• 2021
    • Herrera-Rivero, M., Stoll, M., Hegenbarth, J. C., Ruhle, F., Limperger, V., Junker, R., Franke, A., Hoffmann, P., Shneyder, M., Stach, M., & Nowak-Gottl, U. (2021). Single- and Multimarker Genome-Wide Scans Evidence Novel Genetic Risk Modifiers for Venous Thromboembolism. Thrombosis and Haemostasis, 121(09), 1169-1180. https://doi.org/10.1055/s-0041-1723988
    • ten Cate, H. (2021). Surviving Covid-19 with Heparin?New England Journal of Medicine, 385(9), 845-846. https://doi.org/10.1056/NEJMe2111151
    • Bruggemann, R. A. G., Alnima, T., Brouns, S. H. A., Hanssen, N. M. J., Schols, J. M. G. A., ten Cate, H., Spaetgens, B., & ten Cate-Hoek, A. J. (2021). A known unknown? Pharmacological prevention of venous thromboembolism in nursing home residents. Journal of the American Geriatrics Society. https://doi.org/10.1111/jgs.17422
    • Huckriede, J., Anderberg, S. B., Morales, A., de Vries, F., Hultstrom, M., Bergqvist, A., Ortiz-Perez, J. T., Sels, J. W., Wichapong, K., Lipcsey, M., van de Poll, M., Larsson, A., Luther, T., Reutelingsperger, C., Garcia de Frutos, P., Frithiof, R., & Nicolaes, G. A. F. (2021). Evolution of NETosis markers and DAMPs have prognostic value in critically ill COVID-19 patients. Scientific Reports, 11(1), [15701]. https://doi.org/10.1038/s41598-021-95209-x
    • Ten Cate, H., Guzik, T. J., Eikelboom, J., & Spronk, H. M. H. (2021). Pleiotropic actions of factor Xa inhibition in cardiovascular prevention - mechanistic insights and implications for anti-thrombotic treatment. Cardiovascular Research, 117(9), 2030-2044. https://doi.org/10.1093/cvr/cvaa263
    • Aarsetøy, R., Ten Cate, H., Spronk, H., Van Oerle, R., Aarsetøy, H., Staines, H., & Nilsen, D. W. T. (2021). Activated factor XI-antithrombin complex presenting as an independent predictor of 30-days mortality in out-of-hospital cardiac arrest patients. Thrombosis Research, 204, 1-8. https://doi.org/10.1016/j.thromres.2021.05.014
    • Dahlen, B., Schulz, A., Göbel, S., Tröbs, S-O., Schwuchow-Thonke, S., Spronk, H. M., Prochaska, J. H., Arnold, N., Lackner, K. J., Gori, T., Ten Cate, H., Münzel, T., Wild, P. S., & Panova-Noeva, M. (2021). The impact of platelet indices on clinical outcome in heart failure: results from the MyoVasc study. Esc heart failure, 8(4), 2991-3001. https://doi.org/10.1002/ehf2.13390
    • Martens, L., Ruehle, F., Witten, A., Meder, B., Katus, H. A., Arbustini, E., Hasenfuss, G., Sinner, M. F., Kaeaeb, S., Pankuweit, S., Angermann, C., Bornberg-Bauer, E., & Stoll, M. (2021). A genetic variant alters the secondary structure of the lncRNA H19 and is associated with dilated cardiomyopathy. Rna Biology. https://doi.org/10.1080/15476286.2021.1952756
    • Montague, S. J., Patel, P., Martin, E. M., Slater, A., Quintanilla, L. G., Perrella, G., Kardeby, C., Nagy, M., Mezzano, D., Mendes, P. M., & Watson, S. P. (2021). Platelet activation by charged ligands and nanoparticles: platelet glycoprotein receptors as pattern recognition receptors. Platelets. https://doi.org/10.1080/09537104.2021.1945571
    • Camps, E. C., van Lith, S. A. M., Frielink, C., Lankhof, J., Dijkgraaf, I., Gotthardt, M., & Brock, R. (2021). CPPs to the Test: Effects on Binding, Uptake and Biodistribution of a Tumor Targeting Nanobody. Pharmaceuticals, 14(7), [602]. https://doi.org/10.3390/ph14070602
    • Castoldi, E. (2021). F5-Atlanta: Factor V-short strikes again. Journal of Thrombosis and Haemostasis, 19(7), 1638-1640. https://doi.org/10.1111/jth.15351
