• 2023
    • Van de Berg, T. W., Beckers, E. A. M., Heubel-Moenen, F. C. J. I., Henskens, Y. M. C., Thomassen, M. C. L. G. D., & Hackeng, T. M. (2023). Sensitive Measurement of Clinically Relevant Factor VIII Levels in Thrombin Generation Assays Requires Presence of Factor XIa. Thrombosis and Haemostasis, 123(11), 1034-1041. https://doi.org/10.1055/a-2101-7961
    • Todaro, A. M., Radu, C. M., Ciccone, M., Toffanin, S., Serino, M. L., Campello, E., Bulato, C., Lunghi, B., Gemmati, D., Cuneo, A., Hackeng, T. M., Simioni, P., Bernardi, F., & Castoldi, E. (2023). In vitro and ex vivo rescue of a nonsense mutation responsible for severe coagulation factor V deficiency. Journal of Thrombosis and Haemostasis. Advance online publication. https://doi.org/10.1016/j.jtha.2023.10.007
    • Timmers, M., Peeters, W., Hauwert, N. J., Rijcken, C. J. F., Vermonden, T., Dijkgraaf, I., & Liskamp, R. M. J. (2023). Specific N-terminal attachment of TMTHSI linkers to native peptides and proteins for strain-promoted azide alkyne cycloaddition. Chemical Communications, 59(76), 11397-11400. Article 59. https://doi.org/10.1039/d3cc03397j
    • Denessen, E. J. S., Vroemen, W. H. M., Litjens, E. J. R., Henskens, Y. M. C., van der Sande, F. M., Bekers, O., de Boer, D., & Mingels, A. M. A. (2023). Cardiac Troponin T Degradation in End-Stage Renal Disease Patients Appears to Occur in Vivo. Journal of Applied Laboratory Medicine, 8(5), 1000-1002. https://doi.org/10.1093/jalm/jfad043
    • Schönichen, C., Montague, S. J., Brouns, S. L. N., Burston, J. J., Cosemans, J. M. E. M., Jurk, K., Kehrel, B. E., Koenen, R. R., Ní Áinle, F., O'Donnell, V. B., Soehnlein, O., Watson, S. P., Kuijpers, M. J. E., Heemskerk, J. W. M., & Nagy, M. (2023). Antagonistic Roles of Human Platelet Integrin aIIbβ3 and Chemokines in Regulating Neutrophil Activation and Fate on Arterial Thrombi Under Flow. Arteriosclerosis Thrombosis and Vascular Biology, 43(9), 1700-1712. https://doi.org/10.1161/ATVBAHA.122.318767
    • Huckriede, J. B., Beurskens, D. M. H., Wildhagen, K. C. C. A., Reutelingsperger, C. P. M., Wichapong, K., & Nicolaes, G. A. F. (2023). Design and characterization of novel activated protein C variants for the proteolysis of cytotoxic extracellular histone H3. Journal of Thrombosis and Haemostasis. Advance online publication. https://doi.org/10.1016/j.jtha.2023.08.023
    • Chai, J., Wu, J., Li, J., Liao, H., Lu, W., Guo, R., Shao, Z., Jmel, M. A., Martins, L. A., Hackeng, T., Ippel, H., Dijkgraaf, I., Kotsyfakis, M., & Xu, X. (2023). Novel Amphibian Bowman-Birk-Like Inhibitor with Antioxidant and Anticoagulant Effects Ameliorates Pancreatitis Symptoms in Mice. Journal of Medicinal Chemistry, 66(17), 11869-11880. https://doi.org/10.1021/acs.jmedchem.3c00475
    • Hendriks, F. K., Trommelen, J., van der Sande, F. M., van Kranenburg, J. M. X., Kuijpers, J. H. W., Houtvast, D. C. J., Jetten, G. H. J., Goessens, J. P. B., Meex, S. J. R., Kooman, J. P., & van Loon, L. J. C. (2023). Branched-chain ketoacid co-ingestion with protein lowers amino acid oxidation during hemodialysis: A randomized controlled cross-over trial. Clinical Nutrition, 42(8), 1436-1444. https://doi.org/10.1016/j.clnu.2023.06.034
