Publications
- 2025
- Roselli, C., Surakka, I., Olesen, M. S., Sveinbjornsson, G., Marston, N. A., Choi, S. H., Holm, H., Chaffin, M., Gudbjartsson, D., Hill, M. C., Aegisdottir, H., Albert, C. M., Alonso, A., Anderson, C. D., Arking, D. E., Arnar, D. O., Barnard, J., Benjamin, E. J., Braunwald, E., ... Ellinor, P. T. (2025). Meta-analysis of genome-wide associations and polygenic risk prediction for atrial fibrillation in more than 180,000 cases. Nature Genetics, 57(3), 539-547. Article 11303. https://doi.org/10.1038/s41588-024-02072-3
- van Deutekom, C., van de Lande, M. E., Rama, R., Nguyen, B.-O., Tieleman, R. G., Weberndoerfer, V., Hemels, M. E. W., de Melis, M., Schotten, U., Linz, D., Crijns, H. J. G. M., van Gelder, I. C., & Rienstra, M. (2025). Multimorbidity Is Associated With Symptom Severity and Disease Progression in Patients with Paroxysmal Atrial Fibrillation-Data From the RACE V Study. Journal of the American Heart Association, 14(5), Article e034514. https://doi.org/10.1161/JAHA.123.034514
- van Mourik, M. J. W., Keijsers, L., van der Velden, R. M. J., Vorstermans, B., Crijns, H. J. G. M., Muris, J. W. M., Linz, D. K., & Gidding-Slok, A. (2025). Patients perspectives on integrating eHealth in regular care pathways for atrial fibrillation: evaluating photoplethysmography for remote self-assessment. European Journal of Cardiovascular Nursing, 24(2), 305-313. https://doi.org/10.1093/eurjcn/zvae156
- Lemmens, M.-J. D. K., Heuts, S., Bidar, E., Wildberger, J. E., Mihl, C., & Smulders, M. W. (2025). Integrating Coronary Artery Assessment and Myocardial Late Enhancement Imaging With Photon-Counting Detector CT: Visualizing the Invisible. Circulation-Cardiovascular Imaging, 18(3), e017238. Article e017238. https://doi.org/10.1161/CIRCIMAGING.124.017238
- Isaksen, J. L., Arildsen, B., Lind, C., Nørregaard, M., Vernooy, K., Schotten, U., Jespersen, T., Betz, K., Hermans, A. N. L., Kanters, J. K., & Linz, D. (2025). Raw photoplethysmogram waveforms versus peak-to-peak intervals for machine learning detection of atrial fibrillation: Does waveform matter?Computer Methods and Programs in Biomedicine, 260, Article 108537. https://doi.org/10.1016/j.cmpb.2024.108537
- Beela, A. S., Manetti, C. A., Prinzen, F. W., Delhaas, T., Herbots, L., & Lumens, J. (2025). The mechanistic interaction between mechanical dyssynchrony and filling pressure in cardiac resynchronization therapy candidates. European Heart Journal Cardiovascular Imaging, 26(3), 424-434. Article jeae286. https://doi.org/10.1093/ehjci/jeae286
- Johnson, L. S., Zadrozniak, P., Jasina, G., Grotek-Cuprjak, A., Andrade, J. G., Svennberg, E., Diederichsen, S. Z., McIntyre, W. F., Stavrakis, S., Benezet-Mazuecos, J., Krisai, P., Iakobishvili, Z., Laish-Farkash, A., Bhavnani, S., Ljungström, E., Bacevicius, J., van Vreeswijk, N. L., Rienstra, M., Spittler, R., ... Et al. (2025). Artificial intelligence for direct-to-physician reporting of ambulatory electrocardiography. Nature Medicine, 31(3), 925-931. Article e13090. https://doi.org/10.1038/s41591-025-03516-x
- Gilbers, M. D., Kawczynski, M. J., Bidar, E., Maesen, B., Isaacs, A., Winters, J., Linz, D., Rienstra, M., van Gelder, I., Maessen, J. G., & Schotten, U. (2025). Determinants and impact of postoperative atrial fibrillation burden during 2.5 years of continuous rhythm monitoring after cardiac surgery: Results from the RACE V prospective cohort study. Heart Rhythm, 22(3), 647-660. https://doi.org/10.1016/j.hrthm.2024.08.014
