• 2023
    • Hessels, L. M., Speksnijder, E., Paternotte, N., van Huisstede, A., Thijs, W., Scheer, M., van der Steen-Dieperink, M., Knarren, L., van Den Bergh, J. P., Winckers, K., Henry, R., Simsek, S., Boersma, W. G., Fung, T. Y., & CovidPredict Study Group (2023). Procalcitonin-Guided Antibiotic Prescription in Patients With COVID-19: A Multicenter Observational Cohort Study. Chest, 164(3), 596-605. https://doi.org/10.1016/j.chest.2023.04.032
    • Geraets, A. F. J., Köhler, S., Vergoossen, L. W., Backes, W. H., Stehouwer, C. D. A., Verhey, F. R., Jansen, J. F., van Sloten, T. T., & Schram, M. T. (2023). The association of white matter connectivity with prevalence, incidence and course of depressive symptoms: The Maastricht Study. Psychological Medicine, 53(12), 5558-5568. Article 0033291722002768. https://doi.org/10.1017/S0033291722002768
    • van Dongen, J., Willemsen, G., de Geus, E. J. C., Boomsma, D. I., Neale, M. C., BIOS Consortium, van Greevenbroek, M., Stehouwer, C., van der Kallen, C., & Schalkwijk, C. (2023). Effects of smoking on genome-wide DNA methylation profiles: A study of discordant and concordant monozygotic twin pairs. Elife, 12, Article e83286. https://doi.org/10.7554/eLife.83286
    • van Bakel, S. I. J., Gietema, H. A., Stassen, P. M., Gosker, H. R., Gach, D., van den Bergh, J. P., van Osch, F. H. M., Schols, A. M. W. J., & Beijers, R. J. H. C. G. (2023). CT Scan-Derived Muscle, But Not Fat, Area Independently Predicts Mortality in COVID-19. Chest, 164(2), 314-322. https://doi.org/10.1016/j.chest.2023.02.048
    • Linkens, A. M. A., Eussen, S. J. M. P., Houben, A. J. H. M., Mari, A., Dagnelie, P. C., Stehouwer, C. D. A., & Schalkwijk, C. G. (2023). Habitual intake of advanced glycation endproducts is not associated with worse insulin sensitivity, worse beta cell function, or presence of prediabetes or type 2 diabetes: The Maastricht Study. Clinical Nutrition, 42(8), 1491-1500. https://doi.org/10.1016/j.clnu.2023.05.021
    • Panis, B., Janssen, L. E. F., Lefeber, D. J., Simons, N., Rubio-Gozalbo, M. E., & Brouwers, M. C. G. J. (2023). Development of tools to facilitate the diagnosis of hereditary fructose intolerance. JIMD reports, 64(5), 353-359. https://doi.org/10.1002/jmd2.12379
    • Erdős, B., Van sloun, B., Goossens, G. H., O’donovan, S. D., De galan, B. E., Van greevenbroek, M. M. J., Stehouwer, C. D. A., Schram, M. T., Blaak, E. E., Adriaens, M. E., Van riel, N. A. W., & Arts, I. C. W. (2023). Quantifying postprandial glucose responses using a hybrid modeling approach: Combining mechanistic and data-driven models in The Maastricht Study. PLOS ONE, 18(7), Article e0285820. https://doi.org/10.1371/journal.pone.0285820
    • Kerkhofs, D., Helgers, R., Hermes, D., Steinbusch, H. P. J., Van Essen, H., Leenders, P., Prickaerts, J., Staals, J., Biessen, E. A., Van Oostenbrugge, R. J., & Foulquier, S. (2023). Amlodipine limits microglia activation and cognitive dysfunction in aged hypertensive mice. Journal of Hypertension, 41(7), 1159-1167. https://doi.org/10.1097/HJH.0000000000003445
    • Bakker, L., Kohler, S., Eussen, S. J. P. M., Choe, K., van den Hove, D. L. A., Kenis, G., Rutten, B. P. F., Ulvik, A., Ueland, P. M., Verhey, F. R. J., & Ramakers, I. H. G. B. (2023). Correlations between kynurenines in plasma and CSF, and their relation to markers of Alzheimer's disease pathology. Brain Behavior and Immunity, 111(1), 312-319. https://doi.org/10.1016/j.bbi.2023.04.015