    • Timmers, M., Kipper, A., Frey, R., Notermans, S., Voievudskyi, M., Wilson, C., Hentzen, N., Ringle, M., Bovino, C., Stump, B., Rijcken, C. J. F., Vermonden, T., Dijkgraaf, I., & Liskamp, R. (2023). Exploring the Chemical Properties and Medicinal Applications of Tetramethylthiocycloheptyne Sulfoximine Used in Strain-Promoted Azide-Alkyne Cycloaddition Reactions. Pharmaceuticals, 16(8), Article 1155. https://doi.org/10.3390/ph16081155
    • Mingels, A., Mills, N. L., Mueller, C., & Study Group on Biomarkers of the ESC Association for Acute CardioVascular Care (2023). Cardiac troponin T and I: back to basics. European Heart Journal: Acute Cardiovascular Care. Advance online publication. https://doi.org/10.1093/ehjacc/zuad084
    • Wang, R., Damanik, F., Kuhnt, T., Jaminon, A., Hafeez, S., Liu, H., Ippel, H., Dijkstra, P. J., Bouvy, N., Schurgers, L., ten Cate, A. T., Dias, A., Moroni, L., & Baker, M. B. (2023). Biodegradable Poly(ester) Urethane Acrylate Resins for Digital Light Processing: From Polymer Synthesis to 3D Printed Tissue Engineering Constructs. Advanced Healthcare Materials, 12(17). https://doi.org/10.1002/adhm.202202648
    • Danckwardt, S., Tregouet, D-A., & Castoldi, E. (2023). Post-transcriptional control of haemostatic genes: mechanisms and emerging therapeutic concepts in thrombo-inflammatory disorders. Cardiovascular Research, 119(8), 1624-1640. https://doi.org/10.1093/cvr/cvad046
    • Alaour, B., Kaier, T. E., Hasselbalch, R. B., van Doorn, W., Meex, S., & Marber, M. (2023). Direct Comparison of the Circadian Rhythm of Cardiac Myosin-Binding Protein C (cMyC) and Cardiac Troponin. Journal of Applied Laboratory Medicine, 8(4), 831-834. https://doi.org/10.1093/jalm/jfad025
    • Aakre, K. M., Meex, S. J. R., & Mills, N. L. (2023). Cardiac Troponin Reporting in Children and Young Adults: Time to Change Clinical Practice. Circulation, 148(1), 17-19. https://doi.org/10.1161/CIRCULATIONAHA.123.065297
    • Castoldi, E. (2023). Making sense of FV short. Blood, 141(26), 3134-3135. https://doi.org/10.1182/blood.2023020274
    • Dai, L., Mafra, D., Shiels, P. G., Hackeng, T. M., Stenvinkel, P., & Schurgers, L. J. (2023). Vitamin K and Hallmarks of Ageing: Focus on Diet and Gut Microbiome. Nutrients, 15(12), Article 2727. https://doi.org/10.3390/nu15122727
    • Thomassen, M. C. L. G. D., Bouwens, B. R. C., Wichapong, K., Suylen, D. P., Bouwman, F. G., Hackeng, T. M., & Koenen, R. R. (2023). Protein arginine deiminase 4 inactivates tissue factor pathway inhibitor-alpha by enzymatic modification of functional arginine residues. Journal of Thrombosis and Haemostasis, 21(5), 1214-1226. https://doi.org/10.1016/j.jtha.2023.01.017
    • Denessen, E. J. S., Nass, S. I. J., Bekers, O., Vroemen, W. H. M., & Mingels, A. M. A. (2023). Circulating forms of cardiac troponin: a review with implications for clinical practice. Journal of Laboratory and Precision Medicine, 8. https://doi.org/10.21037/jlpm-22-66
