Publications
- 2025
- Van den Eynde, M. D. G., van der Bruggen, M. M., Houben, A. J. H. M., Reesink, K. D., Spronck, B., Delhaas, T., Scheijen, J. J. L. J. M., Miyata, T., & Schalkwijk, C. G. (2025). Pyridoxamine does not reduce arterial stiffness in an 8-week randomized double-blind placebo-controlled intervention trial with abdominally obese individuals. Diabetes Obesity & Metabolism, 27(9), 5332-5336. https://doi.org/10.1111/dom.16524
- Steens, I. L. M., Schram, M. T., Houben, A. J. H. M., Berendschot, T. T. J. M., Koster, A., Bosma, H., Eussen, S. J. P. M., de Galan, B. E., & van Sloten, T. T. (2025). Type 2 diabetes and depression via microvascular dysfunction, neurodegeneration, inflammation, advanced glycation end products (AGEs), and arterial stiffness. Diabetes Obesity & Metabolism, 27(9), 4847-4858. Article 16527. https://doi.org/10.1111/dom.16527
- Faber, J. G., van Herwijnen, M., Hauser, D., Daemen, S., Caiment, F., & van den Beucken, T. (2025). FOXO3 mediated gene expression modulates doxorubicin sensitivity in human cardiomyocytes. Toxicology, 518, Article 154267. https://doi.org/10.1016/j.tox.2025.154267
- Rao, Y., Yu, E. Y.-W., Lin, T.-Y., Chen, Y., Qin, Y., Koster, A., Eussen, S. J. P. M., Bosma, H., Berendschot, T. T. J. M., van der Kallen, C. J. H., van Greevenbroek, M. M. J., de Galan, B. E., Zeegers, M. P., & Wesselius, A. (2025). Interaction between coffee consumption and polygenic risk score in relation to diabetes: insights from the Maastricht study. European Journal of Nutrition, 64(6), Article 263. https://doi.org/10.1007/s00394-025-03782-y
- Ten Hoope, S., Welvaars, K., van Geijtenbeek, K., Klok-Everaars, M., van Schaik, S., & Karapinar-Çarkit, F. (2025). Applying text-mining to clinical notes: the identification of patient characteristics from electronic health records (EHRs). BMC Medical Informatics and Decision Making, 25(1), Article 302. https://doi.org/10.1186/s12911-025-03137-x
- Tichler, A., Hertroijs, D. F. L., van Mastrigt, G. A. P. G., Brouwers, M. C. G. J., Ruwaard, D., & Elissen, A. M. J. (2025). Evaluating the feasibility of study methods for a future trial-based economic evaluation of a multistage shared decision-making program for type 2 diabetes mellitus: Protocol for a cluster-randomized controlled pilot study. PLOS ONE, 20(8), Article e0300944. https://doi.org/10.1371/journal.pone.0300944
- Janssen, E. B. N. J., Ghossein-Doha, C., Hooijschuur, M. C. E., Mulder, E. G., Schiffer, V. M. M. M., Alers, R.-J., Jorissen, L. M., Jansen, G. E., Kroon, A. A., Brugts, J. J., van 't Hof, A. W. J., & Spaanderman, M. E. A. (2025). Hypertension and cardiometabolic disorders appear 5-10 years earlier in women with pre-eclampsia. European Journal of Preventive Cardiology, 32(10), 822-832. https://doi.org/10.1093/eurjpc/zwaf187
- Weerts, J., Schroen, B. L. M., Barandiaran Aizpurua, A., Berendschot, T. T. J. M., Brandts, L., Webers, C. A. B., Simons, S. O., Meex, S. J. R., Henry, R., van der Kallen, C. J. H., Brunner-La Rocca, H.-P., Knackstedt, C., Heymans, S. R. B., de Boer, R. A., van Empel, V. P. M., & Houben, A. J. H. M. (2025). Microvascular dysfunction across organs in heart failure with preserved ejection fraction: the PROSE-HFpEF case-control study. Cardiovascular Diabetology, 24(1), Article 310. https://doi.org/10.1186/s12933-025-02850-1
