• 2013
    • Cooper, S., Jonak, P., Chouinard-Pelletier, G., Coulombe, S., Jones, E., & Leask, R. L. (2013). Permeabilization of adhered cells using an inert gas jet. Journal of visualized experiment, (79), Article e50612. https://doi.org/10.3791/50612
    • El Azzouzi, H., Leptidis, S., Dirkx, E., Hoeks, J., van Bree, B., van de Brand, K., McClellan, E. A., Poels, E., Sluimer, J. C., van den Hoogenhof, M. M., Armand, A. S., Yin, X., Langley, S., Bourajjaj, M., Olieslagers, S., Krishnan, J., Vooijs, M., Kurihara, H., Stubbs, A., ... De Windt, L. J. (2013). The Hypoxia-Inducible MicroRNA Cluster miR-199a similar to 214 Targets Myocardial PPAR delta and Impairs Mitochondrial Fatty Acid Oxidation. Cell Metabolism, 18(3), 341-354. https://doi.org/10.1016/j.cmet.2013.08.009
    • Caforio, A. L. P., Pankuweit, S., Arbustini, E., Basso, C., Gimeno-Blanes, J., Felix, S. B., Fu, M., Helio, T., Heymans, S., Jahns, R., Klingel, K., Linhart, A., Maisch, B., McKenna, W., Mogensen, J., Pinto, Y. M., Ristic, A., Schultheiss, H.-P., Seggewiss, H., ... Elliott, P. M. (2013). Current state of knowledge on aetiology, diagnosis, management, and therapy of myocarditis: a position statement of the European Society of Cardiology Working Group on Myocardial and Pericardial Diseases. European Heart Journal, 34(33), 2636-2648. https://doi.org/10.1093/eurheartj/eht210
    • Heather, L. C., Pates, K. M., Atherton, H. J., Cole, M. A., Ball, D. R., Evans, R. D., Glatz, J. F., Luiken, J. J., Griffin, J. L., & Clarke, K. (2013). Differential Translocation of the Fatty Acid Transporter, FAT/CD36, and the Glucose Transporter, GLUT4, Coordinates Changes in Cardiac Substrate Metabolism During Ischemia and Reperfusion. Circulation-Heart Failure, 6(5), 1058-1066. https://doi.org/10.1161/CIRCHEARTFAILURE.112.000342
    • Witjas-Paalberends, E. R., Piroddi, N., Stam, K., van Dijk, S. J., Oliviera, V. S., Ferrara, C., Scellini, B., Hazebroek, M., ten Cate, F. J., van Slegtenhorst, M., dos Remedios, C., Niessen, H. W. M., Tesi, C., Stienen, G. J. M., Heymans, S., Michels, M., Poggesi, C., & van der Velden, J. (2013). Mutations in MYH7 reduce the force generating capacity of sarcomeres in human familial hypertrophic cardiomyopathy. Cardiovascular Research, 99(3), 432-441. https://doi.org/10.1093/cvr/cvt119
    • Van Aelst, L. N. L., & Heymans, S. (2013). MicroRNAs as Biomarkers for Ischemic Heart Disease. Journal of Cardiovascular Translational Research, 6(4), 458-470. https://doi.org/10.1007/s12265-013-9466-z
    • Sanders-van Wijk, S., Muzzarelli, S., Neuhaus, M., Kiencke, S., Maeder, M., Estlinbaum, W., Tobler, D., Mayer, K., Erne, P., Pfisterer, M. E., & Brunner-La Rocca, H.-P. (2013). Safety and tolerability of intensified, N-terminal pro brain natriuretic peptide-guided compared with standard medical therapy in elderly patients with congestive heart failure: results from TIME-CHF. European journal of heart failure, 15(8), 910-918. https://doi.org/10.1093/eurjhf/hft079
    • Vanhoutte, D., van Almen, G. C., Van Aelst, L. N. L., Van Cleemput, J., Droogne, W., Jin, Y., Van de Werf, F., Carmeliet, P., Vanhaecke, J., Papageorgiou, A.-P., & Heymans, S. (2013). Matricellular proteins and matrix metalloproteinases mark the inflammatory and fibrotic response in human cardiac allograft rejection. European Heart Journal, 34(25), 1930-1941. https://doi.org/10.1093/eurheartj/ehs375