    • Maasen, K., Eussen, S. J. P. M., Dagnelie, P. C., Stehouwer, C. D. A., Opperhuizen, A., van Greevenbroek, M. M. J., & Schalkwijk, C. G. (2023). Habitual Intake of Dietary Dicarbonyls is Associated with Greater Insulin Sensitivity and Lower Prevalence of Type 2 Diabetes: The Maastricht Study. American Journal of Clinical Nutrition, 118(1), 151-161. https://doi.org/10.1016/j.ajcnut.2023.04.011
    • van Sloten, T. T., Climie, R. E. D., Deraz, O., Périer, M.-C., Valentin, E., Fayosse, A., Sabia, S., Weiderpass, E., Jouven, X., Goldberg, M., Zins, M., Touvier, M., Deschasaux-Tanguy, M., Fezeu, L., Hercberg, S., Singh-Manoux, A., & Empana, J.-P. (2023). Is the number of ideal cardiovascular health metrics in midlife associated with lower risk of cancer? Evidence from 3 European prospective cohorts. CMAJ Open, 11(4), E774-E781. https://doi.org/10.9778/cmajo.20220175
    • Berge, K., Aengevaeren, V. L., Mosterd, A., Velthuis, B. K., Lyngbakken, M. N., Omland, T., Schalkwijk, C. G., & Eijsvogels, T. M. H. (2023). Plasma Advanced Glycation End Products and Dicarbonyl Compounds Are Not Associated with Coronary Atherosclerosis in Athletes. Medicine and Science in Sports and Exercise, 55(7), 1143-1150. https://doi.org/10.1249/MSS.0000000000003152
    • van Kruining, D., Losen, M., Crivelli, S. M., de Jong, J. J. A., Jansen, J. F. A., Backes, W. H., Monereo-Sánchez, J., van Boxtel, M. P. J., Köhler, S., Linden, D. E. J., Schram, M. T., Mielke, M. M., & Martinez-Martinez, P. (2023). Plasma ceramides relate to mild cognitive impairment in middle-aged men: The Maastricht Study. Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, 15(3), Article e12459. https://doi.org/10.1002/dad2.12459
    • Jin, S., Eussen, S. J. P. M., Schalkwijk, C. G., Stehouwer, C. D. A., & van Greevenbroek, M. M. J. (2023). Plasma factor D is cross-sectionally associated with low-grade inflammation, endothelial dysfunction and cardiovascular disease: The Maastricht study. Atherosclerosis, 377(1), 60-67. https://doi.org/10.1016/j.atherosclerosis.2023.06.079
    • Tore, E. C., Eussen, S. J. P. M., Bastani, N. E., Dagnelie, P. C., Elshorbagy, A. K., Grootswagers, P., Kozich, V., Olsen, T., Refsum, H., Retterstol, K., Stehouwer, C. D. A., Stolt, E. T. K., Vinknes, K. J., & van Greevenbroek, M. M. J. (2023). The Associations of Habitual Intake of Sulfur Amino Acids, Proteins and Diet Quality with Plasma Sulfur Amino Acid Concentrations: The Maastricht Study. Journal of Nutrition, 153(7), 2027-2040. https://doi.org/10.1016/j.tjnut.2023.05.008
    • Wauben, B., van der Poel, M. W. M., Greevenbroek, M. M. J., van Yperen, N. C., Schram, M. T., van Boxtel, M. P. J., Sastry, M., Simons, S. O., Stehouwer, C. D. A., Dagnelie, P. C., Wesselius, A., Schouten, H. C., & Köhler, S. (2023). Cognitive Functioning in Survivors of Hematopoietic Stem Cell Transplantation Compared With a Matched General Population Sample—The Maastricht Observational Study of Late Effects After Stem Cell trAnsplantation Study. Transplantation and Cellular Therapy, 29(7), 468.e1-468.e8. https://doi.org/10.1016/j.jtct.2023.03.026
    • de Ritter, R., Sep, S. J. S., van der Kallen, C. J. H., van Greevenbroek, M. M. J., Koster, A., Eussen, S. J. P. M., Dagnelie, P. C., van Boxtel, M., Schram, M. T., Kohler, S., Martens, J. A. J., Snobl, L., Vos, R. C., Stehouwer, C. D. A., & Peters, S. A. E. (2023). Sex comparisons in the association of prediabetes and type 2 diabetes with cognitive function, depression, and quality of life: The Maastricht study. Diabetic Medicine, 40(7). https://doi.org/10.1111/dme.15115
