• 2017
    • Richard, M. A., Huan, T., Ligthart, S., Gondalia, R., Jhun, M. A., Brody, J. A., Irvin, M. R., Marioni, R., Shen, J., Tsai, P.-C., Montasser, M. E., Jia, Y., Syme, C., Salfati, E. L., Boerwinkle, E., Guan, W., Mosley, T. H., Bressler, J., Morrison, A. C., ... Fornage, M. (2017). DNA Methylation Analysis Identifies Loci for Blood Pressure Regulation. American Journal of Human Genetics, 101(6), 888-902. https://doi.org/10.1016/j.ajhg.2017.09.028
    • Houben, A. J. H. M., Martens, R. J. H., & Stehouwer, C. D. A. (2017). Assessing Microvascular Function in Humans from a Chronic Disease Perspective. Journal of the American Society of Nephrology, 28(12), 3461-3472. https://doi.org/10.1681/ASN.2017020157
    • Wachelder, J. J. H., van Drunen, I., Stassen, P. M., Brouns, S. H. A., Lambooij, S. L. E., Aarts, M. J., & Haak, H. R. (2017). Association of socioeconomic status with outcomes in older adult community-dwelling patients after visiting the emergency department: a retrospective cohort study. BMJ Open, 7(12), Article e019318. https://doi.org/10.1136/bmjopen-2017-019318
    • Wachelder, J. J. H., Stassen, P. M., Hubens, L. P. A. M., Brouns, S. H. A., Lambooij, S. L. E., Dieleman, J. P., & Haak, H. R. (2017). Elderly emergency patients presenting with non-specific complaints: Characteristics and outcomes. PLOS ONE, 12(11), Article e0188954. https://doi.org/10.1371/journal.pone.0188954
    • Geijselaers, S. L. C., Sep, S. J. S., Claessens, D., Schram, M. T., van Boxtel, M. P. J., Henry, R. M. A., Verhey, F. R. J., Kroon, A. A., Dagnelie, P. C., Schalkwijk, C. G., van der Kallen, C. J. H., Biessels, G. J., & Stehouwer, C. D. A. (2017). The role of hyperglycemia, insulin resistance, and blood pressure in diabetes: Associated differences in cognitive performance-The Maastricht Study. Diabetes Care, 40(11), 1537-1547. https://doi.org/10.2337/dc17-0330
    • Mandaviya, P. R., Aissi, D., Dekkers, K. F., Joehanes, R., Kasela, S., Vinh Truong, Stolk, L., van Heemst, D., Ikram, M. A., Lindemans, J., Slagboom, P. E., Tregouet, D.-A., Uitterlinden, A. G., Wei, C., Wells, P., Gagnon, F., van Greevenbroek, M. M. J., Heijmans, B. T., Milani, L., ... BIOS Consortium (2017). Homocysteine levels associate with subtle changes in leukocyte DNA methylation: an epigenome-wide analysis. Epigenomics, 9(11), 1403-1422. https://doi.org/10.2217/epi-2017-0038
    • Rutte, A., Rauh, S. P., Schram, M. T., Nijpels, G., DeVries, J. H., Holleman, F., Pijl, H., Dekkers, O. M., Ozcan, B., Sijbrands, E. J. G., Tack, C. J., Abbink, E. J., de Valk, H. W., Silvius, B., Wolffenbuttel, B. H. R., Stehouwer, C. D. A., Schaper, N. C., Dekker, J. M., Beulens, J. W., ... Diabet Pearl Parelsnoer Initiative (2017). Individual and partner's level of occupation and the association with HbA(1c) levels in people with Type 2 diabetes mellitus: the Dutch Diabetes Pearl cohort. Diabetic Medicine, 34(11), 1623-1628. https://doi.org/10.1111/dme.13422
