Maessen, D. E., Brouwers, O., Gaens, K. H., Wouters, K., Cleutjens, J. P., Janssen, B. J., Miyata, T., Stehouwer, C. D., & Schalkwijk, C. G. (2016). Delayed Intervention With Pyridoxamine Improves Metabolic Function and Prevents Adipose Tissue Inflammation and Insulin Resistance in High-Fat Diet-Induced Obese Mice. Diabetes, 65(4), 956-966. https://doi.org/10.2337/db15-1390

Kimenai, D. M., Henry, R. M. A., van der Kallen, C. J. H., Dagnelie, P. C., Schram, M. T., Stehouwer, C. D. A., van Suijlen, J. D. E., Niens, M., Bekers, O., Sep, S. J. S., Schaper, N. C., van Dieijen-Visser, M. P., & Meex, S. J. R. (2016). Direct comparison of clinical decision limits for cardiac troponin T and I. Heart, 102(8), 610-616. https://doi.org/10.1136/heartjnl-2015-308917

Uiterwijk, R., Huijts, M., Staals, J., Rouhl, R. P. W., De Leeuw, P. W., Kroon, A. A., & Van Oostenbrugge, R. J. (2016). Endothelial Activation Is Associated With Cognitive Performance in Patients With Hypertension. American Journal of Hypertension, 29(4), 464-469. https://doi.org/10.1093/ajh/hpv122

BIOS Consortium, van Greevenbroek, M., Stehouwer, C., van der Kallen, C. J. H., & Schalkwijk, C. (2016). Genetic and environmental influences interact with age and sex in shaping the human methylome. Nature Communications, 7, Article 11115. https://doi.org/10.1038/ncomms11115

Fuijkschot, W. W., de Graaff, H. J., Berishvili, E., Kakabadze, Z., Kupreishvili, K., Meinster, E., Houtman, M., van Broekhoven, A., Schalkwijk, C. G., Vonk, A. B. A., Krijnen, P. A. J., Smulders, Y. M., & Niessen, H. W. N. (2016). Prevention of age-induced N(epsilon)-(carboxymethyl)lysine accumulation in the microvasculature. European Journal of Clinical Investigation, 46(4), 334-341. https://doi.org/10.1111/eci.12599

Koning, N. J., de lange, F., Vonk, A. B. A., Ahmed, Y., van den Brom, C. E., Bogaards, S., van Meurs, M., Jongman, R. M., Schalkwijk, C. G., Begieneman, M. P. V., Niessen, H. W., Baufreton, C., & Boer, C. (2016). Impaired microcirculatory perfusion in a rat model of cardiopulmonary bypass: the role of hemodilution. American Journal of Physiology-heart and Circulatory Physiology, 310(5), H550-H558. https://doi.org/10.1152/ajpheart.00913.2015

van Bussel, F. C. G., Backes, W. H., Hofman, P. A. M., van Boxtel, M. P. J., Schram, M. T., Stehouwer, C. D. A., Wildberger, J. E., & Jansen, J. F. A. (2016). Altered Hippocampal White Matter Connectivity in Type 2 Diabetes Mellitus and Memory Decrements. Journal of Neuroendocrinology, 28(3), Article 12366. https://doi.org/10.1111/jne.12366

von Scholten, B. J., Reinhard, H., Hansen, T. W., Schalkwijk, C. G., Stehouwer, C., Parving, H.-H., Jacobsen, P. K., & Rossing, P. (2016). Markers of inflammation and endothelial dysfunction are associated with incident cardiovascular disease, all-cause mortality, and progression of coronary calcification in type 2 diabetic patients with microalbuminuria. Journal of Diabetes and Its Complications, 30(2), 248-255. https://doi.org/10.1016/j.jdiacomp.2015.11.005

