Monard, A., Henskens, Y., & Heubel-Moenen, F. (2025). The diagnostic value of the platelet function analyzer in mild to moderate bleeding disorders. Journal of Thrombosis and Haemostasis, 23(7), 2116-2118. https://doi.org/10.1016/j.jtha.2025.03.041

Mussert, C. M. A., Monard, A. L. L., van Duijl, T. T., Henskens, Y. M. C., van den Biggelaar, M., Schutgens, R. E. G., Schols, S. E. M., Fijnvandraat, K. J., Meijer, K., den Exter, P. L., Nieuwenhuizen, L., van Moort, I., Kruip, M. J. H. A., Cnossen, M. H., Heubel-Moenen, F. C. J. I., & BDUC-iN Study group (2025). Current Practice Regarding Bleeding Disorders of Unknown Cause in the Netherlands: A National Survey. Haemophilia, 31(4), 752-760. https://doi.org/10.1111/hae.70065

Tiels, L. M., Wintjens, M. S. J. N., Waardenburg, S., van Rosmalen, F., van Kuijk, S. M. J., van Der Horst, I. C. C., Luiten, R., van Bussel, B. C. T., van Mook, W. N. K. A., Hemmen, B., & van Santen, S. (2025). More self-efficacy is associated with longitudinally higher health-related quality of life in mechanically ventilated COVID-19 ICU survivors: The prospective MaastrICCht cohort. Nursing in Critical Care, 30(4), Article e13241. https://doi.org/10.1111/nicc.13241

van Dievoet, M.-A., Baaten, C. C., Nagy, M., David, C., Brusa, D., Dahlqvist, G., Coubeau, L., De Bruyne, R., Jannone, G., Scheers, I., Hermans, C., Tambucci, R., Pirotte, T., de Magnee, C., Sokal, E., Horman, S., Douxfils, J., Heemskerk, J. W., Lisman, T., & Stephenne, X. (2025). Primary hemostasis in children with cirrhosis prior to liver transplantation: key roles of liver disease severity, von Willebrand factor, and platelet count. Journal of Thrombosis and Haemostasis, 23(7), 2297-2313. https://doi.org/10.1016/j.jtha.2025.04.010

Janssen, S. L. J. E., van Everdingen, W. M., Saalmink, W. B. J., Lamers, S. K., Vroemen, W. H. M., Denessen, E. J. S., Berge, K., Bekers, O., Hopman, M. T. E., Brink, M., Habets, J., Aengevaeren, V. L., Mingels, A. M. A., Nijveldt, R., Eijsvogels, T. M. H., Aaldering, A., Bambacht, R. C. B., Bongers, C. C. W., Brouwer, C. G., ... TREAT study collaboration (2025). Relationship Between Exercise-Induced Cardiac Troponin Elevations and Occult Coronary Atherosclerosis in Middle-Aged Athletes. Journal of the American College of Cardiology, 85(24), 2370-2382. https://doi.org/10.1016/j.jacc.2025.04.047

Florack, M. C. D. M., Strauch, U., Jansen, J., Ortmanns, S., Ramakers-van Kuijk, M., Felzen, M., Beckers, S., Habers, J., Marx, G., van der Horst, I. C. C., van Bussel, B. C. T., & Bergmans, D. (2025). Critically ill patients undergoing interhospital transportation: a prospective multicentre cohort study in the Euregio Meuse-Rhine. BMJ Open, 15(6), Article e099235. https://doi.org/10.1136/bmjopen-2025-099235

Lauxen, J. S., Vondenhoff, S., Junho, C. V. C., Martin, P., Fleig, S., Schuett, K., Schulze-Spaete, U., Soehnlein, O., Prates-Roma, L., Doering, Y., Baaten, C. C. F. M. J., & Noels, H. (2025). Neutrophil Function in Patients With Chronic Kidney Disease: A Systematic Review and Meta-Analysis. Acta Physiologica, 241(6), Article e70057. https://doi.org/10.1111/apha.70057

