Feng, M., Thevenot, A., Kuntz, S., Liu, C., Schellenberg, C., Charle, L., Brouard, N., Schaeffer, C., Ortiz, S. J., Cosemans, J. M. E. M., Chakfe, N., & Mangin, P. H. (2025). Aortic atherosclerotic plaques are more thrombogenic than carotid and femoral plaques: the role of fibrillar collagen. Atherosclerosis, 411, Article 120552. https://doi.org/10.1016/j.atherosclerosis.2025.120552

D'Italia, G., Coenen, D. M., Lemmens, T. P., Brandts, L., Wielders, S. J. H., Nagy, M., Mourmans, S. G. J., Achten, A., Al-Abadi, A., Weerts, J., Aizpurua, A. B., van Empel, V., Schroen, B., & Cosemans, J. M. E. M. (2025). Immuno-haemostatic dysregulation in heart failure with preserved ejection fraction. Esc heart failure, 12(5), 3444-3460. https://doi.org/10.1002/ehf2.15361

Octave, M., Pirotton, L., de Cartier d'Yves, E., Marino, A., Ambroise, J., Giera, M., Guigas, B., Ginion, A., Robaux, V., Kuijpers, M. J. E., Baaten, C. C. F. M. J., Heemskerk, J. W. M., Nagy, Z., Senis, Y. A., Brusa, D., Bouzin, C., Bertrand, L., Beauloye, C., & Horman, S. (2025). Deleting ACC1 in platelets alters phospholipidome and reduces platelet activation and thrombosis in mice. Blood advances, 9(18), 4553-4567. https://doi.org/10.1182/bloodadvances.2025015796

Baaten, C. C. F. M. J., Wollenhaupt, J., Henning, T. M., Vondenhoff, S., Schröer, J. R., Stamellou, E., Saritas, T., Kurt, B., Boger, L., Antwerpen, A., Hermann, J., Nagy, M., Sternkopf, M., Buhl, E. M., Raffetseder, U., van der Meijden, P. E. J., Kuijpers, M. J. E., Spronk, H. M. H., Schunk, S. J., ... Noels, H. (2025). Impaired Secondary Platelet Response in Chronic Kidney Disease as a Consequence of Prior Platelet Activation. JACC: Basic to Translational Science, 10(9), Article 101355. https://doi.org/10.1016/j.jacbts.2025.101355

D'Italia, G., Schroen, B., & Cosemans, J. M. E. M. (2025). Commonalities of platelet dysfunction in heart failure with preserved ejection fraction and underlying comorbidities. Esc heart failure, 12(2), 1013-1028. Article 15090. https://doi.org/10.1002/ehf2.15090

Lemmens, T. P., Luo, Q., Wielders, S. J. H., Scheijen, J. L. J. M., Al-Nasiry, S., Koenen, R. R., Wenzel, P., & Cosemans, J. M. E. M. (2024). Platelet collagen receptors and their role in modulating platelet adhesion patterns and activation on alternatively processed collagen substrates. Thrombosis Research, 244, Article 109201. https://doi.org/10.1016/j.thromres.2024.109201

Jooss, N. J., Diender, M. G., Fernandez, D. I., Huang, J., Heubel-Moenen, F. C. J., van der Veer, A., Kuijpers, M. J. E., Poulter, N. S., Henskens, Y. M. C., te Loo, M., & Heemskerk, J. W. M. (2024). Restraining of glycoprotein VI- and integrin α2β1-dependent thrombus formation by platelet PECAM1. Cellular and Molecular Life Sciences, 81(1), Article 44. https://doi.org/10.1007/s00018-023-05058-2

Zou, J., Zhang, P., Solari, F. A., Schönichen, C., Provenzale, I., Mattheij, N. J. A., Kuijpers, M. J. E., Rauch, J. S., Swieringa, F., Sickmann, A., Zieger, B., Jurk, K., & Heemskerk, J. W. M. (2024). Suppressed ORAI1-STIM1-dependent Ca2+ entry by protein kinase C isoforms regulating platelet procoagulant activity. Journal of Biological Chemistry, 300(12), Article 107899. https://doi.org/10.1016/j.jbc.2024.107899