- Ahaouari, T., Berendsen, B., Schaper, N., Bosma, H., van Greevenbroek, M., de Galan, B., T. Schram, M., Savelberg, H., & Koster, A. (2025). Combined Associations of Type 2 Diabetes and Peripheral Neuropathy With Device-Measured Physical Activity and Sedentary Behaviour-The Maastricht Study. Diabetes/Metabolism Research and Reviews, 41(5), Article e70069. https://doi.org/10.1002/dmrr.70069
- Langeveld, M., Brouwers, M. C. G. J., van Dussen, L., Koens, L. H., Langendonk, J. G. L., & Janssen, M. C. H. (2025). Erfelijke metabole ziekten bij volwassenen. Nederlands Tijdschrift voor Geneeskunde, 169, Article D8476. https://www.ntvg.nl/artikelen/erfelijke-metabole-ziekten-bij-volwassenen
- Bakker, L., Ramakers, I. H. G. B., Greevenbroek, M. M. J. V., Backes, W. H., Jansen, J. F. A., Schram, M. T., Kallen, C. J. H. V. D., Schalkwijk, C. G., Wesselius, A., Ulvik, A., Ueland, P. M., Verhey, F. R. J., Eussen, S. J. P. M., & Kohler, S. (2025). The kynurenine pathway and markers of neurodegeneration and cerebral small vessel disease: The Maastricht Study. Journal of the Neurological Sciences, 474, Article 123522. https://doi.org/10.1016/j.jns.2025.123522
- Pencheva, M. G., Berends, E., van der Laan, K. W. F., Giudici, A., Niessen, P., Scheijen, J. L. J. M., Vangrieken, P., Leenders, P., Delhaas, T., Caiment, F., Kutmon, M., Trujillo, F. M., Wouters, K., Foulquier, S., Spronck, B., Reesink, K. D., & Schalkwijk, C. G. (2025). Glyoxalase-1 overexpression attenuates arterial wall stiffening in diabetic mice. Cardiovascular Diabetology, 24(1), Article 283. https://doi.org/10.1186/s12933-025-02823-4
- Tian, X., Scheijen, J. L. J. M., Van Pee, J., Van Royen, G., Schalkwijk, C. G., De Smet, S., & Van Hecke, T. (2025). High-moisture extruded pea balls exhibit lower (glyc)oxidative stability than pork balls following barbecuing and simulated gastrointestinal digestion. Food chemistry, 479, Article 143864. https://doi.org/10.1016/j.foodchem.2025.143864
- Zelis, N., Westerman, D., Schevers, A., Eldik, N., & Stassen, P. M. (2025). Telemonitoring starting in the emergency department as an alternative to acute hospital admission: A prospective pilot study focusing on patient preferences and first experience. PLOS Digital Health, 4(7), Article e0000962. https://doi.org/10.1371/journal.pdig.0000962
- Adrien, O., Mohammad, A. K., Hugtenburg, J. G., Mccarthy, L. M., Priester-Vink, S., Visscher, R., van den Bemt, P. M. L. A., Denig, P., & Karapinar-Carkit, F. (2025). Correction: Prescribing Cascades with Recommendations to Prevent or Reverse Them: A Systematic Review (vol 40, pg 1085, 2023). Drugs & Aging, 42(7), 675-686. https://doi.org/10.1007/s40266-025-01213-5
- Sun, D., van Greevenbroek, M. M. J., Scheijen, J. L. J. M., Kelly, J., Schalkwijk, C. G., & Wouters, K. (2025). Methylglyoxal mediates the association between 2-hour plasma glucose and HbA1c with inflammation: The Maastricht Study. Journal of Clinical Endocrinology & Metabolism, 110(7), 2047–2054. https://doi.org/10.1210/clinem/dgae640
- Holthuijsen, D. D. B., van Roekel, E. H., Bours, M. J. L., Ueland, P. M., Breukink, S. O., Janssen-Heijnen, M. L. G., Konsten, J. L., Keulen, E. T. P., McCann, A., Brezina, S., Gigic, B., Kok, D. E., Ulrich, C. M., Weijenberg, M. P., & Eussen, S. J. P. M. (2025). Modeling how iso-caloric macronutrient substitutions are longitudinally associated with plasma kynurenines in colorectal cancer survivors up to 12 months posttreatment. Journal of Nutritional Biochemistry, 141, Article 109910. https://doi.org/10.1016/j.jnutbio.2025.109910