    • Lindhard, K., Jensen, B. L., Pedersen, B. L., Meyer-Olesen, C., Rix, M., Hansen, H. P., Schalkwijk, C., Waarenburg, M., Heaf, J., & Hansen, D. (2023). Far infrared treatment on the arteriovenous fistula induces changes in sVCAM and sICAM in patients on hemodialysis. Nephrology Dialysis Transplantation, 38(7), 1752-1760. https://doi.org/10.1093/ndt/gfad032
    • Chan, J. A., Koster, A., Eussen, S. J. P. M., Pinho, M. G. M., Lakerveld, J., Stehouwer, C. D. A., Dagnelie, P. C., van der Kallen, C. J., van Greevenbroek, M. M. J., Wesselius, A., & Bosma, H. (2023). The association between the food environment and adherence to healthy diet quality: the Maastricht Study. Public Health Nutrition, 26(9), 1775-1783. Article PII S1368980023001180. https://doi.org/10.1017/S1368980023001180
    • van den Kerkhof, M., van der Thiel, M. M., van Oostenbrugge, R. J., Postma, A. A., Kroon, A. A., Backes, W. H., & Jansen, J. F. (2023). Impaired damping of cerebral blood flow velocity pulsatility is associated with the number of perivascular spaces as measured with 7T MRI. Journal of Cerebral Blood Flow and Metabolism, 43(6), 937-946. https://doi.org/10.1177/0271678X231153374
    • Geraets, A. F. J., Schram, M. T., Jansen, J. F. A., Backes, W. H., Schalkwijk, C. G., Stehouwer, C. D. A., van Boxtel, M. P. J., Eussen, S. J. P. M., Kooman, J. P., Verhey, F. R. J., & Köhler, S. (2023). Corrigendum to "The cardiometabolic depression subtype and its association with clinical characteristics: The Maastricht Study" [J. Affect. Disord. 313 (2022) 110-117]. Journal of Affective Disorders, 329, 589-589. https://doi.org/10.1016/j.jad.2023.03.001
    • Buziau, A. M., Scheijen, J. L. J. M., Stehouwer, C. D. A., Schalkwijk, C. G., & Brouwers, M. C. G. J. (2023). Effects of fructose added to an oral glucose tolerance test on plasma glucose excursions in healthy adults. Metabolism open, 18(1), Article 100245. https://doi.org/10.1016/j.metop.2023.100245
    • Dzakpasu, F. Q. S., Koster, A., Owen, N., de Galan, B. E., Carver, A., Brakenridge, C. J., Boonen, A., Bosma, H., Dagnelie, P. C., Sethi, P., Eussen, S. J. P. M., Stehouwer, C. D. A., Schaper, N. C., & Dunstan, D. W. (2023). Device-measured sitting time and musculoskeletal pain in adults with normal glucose metabolism, prediabetes and type 2 diabetes-The Maastricht Study. PLOS ONE, 18(5), Article e0285276. https://doi.org/10.1371/journal.pone.0285276
    • Rinaldi, E., van der Heide, F. C. T., Bonora, E., Trombetta, M., Zusi, C., Kroon, A. A., Schram, M. T., van der Kallen, C. J. H., Wesselius, A., Bonadonna, R., Mari, A., Schalkwijk, C. G., van Greevenbroek, M. M. J., & Stehouwer, C. D. A. (2023). Lower heart rate variability, an index of worse autonomic function, is associated with worse beta cell response to a glycemic load in vivo-The Maastricht Study. Cardiovascular Diabetology, 22(1), Article 105. https://doi.org/10.1186/s12933-023-01837-0
    • Leskinen, T., Lima Passos, V., Dagnelie, P. C., Savelberg, H. H. C. M., De Galan, B. E., Eussen, S. J. P. M., Stehouwer, C. D. A., Stenholm, S., & Koster, A. (2023). Daily Physical Activity Patterns and Their Associations with Cardiometabolic Biomarkers: The Maastricht Study. Medicine and Science in Sports and Exercise, 55(5), 837-846. https://doi.org/10.1249/MSS.0000000000003108