Fernández, D. I., Troitiño, S., Sobota, V., Tullemans, B. M. E., Zou, J., van den Hurk, H., García, Á., Honarnejad, S., Kuijpers, M. J. E., & Heemskerk, J. W. M. (2024). Ultra-high throughput-based screening for the discovery of antiplatelet drugs affecting receptor dependent calcium signaling dynamics. Scientific Reports, 14(1), Article 6229. https://doi.org/10.1038/s41598-024-56799-4

Zhang, P., von Ungern-Sternberg, S., Hastenplug, L., Solari, F., Sickmann, A., Kuijpers, M., Heemskerk, J. W., Walter, U., & Jurk, K. (2024). Multi-phased kinetics and interaction of protein kinase signaling in glycoprotein VI-induced platelet αIIbβ3 integrin activation and degranulation. Thrombosis and Haemostasis, 125(5), 470-483. https://doi.org/10.1055/a-2311-0117

Lemmens, T. P., Bröker, V., Rijpkema, M., Hughes, C. C. W., Schurgers, L. J., & Cosemans, J. M. E. M. (2024). Fundamental considerations for designing endothelialized in vitro models of thrombosis. Thrombosis Research, 236, 179-190. https://doi.org/10.1016/j.thromres.2024.03.004

Melo, S. F., Nondonfaz, A., Aqil, A., Pierrard, A., Hulin, A., Delierneux, C., Ditkowski, B., Gustin, M., Legrand, M., Tullemans, B. M. E., Brouns, S. L. N., Nchimi, A., Carrus, R., Dejosé, A., Heemskerk, J. W. M., Kuijpers, M. J. E., Ritter, J., Steinseifer, U., Clauser, J. C., ... Oury, C. (2024). Design, manufacturing and testing of a green non-isocyanate polyurethane prosthetic heart valve. Biomaterials Science, 12(8), 2149-2164. https://doi.org/10.1039/d3bm01911j

Provenzale, I., Solari, F. A., Schoenichen, C., Brouns, S. L. N., Fernandez, D. I., Kuijpers, M. J. E., van Der Meijden, P. E. J., Gibbins, J. M., Sickmann, A., Jones, C., & Heemskerk, J. W. M. (2024). Endothelium-mediated regulation of platelet activation: Involvement of multiple protein kinases. Faseb Journal, 38(4), Article e23468. https://doi.org/10.1096/fj.202300360RR

Oury, C., Meyers, S., Jacques, N., Leeten, K., Jiang, Z., Musumeci, L., Lox, M., Debuisson, M., Goffin, E., Pirotte, B., Delvenne, P., Nchimi, A., Hubert, C., Heptia, M., Hubert, P., Kuijpers, M. J. E., Vanassche, T., Martinod, K., Verhamme, P., & Lancellotti, P. (2023). Protective Effect of Ticagrelor Against Infective Endocarditis Induced by Virulent Staphylococcus aureus in Mice. JACC: Basic to Translational Science, 8(11), 1439-1453. https://doi.org/10.1016/j.jacbts.2023.02.003

Yakusheva, A., Slater, A., Payrastre, B., Garcia, C., D'Italia, G., Allan, H., Cosemans, J. M. E. M., Harper, M., Gawaz, M., Armstrong, P., Troitiño, S., Trivigno, S. M. G., Naik, U. P., & Senis, Y. A. (2023). Illustrated Abstracts of the 5^th EUPLAN International Conference. Research and practice in thrombosis and haemostasis, 7(7), Article 102140. https://doi.org/10.1016/j.rpth.2023.102140