Zuo, H., Ueland, P. M., Ulvik, A., Eussen, S. J. P. M., Vollset, S. E., Nygard, O., Midttun, O., Theofylaktopoulou, D., Meyer, K., & Tell, G. S. (2016). 9 Plasma Biomarkers of Inflammation, the Kynurenine Pathway, and Risks of All-Cause, Cancer, and Cardiovascular Disease Mortality. American Journal of Epidemiology, 183(4), 249-258. https://doi.org/10.1093/aje/kwv242

Hertle, E., Arts, I. C. W., van der Kallen, C. J. H., Feskens, E. J. M., Schalkwijk, C. G., Stehouwer, C. D. A., & van Greevenbroek, M. M. J. (2016). The alternative complement pathway is longitudinally associated with adverse cardiovascular outcomes The CODAM study. Thrombosis and Haemostasis, 115(2), 446-457. https://doi.org/10.1160/TH15-05-0439

Nielen, J. T., de Vries, F., Dagnelie, P. C., van den Bemt, B. J., Emans, P. J., Lalmohamed, A., de Boer, A., & Boonen, A. E. (2016). Use of thiazolidinediones and the risk of elective hip or knee replacement: a population based case-control study. British Journal of Clinical Pharmacology, 81(2), 370-378. https://doi.org/10.1111/bcp.12786

van Dooren, F., Denollet, J., Verhey, F. R., Stehouwer, C. D., Sep, S., Henry, R., Kremers, S. P. J., Dagnelie, P. C., Schaper, N. C., van der Kallen, C. J., Koster, A., Pouwer, F., & Schram, M. T. (2016). Psychological and personality factors in type 2 diabetes mellitus, presenting the rationale and exploratory results from The Maastricht Study, a population-based cohort study. BMC Psychiatry, 16(1), Article 17. https://doi.org/10.1186/s12888-016-0722-z

Hollak, C. E. M., Biegstraaten, M., Baumgartner, M. R., Belmatoug, N., Bembi, B., Bosch, A., Brouwers, M., Dekker, H., Dobbelaere, D., Engelen, M., Groenendijk, M. C., Lachmann, R., Langendonk, J. G., Langeveld, M., Linthorst, G., Morava, E., Poll-The, B. T., Rahman, S., Rubio Gozalbo, E., ... Hagendijk, R. (2016). Position statement on the role of healthcare professionals, patient organizations and industry in European Reference Networks. Orphanet Journal of Rare Diseases, 11, Article 7. https://doi.org/10.1186/s13023-016-0383-5

Scheijen, J. L. J. M., Clevers, E., Engelen, L., Dagnelie, P. C., Brouns, F., Stehouwer, C. D. A., & Schalkwijk, C. G. (2016). Analysis of advanced glycation endproducts in selected food items by ultra-performance liquid chromatography tandem mass spectrometry: Presentation of a dietary AGE database. Food Chemistry, 190, 1145-1150. https://doi.org/10.1016/j.foodchem.2015.06.049

van Dooren, F., Verhey, F. R. J., Pouwer, F., Schalkwijk, C. G., Sep, S. J. S., Stehouwer, C. D. A., Henry, R. M. A., Dagnelie, P. C., Schaper, N. C., van der Kallen, C. J. H., Koster, A., Schram, M. T., & Denollet, J. (2016). Association of Type D personality with increased vulnerability to depression: is there a role for inflammation or endothelial dysfunction? - the Maastricht Study. Journal of Affective Disorders, 189, 118-125. https://doi.org/10.1016/j.jad.2015.09.028

Sanders, M. F., Blankestijn, P. J., Voskuil, M., Spiering, W., Vonken, E. J., Rotmans, J. I., van der Hoeven, B. L., Daemen, J., van den Meiracker, A. H., Kroon, A. A., de Haan, M. W., Das, M., Bax, M., van der Meer, I. M., van Overhagen, H., van den Born, B. J. H., van Brussel, P. M., van der Valk, P. H. M., Gregoor, P. J. H. S., ... Bots, M. L. (2016). Safety and long-term effects of renal denervation: Rationale and design of the Dutch registry. Netherlands Journal of Medicine, 74(1), 5-15.

