PI group Henri Spronk
- 2026
- Franssen, I. S., Jong, M. J. D., Vievermans, A., Stroo, J. F., Henskens, Y. M. C., Spronk, H., Janssen, D. J. A., Braeken, D., van Kuijk, S. M. J., Winckers, K., & Magdelijns, F. J. H. (2026). Adequacy of Direct Oral Anticoagulant Dosing in Nursing Home Residents: Cross-Sectional Data From the DOAC-FRAIL Study. Journal of the American Medical Directors Association, 27(4), Article 106082. https://doi.org/10.1016/j.jamda.2025.106082
- Aarts, A., Brandts, L., Pavlicic, M., Cate, H. T., & ten Cate-Hoek, A. J. (2026). Apixaban vs vitamin K antagonists in relation to postthrombotic syndrome: data from a prospective cohort study. Journal of Thrombosis and Haemostasis, 24(4), 1388-1396. https://doi.org/10.1016/j.jtha.2025.11.022
- van Ginkel, D. J., Stragier, H., Bor, W. L., Rosseel, L., Konings, J., Ninivaggi, M., de Simone, I., Huskens, D., Roest, M., van Lenthe, I., Overduin, D. C., Aarnink, E. W., Rooijakkers, M. J. P., Peper, J., Brouwer, J., Nijenhuis, V. J., Rensing, B. J. W. M., Timmers, L., Swaans, M. J., ... ten Berg, J. M. (2026). Effects of continuation versus interruption of oral anticoagulation during transcatheter aortic valve implantation on hemostasis function. Journal of Thrombosis and Haemostasis, 24(4), 1263-1278. https://doi.org/10.1016/j.jtha.2025.11.005
- Kempers, E. K., Visser, C., Seelig, J., Chen, Q., Adriaansen, H. J., Beinema, M. J., ten Cate-Hoek, A. J., Faber, L. M., Dronkers, C. E. A., Nierman, M. C., Schindhelm, R. K., Wiersma, N. M., Stork, A. D. M., Klok, F. A., Leebeek, F. W. G., Pisters, R., Cannegieter, S. C., De Caterina, R., Hemels, M. E. W., ... Kruip, M. J. H. A. (2026). Sex differences in outcomes of vitamin K antagonist treatment in patients with a mechanical heart valve: a Dutch population-based cohort study. Journal of Thrombosis and Haemostasis, 24(3), 955-970. https://doi.org/10.1016/j.jtha.2025.09.010
- ten Cate, V., Sulochana, H. R., ten Cate, H., & Nagy, M. (2026). Coagulation factor XI and cardiovascular disease: A complex, cardio-specific conundrum. Med, 7(2), Article 100995. https://doi.org/10.1016/j.medj.2025.100995
- Magdelijns, F. J. H., de Jong, M. J., Winckers, K., Braeken, D. C. W., & Cate, H. T. (2026). Frail older patients and direct oral anticoagulants: trouble in paradise?Journal of Thrombosis and Haemostasis, 24(2), 781-783. https://doi.org/10.1016/j.jtha.2025.10.034
- Kempers, E. K., Acampo-de Jong, M. J. J., ten Cate, H., De Caterina, R., & Kruip, M. J. H. A. (2026). Timeless therapeutics: cardiac indications for vitamin K antagonists in clinical practice. Heart. https://doi.org/10.1136/heartjnl-2024-324551
- Iding, A. F. J., Hupperetz, R. D., Brans, R. J. B., ten Cate, H., van Twist, D. J. L., & ten Cate-Hoek, A. J. (2026). Additional oxerutin therapy to promote deep vein thrombus resolution (RESOLVE-DVT): a randomized controlled pilot trial. Journal of Thrombosis and Haemostasis, 24(2), 644-653. https://doi.org/10.1016/j.jtha.2025.10.018
- Jaakonmäki, N., Helin, T., Szanto, T., Zedde, M., Sarkanen, T., Martinez-Majander, N., Sinisalo, J., Junttola, U., Redfors, P., von Sarnowski, B., Waje-Andreassen, U., Ylikotila, P., Yesilot, N., Ryliskiene, K., Tulkki, L., Amaya Pascasio, L., Licenik, R., Ferdinand, P., Gerdts, E., ... SECRETO Study Group (2026). Anti-beta2-glycoprotein I IgG antibodies are associated with early-onset cryptogenic ischemic stroke. European Stroke Journal, 11(1), Article 23969873251351207. https://doi.org/10.1177/23969873251351207
