PI group Erik Biessen
- 2026
- Hall, I. F., Aikawa, E., Sluimer, J., Baker, A. H., & Kovacic, J. C. (2026). Endothelial to mesenchymal transition in cardiovascular diseases: molecular insights and clinical perspectives. European Heart Journal, 47(10), 1144-1158. Article ehaf670. https://doi.org/10.1093/eurheartj/ehaf670
- Huchzermeier, R., de Jong, R. J., Rakateli, L., Bonnin-Marquez, A., Maas, S. L., Maassen-Pottgens, C., Abschlag, K., Jin, H., Geiselhoringer, A.-L., Triantafyllidou, V., Santovito, D., Jankowski, J., Biessen, E. A. L., Ohnmacht, C., & van der Vorst, E. P. C. (2026). Whole-Body Knockout of the AhR (Aryl Hydrocarbon Receptor) Ameliorates Atherosclerosis Due to Altered Lipid Metabolism-Brief Report. Arteriosclerosis Thrombosis and Vascular Biology, 46(3), Article e323673. https://doi.org/10.1161/ATVBAHA.125.323673
- Al-Bualy, R., Heeneman, S., Skipper, M., & Govaerts, M. (2026). The transformative power of a change laboratory: Experiences from an assessment re-design project in Oman. Medical Education, 60(3), 307-316. https://doi.org/10.1111/medu.70012
- Al-Sulaiman, A., Heeneman, S., Iqbal, M. Z., & van der Vleuten, C. (2026). Factors influencing novice supervisors' trust decisions in postgraduate family medicine training: a qualitative study. Frontiers in medicine, 13, Article 1712735. https://doi.org/10.3389/fmed.2026.1712735
- Baker, A. H., Riley, P. R., & Giacca, M. (2026). The Medical Research Council/British Heart Foundation Centre of Research Excellence in Advanced Cardiac Therapies (REACT). European Heart Journal, 47(4), 399-400. Article ehaf776. https://doi.org/10.1093/eurheartj/ehaf776
- Baker, A. H., & de Vries, M. R. (2026). Insights into arteriovenous fistula (non)maturation: single-cell transcriptomics reveals new drivers of arteriovenous fistula remodeling. Kidney International, 109(1), 37-40. https://doi.org/10.1016/j.kint.2025.09.034
- 2025
- Tsarouchas, T. M., Vacante, F., Kazakou, N.-L., Wagstaff, L., Bennett, M., Zoupi, L., Gibson, E. M., Baker, A. H., & Williams, A. (2025). The LncRNA MYRACL Regulates Human Oligodendrocyte Maturation and Myelination. Molecular Therapy, 33(12), 6025-6032. https://doi.org/10.1016/j.ymthe.2025.08.011
- Peters, L. J. F., Bidzhekov, K., Bonnin-Marquez, A., Sundararaman, S. S., Huchzermeier, R., Maas, S. L., Abschlag, K., Jans, A., Lin, C., Haberbosch, M., Jansen, Y., Yu, B., Sluimer, J. C., Gijbels, M. J., Jankowski, J., Bartneck, M., Biessen, E. A. L., Weber, C., Doring, Y., & Van Der Vorst, E. P. C. (2025). MicroRNA-26b<SUP>-/-</SUP> augments atherosclerosis, while mimic-loaded nanoparticles reduce atherogenesis. Cardiovascular Research, 121(17), 2700-2713. https://doi.org/10.1093/cvr/cvaf234
- Jin, H., Maas, S. L., Zou, Y., Lu, C., Yu, B., Huchzermeier, R., Nadeau, S., Dos Santos, J., Gijbels, M., Mees, B. M. E., Smirnov, E., Matic, L., Hedin, U., Maffia, P., Monaco, C., Sluimer, J. C., Martins, G. A., van der Vorst, E. P. C., & Biessen, E. A. L. (2025). Identification of a PRDM1-regulated T cell network to regulate atherosclerotic plaque inflammation. Genome Medicine, 17(1), Article 109. https://doi.org/10.1186/s13073-025-01541-6