Gomez-Rosas, P., Nagy, M., Spronk, H. M. H., Russo, L., Gamba, S., Tartari, C. J., Bolognini, S., Ticozzi, C., Schieppati, F., Sarmiento, R., De Braud, F., Masci, G., Tondini, C., Petrelli, F., Giuliani, F., D'Alessio, A., Santoro, A., Gasparini, G., Labianca, R., ... HYPERCAN Investigators (2025). Activated factor XI–antithrombin and thrombin–antithrombin complexes in the prediction of venous thromboembolism and mortality in patients with non–small-cell lung cancer. Journal of Thrombosis and Haemostasis, 23(6), 1908-1919. https://doi.org/10.1016/j.jtha.2025.02.029

Beqiri, E., Tas, J., Czosnyka, M., van Kaam, R. C. R., Donnelly, J., Haeren, R. H., van der Horst, I. C. C., Hutchinson, P. J., van Kuijk, S. M. J., Liberti, A. L., Menon, D. K., Hoedemaekers, C. W. E., Depreitere, B., Meyfroidt, G., Ercole, A., Aries, M. J. H., & Smielewski, P. (2025). Does Targeting CPP at CPPopt Actually Improve Cerebrovascular Reactivity? A Secondary Analysis of the COGiTATE Randomized Controlled Trial. Neurocritical Care, 42(3), 937-944. Article e030727. https://doi.org/10.1007/s12028-024-02168-y

Hamulyák, E. N., Wang, T.-F., Kreuziger, L. B., Iyengar, V., Carney, B. J., Hoeben, A., Özdemir, B. C., Serrano, R. D. C., Sanfilippo, K. M., Rozenblatt, S., Beenen, L. F. M., Yust-Katz, S., Halperin, E., Arad, A., Lubetsky, A., Carrier, M., Massat, B., Büller, H. R., Spectre, G., ... ten Cate, H. (2025). Multinational cohort study of intracranial hemorrhage in patients with brain metastases receiving anticoagulation. Haematologica-the Hematology Journal, 110(6), 1417-1421. https://doi.org/10.3324/haematol.2024.286973

Willems, R. A. L., Zanetto, A., Campello, E., de Simone, I., Bulato, C., Konings, J., Kramer, M., Tufaha, S., Russo, F. P., Senzolo, M., Burra, P., Ten Cate, H., de Vos-Geelen, J., Roest, M., Simioni, P., de Laat, B., & Huskens, D. (2025). Patients with cirrhosis have a disbalance between coagulation and fibrinolysis resulting in a prothrombotic phenotype. Journal of Thrombosis and Haemostasis, 23(6), 1974-1987. https://doi.org/10.1016/j.jtha.2025.02.034

Makhoul, M., Mariani, S., van Bussel, B. C. T., Wiedeman, D., Saeed, D., Di Mauro, M., Pozzi, M., Botta, L., Boeken, U., Samalavicius, R., Bounader, K., Hou, X., Bunge, J. J. H., Buscher, H., Salazar, L., Meyns, B., Mazzeffi, M. A., Sacha Matteucci, M. L., Sponga, S., ... PELS-1 Investigators (2025). Postcardiotomy extracorporeal membrane oxygenation in patients older than 70 years: Characteristics, outcomes, and variables associated with mortality. JTCVS open, 25, 163-172. https://doi.org/10.1016/j.xjon.2025.04.004

Stragier, H., Vandersmissen, H., Ordies, S., Thiessen, S., Mesotten, D., Peuskens, D., & Ten Cate, H. (2025). Pathophysiological mechanisms underlying early brain injury and delayed cerebral ischemia in the aftermath of aneurysmal subarachnoid hemorrhage: a comprehensive analysis. Frontiers in Neurology, 16, Article 1587091. https://doi.org/10.3389/fneur.2025.1587091

Nielen, J. T. H., van der Walle, K., Spronk, S., Magdelijns, F., Denig, P., & Karapinar, F. (2025). Real-World Complexity of Prescribing Cascades. Basic & Clinical Pharmacology & Toxicology, 137(1), Article e70063. https://doi.org/10.1111/bcpt.70063

van der Knaap, N., Klinkhammer, S., Postma, A. A., Visser-Meily, J. M. A., Horn, J., van Heugten, C. M., Voorter, P. H. M., van der Thiel, M. M., Drenthen, G. S., Backes, W. H., van Rosmalen, F., van Santen, S., van Bussel, B. C. T., van der Horst, I. C. C., Linden, D. E. J., Aries, M. J. H., & Jansen, J. F. A. (2025). Post-COVID microvascular dysfunction in hospitalized COVID-19 survivors is associated with acute disease severity and persistent cognitive complaints. Journal of the Neurological Sciences, 472, Article 123464. https://doi.org/10.1016/j.jns.2025.123464

