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Tragante, V., Barnes, M. R., Ganesh, S. K., Lanktree, M. B., Guo, W., Franceschini, N., Smith, E. N., Johnson, T., Holmes, M. V., Padmanabhan, S., Karczewski, K. J., Almoguera, B., Barnard, J., Baumert, J., Chang, Y.-P. C., Elbers, C. C., Farrall, M., Fischer, M. E., Gaunt, T. R., ... Keating, B. J. (2014). Gene-centric meta-analysis in 87,736 individuals of European ancestry identifies multiple blood-pressure-related loci. American Journal of Human Genetics, 94(3), 349-60. https://doi.org/10.1016/j.ajhg.2013.12.016

Geenen, I. L., Verbruggen, S., Molin, D. G., Spronk, H. M., Maessen, J. G., Meesters, B., Schurink, G. W., & Post, M. J. (2014). Phenotypic Fitness of Primary Endothelial Cells Cultured from Patients with High Cardiovascular Risk or Chronic Kidney Disease for Vascular Tissue Engineering. Tissue Engineering, 20(5-6), 1049-1059. https://doi.org/10.1089/ten.tea.2013.0163

Spronk, H. M. H., de Jong, A. M., Crijns, H. J., Schotten, U., Van Gelder, I. C., & ten Cate, H. (2014). Pleiotropic effects of factor Xa and thrombin: what to expect from novel anticoagulants. Cardiovascular Research, 101(3), 344-351. https://doi.org/10.1093/cvr/cvt343

Ninivaggi, M., Feijge, M. A. H., Baaten, C. C. F. M. J., Kuiper, G. J. A. J. M., Marcus, M. A. E., ten Cate, H., Lance, M. D., Heemskerk, J. W. M., & van der Meijden, P. E. J. (2014). Additive roles of platelets and fibrinogen in whole-blood fibrin clot formation upon dilution as assessed by thromboelastometry. Thrombosis and Haemostasis, 111(3), 447-457. https://doi.org/10.1160/TH13-06-0493

Segers, O., Simioni, P., Tormene, D., & Castoldi, E. (2014). Influence of single nucleotide polymorphisms on thrombin generation in factor V Leiden heterozygotes. Thrombosis and Haemostasis, 111(3), 438-446. https://doi.org/10.1160/TH13-05-0360

Bosch, Y. P. J., al Dieri, R., ten Cate, H., Nelemans, P. J., Bloemen, S., de Laat, B., Hemker, C., Weerwind, P. W., Maessen, J. G., & Mochtar, B. (2014). Measurement of thrombin generation intra-operatively and its association with bleeding tendency after cardiac surgery. Thrombosis Research, 133(3), 488-494. https://doi.org/10.1016/j.thromres.2013.12.017

Pop, A. S., Levenga, J., de Esch, C. E. F., Buijsen, R. A. M., Nieuwenhuizen, I. M., Li, T., Isaacs, A., Gasparini, F., Oostra, B. A., & Willemsen, R. (2014). Rescue of dendritic spine phenotype in Fmr1 KO mice with the mGluR5 antagonist AFQ056/Mavoglurant. Psychopharmacology, 231(6), 1227-35. https://doi.org/10.1007/s00213-012-2947-y

Kamphuisen, P. W., & ten Cate, H. (2014). Cardiovascular risk in patients with hemophilia. Blood, 123(9), 1297-1301. https://doi.org/10.1182/blood-2013-11-453159

Karagoz, G. E., Duarte, A. M. S., Akoury, E., Ippel, H., Biernat, J., Luengo, T. M., Radli, M., Didenko, T., Nordhues, B. A., Veprintsev, D. B., Dickey, C. A., Mandelkow, E., Zweckstetter, M., Boelens, R., Madl, T., & Rudiger, S. G. D. (2014). Hsp90-Tau Complex Reveals Molecular Basis for Specificity in Chaperone Action. Cell, 156(5), 963-974. https://doi.org/10.1016/j.cell.2014.01.037

Chatzigeorgioua, A., Seijkens, T., Zarzycka, B., Engel, D., Poggi, M., van den Berg, S., van den Berg, S., Soehnlein, O., Winkels, H., Beckers, L., Lievens, D., Driessen, A., Kusters, P., Biessen, E., Garcia-Martin, R., Ameln, A. K., Gijbels, M., Noelle, R., Boon, L., ... Lutgens, E. (2014). Blocking CD40-TRAF6 signaling is a therapeutic target in obesity-associated insulin resistance. Proceedings of the National Academy of Sciences of the United States of America, 111(7), 2686-2691. https://doi.org/10.1073/pnas.1400419111

