Empel, V. P. M., Weerts, J., Mourmans, S., Beckers-Wesche, F., Spanjers, M., Gingele, A., Brunner-La Rocca, H.-P., Sanders-van Wijk, S., & Knackstedt, C. (2024). Changes in the diagnostic trajectory of transthyretin cardiac amyloidosis over six years. Heart and Vessels, 39(10), 857-866. https://doi.org/10.1007/s00380-024-02408-3
    • Patwala, A., Barker, D., Da Costa, A., Bayard, G., Brunner-La Rocca, H. P., Fontes-Carvalho, R., De la Fuente, L., Goralski, M., Mahon, N. G., Roque, D., Santos, M., Yousef, Z., Ben Hamouda, H., Teal, M., Christory, F., Ahmed, F. Z., & Mebazaa, A. (2024). Optimizing heart failure pathways to enhance patient care: the Program to Optimize Heart Failure Patient Pathways (PRO-HF). Esc heart failure, 11(5), 2578-2590. https://doi.org/10.1002/ehf2.14911
    • Dib, M. J., Azzo, J. D., Zhao, L., Salman, O., Gan, S., De Buyzere, M. L., De Meyer, T., Ebert, C., Gunawardhana, K., Liu, L., Gordon, D., Seiffert, D., Ching-Pin, C., Zamani, P., Cohen, J. B., Pourmussa, B., Kun, S., Gill, D., Burgess, S., ... Chirinos, J. A. (2024). Proteome-Wide Genetic Investigation of Large Artery Stiffness. JACC: Basic to Translational Science, 9(10), 1178-1191. https://doi.org/10.1016/j.jacbts.2024.05.017
    • Verdonschot, J. A. J., Heymans, S. R. B., & Van Linthout, S. (2024). The next era of gene-specific clinical care in patients with dilated cardiomyopathy. European journal of heart failure, 26(10), 2169-2172. https://doi.org/10.1002/ejhf.3446
    • Yu, Y.-L., Siwy, J., An, D.-W., González, A., Hansen, T., Latosinska, A., Pellicori, P., Ravassa, S., Mariottoni, B., Verdonschot, J. A., Ahmed, F., Petutschnigg, J., Rossignol, P., Heymans, S., Cuthbert, J. J., Girerd, N., Clark, A. L., Verhamme, P., Nawrot, T. S., ... HOMAGE investigators (2024). Urinary proteomic signature of mineralocorticoid receptor antagonism by spironolactone: evidence from the HOMAGE trial. Heart, 110(19), 1180-1187. Article heartjnl-2023-323796. https://doi.org/10.1136/heartjnl-2023-323796