    • Trouwborst, I., Wouters, K., Jocken, J. W., Jardon, K. M., Gijbels, A., Dagnelie, P. C., van Greevenbroek, M. M. J., van der Kallen, C. J., Stehouwer, C. D. A., Schalkwijk, C. G., Richard, N., Bendik, I., Afman, L. A., Blaak, E. E., & Goossens, G. H. (2023). Circulating and adipose tissue immune cells in tissue-specific insulin resistance in humans with overweight and obesity. Obesity, 31(5), 1326-1337. https://doi.org/10.1002/oby.23714
    • van den Eynde, M. D. G., Houben, A. J. H. M., Scheijen, J. L. J. M., Linkens, A. M. A., Niessen, P. M., Simons, N., Hanssen, N. M. J., Kusters, Y. H. A. M., Eussen, S. J. M. P., Miyata, T., Stehouwer, C. D. A., & Schalkwijk, C. G. (2023). Pyridoxamine reduces methylglyoxal and markers of glycation and endothelial dysfunction, but does not improve insulin sensitivity or vascular function in abdominally obese individuals: A randomized double-blind placebo-controlled trial. Diabetes Obesity & Metabolism, 25(5), 1280-1291. https://doi.org/10.1111/dom.14977
    • de Ritter, R., Sep, S. J. S., van Greevenbroek, M. M. J., Kusters, Y. H. A. M., Vos, R. C., Bots, M. L., Kooi, M. E., Dagnelie, P. C., Eussen, S. J. P. M., Schram, M. T., Koster, A., Brouwers, M. C. G., van der Sangen, N. M. R., Peters, S. A. E., van der Kallen, C. J. H., & Stehouwer, C. D. A. (2023). Sex differences in body composition in people with prediabetes and type 2 diabetes as compared with people with normal glucose metabolism: the Maastricht Study. Diabetologia, 66(5), 861-872. https://doi.org/10.1007/s00125-023-05880-0
    • Vandercappellen, E. J., Koster, A., Savelberg, H. H. C. M., Eussen, S. J. P. M., Dagnelie, P. C., Schram, M. T., van Greevenbroek, M. M. J., Wesselius, A., Kooman, J. P., Kroon, A. A., Henry, R. M. A., & Stehouwer, C. D. A. (2023). Accelerometer-derived physical activity and sedentary time and cardiac biomarkers: The Maastricht Study. Frontiers in Cardiovascular Medicine, 10(1), Article 1081713. https://doi.org/10.3389/fcvm.2023.1081713
    • Buziau, A. M., Blokland, G. A. M., Schalkwijk, C. G., Scheijen, J. L. J. M., Simons, P. I. H. G., Eussen, S. J. P. M., Dagnelie, P. C., van Greevenbroek, M. M. J., Wesselius, A., Stehouwer, C. D. A., & Brouwers, M. C. G. J. (2023). Comment on Lee et al. Relation of Change or Substitution of Low- and No-Calorie Sweetened Beverages With Cardiometabolic Outcomes: A Systematic Review and Meta-analysis of Prospective Cohort Studies. Diabetes Care 2022;45. Diabetes Care, 46(4), E97-E98. https://doi.org/10.2337/dc22-1930
    • van den Kerkhof, M., van der Thiel, M. M., Postma, A. A., van Oostenbrugge, R. J., Kroon, A. A., Jansen, J. F. A., & Backes, W. H. (2023). Hypertension Correlates With Stronger Blood Flow Pulsatility in Small Perforating Cerebral Arteries Assessed With 7 Tesla Magnetic Resonance Imaging. Hypertension, 80(4), 802-810. https://doi.org/10.1161/HYPERTENSIONAHA.122.19866
    • Zhang, X. D., Scheijen, J. L. J. M., Stehouwer, C. D. A., Wouters, K., & Schalkwijk, C. G. (2023). Increased methylglyoxal formation in plasma and tissues during a glucose tolerance test is derived from exogenous glucose. Clinical Science, 137(8), 697-706. https://doi.org/10.1042/CS20220753
    • Alnazer, R. M., Veldhuizen, G. P., de Leeuw, P. W., & Kroon, A. A. (2023). The effect of age, sex and BMI on the aldosterone-to-renin ratio in essential hypertensive individuals. Journal of Hypertension, 41(4), 618-623. https://doi.org/10.1097/HJH.0000000000003377
