• 2021
    • Mills, M. C., Tropf, F. C., Brazel, D. M., van Zuydam, N., Vaez, A., Agbessi, M., Ahsan, H., Alves, I., Andiappan, A. K., Arindrarto, W., Awadalla, P., Battle, A., Beutner, F., Jan Bonder, M., Boomsma, D. I., Christiansen, M. W., Claringbould, A., Deelen, P., Esko, T., ... Human Reproductive Behaviour Consortium (2021). Identification of 371 genetic variants for age at first sex and birth linked to externalising behaviour. Nature human behaviour, 5(12), 1717-1730. https://doi.org/10.1038/s41562-021-01135-3
    • Barutta, F., Corbetta, B., Bellini, S., Guarrera, S., Matullo, G., Scandella, M., Schalkwijk, C., Stehouwer, C. D., Chaturvedi, N., Soedamah-Muthu, S. S., Durazzo, M., & Gruden, G. (2021). MicroRNA 146a is associated with diabetic complications in type 1 diabetic patients from the EURODIAB PCS. Journal of Translational Medicine, 19(1), Article 475. https://doi.org/10.1186/s12967-021-03142-4
    • Gijs, M., Ramakers, I. H. G. B., Visser, P. J., Verhey, F. R. J., van de Waarenburg, M. P. H., Schalkwijk, C. G., Nuijts, R. M. M. A., & Webers, C. A. B. (2021). Association of tear fluid amyloid and tau levels with disease severity and neurodegeneration. Scientific Reports, 11(1), Article 22675. https://doi.org/10.1038/s41598-021-01993-x
    • van der Heide, F. C. T., Steens, I. L. M., Geraets, A. F. J., Foreman, Y. D., Henry, R. M. A., Kroon, A. A., van der Kallen, C. J. H., van Sloten, T. T., Dagnelie, P. C., van Dongen, M. C. J. M., Eussen, S. J. P. M., Berendschot, T. T. J. M., Schouten, J. S. A. G., Webers, C. A. B., van Greevenbroek, M. M. J., Wesselius, A., Koster, A., Schaper, N. C., Schram, M. T., ... Stehouwer, C. D. A. (2021). Association of Retinal Nerve Fiber Layer Thickness, an Index of Neurodegeneration, With Depressive Symptoms Over Time. Jama network open, 4(11), e2134753. Article 2134753. https://doi.org/10.1001/jamanetworkopen.2021.34753
    • Tinnevelt, G. H., Wouters, K., Postma, G. J., Folcarelli, R., & Jansen, J. J. (2021). High-throughput single cell data analysis - A tutorial. Analytica Chimica Acta, 1185, Article 338872. https://doi.org/10.1016/j.aca.2021.338872
    • Bogie, J. F. J., Vanmierlo, T., Vanmol, J., Timmermans, S., Mailleux, J., Nelissen, K., Wijnands, E., Wouters, K., Stinissen, P., Gustafsson, J. A., Steffensen, K. R., Mulder, M., Zelcer, N., & Hendriks, J. J. A. (2021). Liver X receptor beta deficiency attenuates autoimmune-associated neuroinflammation in a T cell-dependent manner. Journal of Autoimmunity, 124, Article 102723. https://doi.org/10.1016/j.jaut.2021.102723
    • Korn, A., Baylan, U., Simsek, S., Schalkwijk, C. G., Niessen, H. W. M., & Krijnen, P. A. J. (2021). Myocardial infarction coincides with increased NOX2 and Nε-(carboxymethyl) lysine expression in the cerebral microvasculature. Open Heart, 8(2), Article e001842. https://doi.org/10.1136/openhrt-2021-001842
    • Strikwerda, M., Beulens, J. W., Remmelzwaal, S., Schoonmade, L. J., van Straten, A., Schram, M. T., Elders, P. J., & Rutters, F. (2021). The Association of Burnout and Vital Exhaustion With Type 2 Diabetes: A Systematic Review and Meta-Analysis. Psychosomatic Medicine, 83(9), 1013-1030. https://doi.org/10.1097/PSY.0000000000000995