Habibi, Z., Verhaert, D. V. M., Betz, K., Hermans, B. J. M., Winters, J., Philippens, S. A. M., Chaldoupi, S. M., Maesen, B., Maessen, J. G., Isaacs, A., Westra, S. W., Nijveldt, R., Gillet, L., Wienhues-Thelen, U. H., Koehler, M., Zeemering, S., Vernooy, K., Linz, D., & Schotten, U. (2025). Association of atrial fibrillation burden and clinical profile with blood biomarkers: Results from the ISOLATION Ablation Cohort. Heart Rhythm O2, 6(5), 661-670. https://doi.org/10.1016/j.hroo.2025.02.017

Castoldi, E. (2025). Thrombophilic thrombomodulin variants. Blood, 145(17), 1837-1839. https://doi.org/10.1182/blood.2024027934

Beukenhorst, A. L., Rice, K. L., Frallicciardi, J., Koldijk, M. H., Boudreau, C. M., Crawford, J., Cornelissen, L. A. H. M., da Costa, K. A. S., de Jong, B. A., Fischinger, S., Julg, B., Klap, J. M., Koch, C. M., Magyarics, Z., Mohamed, F. A. N., Okonkwo, V., Adams, L., McCarthy, C. M., Ronsard, L., ... Goudsmit, J. (2025). Intranasal administration of a panreactive influenza antibody reveals Fc-independent mode of protection. Scientific Reports, 15(1), Article 10309. https://doi.org/10.1038/s41598-025-94314-5

D'Italia, G., Schroen, B., & Cosemans, J. M. E. M. (2025). Commonalities of platelet dysfunction in heart failure with preserved ejection fraction and underlying comorbidities. Esc heart failure, 12(2), 1013-1028. Article 15090. https://doi.org/10.1002/ehf2.15090

De Piero, M. E., Mariani, S., van Bussel, B. C. T., Jarczak, D., Krenner, N., de la Sota, E. P., Silva, P. E., Roemmer, M., Kowalewski, M., Carelli, S., Broman, L. M., Vuylsteke, A., Fortuna, P., Alessandri, F., Martucci, G., Patel, B. V., Lotz, G., Boeken, U., Maier, S., ... EuroECMO-COVID Study Group (2025). In-hospital outcomes and 6-month follow-up results of patients supported with extracorporeal membrane oxygenation for COVID-19 from the second wave to the end of the pandemic (EuroECMO-COVID): a prospective, international, multicentre, observational study. The Lancet Respiratory medicine, 13(4), 307-317. https://doi.org/10.1016/S2213-2600(24)00369-2

Mariani, S., Perazzo, A., De Piero, M. E., van Bussel, B. C. T., Di Mauro, M., Wiedemann, D., Lehmann, S., Pozzi, M., Loforte, A., Boeken, U., Samalavicius, R., Bounader, K., Hou, X., Bunge, J. J. H., Sriranjan, K., Salazar, L., Meyns, B., Mazzeffi, M. A., Matteucci, S., ... PELS Investigators (2025). Postcardiotomy extracorporeal membrane oxygenation after elective, urgent, and emergency cardiac operations: Insights from the PELS observational study. JTCVS open, 24, 280-310. https://doi.org/10.1016/j.xjon.2025.01.018

Mansouritorghabeh, H., Monard, A., Heubel-Moenen, F., Leentjens, J., Stroobants, A., & Henskens, Y. (2025). The Utility of Total Thrombus-Formation Analysis System (T-TAS) in the Thrombosis and Hemostasis Field: A Scoping Review. International Journal of Laboratory Hematology, 47(2), 201-211. https://doi.org/10.1111/ijlh.14403

Nab, L., Visser, C., van Bussel, B. C. T., Beishuizen, A., Bemelmans, R. H. H., Ten Cate, H., Croles, F. N., van Guldener, C., de Jager, C. P. C., Huisman, M. V., Nijziel, M. R., Kamphuisen, P. W., Klok, F. A., Koster, S. C. E., Kusadasi, N., Meijer, K., den Uil, C. A., Schutgens, R. E. G., Stam, F., ... Dutch Covid and Thrombosis Coalition & the CAPACITY-COVID collaborative consortium (2025). Assessing differential application of thromboprophylaxis regimes related to risk of pulmonary embolism and mortality in COVID-19 patients through instrumental variable analysis. Scientific Reports, 15(1), Article 10321. https://doi.org/10.1038/s41598-024-77858-w