- Visser, C., Kempers, E. K., Seelig, J., Chen, Q., Adriaansen, H. J., Beinema, M. J., ten Cate-Hoek, A., Faber, L. M., Klok, F. A., Leebeek, F. W. G., van de Leur, S. J. C. M., Nierman, M. C., Pisters, R., Schindhelm, R. K., Stork, A. D. M., Wiersma, N. M., De Caterina, R., Cannegieter, S. C., Hemels, M. E. W., ... Kruip, M. J. H. A. (2026). Anticoagulation Therapeutic Ranges and Clinical Outcomes in Patients with a Mechanical Heart Valve Treated with Vitamin K Antagonists-a Nationwide Linked-data Dutch Study. Thrombosis and Haemostasis. Advance online publication. https://doi.org/10.1055/a-2773-5810
- Hupperetz, R. D., Iding, A. F. J., van Laanen, J., Brans, R., Notten, P., Asiong, J., Wikkeling, O. R. M., Vleming, L.-J., Jacobs, E. M. G., Koster, A., Wittens, C., ten Cate, H., & ten Cate-Hoek, A. J. (2026). Biomarkers in Relation to Patency, Popliteal Reflux, and Post-thrombotic Syndrome: A Subanalysis of the Ultrasound-accelerated Catheter-directed Thrombolysis versus Anticoagulation for the Prevention of Post-thrombotic Syndrome Trial. Thrombosis and Haemostasis. Advance online publication. https://doi.org/10.1055/a-2794-5116
- 2025
- Wu, Y., Van Dellen, F., Ten Cate, H., Henskens, Y., & Winckers, K. (2025). Challenges in diagnosing sticky platelet syndrome using light transmission aggregometry: a scoping review. Platelets, 36(1), Article 2560380. https://doi.org/10.1080/09537104.2025.2560380
- Vicente-Steijn, R., Spiegelenberg, J., Rijpma, S. R., Henskens, Y. M. C., Leentjens, J., Ponjee, G., & Stroobants, A. (2025). A scoping review protocol on active drug monitoring of direct oral anticoagulants on vulnerable patient groups to detect potential adverse risks. Thrombosis Update, 21, Article 100223. https://doi.org/10.1016/j.tru.2025.100223
- van der Horst, S. F. B., Chu, G., Seelig, J., Trinks-Roerdink, E. M., Voorhout, L., de Vries, T. A. C., van Alem, A. P., Beukema, R. J., Boersma, L. V. A., Brouwer, M. A., ten Cate, H., Faber, L. M., de Groot, J. R., Gu, Y. L., den Hartog, F. R., de Jong, J. S. S. G., de Jong, Y., Kirchhof, C. J. H. J., Kleijwegt, F. S., ... Huisman, M. V. (2025). Predicting clinically relevant bleeding in new-onset atrial fibrillation patients initiating oral anticoagulant therapy: External validation of the AF-BLEED score. Thrombosis Research, 256, Article 109533. https://doi.org/10.1016/j.thromres.2025.109533
- Barakzie, A., van der Steen, W., Jansen, A. J. G., Roozenbeek, B., Donkel, S. J., van der Lugt, A., Lingsma, H., Dippel, D. W. J., Cate, H. T., de Maat, M. P. M., & CONTRAST Consortium (2025). Association of NETs Markers with Clinical and Radiological Outcomes in Patients with Acute Ischemic Stroke Undergoing Thrombectomy: Does Heparin Treatment Modify This?Translational Stroke Research, 16(6), 1985-1995. https://doi.org/10.1007/s12975-025-01362-0
- Obino, G., Nieddu, G., Nagy, M., Ippel, H., Cubeddu, T., Spronk, H. M. H., Hackeng, T. M., Formato, M., Lepedda, A. J., & Moroni, L. (2025). Marine-derived sulfated polysaccharides enhance hemocompatibility and endothelialization of nanofibrous PCL for vascular graft applications. Cell Biomaterials, 1(10), Article 100155. https://doi.org/10.1016/j.celbio.2025.100155