- Albers, J., Koster, A., Sezer, B., Meisters, R., Chan, J., Wesselius, A., Schram, M., de Galan, B., Lakerveld, J., & Bosma, H. (2025). Socioeconomic position and type 2 diabetes: Examining the mediating role of social cohesion—The Maastricht Study. Social Science & Medicine, 376, Article 118046. https://doi.org/10.1016/j.socscimed.2025.118046
- Akinrimisi, O. I., Maasen, K., Scheijen, J. L. J. M., Nemet, I., Nieuwdorp, M., Schalkwijk, C. G., & Hanssen, N. M. J. (2025). Does Gut Microbial Methylglyoxal Metabolism Impact Human Physiology?Antioxidants, 14(7), Article 763. https://doi.org/10.3390/antiox14070763
- Park, J. Y., Van Puyvelde, H., Regazzetti, L., Clasen, J. L., Heath, A. K., Eussen, S., Ueland, P. M., Johansson, M., Biessy, C., Zamora-Ros, R., Huerta, J. M., Sanchez, M.-J., Ocke, M., Schulze, M. B., Schiborn, C., Braaten, T. B., Skeie, G., Sacerdote, C., Castilla, J., ... Ferrari, P. (2025). Association Between Dietary Intake and Blood Concentrations of One-Carbon-Metabolism-Related Nutrients in European Prospective Investigation into Cancer and Nutrition. Nutrients, 17(12), Article 1970. https://doi.org/10.3390/nu17121970
- Janssen, L. E. F., Hiligsmann, M., Timmer, C., van der Ploeg, L. M. C., Kerckhove, K. V., Cox, T., Heras, J. D. L., Cassiman, D., & Brouwers, M. C. G. J. (2025). Treatment preferences of adult patients with hereditary fructose intolerance: A discrete choice experiment. Molecular Genetics and Metabolism, 145(4), Article 109169. https://doi.org/10.1016/j.ymgme.2025.109169
- Nokin, M.-J., Bellier, J., Durieux, F., Peulen, O., Rademaker, G., Gabriel, M., Monseur, C., Charloteaux, B., Verbeke, L., van Laere, S., Roncarati, P., Herfs, M., Lambert, C., Scheijen, J., Schalkwijk, C., Colige, A., Caers, J., Delvenne, P., Turtoi, A., ... Bellahcene, A. (2025). Correction: Methylglyoxal, a glycolysis metabolite, triggers metastasis through MEK/ERK/SMAD1 pathway activation in breast cancer (vol 21, 11, 2019). Breast Cancer Research, 27(1), Article 99. https://doi.org/10.1186/s13058-025-02044-3
- Chan, J. A., Koster, A., Lakerveld, J., Schram, M. T., van Greevenbroek, M., & Bosma, H. (2025). Correction to: Associations of neighborhood social cohesion and changes in BMI-The Maastricht Study. European journal of public health, 35(3), 583. Article ckae170. https://doi.org/10.1093/eurpub/ckae170
- Mohammad, A. K., Hugtenburg, J. G., Ceylan, Y., Kooij, M., Knies, S., van den Bemt, P. M. L. A., Denig, P., & Karapinar-Carkit, F. (2025). Pharmacy-led interventions to reverse and prevent prescribing cascades in primary care: a proof-of-concept study. International Journal of Clinical Pharmacy, 47(3), 784-793. Article e0272418. https://doi.org/10.1007/s11096-025-01873-8
- Nielen, J. T. H., van der Walle, K., Spronk, S., Magdelijns, F., Denig, P., & Karapinar, F. (2025). Real-World Complexity of Prescribing Cascades. Basic & Clinical Pharmacology & Toxicology, 137(1), Article e70063. https://doi.org/10.1111/bcpt.70063