Schönichen, C., Montague, S. J., Brouns, S. L. N., Burston, J. J., Cosemans, J. M. E. M., Jurk, K., Kehrel, B. E., Koenen, R. R., Ní Áinle, F., O'Donnell, V. B., Soehnlein, O., Watson, S. P., Kuijpers, M. J. E., Heemskerk, J. W. M., & Nagy, M. (2023). Antagonistic Roles of Human Platelet Integrin αiIbβ3 and Chemokines in Regulating Neutrophil Activation and Fate on Arterial Thrombi under Flow. Arteriosclerosis Thrombosis and Vascular Biology, 43(9), 1700-1712. https://doi.org/10.1161/ATVBAHA.122.318767

Fernandez, D. I., Diender, M., Hermida-Nogueira, L., Huang, J., Veiras, S., Henskens, Y. M. C., te Loo, M. W. M., Heemskerk, J. W. M., Kuijpers, M. J. E., & Garcia, A. (2023). Role of SHP2 (PTPN11) in glycoprotein VI-dependent thrombus formation: Improved platelet responsiveness by the allosteric drug SHP099 in Noonan syndrome patients. Thrombosis Research, 228(1), 105-116. https://doi.org/10.1016/j.thromres.2023.06.001

Josefsson, E. C., Ramstrom, S., Thaler, J., Lordkipanidze, M., Cosemans, J., & COAGAPO Study Group (2023). Consensus report on markers to distinguish procoagulant platelets from apoptotic platelets: communication from the Scientific and Standardization Committee of the ISTH. Journal of Thrombosis and Haemostasis, 21(8), 2291-2299. https://doi.org/10.1016/j.jtha.2023.05.001

Antunes-Ferreira, M., D'Ambrosi, S., Arkani, M., Post, E., In 't Veld, S. G. J. G., Ramaker, J., Zwaan, K., Kucukguzel, E. D., Wedekind, L. E., Griffioen, A. W., Egbrink, M. O., Kuijpers, M. J. E., van den Broek, D., Noske, D. P., Hartemink, K. J., Sabrkhany, S., Bahce, I., Sol, N., Bogaard, H.-J., ... Wurdinger, T. (2023). Tumor-educated platelet blood tests for Non-Small Cell Lung Cancer detection and management. Scientific Reports, 13(1), Article 9359. https://doi.org/10.1038/s41598-023-35818-w

Sabrkhany, S., Kuijpers, M. J. E., Van Kuijk, S. M. J., Griffioen, A. W., & Oude Egbrink, M. G. A. (2023). Age- and gender-matched controls needed for platelet-based biomarker studies. Haematologica-the Hematology Journal, 108(6), 1667-1670. https://doi.org/10.3324/haematol.2022.281726

Zhang, P., Solari, F. A., Heemskerk, J. W. M., Kuijpers, M. J. E., Sickmann, A., Walter, U., & Jurk, K. (2023). Differential Regulation of GPVI-Induced Btk and Syk Activation by PKC, PKA and PP2A in Human Platelets. International Journal of Molecular Sciences, 24(9), Article 7776. https://doi.org/10.3390/ijms24097776

Maqsood, Z., Clark, J. C., Martin, E. M., Cheung, Y. F. H., Morán, L. A., Watson, S. E. T., Pike, J. A., Di, Y., Poulter, N. S., Slater, A., Lange, B. M. H., Nieswandt, B., Eble, J. A., Tomlinson, M. G., Owen, D. M., Stegner, D., Bridge, L. J., Wierling, C., & Watson, S. P. (2022). Experimental validation of computerised models of clustering of platelet glycoprotein receptors that signal via tandem SH2 domain proteins. PLoS Computational Biology, 18(11), Article e1010708. https://doi.org/10.1371/journal.pcbi.1010708

In 't Veld, S. G. J. G., Arkani, M., Post, E., Antunes-Ferreira, M., D'Ambrosi, S., Vessies, D. C. L., Vermunt, L., Vancura, A., Muller, M., Niemeijer, A.-L. N., Tannous, J., Meijer, L. L., Le Large, T. Y. S., Mantini, G., Wondergem, N. E., Heinhuis, K. M., van Wilpe, S., Smits, A. J., Drees, E. E. E., ... Wurdinger, T. (2022). Detection and localization of early- and late-stage cancers using platelet RNA. Cancer Cell, 40(9), 999-1009.e6. https://doi.org/10.1016/j.ccell.2022.08.006