    • DeJong, N. R., Jansen, J. F. A., van Boxtel, M. P. J., Schram, M. T., Stehouwer, C. D. A., Dagnelie, P. C., van der Kallen, C. J. H., Kroon, A. A., Wesselius, A., Koster, A., Backes, W. H., & Kohler, S. (2023). Cognitive resilience depends on white matter connectivity: The Maastricht Study. Alzheimer's & Dementia, 19(4), 1164-1174. https://doi.org/10.1002/alz.12758
    • Veldhuizen, G. P., Alnazer, R. M., de Leeuw, P. W., & Kroon, A. A. (2023). The Effects of Verapamil, Hydralazine, and Doxazosin on Renin, Aldosterone, and the Ratio Thereof. Cardiovascular Drugs and Therapy, 37(2), 283-289. https://doi.org/10.1007/s10557-021-07262-3
    • van der Heide, F. C. T., Eussen, S. J. P. M., Houben, A. J. H. M., Henry, R. M. A., Kroon, A. A., van der Kallen, C. J. H., Dagnelie, P. C., van Dongen, M. C. J. M., Berendschot, T. T. J. M., Schouten, J. S. A. G., Webers, C. A. B., van Greevenbroek, M. M. J., Wesselius, A., Schalkwijk, C. G., Koster, A., Jansen, J. F. A., Backes, W. H., Beulens, J. W. J., & Stehouwer, C. D. A. (2023). Alcohol consumption and microvascular dysfunction: a J-shaped association: The Maastricht Study. Cardiovascular Diabetology, 22(1), Article 67. https://doi.org/10.1186/s12933-023-01783-x
    • Paschos, S., Lize, N., Eussen, S., van der Padt-pruijsten, A., van den Beuken-van Everdingen, M., van Laarhoven, H., den Boer, M., de Graeff, A., van den Borne, B., ten Have, H., Kennis, M., Beijer, S., Raijmakers, N. J. H., & van de Poll-franse, L. (2023). Are gastrointestinal problems, nutritional care, and nutritional care needs associated with quality of life in patients with advanced cancer? Results of the observational eQuiPe study. Supportive Care in Cancer, 31(3), Article 189. https://doi.org/10.1007/s00520-023-07646-1
    • Tore, E. C., Elshorbagy, A. K., Bakers, F. C. H., Brouwers, M. C. G. J., Dagnelie, P. C., Eussen, S. J. P. M., Jansen, J. F. A., Kooi, M. E., Kusters, Y. H. A. M., Meex, S. J. R., Olsen, T., Refsum, H., Retterstøl, K., Schalkwijk, C. G., Stehouwer, C. D. A., Vinknes, K. J., & van Greevenbroek, M. M. J. (2023). Associations between plasma sulfur amino acids and specific fat depots in two independent cohorts: CODAM and The Maastricht Study. European Journal of Nutrition, 62(2), 891-904. https://doi.org/10.1007/s00394-022-03041-4
    • Buziau, A. M., Law, P. J., Blokland, G., Schalkwijk, C., Scheijen, J., Simons, P., van der Kallen, C., Eussen, S., Dagnelie, P. C., van Greevenbroek, M., Houlston, R. S., Wesselius, A., Went, M., Stehouwer, C., & Brouwers, M. C. (2023). Genetically proxied ketohexokinase function and risk of colorectal cancer: a Mendelian randomisation study. Gut, 72(3), 604-606. https://doi.org/10.1136/gutjnl-2021-326299
    • van Yperen, N. C., Wauben, B., van der Poel, M. W., Köhler, S., van Greevenbroek, M. M., & Schouten, H. C. (2023). Selection bias in follow-up studies of stem cell transplantation survivors: an experience within the Maastricht Observational study of late effects after Stem cell trAnsplantation (MOSA). Annals of Hematology, 102(3), 641-649. https://doi.org/10.1007/s00277-022-05070-9
    • Gianfredi, V., Dinu, M., Nucci, D., Eussen, S. J. P. M., Amerio, A., Schram, M. T., Schaper, N., & Odone, A. (2023). Association between dietary patterns and depression: an umbrella review of meta-analyses of observational studies and intervention trials. Nutrition Reviews, 81(3), 346-359. https://doi.org/10.1093/nutrit/nuac058