van Sloten, T. T., & Stehouwer, C. D. A. (2016). Carotid Stiffness: A Novel Cerebrovascular Disease Risk Factor. Pulse, 4(1), 24-27. https://doi.org/10.1159/000445354

van Greevenbroek, M. M. J., Schalkwijk, C. G., & Stehouwer, C. D. A. (2016). Dysfunctional adipose tissue and low-grade inflammation in the management of the metabolic syndrome: current practices and future advances. F1000Research, 5, Article 2515. https://doi.org/10.12688/f1000research.8971.1

van der Heijden, R. A., Morrison, M. C., Sheedfar, F., Mulder, P., Schreurs, M., Hommelberg, P. P. H., Hofker, M. H., Schalkwijk, C., Kleemann, R., Tietge, U. J. F., Koonen, D. P. Y., & Heeringa, P. (2016). Effects of Anthocyanin and Flavanol Compounds on Lipid Metabolism and Adipose Tissue Associated Systemic Inflammation in Diet-Induced Obesity. Mediators of Inflammation, 2016, Article 2042107. https://doi.org/10.1155/2016/2042107

van Dalem, J., Brouwers, M., Stehouwer, C., Krings, A., Leufkens, H. G. M., Driessen, J. H. M., de Vries, F., & Burden, A. (2016). Het risico op hypoglykemieën bij sulfonylureumderivaten ten opzichte van metformine in relatie tot nierfunctie en metabolietgroep. Nederlands Platform voor Farmaceutisch Onderzoek, 1, Article a1636. https://www.knmp.nl/professie/wetenschap/nederlands-platform-voor-farmaceutisch-onderzoek/het-risico-op-hypoglykemieen-bij-sulfonylureumderivaten-ten-opzichte-van-metformine-in-relatie-tot-nierfunctie-en-metabolietgroep

Potse, M., Lankveld, T. A. R., Zeemering, S., Dagnelie, P. C., Stehouwer, C. D. A., Henry, R. M., Linnenbank, A. C., Kuijpers, N. H. L., & Schotten, U. (2016). P-wave complexity in normal subjects and computer models. Journal of Electrocardiology, 49(4), 545-553. https://doi.org/10.1016/j.jelectrocard.2016.05.005

Alam, N., van de Ven, P. M., Oskam, E., Stassen, P., Kramer, M. H., Exter, P. V., & Nanayakkara, P. W. (2016). Study protocol for a Multi-centre, Investigator-initiated, Randomized Controlled Trial to Compare the Effects of Prehospital Antibiotic Treatment for Sepsis Patients with Usual Care after Training Emergency Medical Services (EMS) Personnel in Early Recognition (- The Prehospital ANTibiotics Against Sepsis (PHANTASi) trial. Acute Medicine, 15(4), 176-184. https://doi.org/10.52964/AMJA.0633

Huber, M., van Vliet, M., Giezenberg, M., Winkens, B., Heerkens, Y., Dagnelie, P. C., & Knottnerus, J. A. (2016). Towards a 'patient-centred' operationalisation of the new dynamic concept of health: a mixed methods study. BMJ Open, 5(1), Article e010091. https://doi.org/10.1136/bmjopen-2015-010091

Brouwers, M. C. G. J. (2015). Electrolyte and Acid-Base Disturbances in Diabetes Mellitus. New England Journal of Medicine, 373(25), 2482-2482.