Navarro, S., Starke, A., Heemskerk, J. W. M., Kuijpers, M. J. E., Stegner, D., & Nieswandt, B. (2022). Targeting of a Conserved Epitope in Mouse and Human GPVI Differently Affects Receptor Function. International journal of molecular sciences, 23(15), Article 8610. https://doi.org/10.3390/ijms23158610

Karel, M. F. A., Roosen, M. G. C. H., Tullemans, B. M. E., Zhang, C. E., Staals, J., Cosemans, J. M. E. M., & Koenen, R. R. (2022). Characterization of cerebral small vessel disease by neutrophil and platelet activation markers using artificial intelligence. Journal of Neuroimmunology, 367, Article 577863. https://doi.org/10.1016/j.jneuroim.2022.577863

Tullemans, B. M. E., Brouns, S. L. N., Swieringa, F., Sabrkhany, S., van den Berkmortel, F. W. P. J., Peters, N. A. J. B., de Bruijn, P., Koolen, S. L. W., Heemskerk, J. W. M., Aarts, M. J. B., & Kuijpers, M. J. E. (2022). Quantitative and qualitative changes in platelet traits of sunitinib-treated patients with renal cell carcinoma in relation to circulating sunitinib levels: a proof-of-concept study. BMC Cancer, 22(1), Article 653. https://doi.org/10.1186/s12885-022-09676-0

Lemmens, T. P., Coenen, D. M., Swieringa, F., Niessen, I. C. L., Coort, S. L. M., Koenen, R. R., Kutmon, M., & Cosemans, J. M. E. M. (2022). Finding the "switch" in platelet activation: prediction of key mediators involved in reversal of platelet activation using a novel network biology approach. Journal of Proteomics, 261, Article 104577. https://doi.org/10.1016/j.jprot.2022.104577

Tamer, F., Tullemans, B. M. E., Kuijpers, M. J. E., Claushuis, T. A. M., & Heemskerk, J. W. M. (2022). Nutrition Phytochemicals Affecting Platelet Signaling and Responsiveness: Implications for Thrombosis and Hemostasis. Thrombosis and Haemostasis, 122(06), 879-894. https://doi.org/10.1055/a-1683-5599

Kuijpers, M. J. E., Heemskerk, J. W. M., & Jurk, K. (2022). Molecular Mechanisms of Hemostasis, Thrombosis and Thrombo-Inflammation. International journal of molecular sciences, 23(10), Article 5825. https://doi.org/10.3390/ijms23105825

Karel, M. F. A., Tullemans, B. M. E., D'Italia, G., Lemmens, T. P., Claushuis, T. A. M., Kuijpers, M. J. E., & Cosemans, J. M. E. M. (2022). Corrigendum to "The effect of Bruton's tyrosine kinase inhibitor ibrutinib on atherothrombus formation under stenotic flow conditions" [Thromb. Res. 212 (2022) 72-80]. Thrombosis Research, 213, 113-113. https://doi.org/10.1016/j.thromres.2022.03.012

Veninga, A., Baaten, C. C. F. M. J., De Simone, I., Tullemans, B. M. E., Kuijpers, M. J. E., Heemskerk, J. W. M., & van der Meijden, P. E. J. (2022). Effects of Platelet Agonists and Priming on the Formation of Platelet Populations. Thrombosis and Haemostasis, 122(05), 726-738. https://doi.org/10.1055/s-0041-1735972

Peters, L. J. F., Baaten, C. C. F. M. J., Maas, S. L., Lu, C., Nagy, M., Jooss, N. J., Bidzhekov, K., Santovito, D., Moreno-Andrés, D., Jankowski, J., Biessen, E. A. L., Döring, Y., Heemskerk, J. W. M., Weber, C., Kuijpers, M. J. E., & van der Vorst, E. P. C. (2022). MicroRNA-26b Attenuates Platelet Adhesion and Aggregation in Mice. Biomedicines, 10(5), Article 983. https://doi.org/10.3390/biomedicines10050983