    • Riemersma, M., Hazebroek, M. R., Helderman-van den Enden, A. T. J. M., Salomons, G. S., Ferdinandusse, S., Brouwers, M. C. G. J., van der Ploeg, L., Heymans, S., Glatz, J. F. C., van den Wijngaard, A., Krapels, I. P. C., Bierau, J., & Brunner, H. G. (2017). Propionic acidemia as a cause of adult-onset dilated cardiomyopathy. European Journal of Human Genetics, 25(11), 1195-1201. https://doi.org/10.1038/ejhg.2017.127
    • Wouters, K., Deleye, Y., Hannou, S. A., Vanhoutte, J., Marechal, X., Coisne, A., Tagzirt, M., Derudas, B., Bouchaert, E., Duhem, C., Vallez, E., Schalkwijk, C. G., Pattou, F., Montaigne, D., Staels, B., & Paumelle, R. (2017). The tumour suppressor CDKN2A/p16(INK4a) regulates adipogenesis and bone marrow-dependent development of perivascular adipose tissue. Diabetes & Vascular Disease Research, 14(6), 516-524. https://doi.org/10.1177/1479164117728012
    • Mandaviya, P. R., Joehanes, R., Aissi, D., Kuehnel, B., Marioni, R. E., Truong, V., Stolk, L., Beekman, M., Bonder, M. J., Franke, L., Gieger, C., Huan, T., Ikram, M. A., Kunze, S., Liang, L., Lindemann, J., Liu, C., McRae, A. F., Mendelson, M. M., ... Charge Consortium Epigenetics Grp (2017). Genetically defined elevated homocysteine levels do not result in widespread changes of DNA methylation in leukocytes. PLOS ONE, 12(10), Article 0182472. https://doi.org/10.1371/journal.pone.0182472
    • Sörensen, B. M., Houben, A. J. H. M., Berendschot, T. T. J. M., Schouten, J. S. A. G., Kroon, A. A., van der Kallen, C. J. H., Henry, R. M. A., Koster, A., Dagnelie, P. C., Schaper, N. C., Schram, M. T., & Stehouwer, C. D. A. (2017). Cardiovascular risk factors as determinants of retinal and skin microvascular function: The Maastricht Study. PLOS ONE, 12(10), Article e0187324. https://doi.org/10.1371/journal.pone.0187324
    • Peeters, S. A., Engelen, L., Buijs, J., Chaturvedi, N., Fuller, J. H., Jorsal, A., Parving, H.-H., Tarnow, L., Theilade, S., Rossing, P., Schalkwijk, C. G., & Stehouwer, C. D. A. (2017). Circulating matrix metalloproteinases are associated with arterial stiffness in patients with type 1 diabetes: pooled analysis of three cohort studies. Cardiovascular Diabetology, 16, Article 139. https://doi.org/10.1186/s12933-017-0620-9
    • Maessen, M. F. H., Schalkwijk, C. G., Verheggen, R. J. H. M., Aengevaeren, V. L., Hopman, M. T. E., & Eijsvogels, T. M. H. (2017). A comparison of dicarbonyl stress and advanced glycation endproducts in lifelong endurance athletes vs. sedentary controls. Journal of Science and Medicine in Sport, 20(10), 921-926. https://doi.org/10.1016/j.jsams.2017.03.011
    • van Agtmaal, M. J. M., & Schram, M. T. (2017). Are structural brain changes driven by aortic atherosclerosis?Atherosclerosis, 265, 248-249. https://doi.org/10.1016/j.atherosclerosis.2017.08.004
    • Kooman, J. P., Dekker, M. J., Usvyat, L. A., Kotanko, P., van der Sande, F. M., Schalkwijk, C. G., Shiels, P. G., & Stenvinkel, P. (2017). Inflammation and premature aging in advanced chronic kidney disease. American Journal of Physiology-Renal Physiology, 313(4), F938-F950. https://doi.org/10.1152/ajprenal.00256.2017
    • Biessen, E. A. L., & Wouters, K. (2017). Macrophage complexity in human atherosclerosis: opportunities for treatment?Current Opinion in Lipidology, 28(5), 419-426. https://doi.org/10.1097/MOL.0000000000000447