- Bonnin-Marquez, A., Maas, S. L., Corcini-Berndt, M., & van der Vorst, E. P. C. (2025). Unbiased kinome profiling identifies key and novel mediators of chronic kidney disease in hyperlipidemic mice. Frontiers in physiology, 16, Article 1684982. https://doi.org/10.3389/fphys.2025.1684982
- Musolino, P. L., Rosser, S. J., Brittan, M., Newby, D. E., Berry, C., Riley, P. R., Giacca, M., Hajjar, R. J., & Baker, A. H. (2025). Gene therapy in cardiac and vascular diseases: a review of approaches to treat genetic and common cardiovascular diseases with novel gene-based therapeutics. Cardiovascular Research, 121(12), 1843-1855. https://doi.org/10.1093/cvr/cvaf109
- Goertzen, L., Heeneman, S., & Schils, T. (2025). The impact of formative assessment on pupil academic achievement: An empirical study of the effects of a formative assessment practices program that was co-designed in a teacher community. Learning and Instruction, 99, Article 102153. https://doi.org/10.1016/j.learninstruc.2025.102153
- Bennett, M., Ulitsky, I., & Baker, A. H. (2025). Missing 'lncs': how insufficient scrutiny can lead to misrepresentation of long non-coding RNAs (lncRNAs) and their function in cardiovascular disease. European Heart Journal, 46(35), 3434-3436. https://doi.org/10.1093/eurheartj/ehaf115
- Brown, S. D., Malinowska, A. L., Bennett, M., Correa-Sánchez, A. F., Horcasitas Valencia, L. L., Lucignoli, A. P., Barton, A. K., Clark, L., Sluimer, J. C., Webster, S. P., Rodor, J., Newby, D. E., Cunningham, M., & Baker, A. H. (2025). Small Interfering RNA Therapy Targeting the Long Noncoding RNA SMILR for Therapeutic Intervention in Coronary Artery Bypass Graft Failure. JACC: Basic to Translational Science, Article 101364. https://doi.org/10.1016/j.jacbts.2025.101364
- Benhmammouch, S., Borowczyk, C., Pierrot-Blanchet, C., Barouillet, T., Murcy, F., Dussaud, S., Blanc, M., Bleriot, C., Ord, T., Habbouche, L., Vaillant, N., Gerber, Y., Cochain, C., Gautier, E. L., Ginhoux, F., Thorp, E. B., Biessen, E. A. L., Sluimer, J. C., Bodoy, S., ... Yvan-Charvet, L. (2025). Slc7a7 licenses macrophage glutaminolysis for restorative functions in atherosclerosis. Nature Metabolism, 7(9), 1924-1938. https://doi.org/10.1038/s42255-025-01354-2
- Monteiro, J. P., Vacante, F., De Pace, A. L., Bennett, M., Rodor, J., O'Carroll, D., Wu, J. C., Quertermous, T., & Baker, A. H. (2025). Targeting Cis-regulatory elements for CRISPR-mediated transcriptional activation of the human MIR503HG locus. Vascular Pharmacology, 160, Article 107521. https://doi.org/10.1016/j.vph.2025.107521
- Luna Buitrago, D., Jover, E., Mameli, E., Mellis, D., Nosalski, R., Charlton, L., Bauza Sanso, R., Dunn-Davies, H., MacAskill, M. G., Tavares, A. A. S., Fletcher, A. J., Nash, J., Lopez-Andres, N., Dweck, M. R., Hadoke, P. W. F., Gilchrist, D. S., Wagner, B. D., Robinson, M. L., Baker, A. H., ... Caporali, A. (2025). The loss of microRNA-26b promotes aortic calcification through the regulation of cell-specific target genes. Cardiovascular Research, 121(11), 1778-1792. Article cvaf117. https://doi.org/10.1093/cvr/cvaf117
- Mcdonald, J., Heeneman, S., & Hu, W. (2025). Discoveries or doubts: a qualitative study of the transformative potential of portfolio meetings. Advances in Health Sciences Education, 30(4), 1045-1064. https://doi.org/10.1007/s10459-024-10387-3