- Shahrbabaki, S. S., Dharmaprani, D., Tiver, K. D., Jenkins, E., Strong, C., Tonchev, I., O'Loughlin, L. P., Linz, D., Chapman, D., Lechat, B., Ullah, S., Stone, K. L., Eckert, D. J., Baumert, M., & Ganesan, A. N. (2025). Power-law properties of nocturnal arrhythmia avalanches: a novel marker for incident cardiovascular events. Heart Rhythm, 22(3), 796-805. https://doi.org/10.1016/j.hrthm.2024.08.015
- de Riva, M., Evertz, R., Lukac, P., Dekker, L. R. C., Blaauw, Y., ter Bekke, R. M. A., Kimura, Y., Beukema, R. J., Ouss, A., Mulder, B. A., Vernooy, K., Wijnmaalen, A. P., & Zeppenfeld, K. (2025). Evoked delayed potential ablation for post-myocardial infarction ventricular tachycardia: results from a large prospective multicentre study. EP Europace, 27(2), Article euaf003. https://doi.org/10.1093/europace/euaf003
- Ganesan, P., Pedron, M., Feng, R., Rogers, A. J., Deb, B., Chang, H. J., Ruiperez-Campillo, S., Srivastava, V., Brennan, K. A., Giles, W., Baykaner, T., Clopton, P., Wang, P. J., Schotten, U., Krummen, D. E., & Narayan, S. M. (2025). Comparing Phenotypes for Acute and Long-Term Response to Atrial Fibrillation Ablation Using Machine Learning. Circulation-Arrhythmia and Electrophysiology, 18(2), Article e012860. https://doi.org/10.1161/CIRCEP.124.012860
- Maass, A. H., Tuinenburg, A., Mairuhu, G., Faes, M. C., Klinkenberg, T. J., Ruigrok, S., Koster, M., Stegeman, B. H., & Luermans, J. G. L. M. (2025). 2021 European Society of Cardiology guidelines on cardiac pacing and cardiac resynchronisation therapy: Statement of endorsement by the NVVC. Netherlands Heart Journal, 33(2), 38-45. https://doi.org/10.1007/s12471-024-01927-y
- Manninger, M., Zweiker, D., Hovakimyan, T., Matusik, P. T., Conti, S., Ollitrault, P., Aro, A., Mulder, B. A., Dichtl, W., Heeger, C. H., ter Bekke, R. M. A., Gul, E. E., Weijs, B., Rahm, A. K., Darma, A., Evranos, B., Sabbag, A., Moroka, K., Traykov, V., ... Linz, D. (2025). Author's Reply to “Digital Devices for Arrhythmia Detection: What Is Still Missing?”. Clinical Cardiology, 48(2), Article e70092. https://doi.org/10.1002/clc.70092
- Isaacs, A., Zeemering, S., Winters, J., Batlle, M., Bidar, E., Boukens, B., Casadei, B., Chua, W., Crijns, H. J. G. M., Fabritz, L., Guasch, E., Hatem, S. N., Hermans, B., Kääb, S., Kawczynski, M., Maesen, B., Maessen, J., Mont, L., Sinner, M. F., ... Stoll, M. (2025). Lateral Atrial Expression Patterns Provide Insights into Local Transcription Disequilibrium Contributing to Disease Susceptibility. Circulation: Genomic and Precision Medicine, 18(1), Article e004594. https://doi.org/10.1161/CIRCGEN.124.004594
- Boukens, B. J., & Porta-Sanchez, A. (2025). Repolarization Mapping in Brugada Syndrome Patients. JACC: Clinical Electrophysiology, 11(2), 418-419. https://doi.org/10.1016/j.jacep.2024.10.036
- Arslan, M., Schaap, J., van Gorsel, B., Aubanell, A., Budde, R. P. J., Hirsch, A., Smulders, M. W., Mihl, C., Damman, P., Sliwicka, O., Habets, J., Dubois, E. A., & Dedic, A. (2025). Coronary computed tomography angiography improves assessment of patients with acute chest pain and inconclusively elevated high-sensitivity troponins. European Radiology, 35(2), 789-797. https://doi.org/10.1007/s00330-024-10930-1
- Munneke, A. G., Lumens, J., & Delhaas, T. (2025). Diagnostic value of reversed differential cyanosis in (supra)cardiac total anomalous pulmonary venous return. Pediatric Research, 97(2), 809-817. Article 113366. https://doi.org/10.1038/s41390-024-03355-5
- Sciacca, V., Sohns, C., Crijns, H. J. G. M., Marrouche, N. F., Schramm, R., Moersdorf, M., Fink, T., Bergau, L., Hindricks, G., Dagres, N., Sossalla, S., Costard-Jaeckle, A., Fox, H., El Hamriti, M., Konietschke, F., Rudolph, V., Gummert, J., Tijssen, J. G. P., Sommer, P., & CASTLE HTx Investigators (2025). Effects of atrial fibrillation ablation on arrhythmia burden and ventricular function in end-stage heart failure: Lessons from CASTLE-HTx. European journal of heart failure, 27(2), 255-263. https://doi.org/10.1002/ejhf.3505
