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Ravassa, S., Lopez, B., Ferreira, J. P., Girerd, N., Bozec, E., Pellicori, P., Mariottoni, B., Cosmi, F., Hazebroek, M., Verdonschot, J. A. J., Cuthbert, J., Petutschnigg, J., Moreno, M. U., Heymans, S., Staessen, J. A., Pieske, B., Edelmann, F., Clark, A. L., Cleland, J. G. F., ... HOMAGE Trial Committees and Investigators (2021). Biomarker-based assessment of collagen cross-linking identifies patients at risk of heart failure more likely to benefit from spironolactone effects on left atrial remodelling. Insights from the HOMAGE clinical trial. European journal of heart failure. https://doi.org/10.1002/ejhf.2394

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van Dalen, D. H., Kragten, J. A., Emans, M. E., Van Ofwegen-Hanekamp, C. E. E., Klaarwater, C. C. R., Spanjers, M. H. A., Hendrick, R., van Deursen, C. T. B. M., & Brunner-La Rocca, H. P. (2021). Acute heart failure and iron deficiency: a prospective, multicentre, observational study. Esc heart failure. https://doi.org/10.1002/ehf2.13737

Radhoe, S. P., Veenis, J. F., Linssen, G. C. M., van der Lee, C., Eurlings, L. W. M., Kragten, H., Al-Windy, N. Y. Y., van der Spank, A., Koudstaal, S., Brunner-La Rocca, H. P., & Brugts, J. J. (2021). Diabetes and treatment of chronic heart failure in a large real-world heart failure population. Esc heart failure. https://doi.org/10.1002/ehf2.13743

Ferreira, J. P., Girerd, N., Rocca, H. P. B. L., Pellicori, P., Cleland, J. G., Rossignol, P., & Zannad, F. (2021). No influence of spironolactone on plasma concentrations of angiotensin-converting enzyme 2: Findings from the HOMAGE randomized trial. Archives of Cardiovascular Diseases, 114(12), 814-817. https://doi.org/10.1016/j.acvd.2021.10.003

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Uszko-Lencer, N. H. M. K., Janssen, D. J. A., Gaffron, S., Vanfleteren, L. E. G. W., Janssen, E., Werter, C., Franssen, F. M. E., Wouters, E. F. M., Rechberger, S., Brunner La Rocca, H-P., & Spruit, M. A. (2021). Clustering based on comorbidities in patients with chronic heart failure: an illustration of clinical diversity. Esc heart failure. https://doi.org/10.1002/ehf2.13704

Omerovic, E., Citro, R., Bossone, E., Redfors, B., Backs, J., Bruns, B., Ciccarelli, M., Couch, L. S., Dawson, D., Grassi, G., Iacoviello, M., Parodi, G., Schneider, B., Templin, C., Ghadri, J. R., Thum, T., Chioncel, O., Tocchetti, C. G., Van der Velden, J., ... Lyon, A. R. (2021). Pathophysiology of Takotsubo syndrome - a joint scientific statement from the Heart Failure Association Takotsubo Syndrome Study Group and Myocardial Function Working Group of the European Society of Cardiology - Part 2: vascular pathophysiology, gender and sex hormones, genetics, chronic cardiovascular problems and clinical implications. European journal of heart failure. https://doi.org/10.1002/ejhf.2368

Gandhi, S., Witten, A., De Majo, F., Gilbers, M., Maessen, J., Schotten, U., de Windt, L. J., & Stoll, M. (2021). Evolutionarily conserved transcriptional landscape of the heart defining the chamber specific physiology. Genomics, 113(6), 3782-3792. https://doi.org/10.1016/j.ygeno.2021.09.002

Ciccarelli, M., Dawson, D., Falcao-Pires, I., Giacca, M., Hamdani, N., Heymans, S., Hooghiemstra, A., Leeuwis, A., Hermkens, D., Tocchetti, C. G., van der Velden, J., Zacchigna, S., & Thum, T. (2021). Reciprocal organ interactions during heart failure: a position paper from the ESC Working Group on Myocardial Function. Cardiovascular Research, 117(12), 2416-2433. https://doi.org/10.1093/cvr/cvab009