Teunissen-Beekman, K. F. M., Dopheide, J., Geleijnse, J. M., Bakker, S. J., Brink, E. J., de Leeuw, P. W., Schalkwijk, C. G., & van Baak, M. A. (2015). Dietary proteins improve endothelial function under fasting conditions but not in the postprandial state, with no effects on markers of low-grade inflammation. British Journal of Nutrition, 114(11), 1819-1828. https://doi.org/10.1017/s0007114515003530

Magdelijns, F. J. H., Pijpers, E., Rouhl, R. P. W., Hannemann, P. F. W., ten Broeke, R. H. M., Dings, J. T. A., Stehouwer, C. D. A., & Stassen, P. M. (2015). Acute Hospital Admissions Because of Health Care-Related Adverse Events: A Retrospective Study of 5 Specialist Departments. Journal of the American Medical Directors Association, 16(12), 1055-1061. https://doi.org/10.1016/j.jamda.2015.06.019

Gaens, K. H. J., Ferreira, I., van de Waarenburg, M. P. H., van Greevenbroek, M. M., van der Kallen, C. J. H., Dekker, J. M., Nijpels, G., Rensen, S. S., Stehouwer, C. D. A., & Schalkwijk, C. G. (2015). Protein-Bound Plasma N-epsilon-(Carboxymethyl) lysine Is Inversely Associated With Central Obesity and Inflammation and Significantly Explain a Part of the Central Obesity-Related Increase in Inflammation The Hoorn and CODAM Studies. Arteriosclerosis Thrombosis and Vascular Biology, 35(12), 2707-2713. https://doi.org/10.1161/ATVBAHA.115.306106

Gijsbers, L., Dower, J. I., Schalkwijk, C. G., Kusters, Y. H. A. M., Bakker, S. J. L., Hollman, P. C. H., & Geleijnse, J. M. (2015). Effects of sodium and potassium supplementation on endothelial function: a fully controlled dietary intervention study. British Journal of Nutrition, 114(9), 1419-1426. https://doi.org/10.1017/S0007114515002986

van der Heijden, R. A., Bijzet, J., Meijers, W. C., Yakala, G. K., Kleemann, R., Nguyen, T. Q., de Boer, R. A., Schalkwijk, C. G., Hazenberg, B. P. C., Tietge, U. J. F., & Heeringa, P. (2015). Obesity-induced chronic inflammation in high fat diet challenged C57BL/6J mice is associated with acceleration of age-dependent renal amyloidosis. Scientific Reports, 5, Article 16474. https://doi.org/10.1038/srep16474

van Sloten, T. T., Sedaghat, S., Laurent, S., London, G. M., Pannier, B., Ikram, M. A., Kavousi, M., Mattace-Raso, F., Franco, O. H., Boutouyrie, P., & Stehouwer, C. D. A. (2015). Carotid Stiffness Is Associated With Incident Stroke A Systematic Review and Individual Participant Data Meta-Analysis. Journal of the American College of Cardiology, 66(19), 2116-2125. https://doi.org/10.1016/j.jacc.2015.08.888

Mbakwa, C. A., Penders, J., Savelkoul, P. H., Thijs, C., Dagnelie, P. C., Mommers, M., & Arts, I. C. W. (2015). Gut colonization with methanobrevibacter smithii is associated with childhood weight development. Obesity, 23(12), 2508-2516. https://doi.org/10.1002/oby.21266

Vossen, L. M., Schurgers, L. J., van Varik, B. J., Kietselaer, B. L. J. H., Vermeer, C., Meeder, J. G., Rahel, B. M., van Cauteren, Y. J. M., Hoffland, G. A., Rennenberg, R. J. M. W., Reesink, K. D., de Leeuw, P. W., & Kroon, A. A. (2015). Menaquinone-7 Supplementation to Reduce Vascular Calcification in Patients with Coronary Artery Disease: Rationale and Study Protocol (VitaK-CAC Trial). Nutrients, 7(11), 8905-8915. https://doi.org/10.3390/nu7115443

Driessen, J. H. M., van Onzenoort, H. A. W., Starup-Linde, J., Henry, R., Burden, A. M., Neef, C., van den Bergh, J. P., Vestergaard, P., & de Vries, F. (2015). Use of Glucagon-Like-Peptide 1 Receptor Agonists and Risk of Fracture as Compared to Use of Other Anti-hyperglycemic Drugs. Calcified Tissue International, 97(5), 506-515. https://doi.org/10.1007/s00223-015-0037-y