    • Tritsch, E., Mallat, Y., Lefebvre, F., Diguet, N., Escoubet, B., Blanc, J., De Windt, L. J., Catalucci, D., Vandecasteele, G., Li, Z., & Mericskay, M. (2013). An SRF/miR-1 axis regulates NCX1 and Annexin A5 protein levels in the normal and failing heart. Cardiovascular Research, 98(3), 372-380. https://doi.org/10.1093/cvr/cvt042
    • Huijts, M., van Oostenbrugge, R. J., Duits, A., Burkard, T., Muzzarelli, S., Maeder, M. T., Schindler, R., Pfisterer, M. E., & Brunner-La Rocca, H.-P. (2013). Cognitive impairment in heart failure: results from the Trial of Intensified versus standard Medical therapy in Elderly patients with Congestive Heart Failure (TIME-CHF) randomized trial. European journal of heart failure, 15(6), 699-707. https://doi.org/10.1093/eurjhf/hft020
    • Daskalopoulos, E. P., Hermans, K. C. M., Janssen, B. J. A., & Blankesteijn, W. M. (2013). Targeting the Wnt/frizzled signaling pathway after myocardial infarction: A new tool in the therapeutic toolbox?Trends in Cardiovascular Medicine, 23(4), 121-127. https://doi.org/10.1016/j.tcm.2012.09.010
    • Stapf, D., Franke, A., Schreckenberg, M., Schummers, G., Mischke, K., Marx, N., Schauerte, P., & Knackstedt, C. (2013). Beat to beat 3-dimensional intracardiac echocardiography: theoretical approach and practical experiences. International Journal of Cardiovascular Imaging, 29(4), 753-764. https://doi.org/10.1007/s10554-012-0136-z
    • Mischke, K., Knackstedt, C., Marx, N., & Vollmann, D. (2013). Insights into atrial fibrillation. Minerva Medica, 104(2), 119-130.
    • Camporeale, A., Marino, F., Papageorgiou, A., Carai, P., Fornero, S., Fletcher, S., Page, B. D. G., Gunning, P., Forni, M., Chiarle, R., Morello, M., Jensen, O., Levi, R., Heymans, S., & Poli, V. (2013). STAT3 activity is necessary and sufficient for the development of immune-mediated myocarditis in mice and promotes progression to dilated cardiomyopathy. EMBO Molecular Medicine, 5(4), 572-590. https://doi.org/10.1002/emmm.201201876
    • Kaufmann, B. A., Min, S. Y., Goetschalckx, K., Bernheim, A. M., Buser, P. T., Pfisterer, M. E., & Brunner-La Rocca, H.-P. (2013). How reliable are left ventricular ejection fraction cut offs assessed by echocardiography for clinical decision making in patients with heart failure?International Journal of Cardiovascular Imaging, 29(3), 581-588. https://doi.org/10.1007/s10554-012-0122-5
    • Leptidis, S., el Azzouzi, H., Lok, S. I., de Weger, R., Olieslagers, S., Kisters, N., Silva, G. J., Heymans, S., Cuppen, E., Berezikov, E., De Windt, L. J., & Martins, P. D. C. (2013). A Deep Sequencing Approach to Uncover the miRNOME in the Human Heart. PLOS ONE, 8(2), Article e57800. https://doi.org/10.1371/journal.pone.0057800
    • Steinbusch, L. K. M., Dirkx, E., Hoebers, N. T. H., Roelants, V., Foretz, M., Viollet, B., Diamant, M., van Eys, G., Ouwens, D. M., Bertrand, L., Glatz, J. F. C., & Luiken, J. J. F. P. (2013). Overexpression of AMP-activated protein kinase or protein kinase D prevents lipid-induced insulin resistance in cardiomyocytes. Journal of Molecular and Cellular Cardiology, 55(1), 165-173. https://doi.org/10.1016/j.yjmcc.2012.11.005
    • Arends, S. J., Damoiseaux, J. G., Duijvestijn, A. M., Debrus-Palmans, L., Boomars, K. A., Brunner-La Rocca, H. P., Tervaert, J. W., & van Paassen, P. (2013). Functional implications of IgG anti-endothelial cell antibodies in pulmonary arterial hypertension. Autoimmunity, 46(7), 463-470. https://doi.org/10.3109/08916934.2013.812080