Wildhagen, K. C. A. A., Garcia de Frutos, P., Reutelingsperger, C. P., Schrijver, R., Areste, C., Ortega-Gomez, A., Deckers, N. M., Hemker, H. C., Soehnlein, O., & Nicolaes, G. A. F. (2014). Nonanticoagulant heparin prevents histone-mediated cytotoxicity in vitro and improves survival in sepsis. Blood, 123(7), 1098-1101. https://doi.org/10.1182/blood-2013-07-514984

Peloso, G. M., Auer, P. L., Bis, J. C., Voorman, A., Morrison, A. C., Stitziel, N. O., Brody, J. A., Khetarpal, S. A., Crosby, J. R., Fornage, M., Isaacs, A., Jakobsdottir, J., Feitosa, M. F., Davies, G., Huffman, J. E., Manichaikul, A., Davis, B., Lohman, K., Joon, A. Y., ... Cupples, L. A. (2014). Association of low-frequency and rare coding-sequence variants with blood lipids and coronary heart disease in 56,000 whites and blacks. American Journal of Human Genetics, 94(2), 223-32. https://doi.org/10.1016/j.ajhg.2014.01.009

Lange, L. A., Hu, Y., Zhang, H., Xue, C., Schmidt, E. M., Tang, Z.-Z., Bizon, C., Lange, E. M., Smith, J. D., Turner, E. H., Jun, G., Kang, H. M., Peloso, G., Auer, P., Li, K.-P., Flannick, J., Zhang, J., Fuchsberger, C., Gaulton, K., ... NHLBI Grand Opportunity Exome Sequencing Project (2014). Whole-exome sequencing identifies rare and low-frequency coding variants associated with LDL cholesterol. American Journal of Human Genetics, 94(2), 233-45. https://doi.org/10.1016/j.ajhg.2014.01.010

Tilstam, P. V., Gijbels, M. J., Habbeddine, M., Cudejko, C., Asare, Y., Theelen, W., Zhou, B., Doering, Y., Drechsler, M., Pawig, L., Simsekyilmaz, S., Koenen, R. R., de Winther, M. P. J., Lawrence, T., Bernhagen, J., Zernecke, A., Weber, C., & Noels, H. (2014). Bone Marrow-Specific Knock-In of a Non-Activatable Ikk alpha Kinase Mutant Influences Haematopoiesis but Not Atherosclerosis in Apoe-Deficient Mice. PLOS ONE, 9(2), Article e87452. https://doi.org/10.1371/journal.pone.0087452

Avery, C. L., Sitlani, C. M., Arking, D. E., Arnett, D. K., Bis, J. C., Boerwinkle, E., Buckley, B. M., Ida Chen, Y.-D., de Craen, A. J. M., Eijgelsheim, M., Enquobahrie, D., Evans, D. S., Ford, I., Garcia, M. E., Gudnason, V., Harris, T. B., Heckbert, S. R., Hochner, H., Hofman, A., ... Psaty, B. M. (2014). Drug-gene interactions and the search for missing heritability: a cross-sectional pharmacogenomics study of the QT interval. Pharmacogenomics Journal, 14(1), 6-13. https://doi.org/10.1038/tpj.2013.4

Jaczewska, J., Abdulreda, M. H., Yau, C. Y., Schmitt, M. M., Schubert, I., Berggren, P.-O., Weber, C., Koenen, R. R., Moy, V. T., & Wojcikiewicz, E. P. (2014). TNF-alpha and IFN-gamma promote lymphocyte adhesion to endothelial junctional regions facilitating transendothelial migration. Journal of Leukocyte Biology, 95(2), 265-274. https://doi.org/10.1189/jlb.0412205

Vaidya, A., Joore, M. A., Hoek - ten Cate, A. J., ten Cate, H., & Severens, J. L. (2014). Screen or not to screen for peripheral arterial disease: guidance from a decision model. BMC Public Health, 14(1), Article 89. https://doi.org/10.1186/1471-2458-14-89

Dockal, M., Hartmann, R., Fries, M., Thomassen, M. C. L. G. D., Heinzmann, A., Ehrlich, H., Rosing, J., Osterkamp, F., Polakowski, T., Reineke, U., Griessner, A., Brandstetter, H., & Scheiflinger, F. (2014). Small Peptides Blocking Inhibition of Factor Xa and Tissue Factor-Factor VIIa by Tissue Factor Pathway Inhibitor (TFPI). Journal of Biological Chemistry, 289(3), 1732-1741. https://doi.org/10.1074/jbc.M113.533836