    • Scheepers, L. E. J. M., Boonen, A., Dagnelie, P. C., Schram, M. T., van der Kallen, C. J. H., Henry, R. M. A., Kroon, A. A., Stehouwer, C. D. A., & Arts, I. C. W. (2017). Uric acid and blood pressure: exploring the role of uric acid production in The Maastricht Study. Journal of Hypertension, 35(10), 1968-1975. https://doi.org/10.1097/HJH.0000000000001417
    • Goeijenbier, M., van Sloten, T. T., Slobbe, L., Mathieu, C., van Genderen, P., Beyer, W. E. P., & Osterhaus, A. D. M. E. (2017). Benefits of flu vaccination for persons with diabetes mellitus: A review. Vaccine, 35(38), 5095-5101. https://doi.org/10.1016/j.vaccine.2017.07.095
    • Cobussen, M., Havenith, T., Posthouwer, D., van Tiel, F. H., Stassen, P. M., & Haeseker, M. B. (2017). Short Course of Empirical Gentamicin in Patients With Severe Sepsis and Septic Shock in the ICU: A Benefit or a Burden?Clinical Infectious Diseases, 65(5), 873-874. https://doi.org/10.1093/cid/cix447
    • Jahja, R., van Spronsen, F. J., de Sonneville, L. M. J., van der Meere, J. J., Bosch, A. M., Hollak, C. E. M., Rubio-Gozalbo, M. E., Brouwers, M. C. G. J., Hofstede, F. C., de Vries, M. C., Janssen, M. C. H., van der Ploeg, A. T., Langendonk, J. G., & Huijbregts, S. C. J. (2017). Long-Term Follow-Up of Cognition and Mental Health in Adult Phenylketonuria: A PKU-COBESO Study. Behavior Genetics, 47(5), 486-497. https://doi.org/10.1007/s10519-017-9863-1
    • Martens, R. J. H., Geijselaers, S. L. C., Stehouwer, C. D. A., Henry, R. M. A., & Maastricht Study Group (2017). Timing of syncope during blood sampling-The Maastricht Study. European journal of internal medicine, 43, E46-E47. https://doi.org/10.1016/j.ejim.2017.05.024
    • van Sloten, T. T. (2017). Vascular dysfunction: At the heart of cardiovascular disease, cognitive impairment and depressive symptoms. Artery Research, 19, 18-23. https://doi.org/10.1016/j.artres.2017.05.002
    • Mitsides, N., Cornelis, T., Broers, N. J. H., Diederen, N. M. P., Brenchley, P., van der Sande, F. M., Schalkwijk, C. G., Kooman, J. P., & Mitra, S. (2017). Extracellular overhydration linked with endothelial dysfunction in the context of inflammation in haemodialysis dependent chronic kidney disease. PLOS ONE, 12(8), Article 0183281. https://doi.org/10.1371/journal.pone.0183281
    • Hanssen, N. M. J., Scheijen, J. L. J. M., Jorsal, A., Parving, H.-H., Tarnow, L., Rossing, P., Stehouwer, C. D. A., & Schalkwijk, C. G. (2017). Higher Plasma Methylglyoxal Levels Are Associated With Incident Cardiovascular Disease in Individuals With Type 1 Diabetes: A 12-Year Follow-up Study. Diabetes, 66(8), 2278-2283. https://doi.org/10.2337/db16-1578
    • Petrie, J. R., Chaturvedi, N., Ford, I., Brouwers, M. C. G. J., Greenlaw, N., Tillin, T., Hramiak, I., Hughes, A. D., Jenkins, A. J., Klein, B. E. K., Klein, R., Ooi, T. C., Rossing, P., Stehouwer, C. D. A., Sattar, N., Colhoun, H. M., & REMOVAL Study Grp (2017). Cardiovascular and metabolic effects of metformin in patients with type 1 diabetes (REMOVAL): a double-blind, randomised, placebo-controlled trial. The Lancet Diabetes & Endocrinology, 5(8), 597-609. https://doi.org/10.1016/S2213-8587(17)30194-8