Winckers, K., Biguzzi, E., Thomassen, S., Heinzmann, A., Rosendaal, F. R., Hackeng, T. M., & van Hylckama-Vlieg, A. (2025). Risk of First Venous Thrombosis by Comparing Different Thrombin Generation Assay Conditions: Results from the MEGA Case-control Study. TH open : companion journal to thrombosis and haemostasis, 9, Article a25346123. https://doi.org/10.1055/a-2534-6123

Koene, E. J., Buziau, A. M., Cassiman, D., Cox, T. M., Bons, J., Scheijen, J. L. J. M., Schalkwijk, C. G., Meex, S. J., Saxena, A. R., Esler, W. P., Schrauwen-Hinderling, V. B., Schrauwen, P., & Brouwers, M. C. (2025). Safety and efficacy of pharmacological inhibition of ketohexokinase in hereditary fructose intolerance. Journal of Clinical Investigation, 135(6), Article e187376. https://doi.org/10.1172/JCI187376

Smits, K. C., Bressi, E., Rademakers, L. M., Rijks, J. H. J., van Stipdonk, A. M. W., Engels, E. B., Isaacs, A., Hermans, B. J. M., Grieco, D., Luermans, J. G. L. M., Vernooy, K., Prinzen, F. W., & Nguyen, U. C. (2025). Time-dependent repolarization changes following left bundle branch area pacing vs. conventional biventricular pacing in patients with dyssynchronous heart failure. EP Europace, 27(3), Article euaf034. https://doi.org/10.1093/europace/euaf034

Ricken, K. W. L. M., Lenselink, C., Venema, C. S., van der Horst, I. C. C., van der Harst, P., Pundziute-Do Prado, G., Voors, A. A., & Lipsic, E. (2025). Left atrial strain predicts long-term heart failure outcomes after ST-elevation myocardial infarction. International Journal of Cardiology, 422, Article 132931. https://doi.org/10.1016/j.ijcard.2024.132931

Mariette, X., Borchmann, S., Aspeslagh, S., Szekanecz, Z., Charles-Schoeman, C., Schreiber, S., Choy, E. H. S., Peyrin-Biroulet, L., Schmalzing, M., Tanaka, Y., ten Cate, H., Westhovens, R., van der Woude, C. J., Omoruyi, E. V. E., Faes, M., Masior, T., Van Hoek, P., Watson, C., Rudolph, C., & Stallmach, A. (2025). Major adverse cardiovascular, thromboembolic and malignancy events in the filgotinib rheumatoid arthritis and ulcerative colitis clinical development programmes. RMD Open, 11(1), Article e005033. https://doi.org/10.1136/rmdopen-2024-005033

Martens, R. J. H., van Doorn, W. P. T. M., Leers, M. P. G., Meex, S. J. R., & Helmich, F. (2025). Unraveling Uncertainty: The Impact of Biological and Analytical Variation on the Prediction Uncertainty of Categorical Prediction Models. Journal of Applied Laboratory Medicine, 10(2), 339-351. Article jfae115. https://doi.org/10.1093/jalm/jfae115

Taha, A., Nagy, M., Hund, H. M., van Doormaal, P. J., van Noorden, K., Spronk, H. M. H., Ceulemans, A., van Oostenbrugge, R. J., Duncker, D. J., ten Cate, H., Dippel, D., van Es, A. C. G. M., Bobi, J., & van Beusekom, H. M. M. (2025). Vascular injury and occurrence of microthrombi after endovascular therapy for acute ischaemic stroke in a thromboembolic model. BMJ Neurology Open, 7(1), Article e000989. https://doi.org/10.1136/bmjno-2024-000989

Gilbers, M. D., Kawczynski, M. J., Bidar, E., Maesen, B., Isaacs, A., Winters, J., Linz, D., Rienstra, M., van Gelder, I., Maessen, J. G., & Schotten, U. (2025). Determinants and impact of postoperative atrial fibrillation burden during 2.5 years of continuous rhythm monitoring after cardiac surgery: Results from the RACE V prospective cohort study. Heart Rhythm, 22(3), 647-660. https://doi.org/10.1016/j.hrthm.2024.08.014