Legein, B., Janssen, E. M., Theelen, T. L., Gijbels, M. J., Walraven, J., Klarquist, J. S., Hennies, C. M., Wouters, K., Seijkens, T. T. P., Wijnands, E., Sluimer, J. C., Lutgens, E., Zenke, M., Hildner, K., Biessen, E. A. L., & Temmerman, L. (2015). Ablation of CD8 alpha(+) dendritic cell mediated cross-presentation does not impact atherosclerosis in hyperlipidemic mice. Scientific Reports, 5, Article 15414. https://doi.org/10.1038/srep15414

Alnima, T., de Leeuw, P. W., & Kroon, A. A. (2015). Baropacing as a new option for treatment of resistant hypertension. European Journal of Pharmacology, 763, 23-27. https://doi.org/10.1016/j.ejphar.2015.03.097

Gilsing, A. M. J., Schouten, L. J., Goldbohm, R. A., Dagnelie, P. C., van den Brandt, P. A., & Weijenberg, M. P. (2015). Vegetarianism, low meat consumption and the risk of colorectal cancer in a population based cohort study. Scientific Reports, 5, Article 13484. https://doi.org/10.1038/srep13484

Wijnands, J. M. A., Boonen, A., van Sloten, T. T., Schram, M. T., Sep, S. J. S., Koster, A., van der Kallen, C. J. H., Henry, R. M. A., Dagnelie, P. C., Stehouwer, C. D. A., van der Linden, S., & Arts, I. C. W. (2015). Association between serum uric acid, aortic, carotid and femoral stiffness among adults aged 40-75 years without and with type 2 diabetes mellitus: The Maastricht Study. Journal of Hypertension, 33(8), 1642-1650. https://doi.org/10.1097/HJH.0000000000000593

Begieneman, M. P. V., Rijvers, L., Kubat, B., Paulus, W. J., Vonk, A. B. A., van Rossum, A. C., Schalkwijk, C. G., Stooker, W., Niessen, H. W. M., & Krijnen, P. A. J. (2015). Atrial Fibrillation Coincides with the Advanced Glycation End Product N-epsilon-Carboxymethyl)Lysine in the Atrium. American Journal of Pathology, 185(8), 2096-2104. https://doi.org/10.1016/j.ajpath.2015.04.018

Driessen, J. H. M., Henry, R. M. A., van Onzenoort, H. A. W., Lalmohamed, A., Burden, A. M., Prieto-Alhambra, D., Neef, C., Leufkens, H. G. M., & de Vries, F. (2015). Bone Fracture Risk is Not Associated with the Use of Glucagon-Like Peptide-1 Receptor Agonists: A Population-Based Cohort Analysis. Calcified Tissue International, 97(2), 104-112. https://doi.org/10.1007/s00223-015-9993-5

Spauwen, P. J. J., van Boxtel, M. P. J., Verhey, F. R. J., Kohler, S., Sep, S. J. S., Koster, A., Dagnelie, P. C., Henry, R. M. A., Schaper, N. C., van der Kallen, C. J. H., Schram, M. T., Kroon, A. A., & Stehouwer, C. D. A. (2015). Both Low and High 24-Hour Diastolic Blood Pressure Are Associated With Worse Cognitive Performance in Type 2 Diabetes: The Maastricht Study. Diabetes Care, 38(8), 1473-1480. https://doi.org/10.2337/dc14-2502

Cornelis, T., Eloot, S., Vanholder, R., Glorieux, G., van der Sande, F. M., Scheijen, J. L., Leunissen, K. M., Kooman, J. P., & Schalkwijk, C. G. (2015). Protein-bound uraemic toxins, dicarbonyl stress and advanced glycation end products in conventional and extended haemodialysis and haemodiafiltration. Nephrology Dialysis Transplantation, 30(8), 1395-1402. https://doi.org/10.1093/ndt/gfv038