    • van Twist, D. J. L., de Leeuw, P. W., & Kroon, A. A. (2017). Coronary Tortuosity: A Clue to the Diagnosis of Fibromuscular Dysplasia?American Journal of Hypertension, 30(8), 776-780. https://doi.org/10.1093/ajh/hpx069
    • Sörensen, B. M., Houben, A. J. H. M., Berendschot, T. T. J. M., Schouten, J. S. A. G., Kroon, A. A., van der Kallen, C. J. H., Henry, R. M. A., Koster, A., Reesink, K. D., Dagnelie, P. C., Schaper, N. C., Schalkwijk, C. G., Schram, M. T., & Stehouwer, C. D. A. (2017). Hyperglycemia Is the Main Mediator of Prediabetes- and Type 2 Diabetes-Associated Impairment of Microvascular Function: The Maastricht Study. Diabetes Care, 40(8), e103-e105. https://doi.org/10.2337/dc17-0574
    • van Twist, D. J. L., Houben, A. J. H. M., de Leeuw, P. W., & Kroon, A. A. (2017). Lateralization of renal blood flow and renin secretion in fibromuscular dysplasia Reply. Journal of Hypertension, 35(8), 1721-1722. https://doi.org/10.1097/HJH.0000000000001387
    • Stehouwer, C. D. A., & van Sloten, T. T. (2017). Microvascular outcomes in type 2 diabetes. The Lancet Diabetes & Endocrinology, 5(8), 579-579. https://doi.org/10.1016/S2213-8587(17)30187-0
    • Simoes-Wust, A. P., Molto-Puigmarti, C., Jansen, E. H. J. M., van Dongen, M. C. J. M., Dagnelie, P. C., & Thijs, C. (2017). Organic food consumption during pregnancy and its association with health-related characteristics: the KOALA Birth Cohort Study. Public Health Nutrition, 20(12), 2145-2156. https://doi.org/10.1017/S1368980017001215
    • Simoes-Wust, A. P., Molto-Puigmarti, C., van Dongen, M. C. J. M., Dagnelie, P. C., & Thijs, C. (2017). Organic food consumption during pregnancy is associated with different consumer profiles, food patterns and intake: the KOALA Birth Cohort Study. Public Health Nutrition, 20(12), 2134-2144. https://doi.org/10.1017/S1368980017000842
    • Houben, A. J. H. M., Berendschot, T. T. J. M., & Grassi, G. (2017). Retinal microvascular diameters: normative data and their use in clinical hypertension. Journal of Hypertension, 35(8), 1573-1574. https://doi.org/10.1097/HJH.0000000000001421
    • Van der Velde, J. H. P. M., Koster, A., Van der Berg, J. D., Sep, S. J. S., Van der Kallen, C. J. H., Dagnelie, P. C., Schram, M. T., Henry, R. M. A., Eussen, S. J. P. M., Van Dongen, M. C. J. M., Stehouwer, C. D. A., Schaper, N. C., & Savelberg, H. H. C. M. (2017). Sedentary Behavior, Physical Activity, and Fitness-The Maastricht Study. Medicine and Science in Sports and Exercise, 49(8), 1583-1591. https://doi.org/10.1249/MSS.0000000000001262
    • de Waard, E. A. C., Driessen, J. H. M., de Jong, J. J. A., van Geel, T. A. C. M., Henry, R. M. A., van Onzenoort, H. A. W., Schram, M. T., Dagnelie, P. C., van der Kallen, C. J., Sep, S. J. S., Stehouwer, C. D. A., Schaper, N. C., Koster, A., Savelberg, H. H. C. M., Neef, C., Geusens, P. P. M. M., de Vries, F., & van den Bergh, J. P. W. (2017). The association between insulin use and volumetric bone mineral density, bone micro-architecture and bone strength of the distal radius in patients with type 2 diabetes - The Maastricht study. Bone, 101, 156-161. https://doi.org/10.1016/j.bone.2017.05.004
