Section Martijn Brouwers
- 2026
- Yu, E. Y. W., Ren, H. Y., Liang, X., Xi, Y., Shuai, M., Miao, Z., Xu, F., Zhang, K., Shen, L., Xia, H., Schram, M. T., van Greevenbroek, M., de Galan, B. E., van der Kallen, C. J. H., Linden, D. E. J., Blokland, G. A. M., Arts, I. C. W., Berendschot, T. T. J. M., Yan, Y., ... Zheng, J. S. (2026). Trans-ethnic estimation and implications of genetic impact on continuous glycemic profiles. Cell Discovery, 12(1), Article 40. https://doi.org/10.1038/s41421-026-00897-2
- Koutroukas, V., Tziannou, A., Thomas, J. J. C., Martine-Edith, G., Heller, S., Mader, J. K., Brosen, J. M. B., Pedersen-Bjergaard, U., De Galan, B. E., Renard, E., Evans, M. L., McCrimmon, R. J., Speight, J., Pouwer, F., Amiel, S. A., & Choudhary, P. (2026). Factors Associated With Progression From Level 1 to Level 2 Sensor-Detected Hypoglycaemia in People With Type 1 and Insulin-Treated Type 2 Diabetes: A Post Hoc Analysis From the Hypo-METRICS Study. Diabetes Obesity & Metabolism, 28(10), 9584-9594. https://doi.org/10.1111/dom.71172
- McCarthy, A., Soholm, U., Zaremba, N., Pouwer, F., Vaag, A. A., Heller, S., Mader, J. K., Pedersen-Bjergaard, U., de Galan, B. E., Renard, E., Evans, M. L., McCrimmon, R. J., Amiel, S. A., Choudhary, P., Divilly, P., & Hypo-RESOLVE Consortium (2026). Hypoglycaemia Was Not Associated With Depression, Anxiety, Diabetes Distress or Fear of Hypoglycaemia Scores in People With Type 1 or Insulin-Treated Type 2 Diabetes in the Hypo-METRICS Study. Diabetes Obesity & Metabolism, 28(10), 9685-9690. https://doi.org/10.1111/dom.71041
- Mirjalili, F., Jambarsang, S., Farashahi-Yazd, E., Dianati, M., Eussen, S. J. P. M., Schram, M. T., Koster, A., Salehi-Abargouei, A., Yi-Wen Yu, E., Zeegers, M. P., & Wesselius, A. (2026). Adherence to empirically derived dietary patterns and risk of depression symptoms and anxiety disorder: The Maastricht Cohort Study. American Journal of Clinical Nutrition, 124(3), Article 101415. https://doi.org/10.1016/j.ajcnut.2026.101415
- Brosen, J. M. B., Malmsio, D., Divilly, P., Martine-Edith, G., Zaremba, N., Ali, N., McCrimmon, R. J., Heller, S., Evans, M., de Galan, B., Mader, J. K., Renard, E., Vaag, A. A., Choudhary, P., & Pedersen-Bjergaard, U. (2026). Person-Reported and Continuous Glucose Monitoring (CGM) Recorded Hypoglycaemia in People With Insulin-Treated Type 2 Diabetes and Mild to Moderate Chronic Kidney Disease; Post Hoc Analysis From the Hypo-METRICS Study. Diabetes Obesity & Metabolism. Advance online publication. https://doi.org/10.1111/dom.71247
- van der Taelen, L., Lambrichts, S. M. P., Temmerman, L., El Ajjouri, R., Gijbels, M. J., Bitsch, N., Scheijen, J., van de Waarenburg, M., Kutmon, M., Unger, T., Staals, J., Schalkwijk, C. G., Briones, A. M., van Oostenbrugge, R. J., & Foulquier, S. (2026). Longitudinal Profiling Reveals Divergent Kidney and Brain Immune Responses during Metabolic Syndrome. Aging and Disease. Advance online publication. https://doi.org/10.14336/AD.2026.0557
- Lintsen, D., Schuetz, L., Lins, P. P., Bronckaers, A., Verboven, K., Wouters, K., & Broux, B. (2026). Adipose tissue-derived extracellular vesicles as drivers of endothelial dysfunction in obesity. Trends in Endocrinology and Metabolism, 37(8), 789-801. https://doi.org/10.1016/j.tem.2026.01.006