- Vacante, F., Sanchez-Esteban, S., Tsarouchas, T., Rodor, J., Bennett, M., Carroll, M. S., Beqqali, A., & Baker, A. H. (2025). Effective Transcriptional Induction of the CARMN/miR-143/145 Complex Locus in Smooth Muscle Cells Using CRISPR Activation. Arteriosclerosis Thrombosis and Vascular Biology. Advance online publication. https://doi.org/10.1161/ATVBAHA.124.322353
- Ganizada, B. H., Reesink, K. D., Parikh, S., Saraber, P. J. M. H., Cleutjens, J. P., Isabella, A., Krebbekx, M. Q. E., Jaminon, A. M., Maassen, C. F. M., Ramaekers, M. J. F. G., Spronck, B., van der Laan, K., Koenen, R. R., Lorusso, R., Maessen, J. G., Bidar, E., & Schurgers, L. J. (2025). Loss of wall stress homeostasis in ascending thoracic aortic aneurysm: histomorphometric insights into patient variants. The Journal of Physiology, 603(14), 3899-3922. https://doi.org/10.1113/JP288734
- Asselberghs, S. E. J., Halder, M., Kramann, R., & Sluimer, J. C. (2025). Fibroblasts—The emerging therapeutic target of the cardiovascular system?Pharmacological Reviews, 77(4), Article 100072. https://doi.org/10.1016/j.pharmr.2025.100072
- Saar-Kovrov, V., Pawlowska, A., Guillot, A., Gijbels, M. J. J., Sluimer, J. C., Temmerman, L., Goossens, P., Mees, B. M. E., Tacke, F., Jankowski, V., Jankowski, J., Donners, M. M. P. C., & Biessen, E. A. L. (2025). Correction: Protein carbamylation in atherosclerotic plaques correlates with uremia and disease progression, localizing predominantly to foam cells. Frontiers in Immunology, 16, Article 1637511. https://doi.org/10.3389/fimmu.2025.1637511
- Xu, H., & Sluimer, J. (2025). IL-1β inhibition in stabilizing atherosclerotic plaques: The critical role of fibroblast-like cells. Vascular Pharmacology, 159, Article 107493. https://doi.org/10.1016/j.vph.2025.107493
- Monteiro, J. P., Saha, D., Spiroski, A.-M., Mahesh, S., Kaltzis, P., Nadavallil, A., Janbandhu, V., Murray, N. J., Severi, F., De Pace, A. L., Sanchez-Esteban, S., Rodor, J., Beqqali, A., Bennett, M., Stewart, K., Thomson, A., Hadoke, P. W. F., Markose, D., Wilson-Kanamori, J. R., ... Baker, A. H. (2025). Loss of conserved long non-coding RNA MIR503HG leads to altered NOTCH pathway signalling and left ventricular non-compaction cardiomyopathy. Cardiovascular Research, 121(7), 988-991. Article cvaf043. https://doi.org/10.1093/cvr/cvaf043
- Sopic, M., Mitic, T., Sluimer, J., Magni, P., Devaux, Y., & AtheroNET COST Action CA 21153 (2025). Editorial: Multiomic approaches in atherosclerosis. Vascular Pharmacology, 159, Article 107501. https://doi.org/10.1016/j.vph.2025.107501
- Yu, B., Sopic, M., & Sluimer, J. C. (2025). Single-cell RNA sequencing (scRNA-seq) and its insights into cellular heterogeneity in atherosclerosis. Vascular Pharmacology, 159, Article 107499. https://doi.org/10.1016/j.vph.2025.107499
- Saar-Kovrov, V., Pawlowska, A., Guillot, A., Gijbels, M. J. J., Sluimer, J. C., Temmerman, L., Goossens, P., Mees, B. M. E., Tacke, F., Jankowski, V., Jankowski, J., Donners, M. M. P. C., & Biessen, E. A. L. (2025). Protein carbamylation in atherosclerotic plaques correlates with uremia and disease progression, localizing predominantly to foam cells. Frontiers in Immunology, 16, Article 1532250. https://doi.org/10.3389/fimmu.2025.1532250