- van Bree, B. E., van der Heijden, D. M. B., van Golde, R. J. T., Brouwers, M. C. G. J., Spaanderman, M. E. A., & Valkenburg, O. (2025). Sex hormone-binding globulin as a biomarker for metabolic risk in European women with polycystic ovary syndrome. Gynecological Endocrinology, 41(1), Article 2500462. Advance online publication. https://doi.org/10.1080/09513590.2025.2500462
- Zhang, X., van Greevenbroek, M. M. J., Scheijen, J. L. J. M., Eussen, S. J. P. M., Kelly, J., Stehouwer, C. D. A., Schalkwijk, C. G., & Wouters, K. (2025). Fasting plasma methylglyoxal concentrations are associated with higher numbers of circulating intermediate and non-classical monocytes but with lower activation of intermediate monocytes: the Maastricht Study. Journal of Endocrinological Investigation, 48(5), 1257-1268. https://doi.org/10.1007/s40618-025-02536-1
- Chen, H., Simons, P. I. H. G., & Brouwers, M. C. G. J. (2025). Is cardiovascular disease in PCOS driven by MASLD?Trends in Endocrinology and Metabolism, 36(5), 389-391. https://doi.org/10.1016/j.tem.2024.10.005
- Holthuijsen, D. D. B., Rijnhart, J. J. M., Bours, M. J. L., van Roekel, E. H., Ueland, P. M., Breukink, S. O., Janssen-Heijnen, M. L. G., Konsten, J. L., Keulen, E. T. P., McCann, A., Brezina, S., Gigic, B., Ulrich, C. M., Weijenberg, M. P., & Eussen, S. J. P. M. (2025). Longitudinal associations of dietary intake with fatigue in colorectal cancer survivors up to 1 year post-treatment, and the potential mediating role of the kynurenine pathway. Brain Behavior and Immunity, 126, 144-159. https://doi.org/10.1016/j.bbi.2025.02.003
- Pouwer, F., Barnard-Kelly, K., Cleal, B. R., Cooke, D., de Groot, M., Deschênes, S., Ehrmann, D., Fernandez, A., Frostholm, L., Hopkins, D., Hermanns, N., Holt, R. I. G., Iversen, M. M., Kubiak, T., Andersen, C. M., Mezuk, B., Nefs, G., Pedersen, S. S., Schram, M., ... international PsychoSocial Aspects of Diabetes (PSAD) Study Group (2025). The missing piece: The clinical translation of precision diabetes medicine requires precision mental health care: A call to action from the international PsychoSocial Aspects of Diabetes (PSAD) Study Group. Diabetic Medicine, 42(5), Article e15514. https://doi.org/10.1111/dme.15514
- Mourmans, S. G. J., Achten, A., Hermans, R., Scheepers, M. J. E., D'Alessandro, E., Swennen, G., Woudstra, J., Appelman, Y., Goor, H. V., Schalkwijk, C., Knackstedt, C., Weerts, J., Eringa, E. C., & van Empel, V. P. M. (2025). The effect of empagliflozin on peripheral microvascular dysfunction in patients with heart failure with preserved ejection fraction. Cardiovascular Diabetology, 24(1), Article 182. https://doi.org/10.1186/s12933-025-02679-8
- Claassen, L., Stassen, P. M., Boumans, T. J. T., Barten, D. G., Kremers, M. N. T., Hermans, A. M. E., Zelis, N., Cals, J. W. L., & Latten, G. H. P. (2025). Characteristics of Dutch ED patients and their journey through the acute care chain: A province-wide flash-mob study. PLOS ONE, 20(4), Article e0318510. https://doi.org/10.1371/journal.pone.0318510
- Doola, R., Griffin, A., Forbes, J. M., Kruger, P. S., Deane, A. M., Schalkwijk, C. G., & White, K. C. (2025). Association between enteral carboxymethyllysine intake and daily glycemic variability in critically ill adults: A retrospective cohort study. Journal of Parenteral and Enteral Nutrition, 49(3), 324-331. https://doi.org/10.1002/jpen.2727