- Deltadahl, S., Gilbey, J., Van Laer, C., Boeckx, N., Leers, M. P. G., Freeman, T., Aiken, L., Farren, T., Smith, M., Zeina, M., MacDonald, S., Gleghorn, D., Rudd, J. H. F., Ouwehand, W. H., Amenga-Etego, L., Sarpong, K., Awandare, G. A., Trompeter, S., Gupta, R., ... BloodCounts! consortium (2025). Deep generative classification of blood cell morphology. Nature Machine Intelligence, 7(11), 1791-1803. https://doi.org/10.1038/s42256-025-01122-7
- Stenger, W. J. E., den Uil, C. A., Rietdijk, W. J. R., Al Amri, I., Montero-Cabezas, J. M., Elzo Kraemer, C. V., van Mens, T. E., Meuwese, C. L., van Mieghem, N. M. D. A., Lauw, M. N., van den Toorn, L. M., Levolger, S., van de Luijtgaarden, K. M., Sprenger, R. A., van Dongen, J. M., Imani, F., Meuwissen, M., Kant, K. M., Aarts, R. A. H. M., ... Klok, F. A. (2025). Thrombectomy in high-risk pulmonary embolism – device versus thrombolysis: rationale and design of the TORPEDO-NL investigator-initiated, academically-sponsored, multicenter, open-label randomized controlled trial. Thrombosis Research, 255, Article 109420. https://doi.org/10.1016/j.thromres.2025.109420
- D'Italia, G., Coenen, D. M., Lemmens, T. P., Brandts, L., Wielders, S. J. H., Nagy, M., Mourmans, S. G. J., Achten, A., Al-Abadi, A., Weerts, J., Aizpurua, A. B., van Empel, V., Schroen, B., & Cosemans, J. M. E. M. (2025). Immuno-haemostatic dysregulation in heart failure with preserved ejection fraction. Esc heart failure, 12(5), 3444-3460. https://doi.org/10.1002/ehf2.15361
- van der Bie, J., Coleon, A., Visser, D., Bogers, W. M., den Dunnen, J., Spronk, H. M. H., Langermans, J. A. M., Willemen, H. L. D. M., De Melo, G. D., Middeldorp, J., & Stammes, M. A. (2025). Post Pandemic Problem, is there an animal model suitable to investigate PASC. npj Imaging, 3(1), Article 41. https://doi.org/10.1038/s44303-025-00101-2
- Klein, D. O., Waardenburg, S. F., Janssen, E. B. N. J., Wintjens, M. S. J. N., Imkamp, M., Heemskerk, S. C. M., Birnie, E., Bonsel, G. J., Warlé, M. C., Jacobs, L. M. C., Hemmen, B., Verbunt, J., van Bussel, B. C. T., van Santen, S., Kietelaer, B. L. J. H., Jansen, G., Klok, F. A., de Kruif, M. D., Vernooy, K., ... CAPACITY-COVID collaborative consortium (2025). Two years and counting: a prospective cohort study on the scope and severity of post-COVID symptoms across diverse patient groups in the Netherlands-insights from the CORFU study. BMJ Open, 15(9), Article e093639. https://doi.org/10.1136/bmjopen-2024-093639
- Wang, M., Taha, A., Nagy, M., Raben, J. D., van Noort, R., Volovici, V., Dammers, R., Duncker, D. J., Spronk, H., Ten Cate, H., Dippel, D., Bobi, J., & van Beusekom, H. M. M. (2025). Microvascular Occlusion and Postrecanalization Hyperperfusion in a Swine Model of Acute Ischemic Stroke. Journal of the American Heart Association, 14(18), Article e042663. https://doi.org/10.1161/JAHA.125.042663
- Monard, A. L. L., Hellenbrand, D., Verhezen, P., Beckers, E. A. M., Henskens, Y. C. M., & Heubel-Moenen, F. C. J. I. (2025). tPA-ROTEM identifies hyperfibrinolytic profile in a significant proportion of patients with bleeding disorder of unknown cause (BDUC). Thrombosis Research, 253, Article 109404. https://doi.org/10.1016/j.thromres.2025.109404
- Erdoes, G., Koster, A., & Cate, H. T. (2025). Not Only Drug Efficacy Counts! A Call for Adequately Powered Safety Trials. Journal of Cardiothoracic and Vascular Anesthesia, 39(9), 2542-2543. https://doi.org/10.1053/j.jvca.2025.05.025