Karel, M. F. A., Tullemans, B. M. E., D'Italia, G., Lemmens, T. P., Claushuis, T. A. M., Kuijpers, M. J. E., & Cosemans, J. M. E. M. (2022). The effect of Bruton's tyrosine kinase inhibitor ibrutinib on atherothrombus formation under stenotic flow conditions. Thrombosis Research, 212, 72-80. https://doi.org/10.1016/j.thromres.2022.02.020

Cosemans, J. M. E. M. (2022). Platelet-derived MMP-2 in the prevention of plaque formation: how many strokes is par?European Heart Journal, 43(6), 515–517. https://doi.org/10.1093/eurheartj/ehab665

Karel, M. F. A., Lemmens, T. P., Tullemans, B. M. E., Wielders, S. J. H., Gubbins, E., van Beurden, D., van Rijt, S., & Cosemans, J. M. E. M. (2022). Characterization of Atherosclerotic Plaque Coating for Thrombosis Microfluidics Assays. Cellular and Molecular Bioengineering, 15(1), 55-65. https://doi.org/10.1007/s12195-021-00713-9

Brouns, S. L. N., Tullemans, B. M. E., Bulato, C., Perrella, G., Campello, E., Spiezia, L., van Geffen, J. P., Kuijpers, M. J. E., van Oerle, R., Spronk, H. M. H., van der Meijden, P. E. J., Simioni, P., & Heemskerk, J. W. M. (2022). Protein C or Protein S deficiency associates with paradoxically impaired platelet-dependent thrombus and fibrin formation under flow. Research and practice in thrombosis and haemostasis, 6(2), Article e12678. https://doi.org/10.1002/rth2.12678

Fernandez, D. I., Provenzale, I., Cheung, H. Y. F., van Groningen, J., Tullemans, B. M. E., Veninga, A., Dunster, J. L., Honarnejad, S., van den Hurk, H., Kuijpers, M. J. E., & Heemskerk, J. W. M. (2022). Ultra-high-throughput Ca2+ assay in platelets to distinguish ITAM-linked and G-protein-coupled receptor activation. iScience, 25(1), Article 103718. https://doi.org/10.1016/j.isci.2021.103718

Navarro, S., Stegner, D., Nieswandt, B., Heemskerk, J. W. M., & Kuijpers, M. J. E. (2022). Temporal Roles of Platelet and Coagulation Pathways in Collagen- and Tissue Factor-Induced Thrombus Formation. International journal of molecular sciences, 23(1), Article 358. https://doi.org/10.3390/ijms23010358

Tullemans, B. M. E., Fernandez, D. I., Veninga, A., Baaten, C. C. F. M. J., Peters, L. J. F., Aarts, M. J. B., Eble, J. A., Campello, E., Spiezia, L., Simioni, P., van der Vorst, E. P. C., van der Meijden, P. E. J., Heemskerk, J. W. M., & Kuijpers, M. J. E. (2022). Tyrosine Kinase Inhibitor Sunitinib Delays Platelet-Induced Coagulation: Additive Effects of Aspirin. Thrombosis and Haemostasis, 122(01), 92-104. https://doi.org/10.1055/s-0041-1730312

Fernandez, D. I., Kuijpers, M. J. E., & Heemskerk, J. W. M. (2021). Platelet calcium signaling by G-protein coupled and ITAM-linked receptors regulating anoctamin-6 and procoagulant activity. Platelets, 32(7), 863-871. https://doi.org/10.1080/09537104.2020.1859103