    • Denisov, S. S., Ippel, J. H., Castoldi, E., Mans, B. J., Hackeng, T. M., & Dijkgraaf, I. (2021). Molecular basis of anticoagulant and anticomplement activity of the tick salivary protein Salp14 and its homologs. Journal of Biological Chemistry, 297(1), [100865]. https://doi.org/10.1016/j.jbc.2021.100865
    • Herfs, L., Swieringa, F., Jooss, N., Kozlowski, M., Heubel-Moenen, F. C. J., van Oerle, R., Machiels, P., Henskens, Y., & Heemskerk, J. W. M. (2021). Multiparameter microfluidics assay of thrombus formation reveals increased sensitivity to contraction and antiplatelet agents at physiological temperature. Thrombosis Research, 203, 46-56. https://doi.org/10.1016/j.thromres.2021.04.014
    • Liu, X., Arfman, T., Wichapong, K., Reutelingsperger, C. P. M., Voorberg, J., & Nicolaes, G. A. F. (2021). PAD4 takes charge during neutrophil activation: Impact of PAD4 mediated NET formation on immune-mediated disease. Journal of Thrombosis and Haemostasis, 19(7), 1607-1617. https://doi.org/10.1111/jth.15313
    • Dickhout, A., Kaczor, D. M., Heinzmann, A. C. A., Brouns, S. L. N., Heemskerk, J. W. M., van Zandvoort, M. A. M. J., & Koenen, R. R. (2021). Rapid Internalization and Nuclear Translocation of CCL5 and CXCL4 in Endothelial Cells. International journal of molecular sciences, 22(14), [7332]. https://doi.org/10.3390/ijms22147332
    • Maag, A., Sharma, P., Schuijt, T. J., Kopatz, W. F., Kruijswijk, D., Marquart, J. A., van Der Poll, T., Hackeng, T. M., Nicolaes, G. A. F., Meijers, J. C. M., Bos, M. H. A., & van 't Veer, C. (2021). Structure-function of anticoagulant TIX-5, the inhibitor of factor Xa-mediated FV activation. Journal of Thrombosis and Haemostasis, 19(7), 1697-1708. https://doi.org/10.1111/jth.15329
    • Hisada, Y., Moser, B., Kawano, T., Revenko, A. S., Crosby, J. R., Spronk, H. M., & Mackman, N. (2021). The Intrinsic Pathway does not Contribute to Activation of Coagulation in Mice Bearing Human Pancreatic Tumors Expressing Tissue Factor. Thrombosis and Haemostasis, 121(07), 967-970. https://doi.org/10.1055/s-0040-1722193
    • van Doorn, W. P. T. M., Foreman, Y. D., Schaper, N. C., Savelberg, H. H. C. M., Koster, A., van der Kallen, C. J. H., Wesselius, A., Schram, M. T., Henry, R. M. A., Dagnelie, P. C., de Galan, B. E., Bekers, O., Stehouwer, C. D. A., Meex, S. J. R., & Brouwers, M. C. G. J. (2021). Machine learning-based glucose prediction with use of continuous glucose and physical activity monitoring data: The Maastricht Study. PLOS ONE, 16(6), [0253125]. https://doi.org/10.1371/journal.pone.0253125
    • Baidildinova, G., Nagy, M., Jurk, K., Wild, P. S., ten Cate, H., & van der Meijden, P. E. J. (2021). Soluble Platelet Release Factors as Biomarkers for Cardiovascular Disease. Frontiers in cardiovascular medicine, 8, [684920]. https://doi.org/10.3389/fcvm.2021.684920
    • Lacy, M., Buerger, C., Shami, A., Ahmadsei, M., Winkels, H., Nitz, K., van Tiel, C. M., Seijkens, T. T. P., Kusters, P. J. H., Karshovka, E., Prange, K. H. M., Wu, Y., Brouns, S. L. N., Unterlugauer, S., Kuijpers, M. J. E., Reiche, M. E., Steffens, S., Edsfeldt, A., Megens, R. T. A., ... Lutgens, E. (2021). Cell-specific and divergent roles of the CD40L-CD40 axis in atherosclerotic vascular disease. Nature Communications, 12(1), [3754]. https://doi.org/10.1038/s41467-021-23909-z
    • Slater, A., Di, Y., Clark, J. C., Jooss, N. J., Martin, E. M., Alenazy, F., Thomas, M. R., Ariens, R. A. S., Herr, A. B., Poulter, N. S., Emsley, J., & Watson, S. P. (2021). Structural characterization of a novel GPVI-nanobody complex reveals a biologically active domain-swapped GPVI dimer. Blood, 137(24), 3443-3453. https://doi.org/10.1182/blood.2020009440