Schmitt, M. M. N., Megens, R. T. A., Zernecke, A., Bidzhekov, K., van den Akker, N. M., Rademakers, T., van Zandvoort, M. A., Hackeng, T. M., Koenen, R. R., & Weber, C. (2014). Endothelial Junctional Adhesion Molecule-A Guides Monocytes Into Flow-Dependent Predilection Sites of Atherosclerosis. Circulation, 129(1), 66–76. https://doi.org/10.1161/CIRCULATIONAHA.113.004149

Berbis, M. A., Andre, S., Canada, F. J., Pipkorn, R., Ippel, H., Mayo, K. H., Kuebler, D., Gabius, H.-J., & Jimenez-Barbero, J. (2014). Peptides derived from human galectin-3 N-terminal tail interact with its carbohydrate recognition domain in a phosphorylation-dependent manner. Biochemical and Biophysical Research Communications, 443(1), 126-131. https://doi.org/10.1016/j.bbrc.2013.11.063

Nicolaes, G. A. F., Kulharia, M., Voorberg, J., Kaijen, P. H., Wroblewska, A., Wielders, S., Schrijver, R., Sperandio, O., & Villoutreix, B. O. (2014). Rational design of small molecules targeting the C2 domain of coagulation factor VIII. Blood, 123(1), 113-120. https://doi.org/10.1182/blood-2013-05-503227

Cornelis, T., van der Sande, F. M., Eloot, S., Cardinaels, E., Bekers, O., Damoiseaux, J., Leunissen, K. M., & Kooman, J. P. (2014). Acute Hemodynamic Response and Uremic Toxin Removal in Conventional and Extended Hemodialysis and Hemodiafiltration: A Randomized Crossover Study.American Journal of Kidney Diseases, 64(2), 247-265. https://doi.org/10.1053/j.ajkd.2014.02.016

Erkens, P. M. G., Lucassen, W. A. M., Geersing, G. J., van Weert, H. C. P. M., Kuijs-Augustijn, M., van Heugten, M., Rietjens, L., ten Cate, H., Prins, M. H., Büller, H. R., Hoes, A. W., Moons, K. G. M., Oudega, R., & Stoffers, H. E. J. H. (2014). Alternative diagnoses in patients in whom the GP considered the diagnosis of pulmonary embolism. Family Practice. https://doi.org/10.1093/fampra/cmu055

Vaarhorst, A. A. M., Verhoeven, A., Weller, C. M., Böhringer, S., Göraler, S., Meissner, A., Deelder, A. M., Henneman, P., Gorgels, A. P. M., van den Brandt, P. A., Schouten, L. J., van Greevenbroek, M. M., Merry, A. H. H., Verschuren, W. M. M., van den Maagdenberg, A. M. J. M., van Dijk, K. W., Isaacs, A., Boomsma, D., Oostra, B. A., ... Slagboom, P. E. (2014). A metabolomic profile is associated with the risk of incident coronary heart disease. American Heart Journal, 168(1), 45-52.e7. https://doi.org/10.1016/j.ahj.2014.01.019

Wijnen, P. A., Cremers, J. P., Nelemans, P. J., Erckens, R. J., Hoitsma, E., Jansen, T. L., Bekers, O., & Drent, M. (2014). Association of the TNF-α G-308A polymorphism with TNF-inhibitor response in sarcoidosis. European Respiratory Journal, 43(6), 1730-1739. https://doi.org/10.1183/09031936.00169413

Vaidya, A., Joore, M. A., ten Cate-Hoek, A. J., Kleinegris, M. C., ten Cate, H., & Severens, J. L. (2014). A systematic review of model-based economic evaluations of diagnostic and therapeutic strategies for lower extremity artery disease. Thrombosis and Haemostasis, 111(1), 19-28. https://doi.org/10.1160/TH13-06-0498

Bouman, A. C., Cheung, Y. W., Spronk, H. M., Schalkwijk, C. G., ten Cate, H., ten Wolde, M., & ten Cate-Hoek, A. J. (2014). Biomarkers for post thrombotic syndrome: A case-control study. Thrombosis Research, 134(2), 369-375. https://doi.org/10.1016/j.thromres.2014.06.010