- Baaten, C. C. F. M. J., Wollenhaupt, J., Henning, T. M., Vondenhoff, S., Schröer, J. R., Stamellou, E., Saritas, T., Kurt, B., Boger, L., Antwerpen, A., Hermann, J., Nagy, M., Sternkopf, M., Buhl, E. M., Raffetseder, U., van der Meijden, P. E. J., Kuijpers, M. J. E., Spronk, H. M. H., Schunk, S. J., ... Noels, H. (2025). Impaired Secondary Platelet Response in Chronic Kidney Disease as a Consequence of Prior Platelet Activation. JACC: Basic to Translational Science, 10(9), Article 101355. https://doi.org/10.1016/j.jacbts.2025.101355
- Vleeshouwers, K., Bastings, J. J. C., Brüggemann, R., de Jong, M. J., van den Boogaart, M., Poeze, M., van Es, N., Hanssen, N. M. J., Brouns, S., Magdelijns, F., & Spaetgens, B. (2025). Antithrombotic Therapy and Mortality Risk in Older Adults with Hip Fractures. Journal of the American Medical Directors Association, 26(8), Article 105690. https://doi.org/10.1016/j.jamda.2025.105690
- Kempers, E. K., Chen, Q., van Rein, N., Atiq, F., Schindhelm, R. K., Wiersma, N. M., Dronkers, C. E. A., Beinema, M., ten Cate-Hoek, A. J., Nierman, M. C., Stork, A. D. M., Moriarty, P., Klok, F. A., Cannegieter, S. C., & Kruip, M. J. H. A. (2025). Changes in quality of vitamin K antagonist treatment and clinical outcomes during Ramadan: a Dutch population-based cohort study. Research and practice in thrombosis and haemostasis, 9(6), Article 103010. https://doi.org/10.1016/j.rpth.2025.103010
- Iding, A. F. J., Ten Cate, V., Ten Cate, H., Wild, P. S., & Ten Cate-Hoek, A. J. (2025). Untangling profiles of post-thrombotic syndrome using unsupervised machine learning. Blood advances, 9(14), 3631-3641. https://doi.org/10.1182/bloodadvances.2025015829
- Barakzie, A., Cavalcante, F., Donkel, S. J., Nagy, M., Dippel, D. W. J., van der Lugt, A., Roos, Y. B. W. E. M., Majoie, C. B. L. M., ten Cate, H., de Maat, M. P. M., Jansen, A. J. G., & CONTRAST Consortium (2025). Association of Fibrinolysis With Acute Ischemic Stroke Outcome in Patients Undergoing Thrombectomy: Modification by Additional Administration of tPA?Stroke: vascular and interventional neurology, 5(4), Article e001574. https://doi.org/10.1161/SVIN.124.001574
- Goldberg, I., Spectre, G., Raanani, P., Cate, H. T., & Leader, A. (2025). Clinical Challenges in Treating Cancer-Associated Thrombosis: A Clinically Oriented Review. Acta Haematologica, 148(4), 477-493. https://doi.org/10.1159/000542872
- Monard, A., Henskens, Y., & Heubel-Moenen, F. (2025). The diagnostic value of the platelet function analyzer in mild to moderate bleeding disorders. Journal of Thrombosis and Haemostasis, 23(7), 2116-2118. https://doi.org/10.1016/j.jtha.2025.03.041
- Mussert, C. M. A., Monard, A. L. L., van Duijl, T. T., Henskens, Y. M. C., van den Biggelaar, M., Schutgens, R. E. G., Schols, S. E. M., Fijnvandraat, K. J., Meijer, K., den Exter, P. L., Nieuwenhuizen, L., van Moort, I., Kruip, M. J. H. A., Cnossen, M. H., Heubel-Moenen, F. C. J. I., & BDUC-iN Study group (2025). Current Practice Regarding Bleeding Disorders of Unknown Cause in the Netherlands: A National Survey. Haemophilia, 31(4), 752-760. https://doi.org/10.1111/hae.70065