    • van Gennip, A. C. E., Stehouwer, C. D. A., van Boxtel, M. P. J., Verhey, F. R. J., Koster, A., Kroon, A. A., Köhler, S., van Greevenbroek, M. M. J., Wesselius, A., Eussen, S. J. P. M., Backes, W. H., Jansen, J. F., Schram, M. T., Henry, R. M. A., Singh-Manoux, A., & van Sloten, T. T. (2021). Association of Type 2 Diabetes, According to the Number of Risk Factors Within Target Range, With Structural Brain Abnormalities, Cognitive Performance, and Risk of Dementia. Diabetes Care, 44(11), 2493-2502. https://doi.org/10.2337/dc21-0149
    • Bakker, L., Ramakers, I. H. G. B., van Boxtel, M. P. J., Schram, M. T., Stehouwer, C. D. A., van der Kallen, C. J. H., Dagnelie, P. C., van Greevenbroek, M. M. J., Wesselius, A., Midttun, Ø., Ueland, P. M., Verhey, F. R. J., Eussen, S. J. P. M., & Köhler, S. (2021). Associations between plasma kynurenines and cognitive function in individuals with normal glucose metabolism, prediabetes and type 2 diabetes: the Maastricht Study. Diabetologia, 64(11), 2445-2457. https://doi.org/10.1007/s00125-021-05521-4
    • Wu, W., Bours, M., Koole, A., Kenkhuis, M. F., Eussen, S., Breukink, S., van Schooten, F., Weijenberg, M., & Hageman, G. (2021). Cross-Sectional Associations between Dietary Daily Nicotinamide Intake and Patient-Reported Outcomes in Colorectal Cancer Survivors, 2 to 10 Years Post-Diagnosis. Nutrients, 13(11), Article 3707. https://doi.org/10.3390/nu13113707
    • van der Bruggen, M. M., Spronck, B., Delhaas, T., Reesink, K. D., & Schalkwijk, C. G. (2021). The Putative Role of Methylglyoxal in Arterial Stiffening: A Review. Heart Lung and Circulation, 30(11), 1681-1693. https://doi.org/10.1016/j.hlc.2021.06.527
    • van Dalem, J., Driessen, J. H. M., Burden, A. M., Stehouwer, C. D. A., Klungel, O. H., de Vries, F., & Brouwers, M. C. G. J. (2021). Thiazolidinediones and Glucagon-Like Peptide-1 Receptor Agonists and the Risk of Nonalcoholic Fatty Liver Disease: A Cohort Study. Hepatology, 74(5), 2467-2477. https://doi.org/10.1002/hep.32012
    • Kremers, S. H. M., Remmelzwaal, S., Schalkwijk, C. G., Elders, P. J. M., Stehouwer, C. D. A., van Ballegooijen, A. J., & Beulens, J. W. J. (2021). The role of serum and dietary advanced glycation endproducts in relation to cardiac function and structure: The Hoorn Study. Nutrition Metabolism and Cardiovascular Diseases, 31(11), 3167-3175. https://doi.org/10.1016/j.numecd.2021.07.020
    • Pinxt, C. M. H., Bogie, R. M. M., Hanssen, N. M. J., & Spaetgens, B. (2021). Antibiotic overuse in older patients: an important clinical reminder of pseudomembranous colitis. QJM: An International Journal of Medicine, 114(10), 755-756. https://doi.org/10.1093/qjmed/hcab198
    • Gianfredi, V., Beran, M., Koster, A., Eussen, S. J. P. M., Odone, A., Signorelli, C., Schaper, N. C., Köhler, S., Bosma, H., Dagnelie, P. C., Stehouwer, C. D. A., Wesselius, A., Amerio, A., Brinkhues, S., Dukers-Muijrers, N., & Schram, M. T. (2021). Association between social network characteristics and prevalent and incident depression: The Maastricht Study. Journal of Affective Disorders, 293, 338-346. https://doi.org/10.1016/j.jad.2021.06.046
    • Gijs, M., Veugen, J. M. J., Wolffs, P. F. G., Savelkoul, P. H. M., Tas, J., van Bussel, B. C. T., de Kruif, M. D., Henry, R. M. A., Webers, C. A. B., Dickman, M. M., & Nuijts, R. M. M. A. (2021). In-Depth Investigation of Conjunctival Swabs and Tear Fluid of Symptomatic COVID-19 Patients, an Observational Cohort Study. Translational Vision Science & Technology, 10(12), Article 32. https://doi.org/10.1167/tvst.10.12.32