    • Smulders, M. W., Kietselaer, B. L. J. H., Das, M., Wildberger, J. E., Crijns, H. J. G. M., Veenstra, L., Brunner La Rocca, H. P., van Dieijen-Visser, M. P., Mingels, A. M. A., Dagnelie, P. C., Post, M. J., Gorgels, A. P. M., van Asselt, A. D. I., Vogel, G., Schalla, S., Kim, R. J., & Bekkers, S. C. A. M. (2013). The role of cardiovascular magnetic resonance imaging and computed tomography angiography in suspected non-ST-elevation myocardial infarction patients: Design and rationale of the CARdiovascular Magnetic rEsoNance imaging and computed Tomography Angiography (CARMENTA) trial. American Heart Journal, 166(6), 968-975. https://doi.org/10.1016/j.ahj.2013.09.012
    • Glatz, J. F. C., Angin, Y., Steinbusch, L. K. M., Schwenk, R. W., & Luiken, J. J. F. P. (2013). CD36 as a target to prevent cardiac lipotoxicity and insulin resistance. Prostaglandins Leukotrienes and Essential Fatty Acids, 88(1), 71-77. https://doi.org/10.1016/j.plefa.2012.04.009
    • Chouinard-Pelletier, G., Jahnsen, E. D., & Jones, E. A. V. (2013). Increased shear stress inhibits angiogenesis in veins and not arteries during vascular development. Angiogenesis, 16(1), 71-83. https://doi.org/10.1007/s10456-012-9300-2
    • Jeger, R. V., Rocca, H. P. B.-L., Bertel, O., Kiowski, W., Pfisterer, M. E., & Kaiser, C. A. (2013). Stent Thrombosis after Coronary Stent Implantation: A Protective Effect of High-Dose Statin Therapy?Cardiology, 126(2), 115-121. https://doi.org/10.1159/000350822
  • 2012
    • van Empel, V. P. M., De Windt, L. J., & Martins, P. A. D. C. (2012). Circulating miRNAs: Reflecting or Affecting Cardiovascular Disease?Current Hypertension Reports, 14(6), 498-509. https://doi.org/10.1007/s11906-012-0310-7
    • Scharf, C., Ng, G. A., Wieczorek, M., Deneke, T., Furniss, S. S., Murray, S., Debruyne, P., Hobson, N., Berntsen, R. F., Schneider, M. A., Hauer, H. A., Halimi, F., Boveda, S., Asbach, S., Boesche, L., Zimmermann, M., Brigadeau, F., Taieb, J., Merkel, M., ... Boersma, L. V. A. (2012). European survey on efficacy and safety of duty-cycled radiofrequency ablation for atrial fibrillation. EP Europace, 14(12), 1700-1707. https://doi.org/10.1093/europace/eus188
    • Angin, Y., Steinbusch, L. K. M., Simons, P. J., Greulich, S., Hoebers, N. T. H., Douma, K., van Zandvoort, M. A. M. J., Coumans, W. A., Wijnen, W., Diamant, M., Ouwens, D. M., Glatz, J. F. C., & Luiken, J. J. F. P. (2012). CD36 inhibition prevents lipid accumulation and contractile dysfunction in rat cardiomyocytes. Biochemical Journal, 448(1), 43-53. https://doi.org/10.1042/BJ20120060
    • Spruit, M. A., Maeder, M. T., Knackstedt, C., Ammann, P., Jeker, U., Uszko-Lencer, N., Kiencke, S., Pfisterer, M. E., Rickli, H., & Brunner La Rocca, H. P. (2012). Prognostic Value of Self-Reported Versus Objectively Measured Functional Capacity in Patients With Heart Failure Results From the TIME-CHF (Trial of Intensified Versus Standard Medical Therapy in Elderly Patients With Congestive Heart Failure). Journal of the American College of Cardiology, 60(20), 2125-2126. https://doi.org/10.1016/j.jacc.2012.08.968
    • Heggermont, W. A., & Heymans, S. (2012). MicroRNAs Are Involved in End-Organ Damage During Hypertension. Hypertension, 60(5), 1088-1093. https://doi.org/10.1161/HYPERTENSIONAHA.111.187104