Wang, S. J., Schianchi, F., Neumann, D., Wong, L. Y., Sun, A. M., van Nieuwenhoven, F. A., Zeegers, M. P., Strzelecka, A., Col, U., Glatz, J. F. C., Nabben, M., & Luiken, J. J. F. P. (2021). Specific amino acid supplementation rescues the heart from lipid overload-induced insulin resistance and contractile dysfunction by targeting the endosomal mTOR-v-ATPase axis. Molecular Metabolism, 53, [101293]. https://doi.org/10.1016/j.molmet.2021.101293

Stroeks, S. L. V. M., Hellebrekers, D. M. E. I., Claes, G. R. F., Tayal, U., Krapels, I. P. C., Vanhoutte, E. K., van den Wijngaard, A., Henkens, M. T. H. M., Ware, J. S., Heymans, S. R. B., Brunner, H. G., & Verdonschot, J. A. J. (2021). Clinical impact of re-evaluating genes and variants implicated in dilated cardiomyopathy. Genetics in Medicine, 23(11), 2186-2193. https://doi.org/10.1038/s41436-021-01255-1

Verhestraeten, C., Heggermont, W. A., & Maris, M. (2021). Clinical inertia in the treatment of heart failure: a major issue to tackle. Heart Failure Reviews, 26(6), 1359-1370. https://doi.org/10.1007/s10741-020-09979-z

Weerts, J., Barandiarán Aizpurua, A., Henkens, M. T. H. M., Lyon, A., van Mourik, M. J. W., van Gemert, M. R. A. A., Raafs, A., Sanders-van Wijk, S., Bayés-Genís, A., Heymans, S. R. B., Crijns, H. J. G. M., Brunner-La Rocca, H-P., Lumens, J., van Empel, V. P. M., & Knackstedt, C. (2021). The prognostic impact of mechanical atrial dysfunction and atrial fibrillation in heart failure with preserved ejection fraction. European Heart Journal Cardiovascular Imaging. https://doi.org/10.1093/ehjci/jeab222

Remmelzwaal, S., Beulens, J. W. J., Elders, P. J. M., Stehouwer, C. D. A., Handoko, M. L., Appelman, Y., van Empel, V., Heymans, S. R. B., & van Ballegooijen, A. J. (2021). Sex-specific associations of body composition measures with cardiac function and structure after 8 years of follow-up. Scientific Reports, 11(1), [21046]. https://doi.org/10.1038/s41598-021-00541-x

EMPEROR-Preserved Trial Investigators (2021). Empagliflozin in Heart Failure with a Preserved Ejection Fraction. New England Journal of Medicine, 385(16), 1451-1461. https://doi.org/10.1056/NEJMoa2107038

Sacchetto, C., Mohseni, Z., Colpaert, R. M. W., Vitiello, L., De Bortoli, M., Vonhogen, I. G. C., Xiao, K., Poloni, G., Lorenzon, A., Romualdi, C., Bariani, R., Mazzotti, E., Daliento, L., Bauce, B., Corrado, D., Thum, T., Rampazzo, A., de Windt, L. J., & Calore, M. (2021). Circulating miR-185-5p as a Potential Biomarker for Arrhythmogenic Right Ventricular Cardiomyopathy. Cells, 10(10), [2578]. https://doi.org/10.3390/cells10102578

Schreurs, J., Sacchetto, C., Colpaert, R. M. W., Vitiello, L., Rampazzo, A., & Calore, M. (2021). Recent Advances in CRISPR/Cas9-Based Genome Editing Tools for Cardiac Diseases. International Journal of Molecular Sciences, 22(20), [10985]. https://doi.org/10.3390/ijms222010985

Verdonschot, J. A. J., Henkens, M. T. H. M., Wang, P., Schummers, G., Raafs, A. G., Krapels, I. P. C., van Empel, V., Heymans, S. R. B., Brunner-La Rocca, H-P., & Knackstedt, C. (2021). A global longitudinal strain cut-off value to predict adverse outcomes in individuals with a normal ejection fraction. Esc heart failure, 8(5), 4343-4345. https://doi.org/10.1002/ehf2.13465

Raafs, A., Verdonschot, J., Ferreira, J. P., Wang, P., Collier, T., Henkens, M., Bjorkman, J., Boccanelli, A., Clark, A. L., Delles, C., Diez, J., Gonzalez, A., Girerd, N., Jukema, J. W., Pinet, F., Rossignol, P., Thum, T., Vodovar, N., de Boer, R. A., ... Heymans, S. (2021). Identification of sex-specific biomarkers predicting new-onset heart failure. Esc heart failure, 8(5), 3512-3520. https://doi.org/10.1002/ehf2.13476