    • Janssen, E. P. C. J., Köhler, S., Geraets, A. F. J., Stehouwer, C. D. A., Schaper, N. C., Sep, S. J. S., Henry, R. M. A., van der Kallen, C. J. H., Schalkwijk, C. G., Koster, A., Verhey, F. R., & Schram, M. T. (2021). Low-grade inflammation and endothelial dysfunction predict four-year risk and course of depressive symptoms: The Maastricht study. Brain Behavior and Immunity, 97, 61-67. https://doi.org/10.1016/j.bbi.2021.06.013
    • Molto-Puigmarti, C., Obeid, R., Mommers, M., Eussen, S. J. P. M., & Thijs, C. (2021). Maternal plasma choline and betaine in late pregnancy and child growth up to age 8 years in the KOALA Birth Cohort Study. American Journal of Clinical Nutrition, 114(4), 1438-1446. https://doi.org/10.1093/ajcn/nqab177
    • Heger, I. S., Deckers, K., Schram, M. T., Stehouwer, C. DA., Dagnelie, P. C., van der Kallen, C. J., Koster, A., Eussen, S. J., Jansen, J. F., Verhey, F. R., van Boxtel, M. P., & Köhler, S. (2021). Associations of the Lifestyle for Brain Health Index With Structural Brain Changes and Cognition: Results From the Maastricht Study. Neurology, 97(13), E1300-E1312. https://doi.org/10.1212/WNL.0000000000012572
    • Aglago, E. K., Mayen, A. L., Knaze, V., Freisling, H., Fedirko, V., Hughes, D. J., Jiao, L., Eriksen, A. K., Tjonneland, A., Boutron-Ruault, M. C., Rothwell, J. A., Severi, G., Kaaks, R., Katzke, V., Schulze, M. B., Birukov, A., Palli, D., Sieri, S., de Magistris, M. S., ... Jenab, M. (2021). Dietary Advanced Glycation End-Products and Colorectal Cancer Risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) Study. Nutrients, 13(9), Article 3132. https://doi.org/10.3390/nu13093132
    • Geraets, A. F. J., Köhler, S., Jansen, J. F. A., Eussen, S. J. P. M., Stehouwer, C. D. A., Schaper, N. C., Wesselius, A., Verhey, F. R. J., & Schram, M. T. (2021). The association of markers of cerebral small vessel disease and brain atrophy with incidence and course of depressive symptoms-the maastricht study. Journal of Affective Disorders, 292, 439-447. https://doi.org/10.1016/j.jad.2021.05.096
    • van Dongen, K. C. W., Linkens, A. M. A., Wetzels, S. M. W., Wouters, K., Vanmierlo, T., van de Waarenburg, M. P. H., Scheijen, J. L. J. M., de Vos, W. M., Belzer, C., & Schalkwijk, C. G. (2021). Dietary advanced glycation endproducts (AGEs) increase their concentration in plasma and tissues, result in inflammation and modulate gut microbial composition in mice; evidence for reversibility. Food Research International, 147, Article 110547. https://doi.org/10.1016/j.foodres.2021.110547
    • Schmieder, R. E., Mahfoud, F., Mancia, G., Azizi, M., Boehm, M., Dimitriadis, K., Kario, K., Kroon, A. A., Lobo, M. D., Ott, C., Pathak, A., Persu, A., Scalise, F., Schlaich, M., Kreutz, R., Tsioufis, C., & ESH Working Group on Device-Based Treatment of Hypertension (2021). European Society of Hypertension position paper on renal denervation 2021. Journal of Hypertension, 39(9), 1733-1741. https://doi.org/10.1097/HJH.0000000000002933
    • Piazza, M., Hanssen, N. M. J., Persson, F., Scheijen, J. L., van de Waarenburg, M. P. H., van Greevenbroek, M. M. J., Rossing, P., Hovind, P., Stehouwer, C. D. A., Parving, H.-H., & Schalkwijk, C. G. (2021). Irbesartan treatment does not influence plasma levels of the dicarbonyls methylglyoxal, glyoxal and 3-deoxyglucosone in participants with type 2 diabetes and microalbuminuria: An IRMA2 sub-study. Diabetic Medicine, 38(9), Article 14405. https://doi.org/10.1111/dme.14405