    • de Winther, M. P. J., Bäck, M., Evans, P., Gomez, D., Goncalves, I., Jørgensen, H. F., Koenen, R. R., Lutgens, E., Norata, G. D., Osto, E., Dib, L., Simons, M., Stellos, K., Ylä-Herttuala, S., Winkels, H., Bochaton-Piallat, M-L., & Monaco, C. (2023). Translational opportunities of single-cell biology in atherosclerosis. European Heart Journal, 44(14), 1216-1230. https://doi.org/10.1093/eurheartj/ehac686
    • Abbas, M. N., Jmel, M. A., Mekki, I., Dijkgraaf, I., & Kotsyfakis, M. (2023). Recent Advances in Tick Antigen Discovery and Anti-Tick Vaccine Development. International Journal of Molecular Sciences, 24(5), Article 4969. https://doi.org/10.3390/ijms24054969
    • Chabronova, A., van den Akker, G. G. H., Housmans, B. A. C., Caron, M. M. J., Cremers, A., Surtel, D. A. M., Wichapong, K., Peffers, M. M. J., van Rhijn, L. W., Marchand, V., Motorin, Y., & Welting, T. J. M. (2023). Ribosomal RNA-based epitranscriptomic regulation of chondrocyte translation and proteome in osteoarthritis. Osteoarthritis and Cartilage, 31(3), 374-385. https://doi.org/10.1016/j.joca.2022.12.010
    • Tore, E. C., Elshorbagy, A. K., Bakers, F. C. H., Brouwers, M. C. G. J., Dagnelie, P. C., Eussen, S. J. P. M., Jansen, J. F. A., Kooi, M. E., Kusters, Y. H. A. M., Meex, S. J. R., Olsen, T., Refsum, H., Retterstøl, K., Schalkwijk, C. G., Stehouwer, C. D. A., Vinknes, K. J., & van Greevenbroek, M. M. J. (2023). Associations between plasma sulfur amino acids and specific fat depots in two independent cohorts: CODAM and The Maastricht Study. European Journal of Nutrition, 62(2), 891-904. https://doi.org/10.1007/s00394-022-03041-4
    • Hendriks, F. K., Kuijpers, J. H. W., van Kranenburg, J. M. X., Senden, J. M. G., van der Sande, F. M., Kooman, J. P., Meex, S. J. R., & van Loon, L. J. C. (2023). Intradialytic protein ingestion and exercise do not compromise uremic toxin removal throughout hemodialysis. Journal of Renal Nutrition, 33(2), 376-385. https://doi.org/10.1053/j.jrn.2022.07.006
    • de Vries, F., Huckriede, J., Wichapong, K., Reutelingsperger, C., & Nicolaes, G. A. F. (2023). The role of extracellular histones in COVID-19. Journal of Internal Medicine, 293(3), 275-292. https://doi.org/10.1111/joim.13585
    • Koenen, R. R. (2023). Platelets: from simple fragments to inflammation regulators. European Heart Journal, 44(8), 633-635. https://doi.org/10.1093/eurheartj/ehac705
    • Pavlic, A., Poelman, H., Wasilewski, G., Wichapong, K., Lux, P., Maassen, C., Lutgens, E., Schurgers, L. J., Reutelingsperger, C. P., & Nicolaes, G. A. F. (2023). Inhibition of Neutral Sphingomyelinase 2 by Novel Small Molecule Inhibitors Results in Decreased Release of Extracellular Vesicles by Vascular Smooth Muscle Cells and Attenuated Calcification. International Journal of Molecular Sciences, 24(3), Article 2027. https://doi.org/10.3390/ijms24032027
    • Yao, T. Y., Chen, H. L., Wang, R., Rivero, R., Wang, F. Y., Kessels, L., Agten, S. M., Hackeng, T. M., Wolfs, T. G. A. M., Fan, D. D., Baker, M. B., & Moroni, L. (2023). Thiol-ene conjugation of a VEGF peptide to electrospun scaffolds for potential applications in angiogenesis. Bioactive Materials, 20, 306-317. https://doi.org/10.1016/j.bioactmat.2022.05.029