Moura, B., Aimo, A., Al-Mohammad, A., Flammer, A., Barberis, V., Bayes-Genis, A., Rocca, H. P. B. L., Fontes-Carvalho, R., Grapsa, J., Hulsmann, M., Ibrahim, N., Knackstedt, C., Januzzi, J. L., Lapinskas, T., Sarrias, A., Matskeplishvili, S., Meijers, W. C., Messroghli, D., Mueller, C., ... Richards, A. M. (2021). Integration of imaging and circulating biomarkers in heart failure: a consensus document by the Biomarkers and Imaging Study Groups of the Heart Failure Association of the European Society of Cardiology. European journal of heart failure, 23(10), 1577-1596. https://doi.org/10.1002/ejhf.2339

McDonagh, T. A., Metra, M., Adamo, M., Gardner, R. S., Baumbach, A., Bohm, M., Burri, H., Butler, J., Celutkiene, J., Chioncel, O., Cleland, J. G. F., Coats, A. J. S., Crespo-Leiro, M. G., Farmakis, D., Gilard, M., Heymans, S., Hoes, A. W., Jaarsma, T., Jankowska, E. A., ... ESC Scientific Document Group (2021). 2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure. European Heart Journal, 42(36), 3599-3726. https://doi.org/10.1093/eurheartj/ehab368

Jedrzejczyk, M. A., Van den Bosch, S., Van Aelst, J., Van Aelst, K., Kouris, P. D., Moalin, M., Haenen, G. R. M. M., Boot, M. D., Hensen, E. J. M., Lagrain, B., Sels, B. F., & Bernaerts, K. V. (2021). Lignin-Based Additives for Improved Thermo-Oxidative Stability of Biolubricants. ACS Sustainable Chemistry & Engineering, 9(37), 12548-12559. https://doi.org/10.1021/acssuschemeng.1c02799

Gingele, A. J., Brandts, L., Vossen, K., Knackstedt, C., Boyne, J., & Rocca, H. P. B. L. (2021). Prognostic value of signs and symptoms in heart failure patients using remote telemonitoring. Journal of Telemedicine and Telecare, [1357633X211039404]. https://doi.org/10.1177/1357633X211039404

De Majo, F., Martens, L., Hegenbarth, J. C., Ruhle, F., Hamczyk, M. R., Nevado, R. M., Andres, V., Hilbold, E., Bar, C., Thum, T., de Boer, M., Duncker, D. J., Schroen, B., Armand, A. S., Stoll, M., & De Windt, L. J. (2021). Genomic instability in the naturally and prematurely aged myocardium. Proceedings of the National Academy of Sciences of the United States of America, 118(36), [e2022974118]. https://doi.org/10.1073/pnas.2022974118

Naesens, L., Penicka, M., & Heggermont, W. (2021). Diagnosis and immunosuppressive treatment of inflammatory cardiomyopathy: a case report. Acta Clinica Belgica, 76(5), 415-419. https://doi.org/10.1080/17843286.2020.1747714

Regeneron Genetics Ctr (2021). The genomics of heart failure: design and rationale of the HERMES consortium. Esc heart failure. https://doi.org/10.1002/ehf2.13517

Ghys, L. F., Martens, P., Heggermont, W. A., Gabriel, L., Heyse, A., Troisfontaines, P., & Maris, M. (2021). The in- and out-of-hospital management of HF patients: results from a nationwide Belgian survey. Acta Cardiologica, 76(6), 632-641. https://doi.org/10.1080/00015385.2020.1765105

Vergaro, G., Gentile, F., Meems, L. M. G., Aimo, A., Januzzi, J. L., Richards, A. M., Lam, C. S. P., Latini, R., Staszewsky, L., Anand, I. S., Cohn, J. N., Ueland, T., Gullestad, L., Aukrust, P., Brunner-La Rocca, H. P., Bayes-Genis, A., Lupon, J., Yoshihisa, A., Takeishi, Y., ... Emdin, M. (2021). NT-proBNP for Risk Prediction in Heart Failure: Identification of Optimal Cutoffs Across Body Mass Index Categories. JACC-Heart Failure, 9(9), 653-663. https://doi.org/10.1016/j.jchf.2021.05.014