    • Schram, M. T., Assendelft, W. J. J., van Tilburg, T. G., & Dukers-Muijrers, N. H. T. M. (2021). Social networks and type 2 diabetes: a narrative review. Diabetologia, 64(9), 1905-1916. https://doi.org/10.1007/s00125-021-05496-2
    • De Clerck, E. E. B., Schouten, J. S. A. G., Berendschot, T. T. J. M., Goezinne, F., Liesenborghs, I., Dagnelie, P. C., Schaper, N. C., Kroon, A. A., Henry, R. M. A., Reesink, K. D., Schram, M. T., Stehouwer, C. D. A., & Webers, C. A. B. (2021). Vascular risk factors for optical coherence tomography-detected macular cysts: The Maastricht Study. Acta Ophthalmologica, 99(6), e860-e868. https://doi.org/10.1111/aos.14677
    • Wouters, K., Cento, A. S., Gaens, K. H., Teunissen, M., Scheijen, J. L. J. M., Barutta, F., Chiazza, F., Collotta, D., Aragno, M., Gruden, G., Collino, M., Schalkwijk, C. G., & Mastrocola, R. (2021). Deletion of RAGE fails to prevent hepatosteatosis in obese mice due to impairment of other AGEs receptors and detoxifying systems. Scientific Reports, 11(1), Article 17373. https://doi.org/10.1038/s41598-021-96859-7
    • Mayen, A.-L., Aglago, E. K., Knaze, V., Cordova, R., Schalkwijk, C. G., Wagner, K.-H., Aleksandrova, K., Fedirko, V., Keski-Rahkonen, P., Leitzmann, M. F., Katzke, V., Srour, B., Schulze, M. B., Masala, G., Krogh, V., Panico, S., Tumino, R., Bueno-de-Mesquita, B., Brustad, M., ... Freisling, H. (2021). Dietary intake of advanced glycation endproducts and risk of hepatobiliary cancers: A multinational cohort study. International Journal of Cancer, 149(4), 854-864. https://doi.org/10.1002/ijc.33612
    • Empana, J. P., Boutouyrie, P., Lemogne, C., Jouven, X., & van Sloten, T. T. (2021). Microvascular Contribution to Late-Onset Depression: Mechanisms, Current Evidence, Association With Other Brain Diseases, and Therapeutic Perspectives. Biological Psychiatry, 90(4), 214-225. https://doi.org/10.1016/j.biopsych.2021.04.012
    • Monereo-Sanchez, J., de Jong, J. J. A., Drenthen, G. S., Beran, M., Backes, W. H., Stehouwer, C. D. A., Schram, M. T., Linden, D. E. J., & Jansen, J. F. A. (2021). Quality control strategies for brain MRI segmentation and parcellation: Practical approaches and recommendations- insights from the Maastricht study. Neuroimage, 237, Article 118174. https://doi.org/10.1016/j.neuroimage.2021.118174
    • Lisan, Q., van Sloten, T., Boutouyrie, P., Laurent, S., Danchin, N., Thomas, F., Guibout, C., Perier, M.-C., Dagnelie, P., Henry, R. M., Schram, M. T., Heinzer, R., Marques-Vidal, P., van der Kallen, C. J., Crijns, H. J., van Greevenbroek, M., Reesink, K., Köhler, S., Sastry, M., ... Empana, J.-P. (2021). Sleep Apnea is Associated With Accelerated Vascular Aging: Results From 2 European Community-Based Cohort Studies. Journal of the American Heart Association, 10(15), Article 021318. https://doi.org/10.1161/JAHA.120.021318
    • Aragones, G., Rowan, S., Francisco, S. G., Whitcomb, E. A., Yang, W. X., Perini-Villanueva, G., Schalkwijk, C. G., Taylor, A., & Bejarano, E. (2021). The Glyoxalase System in Age-Related Diseases: Nutritional Intervention as Anti-Ageing Strategy. Cells, 10(8), Article 1852. https://doi.org/10.3390/cells10081852