- Mourmans, S. G. J., Weerts, J., Baumert, M., Aizpurua, A. B., Achten, A., Knackstedt, C., Linz, D., & van Empel, V. P. M. (2025). Prognostic value of hypoxaemic burden from overnight oximetry in heart failure with preserved ejection fraction. Esc heart failure, 12(1), 622-630. https://doi.org/10.1002/ehf2.15116
- Plesinger, F., Hassouna, S., Carna, Z., Vesela, J., Smisek, R., Vargova, E., Sobota, V., Koscova, Z., Nejedly, P., Viscor, I., Prinzen, F. W., Jurak, P., Halamek, J., & Osmancik, P. (2025). Automatically optimized vectorcardiographic features are associated with recurrence of atrial fibrillation after electrical cardioversion. Scientific Reports, 15(1), Article 1257. https://doi.org/10.1038/s41598-025-85340-4
- Schuijt, E., Scherr, D., Plank, G., Schotten, U., & Heijman, J. (2025). Evolution in electrophysiology 100 years after Einthoven: translational and computational innovations in rhythm control of atrial fibrillation. EP Europace, 27(1), Article euae304. https://doi.org/10.1093/europace/euae304
- Tönnis, T., Becher, N., Birkemeyer, R., Duncker, D., Eckardt, L., Gröschel, K., Linz, D., Meyer, C., Straube, F., Sultan, A., Wachter, R., Zylla, M., & Kirchhof, P. (2025). Device-detektiertes Vorhofflimmern – was nun? Executive Summary des DGK-Positionspapiers. Herzschrittmachertherapie und Elektrophysiologie. Advance online publication. https://doi.org/10.1007/s00399-025-01112-7
- van Loo, C., Toonen, S. M. R. L., Schurgers, L. J., Delhaas, T., & Spronck, B. (2025). Human Aortic Vasoreactivity in Response to Various Stimuli: A Review. Pulse, 13(1), 121-139. https://doi.org/10.1159/000547617
- Parikh, S., Wehrens, A., Giudici, A., Ganizada, B., Saraber, P., Schurgers, L., Debeij, G., Natour, E., Maessen, J., Huberts, W., Delhaas, T., Reesink, K., & Bidar, E. (2025). Interpretation of intra-operative strain differences in ascending thoracic aortic repair patients. Journal of Biomechanics, 179, Article 112447. https://doi.org/10.1016/j.jbiomech.2024.112447
- Neutel, C. H. G., van der Laan, K. W. F., Wesley, C. D., Krueger, D. N., Pencheva, M. G., Schalkwijk, C. G., De Meyer, G. R. Y., Martinet, W., Delhaas, T., Reesink, K. D., Giudici, A., Guns, P.-J., & Spronck, B. (2025). The MAASWERP Study: An International, Comparative Case Study on Measuring Biomechanics of the Aged Murine Aorta. Pulse, 13(1), 1-10. https://doi.org/10.1159/000542694
- Heinen, S. G. H., van den Heuvel, D. A. F., de Vries, J. P. P. M., van de Vosse, F. N., Delhaas, T., & Huberts, W. (2025). Corrigendum to “A geometry-based model for non-invasive estimation of pressure gradients over iliac artery stenosis” [J. Biomech. 92 (2019) 67–75]. Journal of Biomechanics, 178, Article 112248. https://doi.org/10.1016/j.jbiomech.2024.112248
- Deissler, P. M., Volders, P. G. A., & Ter Bekke, R. M. A. (2025). The Electromechanical Window for Arrhythmia-Risk Assessment. Heart Rhythm, 22(1), 118-127. https://doi.org/10.1016/j.hrthm.2024.06.012
- Linz, D., & Stavrakis, S. (2025). Cardioneuroablation for vasovagal syncope: How to move beyond "learning by burning"?Journal of Interventional Cardiac Electrophysiology, 68(2), 241–243. https://doi.org/10.1007/s10840-022-01232-x
- Ozgul, O., Marques, V. G., Hermans, B. JM., van Hunnik, A., Verheule, S., Gharaviri, A., Pezzuto, S., Auricchio, A., Schotten, U., Bonizzi, P., & Zeemering, S. (2025). High-density and high-coverage composite atrial activation maps: an in-silico validation study. Ieee Transactions on Biomedical Engineering, 72(1), 79-89. https://doi.org/10.1109/TBME.2024.3439502