    • Elissen, A. M. J., Hertroijs, D. F. L., Schaper, N. C., Bosma, H., Dagnelie, P. C., Henry, R. M., van der Kallen, C. J., Koster, A., Schram, M. T., Stehouwer, C. D. A., Schouten, J. S. A. G., Berendschot, T. T. J. M., & Ruwaard, D. (2017). Differences in biopsychosocial profiles of diabetes patients by level of glycaemic control and health-related quality of life: The Maastricht Study. PLOS ONE, 12(7), Article e0182053. https://doi.org/10.1371/journal.pone.0182053
    • Kimenai, D. M., Martens, R. J. H., Kooman, J. P., Stehouwer, C. D. A., Tan, F. E. S., Schaper, N. C., Dagnelie, P. C., Schram, M. T., van der Kallen, C. J. H., Sep, S. J. S., van Suijlen, J. D. E., Kroon, A. A., Bekers, O., van Dieijen-Visser, M. P., Henry, R. M. A., & Meex, S. J. R. (2017). Troponin I and T in relation to cardiac injury detected with electrocardiography in a population-based cohort - The Maastricht Study. Scientific Reports, 7, Article 6610. https://doi.org/10.1038/s41598-017-06978-3
    • Kusters, Y. H. A. M., Schalkwijk, C. G., Houben, A. J. H. M., Kooi, M. E., Lindeboom, L., 't Roodt, J. O., Joris, P. J., Plat, J., Mensink, R. P., Barrett, E. J., & Stehouwer, C. D. A. (2017). Independent tissue contributors to obesity-associated insulin resistance. JCI INSIGHT, 2(13), Article e89695. https://doi.org/10.1172/jci.insight.89695
    • van Agtmaal, M. J. M., Houben, A. J. H. M., Pouwer, F., Stehouwer, C. D. A., & Schram, M. T. (2017). Association of Microvascular Dysfunction With Late-Life Depression A Systematic Review and Meta-analysis. JAMA Psychiatry, 74(7), 729-739. https://doi.org/10.1001/jamapsychiatry.2017.0984
    • Van Der Berg, J. D., Van Der Velde, J. P. M., De Waard, E. A. C., Bosma, H., Savelberg, H. H. C. M., Schaper, N. C., Van Den Bergh, J. P. W., Geusens, P. P. M. M., Schram, M. T., Sep, S. J. S., Van Der Kallen, C. J. H., Henry, R. A., Dagnelie, P. C., Eussen, S. J. P. M., Van Dongen, M. C. J. M., Kohler, S., Kroon, A. A., Stehouwer, C. D. A., & Koster, A. (2017). Replacement Effects of Sedentary Time on Metabolic Outcomes: The Maastricht Study. Medicine and Science in Sports and Exercise, 49(7), 1351-1358. https://doi.org/10.1249/MSS.0000000000001248
    • Kraakman, M. J., Lee, M. K. S., Al-Sharea, A., Dragoljevic, D., Barrett, T. J., Montenont, E., Basu, D., Heywood, S., Kammoun, H. L., Flynn, M., Whillas, A., Hanssen, N. M. J., Febbraio, M. A., Westein, E., Fisher, E. A., Chin-Dusting, J., Cooper, M. E., Berger, J. S., Goldberg, I. J., ... Murphy, A. J. (2017). Neutrophil-derived S100 calcium-binding proteins A8/A9 promote reticulated thrombocytosis and atherogenesis in diabetes. Journal of Clinical Investigation, 127(6), 2133-2147. https://doi.org/10.1172/JCI92450
    • Uiterwijk, R., Staals, J., Huijts, M., de Leeuw, P. W., Kroon, A. A., & van Oostenbrugge, R. J. (2017). MRI progression of cerebral small vessel disease and cognitive decline in patients with hypertension. Journal of Hypertension, 35(6), 1263-1270. https://doi.org/10.1097/HJH.0000000000001294