Tullemans, B. M. E., Veninga, A., Fernandez, D. I., Aarts, M. J. B., Eble, J. A., van der Meijden, P. E. J., Heemskerk, J. W. M., & Kuijpers, M. J. E. (2021). Multiparameter Evaluation of the Platelet-Inhibitory Effects of Tyrosine Kinase Inhibitors Used for Cancer Treatment. International Journal of Molecular Sciences, 22(20), Article 11199. https://doi.org/10.3390/ijms222011199

Heinzmann, A. C. A., Coenen, D. M., Vajen, T., Cosemans, J. M. E. M., & Koenen, R. R. (2021). Combined Antiplatelet Therapy Reduces the Proinflammatory Properties of Activated Platelets. TH open : companion journal to thrombosis and haemostasis, 5(4), e533-e542. https://doi.org/10.1055/a-1682-3415

D'Ambrosi, S., Visser, A., Antunes-Ferreira, M., Poutsma, A., Giannoukakos, S., Sol, N., Sabrkhany, S., Bahce, I., Kuijpers, M. J. E., Egbrink, M. G. A. O., Griffioen, A. W., Best, M. G., Koppers-Lalic, D., Oudejans, C., & Wurdinger, T. (2021). The Analysis of Platelet-Derived circRNA Repertoire as Potential Diagnostic Biomarker for Non-Small Cell Lung Cancer. Cancers, 13(18), Article 4644. https://doi.org/10.3390/cancers13184644

Coenen, D. M., Heinzmann, A. C. A., Oggero, S., Albers, H. J., Nagy, M., Hague, P., Kuijpers, M. J. E., Vanderwinden, J. M., van der Meer, A. D., Perretti, M., Koenen, R. R., & Cosemans, J. M. E. M. (2021). Inhibition of Phosphodiesterase 3A by Cilostazol Dampens Proinflammatory Platelet Functions. Cells, 10(8), Article 1998. https://doi.org/10.3390/cells10081998

Lacy, M., Buerger, C., Shami, A., Ahmadsei, M., Winkels, H., Nitz, K., van Tiel, C. M., Seijkens, T. T. P., Kusters, P. J. H., Karshovka, E., Prange, K. H. M., Wu, Y., Brouns, S. L. N., Unterlugauer, S., Kuijpers, M. J. E., Reiche, M. E., Steffens, S., Edsfeldt, A., Megens, R. T. A., ... Lutgens, E. (2021). Cell-specific and divergent roles of the CD40L-CD40 axis in atherosclerotic vascular disease. Nature Communications, 12(1), Article 3754. https://doi.org/10.1038/s41467-021-23909-z

Slater, A., Di, Y., Clark, J. C., Jooss, N. J., Martin, E. M., Alenazy, F., Thomas, M. R., Ariens, R. A. S., Herr, A. B., Poulter, N. S., Emsley, J., & Watson, S. P. (2021). Structural characterization of a novel GPVI-nanobody complex reveals a biologically active domain-swapped GPVI dimer. Blood, 137(24), 3443-3453. https://doi.org/10.1182/blood.2020009440

Sabrkhany, S., Kuijpers, M. J. E., Egbrink, M. G. A. O., & Griffioen, A. W. (2021). Platelets as messengers of early-stage cancer. Cancer and Metastasis Reviews, 40(2), 563-573. https://doi.org/10.1007/s10555-021-09956-4

Mangin, P. H., Neeves, K. B., Lam, W. A., Cosemans, J. M. E. M., Korin, N., Kerrigan, S. W., Panteleev, M. A., & Subcommittee on Biorheology (2021). In vitro flow-based assay: From simple toward more sophisticated models for mimicking hemostasis and thrombosis. Journal of Thrombosis and Haemostasis, 19(2), 582-587. https://doi.org/10.1111/jth.15143

Coenen, D. M., Heinzmann, A. C. A., Karel, M. F. A., Cosemans, J. M. E. M., & Koenen, R. R. (2021). The multifaceted contribution of platelets in the emergence and aftermath of acute cardiovascular events. Atherosclerosis, 319, 132-141. https://doi.org/10.1016/j.atherosclerosis.2020.12.017