    • Bourgonje, V. J. A., Schoenmakers, M., Beekman, J. D. M., van der Nagel, R., Houtman, M. J. C., Miedema, L. F., Antoons, G., Sipido, K., de Windt, L. J., van Veen, T. A. B., & Vos, M. A. (2012). Relevance of calmodulin/CaMKII activation for arrhythmogenesis in the AV block dog. Heart Rhythm, 9(11), 1875-1883.e2. https://doi.org/10.1016/j.hrthm.2012.07.023
    • Rickenbacher, P., Pfisterer, M., Burkard, T., Kiowski, W., Follath, F., Burckhardt, D., Schindler, R., & Rocca, H.-P. B.-L. (2012). Why and how do elderly patients with heart failure die? Insights from the TIME-CHF study. European journal of heart failure, 14(11), 1218-1229. https://doi.org/10.1093/eurjhf/hfs113
    • Schwenk, R. W., Angin, Y., Steinbusch, L. K. M., Dirkx, E., Hoebers, N., Coumans, W. A., Bonen, A., Broers, J. L. V., van Eys, G. J. J. M., Glatz, J. F. C., & Luiken, J. J. F. P. (2012). Overexpression of Vesicle-associated Membrane Protein (VAMP) 3, but Not VAMP2, Protects Glucose Transporter (GLUT) 4 Protein Translocation in an in Vitro Model of Cardiac Insulin Resistance. Journal of Biological Chemistry, 287(44), 37530-37539. https://doi.org/10.1074/jbc.M112.363630
    • Eurlings, L. W., van Wijk, S., van Kimmenade, R., Osinski, A., van Helmond, L., Vallinga, M., Crijns, H. J., van Dieijen-Visser, M. P., Brunner La Rocca, H. P., & Pinto, Y. M. (2012). Multimarker strategy for short-term risk assessment in patients with dyspnea in the emergency department: The marked (multi marker emergency dyspnea)-risk score. Journal of the American College of Cardiology, 60(17), 1668-1677. https://doi.org/10.1016/j.jacc.2012.06.040
    • Foulquier, S., Steckelings, U. M., & Unger, T. (2012). Impact of the AT(2) Receptor Agonist C21 on Blood Pressure and Beyond. Current Hypertension Reports, 14(5), 403-409. https://doi.org/10.1007/s11906-012-0291-6
    • Henderson-Toth, C. E., Jahnsen, E. D., Jamarani, R., Al-Roubaie, S., & Jones, E. A. V. (2012). The glycocalyx is present as soon as blood flow is initiated and is required for normal vascular development. Developmental Biology, 369(2), 330-9. https://doi.org/10.1016/j.ydbio.2012.07.009
    • Chouinard-Pelletier, G., Leduc, M., Guay, D., Coulombe, S., Leask, R. L., & Jones, E. A. V. (2012). Use of inert gas jets to measure the forces required for mechanical gene transfection. Biomedical Engineering Online, 11, 67. https://doi.org/10.1186/1475-925X-11-67
    • Al-Roubaie, S., Hughes, J. H., Filla, M. B., Lansford, R., Lehoux, S., & Jones, E. A. V. (2012). Time-lapse microscopy of macrophages during embryonic vascular development. Developmental Dynamics, 241(9), 1423-31. https://doi.org/10.1002/dvdy.23835
    • Totzeck, M., Hendgen-Cotta, U. B., Rammos, C., Frommke, L.-M., Knackstedt, C., Predel, H.-G., Kelm, M., & Rassaf, T. (2012). Higher endogenous nitrite levels are associated with superior exercise capacity in highly trained athletes. Nitric Oxide-Biology and Chemistry, 27(2), 75-81. https://doi.org/10.1016/j.niox.2012.05.003
    • Knackstedt, C., Becker, M., Mischke, K., Pauling, R., Rocca, H. P. B.-L., & Schauerte, P. (2012). A dedicated cardioversion unit for the treatment of atrial fibrillation. Reducing costs by optimizing processes. Herz, 37(5), 518-526. https://doi.org/10.1007/s00059-011-3546-0
    • Dennert, R., van Paassen, P., Wolffs, P., Bruggeman, C., Velthuis, S., Felix, S., van Suylen, R.-J., Crijns, H. J., Tervaert, J. W. C., & Heymans, S. (2012). Differences in Virus Prevalence and Load in the Hearts of Patients with Idiopathic Dilated Cardiomyopathy with and without Immune-Mediated Inflammatory Diseases. Clinical and Vaccine Immunology, 19(8), 1182-1187. https://doi.org/10.1128/CVI.00281-12