- Luker, J., Strik, M., Andrade, J. G., Raymond-Paquin, A., Elrefai, M. H., Roberts, P. R., Perez, O. C., Kron, J., Koneru, J., Franqui-Rivera, H., Sultan, A., Ernst, A., Schmitt, J., Pott, A., Veltmann, C., Srinivasan, N. T., Collinson, J., van Stipdonk, A. M. W., Linz, D., ... Steven, D. (2025). Incidence of premature battery depletion in subcutaneous cardioverter-defibrillator patients: insights from a multicenter registry. Journal of Interventional Cardiac Electrophysiology, 68(7), 1409–1415. https://doi.org/10.1007/s10840-023-01468-1
- Spoormans, E. M., Thevathasan, T., Van Royen, N., Zwinderman, A. H., Freund, A., Thiele, H., Ziesemer, K., Desch, S., Lemkes, J. S., Janssens, G. N., van der Hoeven, N. W., Jewbali, L. S. D., Dubois, E. A., Meuwissen, M., Rijpstra, T. A., Bosker, H. A., Blans, M. J., Bleeker, G. B., Baak, R., ... COACT and TOMAHAWK Trials Investigators (2025). One-Year Outcomes of Coronary Angiography After Out-of-Hospital Cardiac Arrest Without ST Elevation: An Individual Patient Data Meta-Analysis. JAMA Cardiology, 10(8), 779-786. https://doi.org/10.1001/jamacardio.2025.1194
- Sobota, V., Stoks, J., Patel, K. H. K., Shetty, R., Ni, H., Grandi, E., Ng, F. S., Volders, P. G. A., Cluitmans, M. J. M., & Bayer, J. D. (2025). The apicobasal dispersion of ventricular repolarization in humans is associated with age and affects arrhythmia vulnerability. The Journal of Physiology. Advance online publication. https://doi.org/10.1113/JP288356
- 2024
- Fudim, M., Khan, M. S., Linz, D., Lindenfeld, J., Macrae, C., Kimmeskamp-Kirschbaum, N., Meyer, M., Mondritzki, T., Tinel, H., Dinh, W., & Mentz, R. J. (2024). Safety and tolerability of the M2 muscarinic acetylcholine receptor modulator BAY 2413555 in heart failure with reduced ejection fraction in the REMOTE-HF study. Scientific Reports, 14(1), Article 31585. https://doi.org/10.1038/s41598-024-77111-4
- Rienstra, M., Tzeis, S., Bunting, K., Caso, V., Crijns, H. J. G. M., De Potter, T. J. R., Sanders, P., Svennberg, E., Casado-Arroyo, R., Dwight, J., Guasti, L., Hanke, T., Jaarsma, T., Lettino, M., Lochen, M.-L., Lumbers, R. T., Maesen, B., Molgaard, I., Rosano, G. M. C., ... Van Gelder, I. C. (2024). Spotlight on the 2024 ESC/EACTS management of atrial fibrillation guidelines: 10 novel key aspects. EP Europace, 26(12), Article euae298. https://doi.org/10.1093/europace/euae298
- Velt, M. J. H., Crijns, H. J. G. M., van Gelder, I. C., Linz, D., van de Lande, M. E., Ten Cate, H., Spronk, H. M. H., de Melis, M., Rienstra, M., & Mulder, B. A. (2024). Dynamic biomarker profiles in patients with paroxysmal atrial fibrillation: Assessing the differences between sinus rhythm and acute atrial fibrillation episode. International Journal of Cardiology, 417, Article 132526. https://doi.org/10.1016/j.ijcard.2024.132526
- Fabritz, L., Al-Taie, C., Borof, K., Breithardt, G., Camm, A. J., Crijns, H. J. G. M., Roth Cardoso, V., Chua, W., van Elferen, S., Eckardt, L., Gkoutos, G., Goette, A., Guasch, E., Hatem, S., Metzner, A., Mont, L., Murukutla, V. A., Obergassel, J., Rillig, A., ... Kirchhof, P. (2024). Biomarker-based prediction of sinus rhythm in atrial fibrillation patients: the EAST-AFNET 4 biomolecule study. European Heart Journal, 45(47), 5002-5019. https://doi.org/10.1093/eurheartj/ehae611
- van Loon, T., Rijks, J., van Koll, J., Wolffs, J., Cornelussen, R., van Osta, N., Luermans, J., Prinzen, F., Linz, D., van Empel, V., Delhaas, T., Vernooy, K., & Lumens, J. (2024). Accelerated atrial pacing reduces left-heart filling pressure: a combined clinical-computational study. European Heart Journal, 45(46), 4953-4964. https://doi.org/10.1093/eurheartj/ehae718