- Cigler, M., El-Hakouni, O., Mecani, R., Pouwer, F., Abbink, E. J., Moser, M., de Galan, B. E., Renard, E., Evans, M., Brosen, J. M. B., Pedersen-Bjergaard, U., McCrimmon, R. J., Heller, S., Baumann, P. M., Soholm, U., Basta, S., Divilly, P., Zaremba, N., Amiel, S. A., ... Hypo-RESOLVE Consortium (2026). Exploring the gap between sensor-detected (SDH) and person-reported hypoglycaemia (PRH): The voice of people living with diabetes. Diabetic Medicine, 43(8), Article e70301. https://doi.org/10.1111/dme.70301
- Sezer, B., Albers, J., Meisters, R., Schram, M. T., de Galan, B. E., van der Kallen, C., van Greevenbroek, M., Dagnelie, P., Koster, A., & Bosma, H. (2026). Exploring the role of class stigma in socioeconomic inequalities in type 2 diabetes: The Maastricht Study. Journal of Health Psychology, 31(9), 3578-3588. https://doi.org/10.1177/13591053251395856
- Koutroukas, V., Thomas, J., Martine-Edith, G., Tziannou, A., Divilly, P., Soholm, U., Meek, C. L., Heller, S., Mader, J. K., Pedersen-Bjergaard, U., de Galan, B. E., Renard, E., Evans, M. L., McCrimmon, R. J., Speight, J., Pouwer, F., Amiel, S. A., Choudhary, P., & Hypo-RESOLVE Consortium (2026). Gold and Clarke Questionnaires Identify Different People With Insulin-Treated Diabetes and Impaired Awareness of Hypoglycaemia in Almost 60% of Cases: A Post Hoc Analysis From the Hypo-METRICS Study. Diabetes Obesity & Metabolism, 28(8), 6755-6766. https://doi.org/10.1111/dom.70869
- den Brok, E. J., Svensson, C. H., Olsen, M. T., Dimitropoulou, N. M., van Kuijk, S. M. J., Panagiotou, M., Abdur Rahman, L., Proennecke, S., Mertens, P. R., Athanasopoulos, S., Dingena, C. F., Makrilakis, K., Mougiakakou, S., Pedersen-Bjergaard, U., & de Galan, B. E. (2026). Randomised Controlled Multicentre Trial to Investigate the Effectiveness of a Mobile Artificial Intelligence Solution for Diabetes Adapted Care: The MELISSA Trial Protocol. Diabetes Obesity & Metabolism, 28(8), 6576-6583. https://doi.org/10.1111/dom.70879
- Tore, E. C., Briones, A. M., Bruno, R. M., Dalli, J., Eussen, S. J. P. M., Schalkwijk, C. G., & van Greevenbroek, M. M. J. (2026). Response to: Comment on “Plasma-based low-grade inflammation and endothelial dysfunction explain a small but significant proportion of the association between the n-3 polyunsaturated fatty acids and cardiovascular diseases: The Maastricht Study”. Journal of Clinical Lipidology, 20(8), 1713-1714. https://doi.org/10.1016/j.jacl.2026.06.012
- Mols, E. M., Kornmann, M. N., Haak, H. R., Alsma, J., Stassen, P. M., Kaasjager, K. A. H., Groeneveld, G. H., & Kremers, M. N. T. (2026). Chronic disease related emergency department presentations and potential for redirection to alternative acute care settings ("FOCUS" study): A nationwide flashmob study. PLOS ONE, 21(7), Article e0353157. https://doi.org/10.1371/journal.pone.0353157
- Tore, E. C., Briones, A. M., Bruno, R. M., Dalli, J., Eussen, S. J. P. M., Schalkwijk, C. G., & van Greevenbroek, M. M. J. (2026). Plasma-based low-grade inflammation and endothelial dysfunction explain a small but significant proportion of the association between the n-3 polyunsaturated fatty acids and cardiovascular diseases: The Maastricht Study. Journal of Clinical Lipidology, 20(7), 1352-1366. https://doi.org/10.1016/j.jacl.2026.05.228
- Okoro, C., van der Kallen, C. J. H., Mokhtar, S. B. A., Zhou, T. L., Berendschot, T. T. J. M., Koster, A., Reesink, K., Reulen, J., Mess, W. H., Webers, C. A. B., Kroon, A., & Stehouwer, C. D. A. (2026). Response to correspondence: "Reappraising the neurovascular link between arterial stiffness and neuropathy. Journal of Hypertension, 44(7), Article 1282. https://doi.org/10.1097/HJH.0000000000004299