    • Dahlen, B., Mueller, F., Troebs, S-O., Heidorn, M. W., Schulz, A., Arnold, N., Hermanns, M. I., Schwuchow-Thonke, S., Prochaska, J. H., Gori, T., ten Cate, H., Lackner, K. J., Muenzel, T., Wild, P. S., & Panova-Noeva, M. (2021). Sex-Specific Relationship Between Parathyroid Hormone and Platelet Indices in Phenotypes of Heart Failure - Results From the MyoVasc Study. Frontiers in cardiovascular medicine, 8, [682521]. https://doi.org/10.3389/fcvm.2021.682521
    • Denessen, E. J. S., Van den Kerkhof, D. L., Jeurissen, M. L. J., Wetzels, R. J. H., Verhezen, P. W. M., & Henskens, Y. M. C. (2021). Determining the Optimal Storage Time and Temperature for Performing Platelet Function Assays and Global Hemostasis Assays. Platelets. https://doi.org/10.1080/09537104.2021.1934666
    • Huang, J., Swieringa, F., Solari, F. A., Provenzale, I., Grassi, L., De Simone, I., Baaten, C. C. F. M. J., Cavill, R., Sickmann, A., Frontini, M., & Heemskerk, J. W. M. (2021). Assessment of a complete and classified platelet proteome from genome-wide transcripts of human platelets and megakaryocytes covering platelet functions. Scientific Reports, 11(1), [12358]. https://doi.org/10.1038/s41598-021-91661-x
    • Cao, J., Balluff, B., Arts, M., Dubois, L. J., van Loon, L. J. C., Hackeng, T. M., van Eijk, H. M. H., Eijkel, G., Heij, L. R., Soons, Z., Olde Damink, S. W. M., & Heeren, R. M. A. (2021). Mass spectrometry imaging of L-[ring-13C6]-labeled phenylalanine and tyrosine kinetics in non-small cell lung carcinoma. Cancer & Metabolism, 9(1), [26]. https://doi.org/10.1186/s40170-021-00262-9
    • Ford, D. J., Duggan, N. M., Fry, S. E., Ripoll-Rozada, J., Agten, S. M., Liu, W., Corcilius, L., Hackeng, T. M., van Oerle, R., Spronk, H. M. H., Ashhurst, A. S., Mini Sasi, V., Kaczmarski, J. A., Jackson, C. J., Pereira, P. J. B., Passioura, T., Suga, H., & Payne, R. J. (2021). Potent Cyclic Peptide Inhibitors of FXIIa Discovered by mRNA Display with Genetic Code Reprogramming. Journal of Medicinal Chemistry, 64(11), 7853-7876. https://doi.org/10.1021/acs.jmedchem.1c00651
    • de Breet, C. P. D. M., Zwaveling, S., Vries, M. J. A., van Oerle, R. G., Henskens, Y. M. C., Van't Hof, A. W. J., van der Meijden, P. E. J., Veenstra, L., ten Cate, H., & Olie, R. H. (2021). Thrombin Generation as a Method to Identify the Risk of Bleeding in High Clinical-Risk Patients Using Dual Antiplatelet Therapy. Frontiers in cardiovascular medicine, 8, [679934]. https://doi.org/10.3389/fcvm.2021.679934
    • Notten, P., de Smet, A. A. E. A., Tick, L. W., van de Poel, M. H. W., Wikkeling, O. R. M., Vleming, L-J., Koster, A., Jie, K-S. G., Jacobs, E. M. G., Ebben, H. P., Coppens, M., ten Cate, H., Wittens, C. H. A., & ten Cate-Hoek, A. J. (2021). CAVA (Ultrasound-Accelerated Catheter-Directed Thrombolysis on Preventing Post-Thrombotic Syndrome) Trial: Long-Term Follow-Up Results. Journal of the American Heart Association, 10(11), [018973]. https://doi.org/10.1161/JAHA.120.018973
    • Wasserloos, A., Thomassen, M. C. L. G. D., Costa, S. D., Zenclussen, A., Tchaikovski, V. E., Hackeng, T. M., Stickeler, E., & Tchaikovski, S. N. (2021). Effect of blood loss during caesarean section on coagulation parameters. Thrombosis Research, 202, 84-89. https://doi.org/10.1016/j.thromres.2021.03.010
    • Iding, A. F. J., Witten, A., Isaacs, A., Castoldi, E., ten Cate, H., Stoll, M., & ten Cate-Hoek, A. J. (2021). Leukocyte gene expression in post-thrombotic syndrome. Thrombosis Research, 202, 40-42. https://doi.org/10.1016/j.thromres.2021.03.007
    • Sabrkhany, S., Kuijpers, M. J. E., Egbrink, M. G. A. O., & Griffioen, A. W. (2021). Platelets as messengers of early-stage cancer. Cancer and Metastasis Reviews, 40(2), 563-573. https://doi.org/10.1007/s10555-021-09956-4