    • Beukenhorst, A. L., Frallicciardi, J., Koch, C. M., Klap, J. M., Phillips, A., Desai, M. M., Wichapong, K., Nicolaes, G. A. F., Koudstaal, W., Alter, G., & Goudsmit, J. (2023). The influenza hemagglutinin stem antibody CR9114: Evidence for a narrow evolutionary path towards universal protection ( vol 2 , 1049134 , 2022). Frontiers in Virology, 3, Article 1130102. https://doi.org/10.3389/fviro.2023.1130102
    • van Smaalen, T. C., Beurskens, D. M. H., Kox, J. J. H. F. M., Polonia, R., Vos, R., Duimel, H., van de Wetering, W. J., Lopez-Iglesias, C., Reutelingsperger, C. P., van Heurn, L. W. E., Peutz-Kootstra, C. J., & Nicolaes, G. A. F. (2023). Extracellular histone release by renal cells after warm and cold ischemic kidney injury: Studies in an ex-vivo porcine kidney perfusion model. PLOS ONE, 18(1), Article e0279944. https://doi.org/10.1371/journal.pone.0279944
    • Heuts, S., Gollmann-Tepeköylü, C., Denessen, E. J. S., Olsthoorn, J. R., Romeo, J. L. R., Maessen, J. G., van 't Hof, A. W. J., Bekers, O., Hammarsten, O., Pölzl, L., Holfeld, J., Bonaros, N., van der Horst, I. C. C., Davidson, S. M., Thielmann, M., & Mingels, A. M. A. (2023). Cardiac troponin release following coronary artery bypass grafting: mechanisms and clinical implications. European Heart Journal, 44(2), 100-112. https://doi.org/10.1093/eurheartj/ehac604
    • Moore, G. W., Castoldi, E., Teruya, J., Morishita, E., & Adcock, D. M. (2023). Factor V Leiden-independent activated protein C resistance: Communication from the plasma coagulation inhibitors subcommittee of the International Society on Thrombosis and Haemostasis Scientific and Standardisation Committee. Journal of Thrombosis and Haemostasis, 21(1), 164-174. https://doi.org/10.1016/j.jtha.2022.10.014
    • Dzhanaev, R., Hasberg, C., Gorgels, A., Schmitz, C., Winkler, C. F., Malyaran, H., Graeber, S., Gentier, A., Jaminon, A., Agten, S., Hackeng, T., Akbulut, A. C., Schurgers, L., Mottaghy, F. M., Goettsch, C., & Jahnen-Dechent, W. (2023). Application of the mineral-binding protein fetuin-A for the detection of calcified lesions. Theranostics, 13(2), 659-672. https://doi.org/10.7150/thno.78773
  • 2022
    • Beghi, S., Furmanik, M., Jaminon, A., Veltrop, R., Rapp, N., Wichapong, K., Bidar, E., Buschini, A., & Schurgers, L. J. (2022). Calcium Signalling in Heart and Vessels: Role of Calmodulin and Downstream Calmodulin-Dependent Protein Kinases. International journal of molecular sciences, 23(24), Article 16139. https://doi.org/10.3390/ijms232416139
    • Denessen, E. J., Heuts, S., Daemen, J. H., van Doorn, W. P., Vroemen, W. H., Sels, J-W., Segers, P., Van't Hof, A. W., Maessen, J. G., Bekers, O., Van Der Horst, I. C., & Mingels, A. M. (2022). High-Sensitivity Cardiac Troponin I and T Kinetics Differ following Coronary Bypass Surgery: A Systematic Review and Meta-Analysis. Clinical Chemistry, 68(12), 1564-1575. Article hvac152. https://doi.org/10.1093/clinchem/hvac152