- Holthuijsen, D. D. B., Rijnhart, J. J. M., van Roekel, E. H., Bours, M. J. L., Ueland, P. M., Breukink, S. O., Janssen-heijnen, M. L. G., Konsten, J. L., Keulen, E. T. P., McCann, A., Brezina, S., Gigic, B., Ose, J., Weijenberg, M. P., & Eussen, S. J. P. M. (2026). The mediating role of the kynurenine pathway in longitudinal associations between dietary intake and quality of life in colorectal cancer survivors up to 12 months posttreatment. International Journal of Cancer, 159(1), 122-143. https://doi.org/10.1002/ijc.70363
- Buziau, A. M., Simons, N., Tolan, D. R., Caiment, F., Scheijen, J. L. J. M., van de Waarenburg, M. P., Schalkwijk, C. G., & Brouwers, M. C. G. J. (2026). Endogenous fructose production in patients and mice with aldolase B deficiency. Molecular Genetics and Metabolism, 149(1-2), Article 110219. https://doi.org/10.1016/j.ymgme.2026.110219
- Panis, B., van Golde, R. J. T., Brouwers, M. C. G. J., Körver-Keularts, I. M. L. W., Noga, M. J., & Rubio-Gozalbo, M. E. (2026). Reproductive potential in classical galactosemia: A case series based perspective. European Journal of Obstetrics and Gynecology and Reproductive Biology: X, 31, Article 100470. https://doi.org/10.1016/j.eurox.2026.100470
- Valente, M. J., Cao, B., Holthuijsen, D. D. B., Bours, M. J. L., Eussen, S. J. P. M., Weijenberg, M. P., & Rijnhart, J. J. M. (2026). Response to “Ratios are misleading exposure variables that compromise a regression model unless fundamental scaling assumptions are satisfied: a comment on Valente et al.”. Journal of Clinical Epidemiology, 195, Article 112257. https://doi.org/10.1016/j.jclinepi.2026.112257
- Claassen, L., Baars, V. M. E. P., Cals, J. W. L., Stassen, P. M., & Latten, G. H. P. (2026). Patient-Physician Agreement on Diagnosis in the ED, Part of Diagnostic Excellence. A Prospective Multicenter Study. Academic Emergency Medicine, 33(6), Article e70365. https://doi.org/10.1111/acem.70365
- Ukropcova, K., Deckers, K., Koster, A., de Jong, J. J. A., Jansen, J. F. A., Backes, W. H., Savelberg, H. H. C. M., van der Kallen, C., Schram, M. T., Kohler, S., & van Gils, V. (2026). Associations of cardiorespiratory fitness with structural brain networks in ageing: insights from The Maastricht Study. Geroscience. Advance online publication. https://doi.org/10.1007/s11357-026-02329-1
- Daemen, S., Adelaar, T. I., Barlampas, P., Zhang, X., Schalkwijk, C. G., & Wouters, K. (2026). Managing Autofluorescence in Spectral Flow Cytometry for Macrophage Identification in the Liver. European Journal of Immunology, 56(6), Article e70217. https://doi.org/10.1002/eji.70217
- Vossen, L. M., de Leeuw, P. W., Schurgers, L. J., Heuts, S., Adriaans, B. P., de Haan, C., van Varik, B. J., & Kroon, A. A. (2026). Two Years of Menaquinone-7 Supplementation and Coronary Artery Calcification A Randomized Clinical Trial. JAMA Cardiology. Advance online publication. https://doi.org/10.1001/jamacardio.2026.1279
- Mustafajev, I. F., Hendriksz, M. S., Stienstra, R., Tack, C. J., De Galan, B. E., & Meijer, R. I. (2026). Adrenaline is a prominent driver of inflammatory responses following hypoglycaemia. Diabetologia, 69(6), 1675-1685. https://doi.org/10.1007/s00125-026-06667-9