    • Donkel, S. J., Pater, K., Leebeek, F. W. G., Dippel, D. W. J., Ten Cate, H., & de Maat, M. P. M. (2021). Thrombin generation is associated with ischemic stroke at a young age. Thrombosis Research, 202, 139-144. https://doi.org/10.1016/j.thromres.2021.03.028
    • Hulshof, A. M., Vries, M., Verhezen, P., Wetzels, R., Haartmans, M., Olie, R., Ten Cate, H., & Henskens, Y. (2021). The Influence of Prostaglandin E1 and Use of Inhibitor Percentage on the Correlation between the Multiplate and VerifyNow in Patients on Dual Antiplatelet Therapy. Platelets, 32(4), 463-468. https://doi.org/10.1080/09537104.2020.1754378
    • Zweiker, D., Manninger, M., Sieghartsleitner, R., Ebner, J., Pratl, B., Bisping, E., Lercher, P., von Lewinski, D., Riedlbauer, R., Rohrer, U., Spronk, H. M. H., Zirlik, A., Schotten, U., & Scherr, D. (2021). No antiarrhythmic effect of direct oral anticoagulants versus vitamin K antagonists in paroxysmal atrial fibrillation patients undergoing catheter ablation. International Journal of Cardiology, 331, 106-108. https://doi.org/10.1016/j.ijcard.2021.01.003
    • Ercig, B., Gomes Graca, N. A., Kangro, K., Arfman, T., Wichapong, K., Hrdinova, J., Kaijen, P., van Alphen, F., van den Biggelaar, M., Vanhoorelbeke, K., Veyradier, A., Coppo, P., Reutelingsperger, C., Nicolaes, G. A. F., Männik, A., & Voorberg, J. (2021). N-glycan mediated shielding of ADAMTS13 prevents binding of pathogenic autoantibodies in immune-mediated TTP. Blood, 137(19), 2694-2698. https://doi.org/10.1182/blood.2020007972
    • Nagy, M., Fazaeli, S., van Oerle, R., Ten Cate, H., Schemmann, M., Sherry, J., Kelleher, G., & Spronk, H. M. H. (2021). Evaluation of the analytical performance of the PC100 platelet counter. Thrombosis Journal, 19(1), [29]. https://doi.org/10.1186/s12959-021-00283-w
    • Liu, X., Wichapong, K., Lamers, S., Reutelingsperger, C. P. M., & Nicolaes, G. A. F. (2021). Autocitrullination of PAD4 does not alter its enzymatic activity: In vitro and in silico studies. International Journal of Biochemistry & Cell Biology, 134, 105938. [105938]. https://doi.org/10.1016/j.biocel.2021.105938
    • ten Cate, H. (2021). Colorectal cancer and cardiovascular disease: A thrombo-inflammatory link?European journal of internal medicine, 87, 15-17. https://doi.org/10.1016/j.ejim.2021.03.019
    • van Gorp, R. H., Dijkgraaf, I., Bröker, V., Bauwens, M., Leenders, P., Jennen, D., Dweck, M. R., Bucerius, J., Briedé, J. J., van Ryn, J., Brandenburg, V., Mottaghy, F., Spronk, H. M. H., Reutelingsperger, C. P., & Schurgers, L. J. (2021). Off-target effects of oral anticoagulants - vascular effects of vitamin K antagonist and non-vitamin K antagonist oral anticoagulant dabigatran etexilate. Journal of Thrombosis and Haemostasis, 19(5), 1348-1363. https://doi.org/10.1111/jth.15289
    • Gilbers, M. D., Bidar, E., Maesen, B., Zeemering, S., Isaacs, A., Crijns, H., van Gelder, I., Rienstra, M., Verheule, S., Maessen, J., Stoll, M., & Schotten, U. (2021). Reappraisal of Atrial fibrillation: interaction between hyperCoagulability, Electrical remodelling and Vascular destabilisation in the progression of AF (RACE V) Tissue Bank Project: study design. Netherlands Heart Journal, 29(5), 280-287. https://doi.org/10.1007/s12471-021-01538-x
    • Ninivaggi, M., de Laat-Kremers, R., Tripodi, A., Wahl, D., Zuily, S., Dargaud, Y., Cate, H. T., Ignjatovic, V., Devreese, K. M. J., & de Laat, B. (2021). Recommendations for the measurement of thrombin generation: Communication from the ISTH SSC Subcommittee on Lupus Anticoagulant/Antiphospholipid Antibodies. Journal of Thrombosis and Haemostasis, 19(5), 1372-1378. https://doi.org/10.1111/jth.15287