Schalkwijk, C. G. (2015). Vascular AGE-ing by methylglyoxal: the past, the present and the future. Diabetologia, 58(8), 1715-1719. https://doi.org/10.1007/s00125-015-3597-5

van Sloten, T. T., Czernichow, S., Houben, A. J., Protogerou, A. D., Henry, R. M., Muris, D. M., Schram, M. T., Sep, S. J., Dagnelie, P. C., van der Kallen, C. J., Schaper, N. C., Blacher, J., Hercberg, S., Levy, B. I., & Stehouwer, C. D. (2015). Association Between Arterial Stiffness and Skin Microvascular Function: The SUVIMAX2 Study and The Maastricht Study. American Journal of Hypertension, 28(7), 868-876. https://doi.org/10.1093/ajh/hpu246

Soedamah-Muthu, S. S., Livingstone, S. J., Charlton-Menys, V., Betteridge, D. J., Hitman, G. A., Neil, H. A. W., Bao, W., DeMicco, D. A., Preston, G. M., Fuller, J. H., Stehouwer, C. D. A., Schalkwijk, C. G., Durrington, P. N., & Colhoun, H. M. (2015). Effect of atorvastatin on C-reactive protein and benefits for cardiovascular disease in patients with type 2 diabetes: analyses from the Collaborative Atorvastatin Diabetes Trial. Diabetologia, 58(7), 1494-1502. https://doi.org/10.1007/s00125-015-3586-8

Dower, J. I., Geleijnse, J. M., Gijsbers, L., Schalkwijk, C., Kromhout, D., & Hollman, P. C. (2015). Supplementation of the Pure Flavonoids Epicatechin and Quercetin Affects Some Biomarkers of Endothelial Dysfunction and Inflammation in (Pre)Hypertensive Adults: A Randomized Double-Blind, Placebo-Controlled, Crossover Trial. Journal of Nutrition, 145(7), 1459-1463. https://doi.org/10.3945/jn.115.211888

Eussen, S. J. P. M., Ueland, P. M., Vollset, S. E., Nygard, O., Midttun, O., Sulo, G., Ulvik, A., Meyer, K., Pedersen, E. R., & Tell, G. S. (2015). Kynurenines as predictors of acute coronary events in the Hordaland Health Study. International Journal of Cardiology, 189, 18-24. https://doi.org/10.1016/j.ijcard.2015.03.413

Zuo, H., Ueland, P. M., Eussen, S. J. P. M., Tell, G. S., Vollset, S. E., Nygard, O., Midttun, O., Meyer, K., & Ulvik, A. (2015). Markers of vitamin B6 status and metabolism as predictors of incident cancer: The Hordaland Health Study. International Journal of Cancer, 136(12), 2932-2939. https://doi.org/10.1002/ijc.29345

van Sloten, T. T., Protogerou, A. D., Henry, R. M. A., Schram, M. T., Launer, L. J., & Stehouwer, C. D. A. (2015). Association between arterial stiffness, cerebral small vessel disease and cognitive impairment: A systematic review and meta-analysis. Neuroscience and Biobehavioral Reviews, 53, 121-130. https://doi.org/10.1016/j.neubiorev.2015.03.011

van Sloten, T. T., Sigurdsson, S., van Buchem, M. A., Phillips, C. L., Jonsson, P. V., Ding, J., Schram, M. T., Harris, T. B., Gudnason, V., & Launer, L. J. (2015). Cerebral Small Vessel Disease and Association With Higher Incidence of Depressive Symptoms in a General Elderly Population: The AGES-Reykjavik Study. American Journal of Psychiatry, 172(6), 570-578. https://doi.org/10.1176/appi.ajp.2014.14050578

Maessen, D. E. M., Stehouwer, C. D. A., & Schalkwijk, C. G. (2015). The role of methylglyoxal and the glyoxalase system in diabetes and other age-related diseases. Clinical Science, 128(12), 839-861. https://doi.org/10.1042/CS20140683