- van Dievoet, M.-A., Baaten, C. C., Nagy, M., David, C., Brusa, D., Dahlqvist, G., Coubeau, L., De Bruyne, R., Jannone, G., Scheers, I., Hermans, C., Tambucci, R., Pirotte, T., de Magnee, C., Sokal, E., Horman, S., Douxfils, J., Heemskerk, J. W., Lisman, T., & Stephenne, X. (2025). Primary hemostasis in children with cirrhosis prior to liver transplantation: key roles of liver disease severity, von Willebrand factor, and platelet count. Journal of Thrombosis and Haemostasis, 23(7), 2297-2313. https://doi.org/10.1016/j.jtha.2025.04.010
- Lauxen, J. S., Vondenhoff, S., Junho, C. V. C., Martin, P., Fleig, S., Schuett, K., Schulze-Spaete, U., Soehnlein, O., Prates-Roma, L., Doering, Y., Baaten, C. C. F. M. J., & Noels, H. (2025). Neutrophil Function in Patients With Chronic Kidney Disease: A Systematic Review and Meta-Analysis. Acta Physiologica, 241(6), Article e70057. https://doi.org/10.1111/apha.70057
- Gomez-Rosas, P., Nagy, M., Spronk, H. M. H., Russo, L., Gamba, S., Tartari, C. J., Bolognini, S., Ticozzi, C., Schieppati, F., Sarmiento, R., De Braud, F., Masci, G., Tondini, C., Petrelli, F., Giuliani, F., D'Alessio, A., Santoro, A., Gasparini, G., Labianca, R., ... HYPERCAN Investigators (2025). Activated factor XI–antithrombin and thrombin–antithrombin complexes in the prediction of venous thromboembolism and mortality in patients with non–small-cell lung cancer. Journal of Thrombosis and Haemostasis, 23(6), 1908-1919. https://doi.org/10.1016/j.jtha.2025.02.029
- Hamulyák, E. N., Wang, T.-F., Kreuziger, L. B., Iyengar, V., Carney, B. J., Hoeben, A., Özdemir, B. C., Serrano, R. D. C., Sanfilippo, K. M., Rozenblatt, S., Beenen, L. F. M., Yust-Katz, S., Halperin, E., Arad, A., Lubetsky, A., Carrier, M., Massat, B., Büller, H. R., Spectre, G., ... ten Cate, H. (2025). Multinational cohort study of intracranial hemorrhage in patients with brain metastases receiving anticoagulation. Haematologica-the Hematology Journal, 110(6), 1417-1421. https://doi.org/10.3324/haematol.2024.286973
- Willems, R. A. L., Zanetto, A., Campello, E., de Simone, I., Bulato, C., Konings, J., Kramer, M., Tufaha, S., Russo, F. P., Senzolo, M., Burra, P., Ten Cate, H., de Vos-Geelen, J., Roest, M., Simioni, P., de Laat, B., & Huskens, D. (2025). Patients with cirrhosis have a disbalance between coagulation and fibrinolysis resulting in a prothrombotic phenotype. Journal of Thrombosis and Haemostasis, 23(6), 1974-1987. https://doi.org/10.1016/j.jtha.2025.02.034
- Stragier, H., Vandersmissen, H., Ordies, S., Thiessen, S., Mesotten, D., Peuskens, D., & Ten Cate, H. (2025). Pathophysiological mechanisms underlying early brain injury and delayed cerebral ischemia in the aftermath of aneurysmal subarachnoid hemorrhage: a comprehensive analysis. Frontiers in Neurology, 16, Article 1587091. https://doi.org/10.3389/fneur.2025.1587091
- Nielen, J. T. H., van der Walle, K., Spronk, S., Magdelijns, F., Denig, P., & Karapinar, F. (2025). Real-World Complexity of Prescribing Cascades. Basic & Clinical Pharmacology & Toxicology, 137(1), Article e70063. https://doi.org/10.1111/bcpt.70063
- Mansouritorghabeh, H., Monard, A., Heubel-Moenen, F., Leentjens, J., Stroobants, A., & Henskens, Y. (2025). The Utility of Total Thrombus-Formation Analysis System (T-TAS) in the Thrombosis and Hemostasis Field: A Scoping Review. International Journal of Laboratory Hematology, 47(2), 201-211. https://doi.org/10.1111/ijlh.14403