    • Castoldi, E., Hézard, N., Mourey, G., Wichapong, K., Poggi, M., Ibrahim-Kosta, M., Thomassen, M. C. L. G. D., Fournel, A., Hayward, C. P. M., Alessi, M-C., Hackeng, T. M., Rosing, J., & Morange, P-E. (2021). Severe thrombophilia in a factor V-deficient patient homozygous for the Ala2086Asp mutation (FV Besançon). Journal of Thrombosis and Haemostasis, 19(5), 1186-1199. https://doi.org/10.1111/jth.15274
    • van de Berg, T. W., Hulshof, A-M. M., Nagy, M., van Oerle, R., Sels, J-W., van Bussel, B., Ten Cate, H., Henskens, Y., Spronk, H. M. H., & Dutch Covid-19 and Thrombosis Coalition (2021). Suggestions for global coagulation assays for the assessment of COVID-19 associated hypercoagulability. Thrombosis Research, 201, 84-89. https://doi.org/10.1016/j.thromres.2021.02.026
    • Simioni, P., Cagnin, S., Sartorello, F., Sales, G., Pagani, L., Bulato, C., Gavasso, S., Nuzzo, F., Chemello, F., Radu, C. M., Tormene, D., Spiezia, L., Hackeng, T. M., Campello, E., & Castoldi, E. (2021). Partial F8 gene duplication (factor VIII Padua) associated with high factor VIII levels and familial thrombophilia. Blood, 137(17), 2383-2393. https://doi.org/10.1182/blood.2020008168
    • Bels, J. L. M., van Kuijk, S. M. J., Ghossein-Doha, C., Tijssen, F. H., van Gassel, R. J. J., Tas, J., Schnabel, R. M., Aries, M. J. H., van der Horst, I. C. C., Bergmans, D. C. J. J., Meex, S. J. R., van Mook, W. N. K. A., van der Horst, I. C. C., van Bussel, B. C. T., & MaastrICCht Collaborators (2021). Decreased serial scores of severe organ failure assessments are associated with survival in mechanically ventilated patients; the prospective Maastricht Intensive Care COVID cohort. Journal of Critical Care, 62, 38-45. https://doi.org/10.1016/j.jcrc.2020.11.006
    • van der Beelen, S. H. E., Agten, S. M., Suylen, D. P. L., Wichapong, K., Hrdinova, J., Mees, B. M. E., Spronk, H. M. H., & Hackeng, T. M. (2021). Design and synthesis of a multivalent catch-and-release assay to measure circulating FXIa. Thrombosis Research, 200, 16-22. https://doi.org/10.1016/j.thromres.2021.01.002
    • van den Kerkhof, D. L., van der Meijden, P. E. J., Hackeng, T. M., & Dijkgraaf, I. (2021). Exogenous Integrin αIIbβ3 Inhibitors Revisited: Past, Present and Future Applications. International journal of molecular sciences, 22(7), [3366]. https://doi.org/10.3390/ijms22073366
    • Morales, A., Rojo Rello, S., Cristobal, H., Fiz-Lopez, A., Arribas, E., Mari, M., Tutusaus, A., de la Cal-Sabater, P., Nicolaes, G. A. F., Ortiz-Perez, J. T., Bernardo, D., & Garcia de Frutos, P. (2021). Growth Arrest-Specific Factor 6 (GAS6) Is Increased in COVID-19 Patients and Predicts Clinical Outcome. Biomedicines, 9(4), [335]. https://doi.org/10.3390/biomedicines9040335
    • ten Cate, H., & Leader, A. (2021). Management of Disseminated Intravascular Coagulation in Acute Leukemias. Hämostaseologie, 41(02), 120-126. https://doi.org/10.1055/a-1393-8302
    • van Cauteren, Y. J. M., Smulders, M. W., Theunissen, R. A. L. J., Gerretsen, S. C., Adriaans, B. P., Bijvoet, G. P., Mingels, A. M. A., van Kuijk, S. M. J., Schalla, S., Crijns, H. J. G. M., Kim, R. J., Wildberger, J. E., Heijman, J., & Bekkers, S. C. A. M. (2021). Cardiovascular magnetic resonance accurately detects obstructive coronary artery disease in suspected non-ST elevation myocardial infarction: a sub-analysis of the CARMENTA Trial. Journal of Cardiovascular Magnetic Resonance, 23(1), [40]. https://doi.org/10.1186/s12968-021-00723-6