    • van der Heide, F. C. T., Zhou, T. L., Henry, R. M. A., Houben, A. J. H. M., Kroon, A. A., Dagnelie, P. C., van Dongen, M. C. J. M., Eussen, S. J. P. M., Berendschot, T. T. J. M., Schouten, J. S. A. G., Webers, C. A. B., Schram, M. T., van Greevenbroek, M. M. J., Wesselius, A., Schalkwijk, C. G., Koster, A., Savelberg, H. H. C. M., Schaper, N. C., Reesink, K. D., & Stehouwer, C. D. A. (2021). Carotid stiffness is associated with retinal microvascular dysfunction- The Maastricht Study. Microcirculation, 28(6), Article e12702. https://doi.org/10.1111/micc.12702
    • Foreman, Y. D., van Doorn, W. P. T. M., Schaper, N. C., van Greevenbroek, M. M. J., van der Kallen, C. J. H., Henry, R. M. A., Koster, A., Eussen, S. J. P. M., Wesselius, A., Reesink, K. D., Schram, M. T., Dagnelie, P. C., Kroon, A. A., Brouwers, M. C. G. J., & Stehouwer, C. D. A. (2021). Greater daily glucose variability and lower time in range assessed with continuous glucose monitoring are associated with greater aortic stiffness: The Maastricht Study. Diabetologia, 64(8), 1880-1892. https://doi.org/10.1007/s00125-021-05474-8
    • Vangrieken, P., Al-Nasiry, S., Bast, A., Leermakers, P. A., Tulen, C. B. M., Schiffers, P. M. H., van Schooten, F. J., & Remels, A. H. V. (2021). Placental Mitochondrial Abnormalities in Preeclampsia. Reproductive Sciences, 28(8), 2186-2199. https://doi.org/10.1007/s43032-021-00464-y
    • Simons, P. I. H. G., Valkenburg, O., Stehouwer, C. D. A., & Brouwers, M. C. G. J. (2021). Sex hormone-binding globulin: biomarker and hepatokine?Trends in Endocrinology and Metabolism, 32(8), 544-553. https://doi.org/10.1016/j.tem.2021.05.002
    • Brouwers, M. C. G. J. (2021). When to Consider an Inborn Error of Metabolism in Adults?Journal of Endocrinology and Metabolism, 11(3-4), 65-68. https://doi.org/10.14740/jem750
    • Veugen, M. G. J., Linssen, P. B. C., Henry, R. M. A., Koster, A., Kroon, A. A., Stehouwer, C. D. A., & Brunner-La Rocca, H.-P. (2021). Measures of Left Ventricular Diastolic Function and Cardiorespiratory Fitness According to Glucose Metabolism Status: The Maastricht Study. Journal of the American Heart Association, 10(13), Article 020387. https://doi.org/10.1161/jaha.120.020387
    • Monereo-Sanchez, J., Schram, M. T., Frei, O., O'Connell, K., Shadrin, A. A., Smeland, O. B., Westlye, L. T., Andreassen, O. A., Kaufmann, T., Linden, D. E. J., & van der Meer, D. (2021). Genetic Overlap Between Alzheimer's Disease and Depression Mapped Onto the Brain. Frontiers in Neuroscience, 15, Article 653130. https://doi.org/10.3389/fnins.2021.653130
    • Linkens, A. M. A., Eussen, S. J. M. P., Houben, A. J. H. M., Kroon, A. A., Schram, M. T., Reesink, K. D., Dagnelie, P. C., Henry, R. M. A., van Greevenbroek, M., Wesselius, A., Stehouwer, C. D. A., & Schalkwijk, C. G. (2021). Habitual Intake of Dietary Advanced Glycation End Products Is Not Associated with Arterial Stiffness of the Aorta and Carotid Artery in Adults: The Maastricht Study. Journal of Nutrition, 151(7), 1886-1893. https://doi.org/10.1093/jn/nxab097
    • Simons, P. I. H. G., Valkenburg, O., Telgenkamp, I., van der Waaij, K. M., de Groot, D. M., Veeraiah, P., Bons, J. A. P., Taskinen, M. R., Boren, J., Schrauwen, P., Rutten, J. H. W., Cassiman, D., Schalkwijk, C. G., Stehouwer, C. D. A., Schrauwen-Hinderling, V. B., Hodson, L., & Brouwers, M. C. G. J. (2021). Relationship between de novo lipogenesis and serum sex hormone binding globulin in humans. Clinical Endocrinology, 95(1), 101-106. https://doi.org/10.1111/cen.14459