Klinkenberg, L. J. J., van Dijk, J. W., Tan, F. E. S., van Loon, L. J. C., van Dieijen-Visser, M. P., & Meex, S. J. R. (2014). Circulating Cardiac Troponin T Exhibits a Diurnal Rhythm. Journal of the American College of Cardiology, 63(17), 1788-1795. https://doi.org/10.1016/j.jacc.2014.01.040

Vaidya, A., Joore, M. A., ten Cate-Hoek, A. J., ten Cate, H., & Severens, J. L. (2014). Cost-effectiveness of risk assessment and tailored treatment for peripheral arterial disease patients. Biomarkers in Medicine, 8(8), 989-999. https://doi.org/10.2217/BMM.14.45

Du, J., Bleylevens, I. W. M., Bitorina, A., Wichapong, K., & Nicolaes, G. A. F. (2014). Optimization of compound ranking for structure-based virtual ligand screening using an established FRED-Surflex consensus approach. Chemical Biology & Drug Design, 83(1), 37-51. https://doi.org/10.1111/cbdd.12202

Marsch, E., Theelen, T. L., Demandt, J. A., Jeurissen, M., van Gink, M., Verjans, R., Janssen, A., Cleutjens, J. P., Meex, S. J., Donners, M. M., Haenen, G., Schalkwijk, C. G., Dubois, L. J., Lambin, P., Mallat, Z., Gijbels, M. J., Heemskerk, J. W., Fisher, E. A., Biessen, E. A., ... Sluimer, J. C. (2014). Reversal of hypoxia in murine atherosclerosis prevents necrotic core expansion by enhancing efferocytosis. Arteriosclerosis Thrombosis and Vascular Biology, 34(12), 2545-2553. https://doi.org/10.1161/ATVBAHA.114.304023

ten Cate-Hoek, A. J., Bouman, A. C., Joore, M. A., Prins, M., IDEAL DVT Trial Investigators, T., & ten Cate, H. (2014). The IDEAL DVT study, individualised duration elastic compression therapy against long-term duration of therapy for the prevention of post-thrombotic syndrome: protocol of a randomised controlled trial. BMJ Open, 4(9), Article e005265. https://doi.org/10.1136/bmjopen-2014-005265

Bouman, A. C., & ten Cate-Hoek, A. J. (2014). Timing and duration of compression therapy after deep vein thrombosis. Phlebology: The Journal of Venous Disease, 29(1), 78-82. https://doi.org/10.1177/0268355514528131

Muenzer, P., Borst, O., Walker, B., Schmid, E., Feijge, M. A. H., Cosemans, J. M. E. M., Chatterjee, M., Schmidt, E.-M., Schmidt, S., Towhid, S. T., Leibrock, C., Elvers, M., Schaller, M., Seizer, P., Ferlinz, K., May, A. E., Gulbins, E., Heemskerk, J. W. M., Gawaz, M., & Lang, F. (2014). Acid Sphingomyelinase Regulates Platelet Cell Membrane Scrambling, Secretion, and Thrombus Formation. Arteriosclerosis Thrombosis and Vascular Biology, 34(1), 61–71. https://doi.org/10.1161/ATVBAHA.112.300210

Swieringa, F., Kuijpers, M. J. E., Heemskerk, J. W. M., & van der Meijden, P. E. J. (2014). Targeting platelet receptor function in thrombus formation: The risk of bleeding. Blood Reviews, 28(1), 9-21. https://doi.org/10.1016/j.blre.2013.12.001

Kalz, J., ten Cate, H., & Spronk, H. M. H. (2014). Thrombin generation and atherosclerosis. Journal of Thrombosis and Thrombolysis, 37(1), 45-55. https://doi.org/10.1007/s11239-013-1026-5

Cornelis, T., Broers, N. J. H., Titulaer, D. C. L. M., Henskens, Y. M., van Oerle, R., van der Sande, F. M., Spronk, H. M., Vink, H., Leunissen, K. M., ten Cate, H., & Kooman, J. P. (2014). Effects of Ultrapure Hemodialysis and Low Molecular Weight Heparin on the Endothelial Surface Layer. Blood Purification, 38(3-4), 203-210. https://doi.org/10.1159/000369055

Frielink, L. M. J., Prinzen, L., Henskens, Y., Vossen, R., & Coumans, A. (2014). Kleihauer-Betketest, verre van ideaal. Nederlands tijdschrift voor obstetrie en gynaecologie, 127.