- Noels, H., van der Vorst, E. P. C., Rubin, S., Emmett, A., Marx, N., Tomaszewski, M., & Jankowski, J. (2025). Renal-Cardiac Crosstalk in the Pathogenesis and Progression of Heart Failure. Circulation Research, 136(11), 1306-1334. https://doi.org/10.1161/CIRCRESAHA.124.325488
- Fließer, E., Jandl, K., Chen, S.-H., Wang, M.-T., Schupp, J. C., Kuebler, W. M., Baker, A. H., & Kwapiszewska, G. (2025). Transcriptional signatures of endothelial cells shape immune responses in cardiopulmonary health and disease. JCI INSIGHT, 10(10), Article e191059. https://doi.org/10.1172/jci.insight.191059
- Brown, S. D., Rodor, J., & Baker, A. H. (2025). Targeted approach for next-generation coronary stents. European Heart Journal, 46(17), 1659-1661. https://doi.org/10.1093/eurheartj/ehaf007
- Chteinberg, E., Kolarova, J., Vogt, J., Macamo, A., Bormann, F., Kretzmer, H., Speel, E. J., van den Oord, J., Schneider, C., Stilgenbauer, S., Becker, J. C., Winnepenninckx, V., Biessen, E., Zenke, M., Kurz, A. K., Siebert, R., & zur Hausen, A. (2025). The significance of PAX5 in Merkel cell carcinoma. Journal of Pathology, 266(1), 81-94. https://doi.org/10.1002/path.6410
- Peters, L., Rakateli, L., Huchzermeier, R., Bonnin-Marquez, A., Maas, S. L., Lin, C., Jans, A., Geng, Y., Gorter, A., Gijbels, M., Rensen, S., Olinga, P., Hendrikx, T., Krawczyk, M., Brisbois, M., Jankowski, J., Bidzhekov, K., Weber, C., Biessen, E. A. L., ... van der Vorst, E. (2025). MicroRNA-26b protects against MASH development in mice and can be efficiently targeted with lipid nanoparticles. Elife, 13. https://doi.org/10.7554/eLife.97165
- Krilis, G., Beqqali, A., & Baker, A. H. (2025). ERC-funded Advanced Grant: creating molecular polypills. European Heart Journal, 46(14), 1288-1290. https://doi.org/10.1093/eurheartj/ehae866
- van der Vorst, E. P. C., & Lembo, G. (2025). Harnessing the power of the brain to fight metabolic diseases. Cardiovascular Research, 121(5), 685-687. https://doi.org/10.1093/cvr/cvaf061
- Vermeulen, I., Li, M., van Mourik, H., Yadati, T., Eijkel, G., Balluff, B., Godschalk, R., Temmerman, L., Biessen, E. A. L., Kulkarni, A., Theys, J., Houben, T., Cillero-Pastor, B., & Shiri-Sverdlov, R. (2025). Inhibition of intracellular versus extracellular cathepsin D differentially alters the liver lipidome of mice with metabolic dysfunction-associated steatohepatitis. FEBS Journal, 292(7), 1781-1797. https://doi.org/10.1111/febs.17358
- Ben-Aicha, S., & van der Vorst, E. P. C. (2025). Shaping the future of cardiovascular research: a focus on cardioimmunology. European Heart Journal, 46(9), 778-780. Article ehae783. https://doi.org/10.1093/eurheartj/ehae783
- Huchzermeier, R., & van der Vorst, E. P. C. (2025). Aryl hydrocarbon receptor (AHR) and nuclear factor erythroid-derived 2-like 2 (NRF2): An important crosstalk in the gut-liver axis. Biochemical Pharmacology, 233, Article 116785. https://doi.org/10.1016/j.bcp.2025.116785
- Vacante, F., & Baker, A. H. (2025). Effective CRISPR modulation of complex non-coding RNA loci. Nature Reviews Cardiology, 22(3), 145. Article 145. https://doi.org/10.1038/s41569-025-01117-2