    • Kemp, J. A., Alvarenga, L., Cardozo, L. F. M. F., Dai, L., Stenvinkel, P., Shiels, P. G., Hackeng, T. M., Schurgers, L. J., & Mafra, D. (2022). Dysbiosis in Patients with Chronic Kidney Disease: Let Us Talk About Vitamin K. Current nutrition reports, 11(4), 765-779. https://doi.org/10.1007/s13668-022-00438-9
    • Bol, M. E., Huckriede, J. B., van de Pas, K. G. H., Delhaas, T., Lorusso, R., Nicolaes, G. A. F., Sels, J. E. M., & van de Poll, M. C. G. (2022). Multimodal measurement of glycocalyx degradation during coronary artery bypass grafting. Frontiers in medicine, 9, 1045728. https://doi.org/10.3389/fmed.2022.1045728
    • Mezger, S. T. P., Mingels, A. M. A., Soulié, M., Peutz-Kootstra, C. J., Bekers, O., Mulder, P., Heeren, R. M. A., & Cillero-Pastor, B. (2022). Protein Alterations in Cardiac Ischemia/Reperfusion Revealed by Spatial-Omics. International journal of molecular sciences, 23(22), Article 13847. https://doi.org/10.3390/ijms232213847
    • van de Berg, T. W., Mulder, M. M. G., Alnima, T., Nagy, M., van Oerle, R., Beckers, E. A. M., Hackeng, T. M., Hulshof, A. M., Sels, J. W. E. M., Henskens, Y. M. C., van der Horst, I. C. C., ten Cate, H., Spronk, H. M. H., van Bussel, B. C. T., & Dutch COVID & Thrombosis Coalition (2022). Serial thrombin generation and exploration of alternative anticoagulants in critically ill COVID-19 patients: Observations from Maastricht Intensive Care COVID Cohort. Frontiers in cardiovascular medicine, 9, Article 929284. https://doi.org/10.3389/fcvm.2022.929284
    • Brandhofer, M., Hoffmann, A., Blanchet, X., Siminkovitch, E., Rohlfing, A. K., El Bounkari, O., Nestele, J. A., Bild, A., Kontos, C., Hille, K., Rohde, V., Froehlich, A., Golemi, J., Gokce, O., Krammer, C., Scheiermann, P., Tsilimparis, N., Sachs, N., Kempf, W. E., ... Bernhagen, J. (2022). Heterocomplexes between the atypical chemokine MIF and the CXC-motif chemokine CXCL4L1 regulate inflammation and thrombus formation. Cellular and Molecular Life Sciences, 79(10), Article 512. https://doi.org/10.1007/s00018-022-04539-0
    • Nitz, K., Lacy, M., Bianchini, M., Wichapong, K., Kücükgöze, I. A., Bonfiglio, C. A., Migheli, R., Wu, Y., Burger, C., Li, Y., Forné, I., Ammar, C., Janjic, A., Mohanta, S., Duchene, J., Heemskerk, J. W. M., Megens, R. T. A., Schwedhelm, E., Huveneers, S., ... Atzler, D. (2022). The Amino Acid Homoarginine Inhibits Atherogenesis by Modulating T-Cell Function. Circulation Research, 131(8), 701-712. https://doi.org/10.1161/CIRCRESAHA.122.321094
    • Eurlings, C. G. M. J., Bektas, S., Sanders-van Wijk, S., Tsirkin, A., Vasilchenko, V., Meex, S. J. R., Failer, M., Oehri, C., Ruff, P., Zellweger, M. J., & Brunner-La Rocca, H-P. (2022). Use of artificial intelligence to assess the risk of coronary artery disease without additional (non-invasive) testing: validation in a low-risk to intermediate-risk outpatient clinic cohort. BMJ Open, 12(9), Article e055170. https://doi.org/10.1136/bmjopen-2021-055170