Nagy, M., Bender, M., Poulter, N. S., Pike, J. A., Sickmann, A., Vondenhoff, S., Bielicka, N., van Zandvoort, M. A. M. J., Koenen, R. R., ten Cate, H., Stéphenne, X., Heemskerk, J. W. M., & Baaten, C. C. F. M. J. (2025). Formation of tight junction-like structures of zonula occludens 2 in platelet–platelet interaction. Research and practice in thrombosis and haemostasis, 9(3), Article 102845. https://doi.org/10.1016/j.rpth.2025.102845

de Kok, J. W. T. M., van Bussel, B. C. T., van der Horst, I. C. C., & van Rosmalen, F. (2025). From Introducing Table 0 to Forgetting Figure 1: It is time for a reporting guideline for publishing with real-world clinical data. Author's reply. Journal of Clinical Epidemiology, 179, Article 111656. https://doi.org/10.1016/j.jclinepi.2024.111656

Truijen, S., Austen, S., Magdelijns, F., Boonen, A., & van Onna, M. (2025). Getting prepared for the silver wave: challenges in conducting rheumatic and musculoskeletal disease research in older adults. RMD Open, 11(1), Article e005280. https://doi.org/10.1136/rmdopen-2024-005280

ten Cate-Hoek, A. J. (2025). Konservative Behandlung zur Verhinderung des postthrombotischen Syndroms in der aktuellen klinischen Praxis. Phlebologie, 54(1), 15-25. https://doi.org/10.1055/a-2227-5424

Cramer, I. C., Cox, E. G. M., de Kok, J. W. T. M., Koeze, J., Visser, M., Bouma, H. R., Dekker, A. D. B., van der Horst, I. C. C., Bouwman, R. A., & van Bussel, B. C. T. (2025). Quantification of facial cues for acute illness: a systematic scoping review. Intensive Care Medicine Experimental, 13(1), Article 17. https://doi.org/10.1186/s40635-025-00719-x

Wintjens, M. S. J. N., Aydeniz, E., van Rosmalen, F., Driessen, R. G. H., Hulshof, A.-M., Bergmans, D. C. J. J., van Kuijk, S. M. J., van der Horst, I. C. C., van Bussel, B. C. T., MaastrICCht Collaborators, Bels, J., van de Berg, T., Brandts, L., van Gassel, R., Ghossein, M., Heines, S., de Jongh, S., van der Knaap, N., Meijs, D., ... Schellens, J. (2025). The Maastricht Intensive Care COVID Cohort: A Critical Appraisal of the Predefined Research Questions. Critical care explorations, 7(2), Article e1211. https://doi.org/10.1097/CCE.0000000000001211

Smit, E. R., Kreft, I. C., Camilleri, E., Burggraaf-van Delft, J. L. I., van Rein, N., van Vlijmen, B. J. M., Hulshof, A.-M., van Bussel, B. C. T., van Rosmalen, F., van der Zwaan, C., van de Berg, T., Henskens, Y., ten Cate, H., Coutinho, J. M., Kruip, M. J. H. A., Eikenboom, J. J. C., Hoogendijk, A. J., Cannegieter, S. C., van den Biggelaar, M., ... Dutch COVID & Thrombosis Coalition (2025). Exploration of the plasma proteomic profile of patients at risk of thromboembolic events. Research and practice in thrombosis and haemostasis, 9(2), Article e102713. https://doi.org/10.1016/j.rpth.2025.102713

Isaacs, A., Zeemering, S., Winters, J., Batlle, M., Bidar, E., Boukens, B., Casadei, B., Chua, W., Crijns, H. J. G. M., Fabritz, L., Guasch, E., Hatem, S. N., Hermans, B., Kääb, S., Kawczynski, M., Maesen, B., Maessen, J., Mont, L., Sinner, M. F., ... Stoll, M. (2025). Lateral Atrial Expression Patterns Provide Insights into Local Transcription Disequilibrium Contributing to Disease Susceptibility. Circulation: Genomic and Precision Medicine, 18(1), Article e004594. https://doi.org/10.1161/CIRCGEN.124.004594

van Kwawegen, C. B., Pastoor, H., Eikenboom, J., Fijnvandraat, K., Ypma, P., Heubel-Moenen, F. C. J. I., van Galen, K. P. M., Mauser-Bunschoten, E. P., Meijer, K., Schols, S. E. M., Cnossen, M. H., van der Bom, J. G., de Meris, J., Atiq, F., Kruip, M. J. H. A., Leebeek, F. W. G., & WiN Study Group (2025). Sexuality and bleeding in von Willebrand disease. Research and practice in thrombosis and haemostasis, 9(2), Article e102712. https://doi.org/10.1016/j.rpth.2025.102712