- Choe, K., Bakker, L., van den Hove, D. L. A., Eussen, S. J. P. M., Kenis, G., Ramakers, I. H. G. B., Verhey, F. R. J., Rutten, B. P. F., & Kohler, S. (2026). Kynurenine pathway dysregulation in cognitive impairment and dementia: a systematic review and meta-analysis. Geroscience, 48(3), 4585-4619. Article 120819. https://doi.org/10.1007/s11357-025-01636-3
- Arts, J., Kremers, S. P. J., Mommers, M., Eussen, S. J. M. P., & Gubbels, J. S. (2026). Associations of food parenting practices in early childhood with dietary intake, BMI, and weight status in young adulthood: the KOALA Birth Cohort Study. Nutrition Journal, 25(1), Article 72. https://doi.org/10.1186/s12937-026-01331-9
- Okoro, C., Zhou, T. L., van der Kallen, C. J. H., Koster, A., Sutedja, N. A., Berendschot, T. T. J. M., de Galan, B. E., Eussen, S. J. P. M., Schram, M. T., & Kroon, A. A. (2026). Association of type 2 diabetes according to the number of cardiovascular risk factors within the recommended range with neuropathy - The Maastricht Study. Diabetes Research and Clinical Practice, 235, Article 113212. https://doi.org/10.1016/j.diabres.2026.113212
- Buziau, A. M., Wesselius, A., Yu, E. Y.-W., Korver-Keularts, I. M. L. W., Visser, D., Steinbusch, L. K. M., Simons, P. I. H. G., van Greevenbroek, M. M. J., Dagnelie, P. C., Kooi, M. E., Eussen, S. J. P. M., Arts, I. C. W., van der Kallen, C. J. H., Schalkwijk, C. G., & Brouwers, M. C. G. J. (2026). Metabolite Erythritol in 24-Hour Urine Is Associated With Higher Intrahepatic Lipid Content: The Maastricht Study. Diabetes, 75(5), 762-771. https://doi.org/10.2337/db25-0881
- Tokgoz, S., Deden, L. N., Hofboer, A., Meijer, R. I., Hazebroek, E. J., Van Bon, A. C., De Galan, B. E., Tack, C. J., Boss, M., & Gotthardt, M. (2026). Beta cell function and mass in individuals with and without remission of type 2 diabetes after Roux-en-Y gastric bypass. Diabetologia, 69(5), 1295-1300. https://doi.org/10.1007/s00125-025-06659-1
- Tokgoz, S., Boss, M., Meijer, R. I., Jansen, T. J. P., Deden, L. N., Tack, C. J., de Galan, B. E., & Gotthardt, M. (2026). Sex Differences in [<SUP>68</SUP>Ga]Ga-NODAGA-Exendin-4 Uptake in the Pituitary of Individuals With Type 2 Diabetes. Diabetes Obesity & Metabolism, 28(5), 4387-4390. https://doi.org/10.1111/dom.70600
- Powell, P. A., Frances, S. M., de Galan, B. E., Heller, S., Speight, J., Rosilio, M., Pouwer, F., Gall, M.-A., Child, C. J., McCrimmon, R. J., Tait, K., Carlton, J., & Hypo-RESOLVE Consortium (2026). 'There is more to life than HbA1c': A comprehensive qualitative framework from the Hypo-RESOLVE project evidencing the impacts of hypoglycaemia on the quality of life of adults living with type 1 or type 2 diabetes. Diabetic Medicine, 43(5), Article e70240. https://doi.org/10.1111/dme.70240
- Yu, Y., Berendschot, T. T. J. M., Eussen, S. J. P. M., van der Kallen, C. J. H., Webers, C. A. B., & Ramdas, W. D. (2026). The Association Between Adherence to the Dutch Healthy Diet Index and Glaucoma Prevalence-The Maastricht Study. Nutrients, 18(9), Article 1360. https://doi.org/10.3390/nu18091360
- Chong, M. Y., Koster, A., de Galan, B. E., van der Kallen, C. J. H., van Greevenbroek, M. M. J., Bours, M. J. L., Weijenberg, M. P., & Eussen, S. J. P. M. (2026). Associations between chrono-nutrition and glucose metabolism across levels of glucose impairment: The Maastricht Study. European Journal of Nutrition, 65(4), Article 119. https://doi.org/10.1007/s00394-026-03964-2