    • Sanjurjo, L., Broekhuizen, E. C., Koenen, R. R., & Thijssen, V. L. J. L. (2022). Galectokines: The Promiscuous Relationship between Galectins and Cytokines. Biomolecules, 12(9), Article 1286. https://doi.org/10.3390/biom12091286
    • Drent, M., Jessurun, N. T., Wijnen, P. A., Bekers, O., & Bast, A. (2022). Drug-induced comorbidities in patients with sarcoidosis. Current Opinion in Pulmonary Medicine, 28(5), 468-477. https://doi.org/10.1097/MCP.0000000000000889
    • van den Kerkhof, D. L., Nagy, M., Wichapong, K., Brouns, S. L. N., Suylen, D. P. L., Hackeng, T. M., & Dijkgraaf, I. (2022). Unraveling the role of the homoarginine residue in antiplatelet drug eptifibatide in binding to the αIIbβ3 integrin receptor. Thrombosis Research, 217, 96-103. https://doi.org/10.1016/j.thromres.2022.07.011
    • Blanas, A., Karsjens, H., de Ligt, A., Huijbers, E. J. M., van Loon, K., Denisov, S., Durukan, C., Engbersen, D., Groen, J., Hennig, S., Hackeng, T., van Beijnum, J. R., & Griffioen, A. W. (2022). Vaccination with a bacterial peptide conjugated to SARS-CoV-2 receptor-binding domain accelerates immunity and protects against COVID-19. iScience, 25(8), Article 104719. https://doi.org/10.1016/j.isci.2022.104719
    • Pavlic, A., Bahram Sangani, N., Kerins, J., Nicolaes, G., Schurgers, L., & Reutelingsperger, C. (2022). Vascular Smooth Muscle Cell Neutral Sphingomyelinase 2 in the Release of Exosomes and Vascular Calcification. International journal of molecular sciences, 23(16), Article 9178. https://doi.org/10.3390/ijms23169178
    • Huang, J., Jooss, N. J., Fernández, D. I., Sickmann, A., García, Á., Wichapong, K., Dijkgraaf, I., & Heemskerk, J. W. M. (2022). Roles of Focal Adhesion Kinase PTK2 and Integrin αIIbβ3 Signaling in Collagen- and GPVI-Dependent Thrombus Formation under Shear. International journal of molecular sciences, 23(15), Article 8688. https://doi.org/10.3390/ijms23158688
    • Brouwers, M. C. G. J., Simons, N., Kooi, M. E., de Ritter, R., van Dongen, M. C. J. M., Eussen, S. J. P. M., Bekers, O., Kooman, J., van Greevenbroek, M. M. J., van der Kallen, C. J. H., Schram, M. T., Schaper, N. C., Schalkwijk, C. G., & Stehouwer, C. D. A. (2022). Intrahepatic lipid content is independently associated with soluble E-selectin levels: The Maastricht study. Digestive and Liver Disease, 54(8), 1038-1043. https://doi.org/10.1016/j.dld.2022.01.130
    • Sedzro, J. C., Adam, F., Auditeau, C., Bianchini, E., De Carvalho, A., Peyron, I., Daramé, S., Gandrille, S., Thomassen, S., Hackeng, T. M., Christophe, O. D., Lenting, P. J., Denis, C. V., Borgel, D., & Saller, F. (2022). Antithrombotic potential of a single-domain antibody enhancing the activated protein C-cofactor activity of protein S. Journal of Thrombosis and Haemostasis, 20(7), 1653-1664. https://doi.org/10.1111/jth.15736
    • Duim, S. N., Vlasveld, L. T., Mezger, S. T. P., Mingels, A. M. A., Ramakers, C. R. B., De Boer, D., Heil, S. G., Nexo, E., & Van Rossum, A. P. (2022). "Macro transcobalamin causing raised vitamin B12: Case-based laboratory investigation". Annals of Clinical Biochemistry, 59(4), 302-307. Article 00045632221087132. https://doi.org/10.1177/00045632221087132