Herrera-Rivero, M., Garvert, L., Horn, K., Löbner, M., Weitzel, E. C., Stoll, M., Lichtner, P., Teismann, H., Teumer, A., Van der Auwera, S., Völzke, H., Völker, U., Andlauer, T. F. M., Meinert, S., Heilmann-Heimbach, S., Forstner, A. J., Streit, F., Witt, S. H., Kircher, T., ... Berger, K. (2025). A meta-analysis of genome-wide studies of resilience in the German population. Molecular Psychiatry, 30(2), 497-505. Article e12439. https://doi.org/10.1038/s41380-024-02688-1

Heines, S. J. H., de Jongh, S. A. M., de Jongh, F. H. C., Segers, R. P. J., Gilissen, K. M. H., van der Horst, I. C. C., van Bussel, B. C. T., & Bergmans, D. C. J. J. (2025). A novel positive end-expiratory pressure titration using electrical impedance tomography in spontaneously breathing acute respiratory distress syndrome patients on mechanical ventilation: an observational study from the MaastrICCht cohort. Journal of Clinical Monitoring and Computing, 39(1), 127-139. https://doi.org/10.1007/s10877-024-01212-8

Bouwens, B. R. C., Magdeleyns, E., Thomassen, M. C. L. G. D., Bouwman, F. G., Suylen, D. P., Hackeng, T. M., & Koenen, R. R. (2025). Citrullination of tissue factor pathway inhibitor alpha by peptidylarginine deiminase 4 impairs its natural anticoagulant activity toward factors Xa and VIIa/tissue factor and reduces binding to its cofactor protein S. Journal of Thrombosis and Haemostasis, 23(2), 641-650. https://doi.org/10.1016/j.jtha.2024.11.009

Ganar, K. A., Nandy, M., Turbina, P., Chen, C., Suylen, D., Nihoul, E., Pascoe, E. L., van der Beelen, S., Plaum, M., van den Bos, L., Koenraadt, C. J. M., Dijkgraaf, I., & Deshpande, S. (2025). Phase separation and ageing of glycine-rich protein from tick adhesive. Nature Chemistry, 17(2), 186-197. Article 490. https://doi.org/10.1038/s41557-024-01686-8

Cox, E. G. M., Meijs, D. A. M., Wynants, L., Sels, J.-W. E. M., Koeze, J., Keus, F., Bos-van Dongen, B., van der Horst, I. C. C., & van Bussel, B. C. T. (2025). "The definition of predictor and outcome variables in mortality prediction models: a scoping review and quality of reporting study". Journal of Clinical Epidemiology, 178, Article 111605. https://doi.org/10.1016/j.jclinepi.2024.111605

Koenen, R. R. (2025). TH Open-Editor's Highlights of 2024. TH open : companion journal to thrombosis and haemostasis, 09, Article a25134445. https://doi.org/10.1055/a-2513-4445

Ten Cate, H. (2025). The wonders of anticoagulation. Frontiers in Cardiovascular Medicine, 11, Article 1517109. https://doi.org/10.3389/fcvm.2024.1517109

Shaw, J. R., Nopp, S., Stavik, B., Youkhana, K., Michels, A. L., Kennes, S., Rak, J., & ten Cate, H. (2025). Thrombosis, Translational Medicine, and Biomarker Research: Moving the Needle. Journal of the American Heart Association, 14(1), Article e038782. https://doi.org/10.1161/JAHA.124.038782

De Caterina, R., Ten Cate, H., & Pengo, V. (2025). Non-vitamin K oral anticoagulants in valvular heart disease before surgery: a tale of bridging vs. no bridging. European Heart Journal, 46(1), 35-37. https://doi.org/10.1093/eurheartj/ehae615