    • van Gennip, A. C. E., Schram, M., Kohler, S., Kroon, A. A., Koster, A., Eussen, S. J. P. M., de Galan, B. E., van Sloten, T. T., & Stehouwer, C. D. A. (2023). Association of type 2 diabetes according to the number of risk factors within the recommended range with incidence of major depression and clinically relevant depressive symptoms: a prospective analysis. The Lancet Healthy Longevity, 4(2), e63-e71. https://doi.org/10.1016/S2666-7568(22)00291-4
    • Dekkers, K. F., Slieker, R. C., Ioan-Facsinay, A., van Iterson, M., Ikram, M. A., van Greevenbroek, M. M. J., Veldink, J. H., Franke, L., Boomsma, D. I., Slagboom, P. E., Jukema, J. W., Heijmans, B. T., & BIOS Consortium (2023). Lipid-induced transcriptomic changes in blood link to lipid metabolism and allergic response. Nature Communications, 14(1), Article 544. https://doi.org/10.1038/s41467-022-35663-x
    • Hanssen, N. M. J., Tikellis, C., Pickering, R. J., Dragoljevic, D., Lee, M. K. S., Block, T., Scheijen, J. L. J. M., Wouters, K., Miyata, T., Cooper, M. E., Murphy, A. J., Thomas, M. C., & Schalkwijk, C. G. (2023). Pyridoxamine prevents increased atherosclerosis by intermittent methylglyoxal spikes in the aortic arches of ApoE-/- mice. Biomedicine & Pharmacotherapy, 158(1), Article 114211. https://doi.org/10.1016/j.biopha.2022.114211
    • Zhou, T. L., Reulen, J. P. H., Van Der Staaij, H., Stehouwer, C. D. A., Van Greevenbroek, M., Henry, R. M. A., & Kroon, A. A. (2023). Cardiovagal baroreflex sensitivity, blood pressure and blood pressure variability - the Maastricht study. Journal of Hypertension, 41(2), 254-261. https://doi.org/10.1097/HJH.0000000000003323
    • Nguyen, B. O., Weberndorfer, V., Crijns, H. J. G. M., Geelhoed, B., Ten Cate, H., Spronk, H., Kroon, A., De With, R., Al-Jazairi, M., Maass, A. H., Blaauw, Y., Tieleman, R. G., Hemels, M. E. W., Luermans, J., de Groot, J., Allaart, C. P., Elvan, A., De Melis, M., Scheerder, C., ... Rienstra, M. (2023). Prevalence and determinants of atrial fibrillation progression in paroxysmal atrial fibrillation. Heart, 109(3), 186-194. https://doi.org/10.1136/heartjnl-2022-321027
    • Zhou, T. L., Schutten, M. T. J., Kroon, A. A., Henry, R. M. A., Houben, A. J. H. M., van der Kallen, C. J. H., van Greevenbroek, M. M. J., de Leeuw, P. W., & Stehouwer, C. D. A. (2023). Urinary Sodium Excretion and Salt Intake Are Not Associated With Blood Pressure Variability in a White General Population. Journal of the American Heart Association, 12(1), Article e026578. https://doi.org/10.1161/JAHA.122.026578
    • Schalkwijk, C. G., Micali, L. R., & Wouters, K. (2023). Advanced glycation endproducts in diabetes-related macrovascular complications: focus on methylglyoxal. Trends in Endocrinology and Metabolism, 34(1), 49-60. https://doi.org/10.1016/j.tem.2022.11.004
    • Monereo-Sánchez, J., Jansen, J. F. A., Köhler, S., van Boxtel, M. P. J., Backes, W. H., Stehouwer, C. D. A., Kroon, A. A., Kooman, J. P., Schalkwijk, C. G., Linden, D. E. J., & Schram, M. T. (2023). The association of prediabetes and type 2 diabetes with hippocampal subfields volume: The Maastricht study. NeuroImage: Clinical, 39, Article 103455. https://doi.org/10.1016/j.nicl.2023.103455
    • Ren, Z., Simons, P. I. H. G., Wesselius, A., Stehouwer, C. D. A., & Brouwers, M. C. G. J. (2023). Relationship between NAFLD and coronary artery disease: A Mendelian randomization study. Hepatology, 77(1), 230-238. https://doi.org/10.1002/hep.32534