- Nab, L., Visser, C., van Bussel, B. C. T., Beishuizen, A., Bemelmans, R. H. H., Ten Cate, H., Croles, F. N., van Guldener, C., de Jager, C. P. C., Huisman, M. V., Nijziel, M. R., Kamphuisen, P. W., Klok, F. A., Koster, S. C. E., Kusadasi, N., Meijer, K., den Uil, C. A., Schutgens, R. E. G., Stam, F., ... Dutch Covid and Thrombosis Coalition & the CAPACITY-COVID collaborative consortium (2025). Assessing differential application of thromboprophylaxis regimes related to risk of pulmonary embolism and mortality in COVID-19 patients through instrumental variable analysis. Scientific Reports, 15(1), Article 10321. https://doi.org/10.1038/s41598-024-77858-w
- Winckers, K., Biguzzi, E., Thomassen, S., Heinzmann, A., Rosendaal, F. R., Hackeng, T. M., & van Hylckama-Vlieg, A. (2025). Risk of First Venous Thrombosis by Comparing Different Thrombin Generation Assay Conditions: Results from the MEGA Case-control Study. TH open : companion journal to thrombosis and haemostasis, 09, Article a25346123. Advance online publication. https://doi.org/10.1055/a-2534-6123
- Mariette, X., Borchmann, S., Aspeslagh, S., Szekanecz, Z., Charles-Schoeman, C., Schreiber, S., Choy, E. H. S., Peyrin-Biroulet, L., Schmalzing, M., Tanaka, Y., ten Cate, H., Westhovens, R., van der Woude, C. J., Omoruyi, E. V. E., Faes, M., Masior, T., Van Hoek, P., Watson, C., Rudolph, C., & Stallmach, A. (2025). Major adverse cardiovascular, thromboembolic and malignancy events in the filgotinib rheumatoid arthritis and ulcerative colitis clinical development programmes. RMD Open, 11(1), Article e005033. https://doi.org/10.1136/rmdopen-2024-005033
- Taha, A., Nagy, M., Hund, H. M., van Doormaal, P. J., van Noorden, K., Spronk, H. M. H., Ceulemans, A., van Oostenbrugge, R. J., Duncker, D. J., ten Cate, H., Dippel, D., van Es, A. C. G. M., Bobi, J., & van Beusekom, H. M. M. (2025). Vascular injury and occurrence of microthrombi after endovascular therapy for acute ischaemic stroke in a thromboembolic model. BMJ Neurology Open, 7(1), Article e000989. https://doi.org/10.1136/bmjno-2024-000989
- Nagy, M., Bender, M., Poulter, N. S., Pike, J. A., Sickmann, A., Vondenhoff, S., Bielicka, N., van Zandvoort, M. A. M. J., Koenen, R. R., ten Cate, H., Stéphenne, X., Heemskerk, J. W. M., & Baaten, C. C. F. M. J. (2025). Formation of tight junction-like structures of zonula occludens 2 in platelet–platelet interaction. Research and practice in thrombosis and haemostasis, 9(3), Article 102845. https://doi.org/10.1016/j.rpth.2025.102845
- Truijen, S., Austen, S., Magdelijns, F., Boonen, A., & van Onna, M. (2025). Getting prepared for the silver wave: challenges in conducting rheumatic and musculoskeletal disease research in older adults. RMD Open, 11(1), Article e005280. https://doi.org/10.1136/rmdopen-2024-005280
- ten Cate-Hoek, A. J. (2025). Konservative Behandlung zur Verhinderung des postthrombotischen Syndroms in der aktuellen klinischen Praxis. Phlebologie, 54(1), 15-25. https://doi.org/10.1055/a-2227-5424
- Smit, E. R., Kreft, I. C., Camilleri, E., Burggraaf-van Delft, J. L. I., van Rein, N., van Vlijmen, B. J. M., Hulshof, A.-M., van Bussel, B. C. T., van Rosmalen, F., van der Zwaan, C., van de Berg, T., Henskens, Y., ten Cate, H., Coutinho, J. M., Kruip, M. J. H. A., Eikenboom, J. J. C., Hoogendijk, A. J., Cannegieter, S. C., van den Biggelaar, M., ... Dutch COVID & Thrombosis Coalition (2025). Exploration of the plasma proteomic profile of patients at risk of thromboembolic events. Research and practice in thrombosis and haemostasis, 9(2), Article e102713. https://doi.org/10.1016/j.rpth.2025.102713