- Phillips, N. E., Ajdacic-Gross, V., Rebeaud, J., Thevoz, G., Iaquinto, S., Baum, C., Kamm, C. P., Kuhle, J., Rapold, I., Roth, P., Zecca, C., von Wyl, V., Eussen, S. J. P. M., Steinemann, N., Pot, C., & Collet, T.-H. (2026). Associations of chrononutrition and sleep with fatigue in multiple sclerosis: an analysis of the Swiss Multiple Sclerosis Registry. BMJ Neurology Open, 8(1), Article e001471. https://doi.org/10.1136/bmjno-2025-001471
- Chong, M. Y., Koster, A., Meertens, R. M., Pot, G. K., Galan, B. E. D., Kallen, C. J. H. V. D., Savelberg, H. H. C. M., Bosma, H., Simons, S. O., Bours, M. J. L., Weijenberg, M. P., & Eussen, S. J. P. M. (2026). Associations of chrono-nutrition with sleep and quality of life: The Maastricht Study. Clinical Nutrition, 59, Article 106593. https://doi.org/10.1016/j.clnu.2026.106593
- Weerts, J., Voorrips, S. N., Jeneson, J. A. L., Barandiaran Aizpurua, A., Mevenkamp, J., Sibeijn-Kuiper, A. J., Renken, R. J., Schroen, B. L. M., Knackstedt, C., Houben, A. J. H. M., van der Meer, P., Schrauwen-Hinderling, V. B., Westenbrink, B. D., & van Empel, V. P. M. (2026). Quantifying skeletal muscle energy metabolism during exercise in heart failure with preserved ejection fraction using in vivo <SUP>31</SUP>P magnetic resonance spectroscopy. Esc heart failure, 13(2), Article xvaf035. https://doi.org/10.1093/eschf/xvaf035
- Soholm, U., Holmes-truscott, E., Amiel, S. A., De Galan, B., Pedersen-bjergaard, U., Mccrimmon, R. J., Heller, S., Evans, M., Mader, J. K., Choudhary, P., Pouwer, F., Shaw, J. A. M., Speight, J., & Hypo-RESOLVE Consortium (2026). Assessing thoughts, feelings and behaviours related to hypoglycaemia: Psychometric evaluation of the Hypoglycaemia Cues Questionnaire (HypoC-Q). Diabetic Medicine, 43(4), Article e70231. https://doi.org/10.1111/dme.70231
- Chong, M. Y., Henson, J., Bours, M. J. L., Bosma, H., de Galan, B. E., van der Kallen, C. J. H., Meertens, R. M., Savelberg, H. H. C. M., Schram, M. T., Weijenberg, M. P., Yates, T., Koster, A., & Eussen, S. J. P. M. (2026). Physical activity and meal timing alignment with chronotype and their associations with glucose metabolism: The Maastricht Study. Diabetes Obesity & Metabolism, 28(4), 3295-3304. https://doi.org/10.1111/dom.70526
- Chong, M. Y., Eussen, S. J. P. M., van der Velde, J. H. P. M., de Galan, B. E., Savelberg, H. H. C. M., Bosma, H., Bours, M. J. L., Weijenberg, M. P., & Koster, A. (2026). Reallocating morning physical activity to later-day activity and its association with type 2 diabetes incidence: The Maastricht Study. Diabetes Obesity & Metabolism, 28(4), 2642-2650. https://doi.org/10.1111/dom.70438
- Maasen, K., Mayen, A.-L., Hana, C., Knaze, V., Van Greevenbroek, M. M. J., Eussen, S. J. P. M., Debras, C., Stehouwer, C. D. A., Tjonneland, A., Kyro, C., Ibsen, D. B., Dah, C. C., Mancini, F., Laouali, N., Hajji, M., Schulze, M. B., Bajracharya, R., Katzke, V., Masala, G., ... Schalkwijk, C. G. (2026). Higher intake of dietary dicarbonyl compounds is associated with lower incidence of type 2 diabetes: European Prospective Investigation into Cancer and Nutrition (EPIC)-InterAct case-cohort study. European Journal of Nutrition, 65(3), Article 98. https://doi.org/10.1007/s00394-026-03904-0