Amin, H., Weerts, J., Brunner-La Rocca, H. P., Knackstedt, C., & Sanders-van Wijk, S. (2021). Future perspective of heart failure care: benefits and bottlenecks of artificial intelligence and eHealth. Future Cardiology, 17(6), 917-921. https://doi.org/10.2217/fca-2021-0008

CHECK-HF Investigators (2021). Impact of sex-specific target dose in chronic heart failure patients with reduced ejection fraction. European Journal of Preventive Cardiology, 28(9), 957-965. [2047487320923185]. https://doi.org/10.1177/2047487320923185

Raso, A., Dirkx, E., Sampaio-Pinto, V., el Azzouzi, H., Cubero, R. J., Sorensen, D. W., Ottaviani, L., Olieslagers, S., Huibers, M. M., de Weger, R., Siddiqi, S., Moimas, S., Torrini, C., Zentillin, L., Braga, L., Nascimento, D. S., da Costa Martins, P. A., van Berlo, J. H., Zacchigna, S., ... De Windt, L. J. (2021). A microRNA program regulates the balance between cardiomyocyte hyperplasia and hypertrophy and stimulates cardiac regeneration. Nature Communications, 12(1), [4808]. https://doi.org/10.1038/s41467-021-25211-4

Verdonschot, J. A. J., Ferreira, J. P., Pellicori, P., Brunner-La Rocca, H. P., Clark, A. L., Cosmi, F., Cuthbert, J., Girerd, N., Mariottoni, B., Petutschnigg, J., Rossignol, P., Cleland, J. G. F., Zannad, F., Heymans, S. R. B., & HOMAGE “Heart Omics in AGEing” consortium (2021). Proteomic mechanistic profile of patients with diabetes at risk of developing heart failure: insights from the HOMAGE trial. Cardiovascular Diabetology, 20(1), [163]. https://doi.org/10.1186/s12933-021-01357-9

Russcher, A., Verdonschot, J., Molenaar-de Backer, M. W. A., Heymans, S. R. B., Kroes, A. C. M., & Zaaijer, H. L. (2021). Parvovirus B19 DNA detectable in hearts of patients with dilated cardiomyopathy, but absent or inactive in blood. Esc heart failure, 8(4), 2723-2730. https://doi.org/10.1002/ehf2.13341

Abreu, R. C., Ramos, C., Becher, C., Lino, M., Jesus, C., da Costa Martins, P. A., Martins, P. A. T., Moreno, M. J., Fernandes, H., & Ferreira, L. (2021). Exogenous loading of miRNAs into small extracellular vesicles. Journal of Extracellular Vesicles , 10(10), [12111]. https://doi.org/10.1002/jev2.12111

Simonavicius, J., Maeder, M. T., Eurlings, C. G. M. J., Aizpurua, A. B., Celutkiene, J., Barysiene, J., Toggweiler, S., Kaufmann, B. A., & Brunner-La Rocca, H-P. (2021). Intensification of pharmacological decongestion but not the actual daily loop diuretic dose predicts worse chronic heart failure outcome: insights from TIME-CHF. Clinical research in cardiology, 110(8), 1221-1233. https://doi.org/10.1007/s00392-020-01779-7

Vangrieken, P., Al-Nasiry, S., Bast, A., Leermakers, P. A., Tulen, C. B. M., Schiffers, P. M. H., van Schooten, F. J., & Remels, A. H. V. (2021). Placental Mitochondrial Abnormalities in Preeclampsia. Reproductive Sciences, 28(8), 2186-2199. https://doi.org/10.1007/s43032-021-00464-y