    • Driessen, R. G. H., Kiers, D., Schalkwijk, C. G., Scheijen, J. L. J. M., Gerretsen, J., Pickkers, P., van de Poll, M. C. G., van der Horst, I. C. C., Bergmans, D. C. J. J., Kox, M., & van Bussel, B. C. T. (2021). Systemic inflammation down-regulates glyoxalase-1 expression: an experimental study in healthy males. Bioscience Reports, 41(7), Article BSR20210954. https://doi.org/10.1042/BSR20210954
    • Van den Eynde, M. D. G., Scheijen, J. L. J. M., Stehouwer, C. D. A., Miyata, T., & Schalkwijk, C. G. (2021). Quantification of the B6 vitamers in human plasma and urine in a study with pyridoxamine as an oral supplement; pyridoxamine as an alternative for pyridoxine. Clinical Nutrition, 40(7), 4624-4632. https://doi.org/10.1016/j.clnu.2021.05.028
    • Borg, D. J., Faridi, P., Giam, K. L., Reeves, P., Fotheringham, A. K., McCarthy, D. A., Leung, S., Ward, M. S., Harcourt, B. E., Ayala, R., Scheijen, J. L., Briskey, D., Dudek, N. L., Schalkwijk, C. G., Steptoe, R., Purcell, A. W., & Forbes, J. M. (2021). Short Duration Alagebrium Chloride Therapy Prediabetes Does Not Inhibit Progression to Autoimmune Diabetes in an Experimental Model. Metabolites, 11(7), Article 426. https://doi.org/10.3390/metabo11070426
    • Simons, P. I. H. G., Valkenburg, O., Bons, J. A. P., Stehouwer, C. D. A., & Brouwers, M. C. G. J. (2021). The relationships of sex hormone-binding globulin, total testosterone, androstenedione and free testosterone with metabolic and reproductive features of polycystic ovary syndrome. Endocrinology, Diabetes & Metabolism, 4(3), Article 00267. https://doi.org/10.1002/edm2.267
    • Azizi, M., Sanghvi, K., Saxena, M., Gosse, P., Reilly, J. P., Levy, T., Rump, L. C., Persu, A., Basile, J., Bloch, M. J., Daemen, J., Lobo, M. D., Mahfoud, F., Schmieder, R. E., Sharp, A. S. P., Weber, M. A., Sapoval, M., Fong, P., Pathak, A., ... de Haan, C. (2021). Ultrasound renal denervation for hypertension resistant to a triple medication pill (RADIANCE-HTN TRIO): a randomised, multicentre, single-blind, sham-controlled trial. Lancet, 397(10293), 2476-2486. https://doi.org/10.1016/s0140-6736(21)00788-1
    • van Doorn, W. P. T. M., Foreman, Y. D., Schaper, N. C., Savelberg, H. H. C. M., Koster, A., van der Kallen, C. J. H., Wesselius, A., Schram, M. T., Henry, R. M. A., Dagnelie, P. C., de Galan, B. E., Bekers, O., Stehouwer, C. D. A., Meex, S. J. R., & Brouwers, M. C. G. J. (2021). Machine learning-based glucose prediction with use of continuous glucose and physical activity monitoring data: The Maastricht Study. PLOS ONE, 16(6), Article 0253125. https://doi.org/10.1371/journal.pone.0253125
    • Timmons, J. G., Greenlaw, N., Boyle, J. G., Chaturvedi, N., Ford, I., Brouwers, M. C. G. J., Tillin, T., Hramiak, I., Hughes, A. D., Jenkins, A. J., Klein, B. E. K., Klein, R., Ooi, T. C., Rossing, P., Stehouwer, C. D. A., Sattar, N., Colhoun, H. M., Petrie, J. R., & REMOVAL Study Grp (2021). Metformin and carotid intima-media thickness in never-smokers with type 1 diabetes: The REMOVAL trial. Diabetes Obesity & Metabolism, 23(6), 1371-1378. https://doi.org/10.1111/dom.14350
    • Mastrocola, R., Dal Bello, F., Cento, A. S., Gaens, K., Collotta, D., Aragno, M., Medana, C., Collino, M., Wouters, K., & Schalkwijk, C. G. (2021). Altered hepatic sphingolipid metabolism in insulin resistant mice: Role of advanced glycation endproducts. Free Radical Biology and Medicine, 169, 425-435. https://doi.org/10.1016/j.freeradbiomed.2021.04.028