- Ferrero, G., Mastrocola, R., Tarallo, S., Pardini, B., Scheijen, J., Van De Waarenburg, M., Gallo, G., Chatziioannou, A. C., Robinot, N., Keski-Rahkonen, P., Piccinno, G., Segata, N., Aglago, E. K., Hughes, D. J., Jenab, M., Schalkwijk, C. G., & Naccarati, A. (2026). Integrative analyses of dicarbonyls and advanced glycation end-products with multiomic profiles across tissue, plasma and stool samples reveal methylglyoxal accumulation in colon cancer. Free Radical Biology and Medicine, 246, 518-530. https://doi.org/10.1016/j.freeradbiomed.2026.01.034
- Schaarup, J. R., Bjerg, L., Hansen, C. S., Andersen, S. T., van Greevenbroek, M. M. J., Schram, M. T., De Galan, B. E., Stehouwer, C., & Witte, D. R. (2026). Cardiovascular autonomic dysfunction is linked with arterial stiffness across glucose metabolism: the Maastricht study. BMJ Open Diabetes Research & Care, 14(2), Article e004995. https://doi.org/10.1136/bmjdrc-2025-004995
- Berends, E., Eussen, S. J. P. M., Backes, W. H., Dagnelie, P. C., Jansen, J. F. A., Galan, B. E. D., Greevenbroek, M. M. J. V., Kohler, S., Schram, M. T., Wesselius, A., Oostenbrugge, R. J., Foulquier, S., & Schalkwijk, C. G. (2026). Associations between methylglyoxal and cerebral small vessel disease and cognitive function-The Maastricht Study. Journal of Stroke & Cerebrovascular Diseases, 35(3), Article 108578. https://doi.org/10.1016/j.jstrokecerebrovasdis.2026.108578
- Wang, K., Kroon, A. A., De Galan, B. E., Berendschot, T. T. J. M., Schram, M. T., Houben, A. J. H. M., & van Greevenbroek, M. M. J. (2026). Associations of blood pressure with retinal arteriolar narrowing and urinary albumin excretion are modified by prediabetes: the Maastricht study. Journal of Hypertension, 44(3), 461-469. https://doi.org/10.1097/HJH.0000000000004225
- van Baal, T. L., Köhler, S., Koster, A., Meertens, R. M., Bosma, H., Schram, M. T., Jansen, J. F. A., Simons, S. O., de Galan, B. E., Eussen, S. J. P. M., Janssen, N., & Deckers, K. (2026). The association between sleep parameters, cognitive functioning, and markers of brain morphology: The Maastricht Study. Sleep, 49(3), Article zsaf218. https://doi.org/10.1093/sleep/zsaf218
- Drenthen, G. S., Backes, W. H., Kohler, S., Deckers, K., Schram, M. T., Eussen, S. J. P. M., Jansen, W. J., & Jansen, J. F. A. (2026). The role of modifiable risk factors on the cerebral myelin content and cognition: findings from The Maastricht Study. Geroscience. Advance online publication. https://doi.org/10.1007/s11357-026-02206-x
- Ali, N., van Erp, S., Kramers, C., Tack, C. J., & de Galan, B. E. (2026). The Prevalence and Implications of Polypharmacy in Individuals With Type 1 Diabetes. Clinical Pharmacology & Therapeutics, 119(3), 696-702. https://doi.org/10.1002/cpt.70130
- Cigler, M., Soholm, U., Broadley, M., Pouwer, F., Abbink, E. J., Ali, N., de Galan, B. E., Renard, E., Evans, M., Boggild Brosen, J. M., Pedersen-Bjergaard, U., Mc Crimmon, R. J., Heller, S., Caunt, S., Amiel, S. A., Divilly, P., Zaremba, N., Choudhary, P., Mader, J. K., & Hypo-RESOLVE Consortium (2026). User evaluation of the Hypo-METRICS app: A tool for real-time symptom reporting of hypoglycaemia. Diabetic Medicine, 43(3), Article e70185. https://doi.org/10.1111/dme.70185
- Setjiadi, D., Delles, C., Kroon, A. A., Ressink, K., Bekers, O., Meex, S. J. R., Köhler, S., Kooman, J. P., Jansen, J. F. A., Brunner-La Rocca, H.-P., Wesselius, A., Houben, A. J. H. M., & van Greevenbroek, M. M. J. (2026). Characterization of participants with a disproportionate degree of hypertension-mediated organ damage: the Maastricht study. Journal of Hypertension, 44, 1329-1336. https://doi.org/10.1097/HJH.0000000000004265