    • de Leeuw, P. W., Fagard, R., & Kroon, A. A. (2017). The effects of missed doses of amlodipine and losartan on blood pressure in older hypertensive patients. Hypertension Research, 40(6), 568-572. https://doi.org/10.1038/hr.2016.190
    • Koole, D., van Herwaarden, J. A., Schalkwijk, C. G., Lafeber, F. P. J. G., Vink, A., Smeets, M. B., Pasterkamp, G., & Moll, F. L. (2017). A potential role for glycated cross-links in abdominal aortic aneurysm disease. Journal of Vascular Surgery, 65(5), 1493-1503.e3. https://doi.org/10.1016/j.jvs.2016.04.028
    • Slot, M. C., Kroon, A. A., Damoiseaux, J. G. M. C., Theunissen, R., Houben, A. J. H. M., de Leeuw, P. W., & Tervaert, J. W. C. (2017). CD4+CD28null T Cells are related to previous cytomegalovirus infection but not to accelerated atherosclerosis in ANCA-associated vasculitis. Rheumatology International, 37(5), 791-798. https://doi.org/10.1007/s00296-016-3643-8
    • Jahja, R., van der Meere, J. J., Legemaat, A. M., Rubio-Gozalbo, M. E., Hofstede, F. C., van der Ploeg, A. T., Langendonk, J. G., Huijbregts, S. C. J., de Sonneville, L. M. J., Bosch, A. M., Hollak, C. E. M., Brouwers, M. C. G. J., de Vries, M. C., Janssen, M. C. H., & van Spronsen, F. J. (2017). Cognitive Profile and Mental Health in Adult Phenylketonuria: A PKU-COBESO Study. Neuropsychology, 31(4), 437-447. https://doi.org/10.1037/neu0000358
    • Geijselaers, S. L. C., Sep, S. J. S., Schram, M. T., van Boxtel, M. P. J., Henry, R. M. A., Verhey, F. R. J., Kroon, A. A., Schaper, N. C., Dagnelie, P. C., Kallen, C. J. H. V. D., Stehouwer, C. D. A., & Biessels, G. J. (2017). Insulin resistance and cognitive performance in type 2 diabetes - The Maastricht study. Journal of Diabetes and Its Complications, 31(5), 824-830. https://doi.org/10.1016/j.jdiacomp.2017.01.020
    • Snijders, T., Nederveen, J. P., Verdijk, L. B., Houben, A. J. H. M., Goossens, G. H., Parise, G., & van Loon, L. J. C. (2017). Muscle fiber capillarization as determining factor on indices of insulin sensitivity in humans. Physiological Reports, 5(10), Article e13278. https://doi.org/10.14814/phy2.13278
    • Sthijns, M. M. J. P. E., Schiffers, P. M., Janssen, G. M., Lemmens, K. J. A., Ides, B., Vangrieken, P., Bouwman, F. G., Mariman, E. C., Pader, I., Arner, E. S. J., Johansson, K., Bast, A., & Haenen, G. R. M. M. (2017). Rutin protects against H2O2-triggered impaired relaxation of placental arterioles and induces Nrf2-mediated adaptation in Human Umbilical Vein Endothelial Cells exposed to oxidative stress. Biochimica et Biophysica Acta-general Subjects, 1861(5), 1177-1189. https://doi.org/10.1016/j.bbagen.2017.03.004
    • de Leeuw, P. W., Bisognano, J. D., Bakris, G. L., Nadim, M. K., Haller, H., Kroon, A. A., & DEBuT- HT Rheos Trial Investig (2017). Sustained Reduction of Blood Pressure With Baroreceptor Activation Therapy Results of the 6-Year Open Follow-Up. Hypertension, 69(5), 836-843. https://doi.org/10.1161/HYPERTENSIONAHA.117.09086
    • Schutten, M. T. J., Houben, A. J. H. M., de Leeuw, P. W., & Stehouwer, C. D. A. (2017). The Link Between Adipose Tissue Renin-Angiotensin- Aldosterone System Signaling and Obesity-Associated Hypertension. Physiology, 32(3), 197-209. https://doi.org/10.1152/physiol.00037.2016