Grottke, O., van Ryn, J., Spronk, H. M. H., & Rossaint, R. (2014). Prothrombin complex concentrates and a specific antidote to dabigatran are effective ex-vivo in reversing the effects of dabigatran in an anticoagulation/liver trauma experimental model. Critical Care, 18(1), Article R27. https://doi.org/10.1186/cc13717

van Dongen, M., van Kraaij, D., Schalla, S., Brunner-La Rocca, H., & Driessen, R. (2014). Severe mitral regurgitation caused by eosinophilic endocarditis. Journal of Cardiology Cases, 10(3). https://doi.org/10.1016/j.jccase.2014.05.012

van Leeuwen, E. M., Smouter, F. A. S., Kam-Thong, T., Karbalai, N., Smith, A. V., Harris, T. B., Launer, L. J., Sitlani, C. M., Li, G., Brody, J. A., Bis, J. C., White, C. C., Jaiswal, A., Oostra, B. A., Hofman, A., Rivadeneira, F., Uitterlinden, A. G., Boerwinkle, E., Ballantyne, C. M., ... van Duijn, C. M. (2014). The challenges of genome-wide interaction studies: lessons to learn from the analysis of HDL blood levels. PLOS ONE, 9(10), e109290. https://doi.org/10.1371/journal.pone.0109290

Agten, S. M., Suylen, D., Ippel, H., Kokozidou, M., Tans, G., van de Vijver, P., Koenen, R. R., & Hackeng, T. M. (2013). Chemoselective Oxime Reactions in Proteins and Peptides by Using an Optimized Oxime Strategy: The Demise of Levulinic Acid. Chembiochem, 14(18), 2431-2434. https://doi.org/10.1002/cbic.201300598

Manthey, H. D., Cochain, C., Barnsteiner, S., Karshovska, E., Pelisek, J., Koch, M., Chaudhari, S. M., Busch, M., Eckstein, H.-H., Weber, C., Koenen, R. R., & Zernecke, A. (2013). CCR6 selectively promotes monocyte mediated inflammation and atherogenesis in mice. Thrombosis and Haemostasis, 110(6), 1267-77. https://doi.org/10.1160/TH13-01-0017

Parsa, A., Fuchsberger, C., Köttgen, A., O'Seaghdha, C. M., Pattaro, C., de Andrade, M., Chasman, D. I., Teumer, A., Endlich, K., Olden, M., Chen, M.-H., Tin, A., Kim, Y. J., Taliun, D., Li, M., Feitosa, M., Gorski, M., Yang, Q., Hundertmark, C., ... Böger, C. A. (2013). Common variants in Mendelian kidney disease genes and their association with renal function. Journal of the American Society of Nephrology, 24(12), 2105-17. https://doi.org/10.1681/ASN.2012100983

Hilhorst, M., Winckers, K., Wilde, B., van Oerle, R., ten Cate, H., & Tervaert, J. W. C. (2013). Patients with Antineutrophil Cytoplasmic Antibodies Associated Vasculitis in Remission Are Hypercoagulable. Journal of Rheumatology, 40(12), 2042-2046. https://doi.org/10.3899/jrheum.130200

Nuzzo, F., Radu, C., Baralle, M., Spiezia, L., Hackeng, T. M., Simioni, P., & Castoldi, E. (2013). Antisense-based RNA therapy of factor V deficiency: in vitro and ex vivo rescue of a F5 deep-intronic splicing mutation. Blood, 122(23), 3825-3831. https://doi.org/10.1182/blood-2013-04-499657

Nickel, K. F., Spronk, H. M., Mutch, N. J., & Renné, T. (2013). Time-dependent degradation and tissue factor addition mask the ability of platelet polyphosphates in activating factor XII-mediated coagulation. Blood, 122(23), 3847-3849. https://doi.org/10.1182/blood-2013-09-525840

Hoefer, I. E., Sels, J.-W., Jukema, J. W., Bergheanu, S., Biessen, E., McClellan, E., Daemen, M., Doevendans, P., de Groot, P., Hillaert, M., Horsman, S., Ilhan, M., Kuiper, J., Pijls, N., Redekop, K., van der Spek, P., Stubbs, A., van de Veer, E., Waltenberger, J., ... Pasterkamp, G. (2013). Circulating cells as predictors of secondary manifestations of cardiovascular disease: design of the CIRCULATING CELLS study. Clinical research in cardiology, 102(11), 847-856. https://doi.org/10.1007/s00392-013-0607-9