- Steens, I. L. M., Ji, Y., Sedaghat, S., Pankow, J., Klein, B. E. K., Cotch, M. F., Mcclelland, R. L., Hayden, K. M., Hughes, T. M., Bancks, M. P., Houben, A. J. H. M., Kroon, A. A., Koster, A., Bosma, H., Berendschot, T. T. J. M., de Galan, B. E., & van Sloten, T. T. (2025). Diabetes and incident stroke and mediation by microvascular dysfunction: Pooled analysis of three population-based studies. Diabetes Obesity & Metabolism, 27(4), 2299-2304. Article 16217. https://doi.org/10.1111/dom.16217
- Berends, E., Vangrieken, P., Amiri, N., van de Waarenburg, M. P. H., Scheijen, J. L. J. M., Hermes, D. J. H. P., Wouters, K., van Oostenbrugge, R. J., Schalkwijk, C. G., & Foulquier, S. (2025). Increased Levels of Circulating Methylglyoxal Have No Consequence for Cerebral Microvascular Integrity and Cognitive Function in Young Healthy Mice. Molecular Neurobiology, 62(4), 4190-4202. Article 101148. https://doi.org/10.1007/s12035-024-04552-3
- Choe, K., Bakker, L., van den Hove, D. L. A., Eussen, S. J. P. M., Kenis, G., Ramakers, I. H. G. B., Verhey, F. R. J., Rutten, B. P. F., & Kohler, S. (2025). Kynurenine pathway dysregulation in cognitive impairment and dementia: a systematic review and meta-analysis. Geroscience, Article 120819. Advance online publication. https://doi.org/10.1007/s11357-025-01636-3
- Loef, B., Boer, J. M. A., Beekman, M., Campman, S. L., Hoogendijk, E. O., Huider, F., Pagen, D. M. E., Splinter, M. J., van der Velde, J. H. P. M., Boomsma, D. I., Dagnelie, P. C., van Dongen, J., de Geus, E. J. C., Huisman, M., Ikram, M. A., Koster, A., Licher, S., Mierau, J. O., de Mutsert, R., ... Lifelines Corona Research Initiative (2025). The association of overweight, obesity, and long-term obesity with SARS-CoV-2 infection: a meta-analysis of 9 population-based cohorts from the Netherlands Cohorts Consortium. International Journal of Obesity, 49(4), 586-595. Article e13128. https://doi.org/10.1038/s41366-024-01660-x
- Tichler, A., Hertroijs, D. F. L., Ruwaard, D., Brouwers, M. C. G. J., & Elissen, A. M. J. (2025). Development of a patient decision aid for type 2 diabetes mellitus: a patient-centered approach. BMC primary care, 26(1), Article 81. https://doi.org/10.1186/s12875-025-02772-7
- Pereboom, J., Meulenbroeks, D., Gerards, S. M. P. L., Eussen, S. J. P. M., Scheepers, H. C. J., Jonkers, D. M. A. E., & Gubbels, J. S. (2025). Mothers adhering to a vegan diet: feeding practices of their young children and underlying determinants - a qualitative exploration. Journal of Nutritional Science, 14, Article e26. https://doi.org/10.1017/jns.2025.14
- Koene, E. J., Buziau, A. M., Cassiman, D., Cox, T. M., Bons, J., Scheijen, J. L. J. M., Schalkwijk, C. G., Meex, S. J., Saxena, A. R., Esler, W. P., Schrauwen-Hinderling, V. B., Schrauwen, P., & Brouwers, M. C. (2025). Safety and efficacy of pharmacological inhibition of ketohexokinase in hereditary fructose intolerance. Journal of Clinical Investigation, 135(6), Article e187376. https://doi.org/10.1172/JCI187376
- Tore, E. C., Adriaans, B. C., Olsen, T., Vinknes, K. J., Kooi, M. E., Elshorbagy, A. K., Bastani, N. E., Dagnelie, P. C., Eussen, S. J. P. M., Gundersen, T. E., Kožich, V., Refsum, H., Retterstøl, K., Stolt, E. T. K., & van Greevenbroek, M. M. J. (2025). Estimated stearoyl-CoA desaturase activity mediates the associations of total cysteine with adiposity: The Maastricht Study. Journal of Clinical Lipidology, 19(2), 348-357. https://doi.org/10.1016/j.jacl.2024.11.005