- Halmos, B., La Rose, A. M., Methorst, D., Groenen, A. G., Nakládal, D., Bazioti, V., Koster, M. H., Kloosterhuis, N. J., Buiten, A. V., Schouten, E. M., Huijkman, N. C. A., Langelaar-Makkinje, M., Bongiovanni, L., De Neck, S. M., de Bruin, A., Buikema, H., Deelman, L. E., van den Heuvel, M. C., Kuipers, F., ... Westerterp, M. (2025). SMC Abca1 and Abcg1 Deficiency Enhances Urinary Bladder Distension but Not Atherosclerosis. Circulation Research, 136(5), 491-507. https://doi.org/10.1161/CIRCRESAHA.124.325103
- Fuentes-Cimma, J., Sluijsmans, D., Mejias, P. P., Villagran, I., Riquelme, A., & Heeneman, S. (2025). Psychometric properties of the Feedback Orientation Scale in the clinical workplace of health professions students. International Journal of Medical Education, 16, 36-44. https://doi.org/10.5116/ijme.679e.07de
- Rodor, J., Klimi, E., Brown, S. D., Krilis, G., Braga, L., Ring, N. A. R., Ballantyne, M. D., Kesidou, D., Dinh Cat, A. N., Miscianinov, V., Vacante, F., Miteva, K., Bennett, M., Beqqali, A., Giacca, M., Zacchigna, S., & Baker, A. H. (2025). Functional screening identifies miRNAs with a novel function inhibiting Vascular Smooth Muscle Cell proliferation. Molecular Therapy, 33(2), 615-630. https://doi.org/10.1016/j.ymthe.2024.12.037
- Baker, A. H., Giacca, M., & Thum, T. (2025). miRNA discovery to therapy: The field is sufficiently mature to assess the value of miRNA-based therapeutics. Molecular Therapy, 33(1), 3-4. https://doi.org/10.1016/j.ymthe.2024.12.024
- Bink, D. I., Ritz, K., Mackaaij, C., Stam, O., Scheffer, S., Mizee, M. R., Ploegmakers, H. J., van Het Hof, B. J., de Boer, O. J., Sluimer, J., De Meyer, G. R., van der Weerd, L., de Vries, H. E., & Daemen, M. J. (2025). Lack of intracranial atherosclerosis in various atherosclerotic mouse models. Vascular Biology, 7(1), Article e230013. https://doi.org/10.1530/VB-23-0013
- Bleckwehl, T., Babler, A., Tebens, M., Maryam, S., Nyberg, M., Bosteen, M., Halder, M., Shaw, I., Fleig, S., Pyke, C., Hvid, H., Voetmann, L. M., van Buul, J. D., Sluimer, J. C., Das, V., Baumgart, S., Kramann, R., & Hayat, S. (2025). Encompassing view of spatial and single-cell RNA sequencing renews the role of the microvasculature in human atherosclerosis. Nature cardiovascular research, 4(1), 26-44. https://doi.org/10.1038/s44161-024-00582-1
- Brown, S. D., Klimi, E., Bakker, W. A. M., Beqqali, A., & Baker, A. H. (2025). Non-coding RNAs to treat vascular smooth muscle cell dysfunction. British Journal of Pharmacology, 182(2), 246-280. https://doi.org/10.1111/bph.16409
- Lee, A., Jere, A., Du Plessis, L., Van Gerven, P. W. M., Heeneman, S., & Ross, S. (2025). Continuity of supervision: Balancing continuous and episodic relationships for assessment and learning. Medical Education, 59(6), 596-605. https://doi.org/10.1111/medu.15595
- van Mourik, H., Westheim, A., Schneider, C. V., Stoffels, L., Wieczerzak, E., Steeghs, J., Schneider, K. M., Temmerman, L., Biessen, E., Godschalk, R., Theys, J., & Shiri - Sverdlov, R. (2025). Extracellular Cathepsin B Is a potential Therapeutic Target in Hepatocellular Carcinoma. Liver International, 6(1), Article e70016. https://doi.org/10.1002/lci2.70016