    • Hazebroek, M., Dennert, R., & Heymans, S. (2012). Idiopathic dilated cardiomyopathy: possible triggers and treatment strategies. Netherlands Heart Journal, 20(7-8), 332-335. https://doi.org/10.1007/s12471-012-0285-7
    • Dirkx, E., Cazorla, O., Schwenk, R. W., Lorenzen-Schmidt, I., Sadayappan, S., Van Lint, J., Carrier, L., van Eys, G. J. J. M., Glatz, J. F. C., & Luiken, J. J. F. P. (2012). Protein kinase D increases maximal Ca2+-activated tension of cardiomyocyte contraction by phosphorylation of cMyBP-C-Ser(315). American Journal of Physiology-heart and Circulatory Physiology, 303(3), H323-H331. https://doi.org/10.1152/ajpheart.00749.2011
    • Jain, S. S., Snook, L. A., Glatz, J. F. C., Luiken, J. J. F. P., Holloway, G. P., Thurmond, D. C., & Bonen, A. (2012). Munc18c provides stimulus-selective regulation of GLUT4 but not fatty acid transporter trafficking in skeletal muscle. Febs Letters, 586(16), 2428-2435. https://doi.org/10.1016/j.febslet.2012.05.061
    • Timmers, S., Nabben, M., Bosma, M., van Bree, B., Lenaers, E., Van Beurden, D., Schaart, G., Westerterp-Plantenga, M. S., Langhans, W., Hesselink, M. K. C., Schrauwen-Hinderling, V. B., & Schrauwen, P. (2012). Augmenting muscle diacylglycerol and triacylglycerol content by blocking fatty acid oxidation does not impede insulin sensitivity. Proceedings of the National Academy of Sciences of the United States of America, 109(29), 11711-11716. https://doi.org/10.1073/pnas.1206868109
    • McFarlan, J. T., Yoshida, Y., Jain, S. S., Han, X.-X., Snook, L. A., Lally, J., Smith, B. K., Glatz, J. F. C., Luiken, J. J. F. P., Sayer, R. A., Tupling, A. R., Chabowski, A., Holloway, G. P., & Bonen, A. (2012). In Vivo, Fatty Acid Translocase (CD36) Critically Regulates Skeletal Muscle Fuel Selection, Exercise Performance, and Training-induced Adaptation of Fatty Acid Oxidation. Journal of Biological Chemistry, 287(28), 23502-23516. https://doi.org/10.1074/jbc.M111.315358
    • Corsten, M. F., Schroen, B., & Heymans, S. (2012). Inflammation in viral myocarditis: friend or foe?Trends in Molecular Medicine, 18(7), 426-437. https://doi.org/10.1016/j.molmed.2012.05.005
    • el Azzouzi, H., Leptidis, S., Bourajjaj, M., van Bilsen, M., Martins, P. A. D. C., & De Windt, L. J. (2012). MEK1 Inhibits Cardiac PPAR alpha Activity by Direct Interaction and Prevents Its Nuclear Localization. PLOS ONE, 7(6), Article e36799. https://doi.org/10.1371/journal.pone.0036799
    • Daamen, M. A. M. J., Hamers, J. P. H., Gorgels, A. P. M., Brunner-La Rocca, H. P., Tan, F. E. S., van Dieijen-Visser, M. P., & Schols, J. M. G. A. (2012). The prevalence and management of heart failure in Dutch nursing homes: design of a multi-centre cross-sectional study. BMC Geriatrics, 12, Article 29. https://doi.org/10.1186/1471-2318-12-29
    • Salic, K., & De Windt, L. J. (2012). MicroRNAs as Biomarkers for Myocardial Infarction. Current Atherosclerosis Reports, 14(3), 193-200. https://doi.org/10.1007/s11883-012-0238-z
    • Tivig, C., Dang, L., Brunner-La Rocca, H.-P., Oezcan, S., Duru, F., & Scharf, C. (2012). Duty-cycled unipolar/bipolar versus conventional radiofrequency ablation in paroxysmal and persistent atrial fibrillation. International Journal of Cardiology, 157(2), 185-191. https://doi.org/10.1016/j.ijcard.2010.12.010