- Chan, J. A., Meisters, R., Lakerveld, J., Schram, M. T., Bosma, H., & Koster, A. (2025). The association of neighborhood walkability and food environment with incident cardiovascular disease in The Maastricht Study. Health & Place, 92, Article 103432. https://doi.org/10.1016/j.healthplace.2025.103432
- Gaartman, A. E., Beuger, B. M., de Ligt, L. A., Veldthuis, M., Matlung, H. L., Meijers, J. C. M., Schalkwijk, C. G., de Heer, K., Heijmans, J., van Zwieten, R., Biemond, B. J., van Bruggen, R., & Nur, E. (2025). Low-dose iron chelation as anti-oxidative therapy in patients with sickle cell disease: A single-centre pilot study. British Journal of Haematology, 206(3), 1010-1013. https://doi.org/10.1111/bjh.19943
- Vangrieken, P., Scheijen, J. L. J. M., Schiffers, P. M. H., van de Waarenburg, M. P. H., Foulquier, S., & Schalkwijk, C. C. G. (2025). Modelling the effects of elevated methylglyoxal levels on vascular and metabolic complications. Scientific Reports, 15(1), Article 6025. https://doi.org/10.1038/s41598-025-90661-5
- Oomens, J. E., Moonen, J. E. F., Vos, S. J. B., Beran, M., Mateus, P., De Deyn, P. P., van der Flier, W. M., Geerlings, M. I., Huisman, M. A., Ikram, M. A., Schram, M. T., Slagboom, P. E., Verschuren, W. M. M., Beekman, M., Bermejo, I., Birhanu, M., Bron, E. E., Dekker, A., Frentz, I., ... Visser, P. J. (2025). Identifying pathways to the prevention of dementia: the Netherlands consortium of dementia cohorts. BMC Neurology, 25(1), Article 59. https://doi.org/10.1186/s12883-024-03995-4
- Beuken, M. J., Kleynen, M., Braun, S., Van Berkel, K., van der Kallen, C., Koster, A., Bosma, H., Berendschot, T. T., Houben, A. J., Dukers-Muijrers, N., van den Bergh, J. P., Kroon, A. A., Kanera, I. M., & Maastricht Study Management (2025). Identification of Clusters in a Population With Obesity Using Machine Learning: Secondary Analysis of The Maastricht Study. JMIR Medical Informatics, 13, Article e64479. https://doi.org/10.2196/64479
- Coral, D. E., Smit, F., Farzaneh, A., Gieswinkel, A., Tajes, J. F., Sparsø, T., Delfin, C., Bauvin, P., Wang, K., Temprosa, M., De Cock, D., Blanch, J., Fernández-Real, J. M., Ramos, R., Ikram, M. K., Gomez, M. F., Kavousi, M., Panova-Noeva, M., Wild, P. S., ... Franks, P. W. (2025). Author Correction: Subclassification of obesity for precision prediction of cardiometabolic diseases. Nature Medicine, 31(2). https://doi.org/10.1038/s41591-024-03403-x
- van Oeteren, M. A. J., Simons, N., Simons, P. I. H. G., van de Waarenburg, M. P. H., Kooi, M. E., Feskens, E. J. M., van der Ploeg, E. M. C. L., Van den Eynde, M. D. G., Houben, A. J. H. M., Schalkwijk, C. G., & Brouwers, M. C. G. J. (2025). Fructose restriction has beneficial effects on adipose tissue distribution but not on serum adipokine levels: Post-hoc analysis of a double-blind randomized controlled trial. Clinical Obesity, 15(1), Article e12714. https://doi.org/10.1111/cob.12714
- Coral, D. E., Smit, F., Farzaneh, A., Gieswinkel, A., Tajes, J. F., Sparsø, T., Delfin, C., Bauvain, P., Wang, K., Temprosa, M., De Cock, D., Blanch, J., Fernández-Real, J. M., Ramos, R., Ikram, M. K., Gomez, M. F., Kavousi, M., Panova-Noeva, M., Wild, P. S., ... Franks, P. W. (2025). Subclassification of obesity for precision prediction of cardiometabolic diseases. Nature Medicine, 31(2), 534-543. https://doi.org/10.1038/s41591-024-03299-7