Marcks, N., Aimo, A., Januzzi, J. L., Vergaro, G., Clerico, A., Latini, R., Meessen, J., Anand, I. S., Cohn, J. N., Gravning, J., Ueland, T., Bayes-Genis, A., Lupón, J., de Boer, R. A., Yoshihisa, A., Takeishi, Y., Egstrup, M., Gustafsson, I., Gaggin, H. K., ... Brunner-La Rocca, H-P. (2021). Re-appraisal of the obesity paradox in heart failure: a meta-analysis of individual data. Clinical research in cardiology, 110(8), 1280-1291. https://doi.org/10.1007/s00392-021-01822-1

van Woerden, G., van Veldhuisen, D. J., Gorter, T. M., Willems, T. P., van Empel, V. P. M., Peters, A., Pundziute, G., Op den Akker, J. W., Rienstra, M., & Westenbrink, B. D. (2021). The clinical and prognostic value of late Gadolinium enhancement imaging in heart failure with mid-range and preserved ejection fraction. Heart and Vessels. https://doi.org/10.1007/s00380-021-01910-2

Veugen, M. G. J., Linssen, P. B. C., Henry, R. M. A., Koster, A., Kroon, A. A., Stehouwer, C. D. A., & Brunner-La Rocca, H-P. (2021). Measures of Left Ventricular Diastolic Function and Cardiorespiratory Fitness According to Glucose Metabolism Status: The Maastricht Study. Journal of the American Heart Association, 10(13), [020387]. https://doi.org/10.1161/jaha.120.020387

Breuls, N., Giarratana, N., Yedigaryan, L., Garrido, G. M., Carai, P., Heymans, S., Ranga, A., Deroose, C., & Sampaolesi, M. (2021). Valproic acid stimulates myogenesis in pluripotent stem cell-derived mesodermal progenitors in a NOTCH-dependent manner. Cell Death & Disease, 12(7), [677]. https://doi.org/10.1038/s41419-021-03936-w

Badimon, L., Robinson, E. L., Jusic, A., Carpusca, I., DeWindt, L. J., Emanueli, C., Ferdinandy, P., Gu, W., Gyongyosi, M., Hackl, M., Karaduzovic-Hadziabdic, K., Lustrek, M., Martelli, F., Nham, E., Potocnjak, I., Satagopam, V., Schneider, R., Thum, T., & Devaux, Y. (2021). Cardiovascular RNA markers and artificial intelligence may improve COVID-19 outcome: a position paper from the EU-CardioRNA COST Action CA17129. Cardiovascular Research, 117(8), 1823-1840. https://doi.org/10.1093/cvr/cvab094

van Woerden, G., van Veldhuisen, D. J., Gorter, T. M., van Empel, V. P. M., Hemels, M. E. W., Hazebroek, E. J., van Veldhuisen, S. L., Willems, T. P., Rienstra, M., & Westenbrink, B. D. (2021). Importance of epicardial adipose tissue localization using cardiac magnetic resonance imaging in patients with heart failure with mid-range and preserved ejection fraction. Clinical Cardiology, 44(7), 987-993. https://doi.org/10.1002/clc.23644

Uijl, A., Veenis, J. F., Brunner-La Rocca, H. P., van Empel, V., Linssen, G. C. M., Asselbergs, F. W., van der Lee, C., Eurlings, L. W. M., Kragten, H., Al-Windy, N. Y. Y., van der Spank, A., Koudstaal, S., Brugts, J. J., & Hoes, A. W. (2021). Clinical profile and contemporary management of patients with heart failure with preserved ejection fraction: results from the CHECK-HF registry. Netherlands Heart Journal, 29(7-8), 370-376. https://doi.org/10.1007/s12471-020-01534-7

Ploeg, M. C., Munts, C., Prinzen, F. W., Turner, N. A., van Bilsen, M., & van Nieuwenhoven, F. A. (2021). Piezo1 Mechanosensitive Ion Channel Mediates Stretch-Induced Nppb Expression in Adult Rat Cardiac Fibroblasts. Cells, 10(7), [1745]. https://doi.org/10.3390/cells10071745

Tayal, U., Ware, J. S., Lakdawala, N. K., Heymans, S., & Prasad, S. K. (2021). Understanding the genetics of adult-onset dilated cardiomyopathy: what a clinician needs to know. European Heart Journal, 42(24), 2384-2396. https://doi.org/10.1093/eurheartj/ehab286

Parcha, V., Malla, G., Kalra, R., Patel, N., Wijk, S. S., Pandey, A., Shah, S. J., Arora, G., & Arora, P. (2021). Diagnostic and prognostic implications of heart failure with preserved ejection fraction scoring systems. Esc heart failure, 8(3), 2089-2102. https://doi.org/10.1002/ehf2.13288