- Schnabel, R. B., Benezet-Mazuecos, J., Becher, N., McIntyre, W. F., Fierenz, A., Lee, S. F., Goette, A., Atar, D., Bertaglia, E., Benz, A. P., Chlouverakis, G., Birnie, D. H., Dichtl, W., Blomstrom-Lundqvist, C., Camm, A. J., Erath, J. W., Simantirakis, E., Kutyifa, V., Lip, G. Y. H., ... Kirchhof, P. (2024). Anticoagulation in device-detected atrial fibrillation with or without vascular disease: a combined analysis of the NOAH-AFNET 6 and ARTESiA trials. European Heart Journal, 45(46), 4902-4916. https://doi.org/10.1093/eurheartj/ehae596
- Joza, J., Burri, H., Andrade, J. G., Linz, D., Ellenbogen, K. A., & Vernooy, K. (2024). Atrioventricular node ablation for atrial fibrillation in the era of conduction system pacing. European Heart Journal, 45(46), 4887-4901. Article ehae656. https://doi.org/10.1093/eurheartj/ehae656
- Reyat, J. S., Sommerfeld, L. C., O'Reilly, M., Cardoso, V. R., Thiemann, E., Khan, A. O., O'Shea, C., Harder, S., Müller, C., Barlow, J., Stapley, R. J., Chua, W., Kabir, S. N., Grech, O., Hummel, O., Hübner, N., Kääb, S., Mont, L., Hatem, S. N., ... Fabritz, L. (2024). PITX2 deficiency leads to atrial mitochondrial dysfunction. Cardiovascular Research, 120(15), 1907-1923. https://doi.org/10.1093/cvr/cvae169
- Sohns, C., Moersdorf, M., Marrouche, N. F., Bergau, L., Costard-Jaeckle, A., Crijns, H. J. G. M., Fox, H., Hindricks, G., Dagres, N., Sossalla, S., Schramm, R., Fink, T., El Hamriti, M., Sciacca, V., Didenko, M., Konietschke, F., Rudolph, V., Gummert, J., Tijssen, J. G. P., ... CASTLE HTx Investigators (2024). Catheter Ablation in Patients with End-Stage Heart Failure and Atrial Fibrillation: Two-year Follow-up of the CASTLE-HTx Trial. Circulation, 150(23), 1904-1906. https://doi.org/10.1161/CIRCULATIONAHA.124.071517
- Olde Nordkamp, L. R. A., Pepplinkhuizen, S., Ghani, A., Boersma, L. V. A., Kuschyk, J., El-Chami, M. F., Behr, E. R., Brouwer, T. F., Kaab, S., Mittal, S., Quast, A.-F. B. E., van der Stuijt, W., Smeding, L., de Veld, J. A., Tijssen, J. G. P., Bijsterveld, N. R., Richter, S., Brouwer, M. A., de Groot, J. R., ... PRAETORIAN Investigators (2024). Inappropriate Therapy and Shock Rates Between the Subcutaneous and Transvenous Implantable Cardiac Defibrillator: A Secondary Analysis of the PRAETORIAN Trial. Circulation-Arrhythmia and Electrophysiology, 17(12), Article e012836. https://doi.org/10.1161/CIRCEP.124.012836
- Zanelli, S., Agnoletti, D., Alastruey, J., Allen, J., Bianchini, E., Bikia, V., Boutouyrie, P., Bruno, R. M., Climie, R., Djamaleddine, D., Gkaliagkousi, E., Giudici, A., Gopcevic, K., Grillo, A., Guala, A., Hametner, B., Joseph, J., Karimpour, P., Kodithuwakku, V., ... Charlton, P. H. (2024). Developing technologies to assess vascular ageing: a roadmap from VascAgeNet. Physiological Measurement, 45(12), Article 121001. https://doi.org/10.1088/1361-6579/ad548e
- van Koll, J., Rijks, J. H. J., Vernooy, K., & Joza, J. (2024). Different levels of recruitment during conduction system pacing. HeartRhythm Case Reports, 10(12), 861-866. https://doi.org/10.1016/j.hrcr.2024.09.013
- Hutschalik, T., Özgül, O., Casini, M., Szabó, B., Peyronnet, R., Bártulos, Ó., Argenziano, M., Schotten, U., & Matsa, E. (2024). Immune response caused by M1 macrophages elicits atrial fibrillation-like phenotypes in coculture model with isogenic hiPSC-derived cardiomyocytes. Stem Cell Research & Therapy, 15(1), Article 280. https://doi.org/10.1186/s13287-024-03814-0




